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Items: 1 to 50 of 53

1.

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.

Bery N, Legg S, Debreczeni J, Breed J, Embrey K, Stubbs C, Kolasinska-Zwierz P, Barrett N, Marwood R, Watson J, Tart J, Overman R, Miller A, Phillips C, Minter R, Rabbitts TH.

Nat Commun. 2019 Jun 13;10(1):2607. doi: 10.1038/s41467-019-10419-2.

2.

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.

Guillard S, Kolasinska-Zwierz P, Debreczeni J, Breed J, Zhang J, Bery N, Marwood R, Tart J, Overman R, Stocki P, Mistry B, Phillips C, Rabbitts T, Jackson R, Minter R.

Nat Commun. 2017 Jul 14;8:16111. doi: 10.1038/ncomms16111.

3.

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.

Harper J, Lloyd C, Dimasi N, Toader D, Marwood R, Lewis L, Bannister D, Jovanovic J, Fleming R, D'Hooge F, Mao S, Marrero AM, Korade M 3rd, Strout P, Xu L, Chen C, Wetzel L, Breen S, van Vlerken-Ysla L, Jalla S, Rebelatto M, Zhong H, Hurt EM, Hinrichs MJ, Huang K, Howard PW, Tice DA, Hollingsworth RE, Herbst R, Kamal A.

Mol Cancer Ther. 2017 Aug;16(8):1576-1587. doi: 10.1158/1535-7163.MCT-16-0825. Epub 2017 May 18.

4.

The effect of foetal bovine serum supplementation upon the lactate dehydrogenase cytotoxicity assay: Important considerations for in vitro toxicity analysis.

Thomas MG, Marwood RM, Parsons AE, Parsons RB.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):300-8. doi: 10.1016/j.tiv.2015.10.007. Epub 2015 Oct 21.

PMID:
26498060
5.

Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1.

Douthwaite JA, Sridharan S, Huntington C, Hammersley J, Marwood R, Hakulinen JK, Ek M, Sjögren T, Rider D, Privezentzev C, Seaman JC, Cariuk P, Knights V, Young J, Wilkinson T, Sleeman M, Finch DK, Lowe DC, Vaughan TJ.

MAbs. 2015;7(1):152-66. doi: 10.4161/19420862.2014.985158.

6.

An unusual cause of delayed postpartum haemorrhage following caesarean section.

Samad S, Jonetzko P, Hawkins AP, Booth J, Thorpe-Beeston G, Marwood R.

Emerg Med J. 2009 Aug;26(8):621-2. doi: 10.1136/emj.2008.066407.

PMID:
19625573
7.

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.

Elliott JM, Carling RW, Chambers M, Chicchi GG, Hutson PH, Jones AB, MacLeod A, Marwood R, Meneses-Lorente G, Mezzogori E, Murray F, Rigby M, Royo I, Russell MG, Sohal B, Tsao KL, Williams B.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5748-51. Epub 2006 Sep 6.

PMID:
16950620
8.

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.

Elliott JM, Carling RW, Chicchi GG, Crawforth J, Hutson PH, Jones AB, Kelly S, Marwood R, Meneses-Lorente G, Mezzogori E, Murray F, Rigby M, Royo I, Russell MG, Shaw D, Sohal B, Tsao KL, Williams B.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5752-6. Epub 2006 Sep 6.

PMID:
16950617
9.

Synthesis of glucopyranoside-based ligands for D-myo-inositol 1,4,5-trisphosphate receptors.

Riley AM, Jenkins DJ, Marwood RD, Potter BV.

Carbohydr Res. 2002 Jun 12;337(12):1067-82.

PMID:
12062522
10.

4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.

Fletcher SR, Burkamp F, Blurton P, Cheng SK, Clarkson R, O'Connor D, Spinks D, Tudge M, van Niel MB, Patel S, Chapman K, Marwood R, Shepheard S, Bentley G, Cook GP, Bristow LJ, Castro JL, Hutson PH, MacLeod AM.

J Med Chem. 2002 Jan 17;45(2):492-503.

PMID:
11784153
11.

Total synthesis of nucleobase-modified adenophostin A mimics.

Shuto S, Horne G, Marwood RD, Potter BV.

Chemistry. 2001 Nov 19;7(22):4937-46.

PMID:
11763462
12.

Xylopyranoside-based agonists of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and effect of stereochemistry on biological activity.

Rosenberg HJ, Riley AM, Marwood RD, Correa V, Taylor CW, Potter BVL.

Carbohydr Res. 2001 May 8;332(1):53-66.

PMID:
11403088
13.

3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.

Rowley M, Hallett DJ, Goodacre S, Moyes C, Crawforth J, Sparey TJ, Patel S, Marwood R, Patel S, Thomas S, Hitzel L, O'Connor D, Szeto N, Castro JL, Hutson PH, MacLeod AM.

J Med Chem. 2001 May 10;44(10):1603-14.

PMID:
11334570
14.

Structural determinants of adenophostin A activity at inositol trisphosphate receptors.

Correa V, Riley AM, Shuto S, Horne G, Nerou EP, Marwood RD, Potter BV, Taylor CW.

Mol Pharmacol. 2001 May;59(5):1206-15.

PMID:
11306705
15.

3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists.

Crawforth J, Goodacre S, Maxey R, Bourrain S, Patel S, Marwood R, O'Connor D, Herbert R, Hutson P, Rowley M.

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3.

PMID:
11133072
16.

2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor.

Stevenson GI, Smith AL, Lewis S, Michie SG, Neduvelil JG, Patel S, Marwood R, Patel S, Castro JL.

Bioorg Med Chem Lett. 2000 Dec 18;10(24):2697-9.

PMID:
11133071
17.

Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy.

Marwood RD, Jenkins DJ, Correa V, Taylor CW, Potter BV.

J Med Chem. 2000 Nov 2;43(22):4278-87.

PMID:
11063623
18.

Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.

Felemez M, Marwood RD, Potter BV, Spiess B.

Biochem Biophys Res Commun. 1999 Dec 20;266(2):334-40.

PMID:
10600504
19.

A multidisciplinary vulva clinic: the role of genito-urinary medicine.

Sullivan AK, Straughair GJ, Marwood RP, Staughton RC, Barton SE.

J Eur Acad Dermatol Venereol. 1999 Jul;13(1):36-40.

PMID:
10565628
20.

1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.

Carling RW, Moore KW, Moyes CR, Jones EA, Bonner K, Emms F, Marwood R, Patel S, Patel S, Fletcher AE, Beer M, Sohal B, Pike A, Leeson PD.

J Med Chem. 1999 Jul 15;42(14):2706-15.

PMID:
10411491
21.

4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.

Moore KW, Bonner K, Jones EA, Emms F, Leeson PD, Marwood R, Patel S, Patel S, Rowley M, Thomas S, Carling RW.

Bioorg Med Chem Lett. 1999 May 3;9(9):1285-90.

PMID:
10340615
22.

Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate.

Marwood RD, Riley AM, Correa V, Taylor CW, Potter BV.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):453-8.

PMID:
10091701
23.

Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor.

Bourrain S, Collins I, Neduvelil JG, Rowley M, Leeson PD, Patel S, Patel S, Emms F, Marwood R, Chapman KL, Fletcher AE, Showell GA.

Bioorg Med Chem. 1998 Oct;6(10):1731-43.

PMID:
9839003
24.

3-(1-piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels.

Collins I, Rowley M, Davey WB, Emms F, Marwood R, Patel S, Patel S, Fletcher A, Ragan IC, Leeson PD, Scott AL, Broten T.

Bioorg Med Chem. 1998 Jun;6(6):743-53. Erratum in: Bioorg Med Chem 1998 Sep;6(9):1655.

PMID:
9681140
25.

Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors.

Showell GA, Emms F, Marwood R, O'Connor D, Patel S, Leeson PD.

Bioorg Med Chem. 1998 Jan;6(1):1-8.

PMID:
9502100
26.

Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.

Patel S, Freedman S, Chapman KL, Emms F, Fletcher AE, Knowles M, Marwood R, Mcallister G, Myers J, Curtis N, Kulagowski JJ, Leeson PD, Ridgill M, Graham M, Matheson S, Rathbone D, Watt AP, Bristow LJ, Rupniak NM, Baskin E, Lynch JJ, Ragan CI.

J Pharmacol Exp Ther. 1997 Nov;283(2):636-47.

PMID:
9353380
27.

Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.

Marchant JS, Beecroft MD, Riley AM, Jenkins DJ, Marwood RD, Taylor CW, Potter BV.

Biochemistry. 1997 Oct 21;36(42):12780-90.

PMID:
9335535
28.

4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.

Rowley M, Collins I, Broughton HB, Davey WB, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Ball R, Leeson PD.

J Med Chem. 1997 Jul 18;40(15):2374-85.

PMID:
9240352
29.

Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor.

Patel S, Patel S, Marwood R, Emms F, Marston D, Leeson PD, Curtis NR, Kulagowski JJ, Freedman SB.

Mol Pharmacol. 1996 Dec;50(6):1658-64.

PMID:
8967990
30.

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

Rowley M, Broughton HB, Collins I, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Leeson PD.

J Med Chem. 1996 May 10;39(10):1943-5. No abstract available.

PMID:
8642551
31.

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, Patel S, Ragan CI, Leeson PD.

J Med Chem. 1996 May 10;39(10):1941-2. No abstract available.

PMID:
8642550
32.

Functional coupling of human D2, D3, and D4 dopamine receptors in HEK293 cells.

McAllister G, Knowles MR, Ward-Booth SM, Sinclair HA, Patel S, Marwood R, Emms F, Patel S, Smith A, Seabrook GR, et al.

J Recept Signal Transduct Res. 1995 Jan-Mar;15(1-4):267-81.

PMID:
8903944
33.

Antinociceptive and toxic effects of (+)-epibatidine oxalate attributable to nicotinic agonist activity.

Rupniak NM, Patel S, Marwood R, Webb J, Traynor JR, Elliott J, Freedman SB, Fletcher SR, Hill RG.

Br J Pharmacol. 1994 Dec;113(4):1487-93.

34.

Expression and pharmacological characterization of the human D3 dopamine receptor.

Freedman SB, Patel S, Marwood R, Emms F, Seabrook GR, Knowles MR, McAllister G.

J Pharmacol Exp Ther. 1994 Jan;268(1):417-26.

PMID:
8301582
35.

Psychiatric morbidity in women attending a clinic for vulval problems--is there a higher rate in vulvodynia?

Jadresic D, Barton S, Neill S, Staughton R, Marwood R.

Int J STD AIDS. 1993 Jul-Aug;4(4):237-9.

PMID:
8399507
36.

Characterisation of a chimeric hD3/D2 dopamine receptor expressed in CHO cells.

McAllister G, Knowles MR, Patel S, Marwood R, Emms F, Seabrook GR, Graziano M, Borkowski D, Hey PJ, Freedman SB.

FEBS Lett. 1993 Jun 7;324(1):81-6.

37.

Stable expression of human D3 dopamine receptors in GH4C1 pituitary cells.

Seabrook GR, Patel S, Marwood R, Emms F, Knowles MR, Freedman SB, McAllister G.

FEBS Lett. 1992 Nov 9;312(2-3):123-6.

38.

Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.

Street LJ, Baker R, Book T, Reeve AJ, Saunders J, Willson T, Marwood RS, Patel S, Freedman SB.

J Med Chem. 1992 Jan 24;35(2):295-305.

PMID:
1732546
39.

A maternal death caused by AIDS. Case report.

Kell PD, Barton SE, Smith DE, Nelson M, Marwood RP, Gazzard B.

Br J Obstet Gynaecol. 1991 Jul;98(7):725-7.

PMID:
1883802
40.

The clinical presentation of women with human immunodeficiency virus infection.

Kell PD, Barton SE, Hawkins DA, Marwood R, Howard LC.

Br J Obstet Gynaecol. 1991 Jan;98(1):103-4. No abstract available.

PMID:
1998618
41.

Recurrent pulmonary embolism in pregnancy managed with the Greenfield vena caval filter.

Banfield PJ, Pittam M, Marwood R.

Int J Gynaecol Obstet. 1990 Nov;33(3):275-8.

PMID:
1977649
42.

In vivo characterisation of novel efficacious muscarinic receptor agonists.

Freedman SB, Harley EA, Marwood RS, Patel S.

Eur J Pharmacol. 1990 Oct 9;187(2):193-9.

PMID:
2272360
43.

HIV infection and pregnancy.

Marwood RP.

Br J Hosp Med. 1990 Apr;43(4):287-9.

PMID:
2346825
44.

Transmission of human immunodeficiency virus by heterosexual contact with reference to antenatal screening.

Howard LC, Hawkins DA, Marwood R, Shanson DC, Gazzard BG.

Br J Obstet Gynaecol. 1989 Feb;96(2):135-9.

PMID:
2930736
45.

AIDS--a conspiracy of misinformation?

Marwood RP.

Br J Hosp Med. 1987 Feb;37(2):99. No abstract available.

PMID:
3828641
46.

The effect of intrapartum chemoprophylaxis on the vertical transmission of group B streptococci.

Easmon CS, Hastings MJ, Deeley J, Bloxham B, Rivers RP, Marwood R.

Br J Obstet Gynaecol. 1983 Jul;90(7):633-5.

PMID:
6347246
47.

Epidemiology of group B streptococci: one year's experience in an obstetric and special care baby unit.

Easmon CS, Hastings MJ, Blowers A, Bloxham B, Deeley J, Marwood R, Rivers RP, Stringer J.

Br J Obstet Gynaecol. 1983 Mar;90(3):241-6.

PMID:
6338902
48.

Fraser syndrome presenting as bilateral renal agenesis in three sibs.

Burn J, Marwood RP.

J Med Genet. 1982 Oct;19(5):360-1. No abstract available.

49.

Nosocomial transmission of group B streptococci.

Easmon CS, Hastings MJ, Clare AJ, Bloxham B, Marwood R, Rivers RP, Stringer J.

Br Med J (Clin Res Ed). 1981 Aug 15;283(6289):459-61.

50.

Antenatal diagnosis of diaphragmatic hernia. Case report.

Marwood RP, Davison OW.

Br J Obstet Gynaecol. 1981 Jan;88(1):71-2. No abstract available.

PMID:
7006675

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