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Items: 32

1.

Correction to "Catalyst Selection Facilitates the Use of Heterocyclic Sulfinates as General Nucleophilic Coupling Partners in Palladium-Catalyzed Coupling Reactions".

Markovic T, Rocke BN, Blakemore DC, Mascitti V, Willis MC.

Org Lett. 2018 May 18;20(10):3148-3149. doi: 10.1021/acs.orglett.8b01120. Epub 2018 May 9. No abstract available.

PMID:
29741085
2.

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.

Rouet R, Thuma BA, Roy MD, Lintner NG, Rubitski DM, Finley JE, Wisniewska HM, Mendonsa R, Hirsh A, de Oñate L, Compte Barrón J, McLellan TJ, Bellenger J, Feng X, Varghese A, Chrunyk BA, Borzilleri K, Hesp KD, Zhou K, Ma N, Tu M, Dullea R, McClure KF, Wilson RC, Liras S, Mascitti V, Doudna JA.

J Am Chem Soc. 2018 May 30;140(21):6596-6603. doi: 10.1021/jacs.8b01551. Epub 2018 May 18.

3.

Catalyst Selection Facilitates the Use of Heterocyclic Sulfinates as General Nucleophilic Coupling Partners in Palladium-Catalyzed Coupling Reactions.

Markovic T, Rocke BN, Blakemore DC, Mascitti V, Willis MC.

Org Lett. 2017 Nov 17;19(22):6033-6035. doi: 10.1021/acs.orglett.7b02944. Epub 2017 Oct 18. Erratum in: Org Lett. 2018 May 18;20(10 ):3148-3149.

PMID:
29043813
4.

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides.

Markovic T, Rocke BN, Blakemore DC, Mascitti V, Willis MC.

Chem Sci. 2017 Jun 1;8(6):4437-4442. doi: 10.1039/c7sc00675f. Epub 2017 Apr 28.

5.

C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation.

Tran G, Confair D, Hesp KD, Mascitti V, Ellman JA.

J Org Chem. 2017 Sep 1;82(17):9243-9252. doi: 10.1021/acs.joc.7b01723. Epub 2017 Aug 22.

6.

Base-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C-H ortho-Alkylation of Azines without Preactivation.

Tran G, Hesp KD, Mascitti V, Ellman JA.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5899-5903. doi: 10.1002/anie.201702409. Epub 2017 Apr 21.

7.

Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.

Sanhueza CA, Baksh MM, Thuma B, Roy MD, Dutta S, Préville C, Chrunyk BA, Beaumont K, Dullea R, Ammirati M, Liu S, Gebhard D, Finley JE, Salatto CT, King-Ahmad A, Stock I, Atkinson K, Reidich B, Lin W, Kumar R, Tu M, Menhaji-Klotz E, Price DA, Liras S, Finn MG, Mascitti V.

J Am Chem Soc. 2017 Mar 8;139(9):3528-3536. doi: 10.1021/jacs.6b12964. Epub 2017 Feb 23.

PMID:
28230359
8.

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers.

Zhang QW, Brusoe AT, Mascitti V, Hesp KD, Blakemore DC, Kohrt JT, Hartwig JF.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9758-62. doi: 10.1002/anie.201604793. Epub 2016 Jul 7.

PMID:
27384710
9.

One-Step Synthesis of Sulfonamides from N-Tosylhydrazones.

Tsai AS, Curto JM, Rocke BN, Dechert-Schmitt AM, Ingle GK, Mascitti V.

Org Lett. 2016 Feb 5;18(3):508-11. doi: 10.1021/acs.orglett.5b03545. Epub 2016 Jan 15.

PMID:
26771228
10.

Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite.

Shavnya A, Hesp KD, Mascitti V, Smith AC.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13571-5. doi: 10.1002/anie.201505918. Epub 2015 Sep 18.

PMID:
26383866
11.

Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.

Hoang HN, Song K, Hill TA, Derksen DR, Edmonds DJ, Kok WM, Limberakis C, Liras S, Loria PM, Mascitti V, Mathiowetz AM, Mitchell JM, Piotrowski DW, Price DA, Stanton RV, Suen JY, Withka JM, Griffith DA, Fairlie DP.

J Med Chem. 2015 May 14;58(9):4080-5. doi: 10.1021/acs.jmedchem.5b00166. Epub 2015 Apr 16.

PMID:
25839426
12.

Application of fundamental organometallic chemistry to the development of a gold-catalyzed synthesis of sulfinate derivatives.

Johnson MW, Bagley SW, Mankad NP, Bergman RG, Mascitti V, Toste FD.

Angew Chem Int Ed Engl. 2014 Apr 22;53(17):4404-7. doi: 10.1002/anie.201400037. Epub 2014 Mar 20.

13.

Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides.

Rocke BN, Bahnck KB, Herr M, Lavergne S, Mascitti V, Perreault C, Polivkova J, Shavnya A.

Org Lett. 2014 Jan 3;16(1):154-7. doi: 10.1021/ol4031233. Epub 2013 Dec 5.

PMID:
24308287
14.

Palladium-catalyzed sulfination of aryl and heteroaryl halides: direct access to sulfones and sulfonamides.

Shavnya A, Coffey SB, Smith AC, Mascitti V.

Org Lett. 2013 Dec 20;15(24):6226-9. doi: 10.1021/ol403072r. Epub 2013 Nov 20.

PMID:
24256546
15.

Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.

Darout E, Robinson RP, McClure KF, Corbett M, Li B, Shavnya A, Andrews MP, Jones CS, Li Q, Minich ML, Mascitti V, Guimarães CR, Munchhof MJ, Bahnck KB, Cai C, Price DA, Liras S, Bonin PD, Cornelius P, Wang R, Bagdasarian V, Sobota CP, Hornby S, Masterson VM, Joseph RM, Kalgutkar AS, Chen Y.

J Med Chem. 2013 Jan 10;56(1):301-19. doi: 10.1021/jm301626p. Epub 2012 Dec 31.

PMID:
23234271
16.

From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.

Futatsugi K, Mascitti V, Guimarães CR, Morishita N, Cai C, DeNinno MP, Gao H, Hamilton MD, Hank R, Harris AR, Kung DW, Lavergne SY, Lefker BA, Lopaze MG, McClure KF, Munchhof MJ, Preville C, Robinson RP, Wright SW, Bonin PD, Cornelius P, Chen Y, Kalgutkar AS.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):194-7. doi: 10.1016/j.bmcl.2012.10.119. Epub 2012 Nov 5.

PMID:
23177788
17.

Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects.

Miao Z, Nucci G, Amin N, Sharma R, Mascitti V, Tugnait M, Vaz AD, Callegari E, Kalgutkar AS.

Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551. Epub 2012 Nov 20.

PMID:
23169609
18.

Glycomimetic ligands for the human asialoglycoprotein receptor.

Mamidyala SK, Dutta S, Chrunyk BA, Préville C, Wang H, Withka JM, McColl A, Subashi TA, Hawrylik SJ, Griffor MC, Kim S, Pfefferkorn JA, Price DA, Menhaji-Klotz E, Mascitti V, Finn MG.

J Am Chem Soc. 2012 Feb 1;134(4):1978-81. doi: 10.1021/ja2104679. Epub 2012 Jan 24.

PMID:
22280495
19.

Pharmacodynamic model of sodium-glucose transporter 2 (SGLT2) inhibition: implications for quantitative translational pharmacology.

Maurer TS, Ghosh A, Haddish-Berhane N, Sawant-Basak A, Boustany-Kari CM, She L, Leininger MT, Zhu T, Tugnait M, Yang X, Kimoto E, Mascitti V, Robinson RP.

AAPS J. 2011 Dec;13(4):576-84. doi: 10.1208/s12248-011-9297-2. Epub 2011 Aug 26.

20.

Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus.

Kalgutkar AS, Tugnait M, Zhu T, Kimoto E, Miao Z, Mascitti V, Yang X, Tan B, Walsky RL, Chupka J, Feng B, Robinson RP.

Drug Metab Dispos. 2011 Sep;39(9):1609-19. doi: 10.1124/dmd.111.040675. Epub 2011 Jun 20.

PMID:
21690265
21.

Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors.

Mascitti V, Maurer TS, Robinson RP, Bian J, Boustany-Kari CM, Brandt T, Collman BM, Kalgutkar AS, Klenotic MK, Leininger MT, Lowe A, Maguire RJ, Masterson VM, Miao Z, Mukaiyama E, Patel JD, Pettersen JC, Préville C, Samas B, She L, Sobol Z, Steppan CM, Stevens BD, Thuma BA, Tugnait M, Zeng D, Zhu T.

J Med Chem. 2011 Apr 28;54(8):2952-60. doi: 10.1021/jm200049r. Epub 2011 Mar 30.

PMID:
21449606
22.

Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response.

McClure KF, Darout E, Guimarães CR, DeNinno MP, Mascitti V, Munchhof MJ, Robinson RP, Kohrt J, Harris AR, Moore DE, Li B, Samp L, Lefker BA, Futatsugi K, Kung D, Bonin PD, Cornelius P, Wang R, Salter E, Hornby S, Kalgutkar AS, Chen Y.

J Med Chem. 2011 Mar 24;54(6):1948-52. doi: 10.1021/jm200003p. Epub 2011 Mar 1.

PMID:
21361292
23.

Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.

Mascitti V, Stevens BD, Choi C, McClure KF, Guimarães CR, Farley KA, Munchhof MJ, Robinson RP, Futatsugi K, Lavergne SY, Lefker BA, Cornelius P, Bonin PD, Kalgutkar AS, Sharma R, Chen Y.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1306-9. doi: 10.1016/j.bmcl.2011.01.088. Epub 2011 Jan 25.

PMID:
21310611
24.

Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro.

Kalgutkar AS, Mascitti V, Sharma R, Walker GW, Ryder T, McDonald TS, Chen Y, Preville C, Basak A, McClure KF, Kohrt JT, Robinson RP, Munchhof MJ, Cornelius P.

Chem Res Toxicol. 2011 Feb 18;24(2):269-78. doi: 10.1021/tx100429x. Epub 2011 Feb 3.

PMID:
21288051
25.

Stereoselective synthesis of a dioxa-bicyclo[3.2.1]octane SGLT2 inhibitor.

Mascitti V, Préville C.

Org Lett. 2010 Jul 2;12(13):2940-3. doi: 10.1021/ol100940w.

PMID:
20527898
26.

C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization.

Robinson RP, Mascitti V, Boustany-Kari CM, Carr CL, Foley PM, Kimoto E, Leininger MT, Lowe A, Klenotic MK, Macdonald JI, Maguire RJ, Masterson VM, Maurer TS, Miao Z, Patel JD, Préville C, Reese MR, She L, Steppan CM, Thuma BA, Zhu T.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1569-72. doi: 10.1016/j.bmcl.2010.01.075. Epub 2010 Jan 21.

PMID:
20149653
27.

2-[4-Chloro-3-(4-ethoxy-benz-yl)phen-yl]-1,3-dithiane.

Samas B, Préville C, Thuma BA, Mascitti V.

Acta Crystallogr Sect E Struct Rep Online. 2010 May 19;66(Pt 6):o1386. doi: 10.1107/S1600536810017393.

28.

Enantioselective synthesis of pentacycloanammoxic acid.

Mascitti V, Corey EJ.

J Am Chem Soc. 2006 Mar 15;128(10):3118-9.

PMID:
16522072
29.

Total synthesis of (+/-)-pentacycloanammoxic acid.

Mascitti V, Corey EJ.

J Am Chem Soc. 2004 Dec 8;126(48):15664-5.

PMID:
15571387
30.

Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates.

Hanessian S, Mascitti V, Giroux S.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):11996-2001. Epub 2004 Jun 21.

31.

Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate.

Hanessian S, Yang Y, Giroux S, Mascitti V, Ma J, Raeppel F.

J Am Chem Soc. 2003 Nov 12;125(45):13784-92.

PMID:
14599218
32.

Synthesis of a potent antagonist of E-selectin.

Hanessian S, Mascitti V, Rogel O.

J Org Chem. 2002 May 17;67(10):3346-54.

PMID:
12003545

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