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Items: 47

1.

Synthesis of New GABAA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold.

Guerrini G, Vergelli C, Cantini N, Giovannoni MP, Daniele S, Mascia MP, Martini C, Crocetti L.

Int J Mol Sci. 2019 Mar 21;20(6). pii: E1438. doi: 10.3390/ijms20061438.

2.

Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.

Cappelli A, Anzini M, Castriconi F, Grisci G, Paolino M, Braile C, Valenti S, Giuliani G, Vomero S, Di Capua A, Betti L, Giannaccini G, Lucacchini A, Ghelardini C, Di Cesare Mannelli L, Frosini M, Ricci L, Giorgi G, Mascia MP, Biggio G.

J Med Chem. 2016 Apr 14;59(7):3353-72. doi: 10.1021/acs.jmedchem.6b00034. Epub 2016 Mar 24.

PMID:
26982523
3.

Differential modulation of GABA(A) receptor function by aryl pyrazoles.

Mascia MP, Ledda G, Orrù A, Marongiu A, Loriga G, Maciocco E, Biggio G, Ruiu S.

Eur J Pharmacol. 2014 Jun 15;733:1-6. doi: 10.1016/j.ejphar.2014.03.039. Epub 2014 Apr 1.

PMID:
24704372
4.

Withania somnifera root extract prolongs analgesia and suppresses hyperalgesia in mice treated with morphine.

Orrù A, Marchese G, Casu G, Casu MA, Kasture S, Cottiglia F, Acquas E, Mascia MP, Anzani N, Ruiu S.

Phytomedicine. 2014 Apr 15;21(5):745-52. doi: 10.1016/j.phymed.2013.10.021. Epub 2013 Nov 20.

PMID:
24268297
5.

New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.

Anzini M, Valenti S, Braile C, Cappelli A, Vomero S, Alcaro S, Ortuso F, Marinelli L, Limongelli V, Novellino E, Betti L, Giannaccini G, Lucacchini A, Daniele S, Martini C, Ghelardini C, Di Cesare Mannelli L, Giorgi G, Mascia MP, Biggio G.

J Med Chem. 2011 Aug 25;54(16):5694-711. doi: 10.1021/jm2001597. Epub 2011 Jul 27.

PMID:
21751815
6.

Voluntary Ethanol Consumption Induced by Social Isolation Reverses the Increase of α(4)/δ GABA(A) Receptor Gene Expression and Function in the Hippocampus of C57BL/6J Mice.

Sanna E, Talani G, Obili N, Mascia MP, Mostallino MC, Secci PP, Pisu MG, Biggio F, Utzeri C, Olla P, Biggio G, Follesa P.

Front Neurosci. 2011 Feb 10;5:15. doi: 10.3389/fnins.2011.00015. eCollection 2011.

7.

Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes.

Mascia MP, Bachis E, Obili N, Maciocco E, Cocco GA, Sechi GP, Biggio G.

Eur J Pharmacol. 2007 Mar 8;558(1-3):37-42. Epub 2006 Dec 12.

PMID:
17234181
8.

Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.

Mascia MP, Asproni B, Busonero F, Talani G, Maciocco E, Pau A, Cerri R, Sanna E, Biggio G.

Eur J Pharmacol. 2005 Jun 15;516(3):204-11.

PMID:
15967425
9.

Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity.

Ferlin MG, Chiarelotto G, Dall'Acqua S, Maciocco E, Mascia MP, Pisu MG, Biggio G.

Bioorg Med Chem. 2005 May 16;13(10):3531-41.

PMID:
15848766
10.
11.

Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons.

Mostallino MC, Mascia MP, Pisu MG, Busonero F, Talani G, Biggio G.

Eur J Pharmacol. 2004 Jun 28;494(2-3):83-90.

PMID:
15212961
12.

Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics.

Lobo IA, Mascia MP, Trudell JR, Harris RA.

J Biol Chem. 2004 Aug 6;279(32):33919-27. Epub 2004 May 28.

13.

High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-ones.

Carotti A, Altomare C, Savini L, Chiasserini L, Pellerano C, Mascia MP, Maciocco E, Busonero F, Mameli M, Biggio G, Sanna E.

Bioorg Med Chem. 2003 Nov 17;11(23):5259-72.

PMID:
14604690
14.

Gamma-hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells.

Follesa P, Mancuso L, Biggio F, Mostallino MC, Manca A, Mascia MP, Busonero F, Talani G, Sanna E, Biggio G.

Mol Pharmacol. 2003 Apr;63(4):896-907.

PMID:
12644591
15.

Synthesis and biological evaluation of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines as new ligands of central and peripheral benzodiazepine receptors.

Campagna F, Palluotto F, Mascia MP, Maciocco E, Marra C, Carotti A, Carrieri A.

Farmaco. 2003 Feb;58(2):129-40.

PMID:
12581779
16.

Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebellar granule cells.

Mascia MP, Biggio F, Mancuso L, Cabras S, Cocco PL, Gorini G, Manca A, Marra C, Purdy RH, Follesa P, Biggio G.

J Pharmacol Exp Ther. 2002 Dec;303(3):1014-20.

PMID:
12438522
17.

Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice.

Findlay GS, Wick MJ, Mascia MP, Wallace D, Miller GW, Harris RA, Blednov YA.

J Pharmacol Exp Ther. 2002 Feb;300(2):526-34.

PMID:
11805213
18.

Does acetaldehyde mediate ethanol action in the central nervous system?

Mascia MP, Maiya R, Borghese CM, Lobo IA, Hara K, Yamakura T, Gong DH, Beckstead MJ.

Alcohol Clin Exp Res. 2001 Nov;25(11):1570-5.

PMID:
11707631
19.

Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior.

Ueno S, Harris RA, Messing RO, Sanchez-Perez AM, Hodge CW, McMahon T, Wang D, Mehmert KK, Kelley SP, Haywood A, Olive MF, Buck KJ, Hood HM, Blednov Y, Findlay G, Mascia MP.

Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):76S-81S. Review.

PMID:
11391054
20.

The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis.

Zhang Y, Trudell JR, Mascia MP, Laster MJ, Gong DH, Harris RA, Eger EI 2nd.

Anesth Analg. 2000 Nov;91(5):1294-9.

PMID:
11049925
21.
22.

Behavioural changes produced by transgenic overexpression of gamma2L and gamma2S subunits of the GABAA receptor.

Wick MJ, Radcliffe RA, Bowers BJ, Mascia MP, Lüscher B, Harris RA, Wehner JM.

Eur J Neurosci. 2000 Jul;12(7):2634-8.

PMID:
10947837
23.

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.

Mascia MP, Trudell JR, Harris RA.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9305-10.

24.

Enhancement of glycine receptor function by ethanol: role of phosphorylation.

Mascia MP, Wick MJ, Martinez LD, Harris RA.

Br J Pharmacol. 1998 Sep;125(2):263-70.

25.

Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

Wick MJ, Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL, Harris RA.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6504-9.

26.

Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267.

Ye Q, Koltchine VV, Mihic SJ, Mascia MP, Wick MJ, Finn SE, Harrison NL, Harris RA.

J Biol Chem. 1998 Feb 6;273(6):3314-9.

27.

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL.

Nature. 1997 Sep 25;389(6649):385-9.

PMID:
9311780
28.

Glycine receptors from long-sleep and short-sleep mice: genetic differences in drug sensitivity.

Mascia MP, Bleck VG, Harris RA.

Brain Res Mol Brain Res. 1997 Apr;45(1):169-72.

PMID:
9105687
29.

Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics.

Mascia MP, Machu TK, Harris RA.

Br J Pharmacol. 1996 Dec;119(7):1331-6.

30.

A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.

Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR, Harris RA.

Mol Pharmacol. 1996 Aug;50(2):402-6.

PMID:
8700149
31.

Chronic ethanol intoxication enhances [3H]CCPA binding and does not reduce A1 adenosine receptor function in rat cerebellum.

Concas A, Mascia MP, Cuccheddu T, Floris S, Mostallino MC, Perra C, Satta S, Biggio G.

Pharmacol Biochem Behav. 1996 Feb;53(2):249-55.

PMID:
8808128
32.

GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.

Klein RL, Mascia MP, Whiting PJ, Harris RA.

Alcohol Clin Exp Res. 1995 Oct;19(5):1338-44.

PMID:
8561312
33.

Regulation of allosteric coupling and function of stably expressed gamma-aminobutyric acid (GABA)A receptors by chronic treatment with GABAA and benzodiazepine agonists.

Klein RL, Mascia MP, Harkness PC, Hadingham KL, Whiting PJ, Harris RA.

J Pharmacol Exp Ther. 1995 Sep;274(3):1484-92.

PMID:
7562525
34.

Actions of the general anesthetic propofol on recombinant human GABAA receptors: influence of receptor subunits.

Sanna E, Mascia MP, Klein RL, Whiting PJ, Biggio G, Harris RA.

J Pharmacol Exp Ther. 1995 Jul;274(1):353-60.

PMID:
7616420
35.

Ethanol increases GABAA responses in cells stably transfected with receptor subunits.

Harris RA, Proctor WR, McQuilkin SJ, Klein RL, Mascia MP, Whatley V, Whiting PJ, Dunwiddie TV.

Alcohol Clin Exp Res. 1995 Feb;19(1):226-32.

PMID:
7771653
36.

2-Chloro-N6-cyclopentyladenosine (CCPA), an adenosine A1 receptor agonist, suppresses ethanol withdrawal syndrome in rats.

Concas A, Cuccheddu T, Floris S, Mascia MP, Biggio G.

Alcohol Alcohol. 1994 May;29(3):261-4.

PMID:
7945566
37.

Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex.

Concas A, Santoro G, Mascia MP, Maciocco E, Dazzi L, Biggio G.

Eur J Pharmacol. 1994 Apr 15;267(2):207-13.

PMID:
8050480
38.

Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.

Concas A, Santoro G, Mascia MP, Maciocco E, Dazzi L, Ongini E, Biggio G.

J Pharmacol Exp Ther. 1993 Nov;267(2):844-51.

PMID:
8246158
39.

Carbon dioxide inhalation, stress and anxiogenic drugs reduce the function of GABAA receptor complex in the rat brain.

Concas A, Sanna E, Cuccheddu T, Mascia MP, Santoro G, Maciocco E, Biggio G.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Jul;17(4):651-61.

PMID:
7689736
40.

The general anesthetic propofol: a biochemical tool to study the function of the GABA-coupled chloride channel.

Concas A, Santoro G, Mascia MP, Maciocco E, Biggio G.

Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:685A-686A. No abstract available.

PMID:
1379880
41.

Involvement of GABA-dependent chloride channel in the action of anticonvulsant and convulsant drugs.

Concas A, Serra M, Sanna E, Pepitoni S, Mascia MP, Biggio G.

Epilepsy Res Suppl. 1992;8:77-85. No abstract available.

PMID:
1329830
42.

The action of the general anesthetic propofol on GABAA receptors.

Concas A, Santoro G, Mascia MP, Serra M, Sanna E, Biggio G.

Adv Biochem Psychopharmacol. 1992;47:349-63. Review. No abstract available.

PMID:
1324582
43.

"In vivo" administration of valproate decreases t-[35S]butylbicyclophosphorothionate binding in the rat brain.

Concas A, Mascia MP, Sanna E, Santoro G, Serra M, Biggio G.

Naunyn Schmiedebergs Arch Pharmacol. 1991 Mar;343(3):296-300.

PMID:
1650919
44.

The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex.

Concas A, Santoro G, Mascia MP, Serra M, Sanna E, Biggio G.

J Neurochem. 1990 Dec;55(6):2135-8.

PMID:
2172469
45.
46.

"Ex vivo" binding of 35S-TBPS as a tool to study the pharmacology of GABAA receptors.

Concas A, Sanna E, Serra M, Mascia MP, Santoro V, Biggio G.

Adv Biochem Psychopharmacol. 1990;46:89-108. No abstract available.

PMID:
1963271
47.

[Statistical analysis of hospitalization for stroke in an internal medicine unit].

Dessì G, Usai N, Loi P, Montaldo C, Mastio F, Mascia MP, Pilleri L.

Recenti Prog Med. 1987 Sep;78(9):384-9. Italian. No abstract available.

PMID:
3423408

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