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Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers.

Eso Y, Shimizu T, Takeda H, Takai A, Marusawa H.

J Gastroenterol. 2019 Sep 7. doi: 10.1007/s00535-019-01620-7. [Epub ahead of print] Review.


Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

Kim SK, Takeda H, Takai A, Matsumoto T, Kakiuchi N, Yokoyama A, Yoshida K, Kaido T, Uemoto S, Minamiguchi S, Haga H, Shiraishi Y, Miyano S, Seno H, Ogawa S, Marusawa H.

J Gastroenterol. 2019 Jul;54(7):628-640. doi: 10.1007/s00535-019-01555-z. Epub 2019 Feb 12.


Gastrointestinal: Glomus tumor: A rare submucosal tumor of the stomach.

Yoshida H, Asada M, Marusawa H.

J Gastroenterol Hepatol. 2019 May;34(5):815. doi: 10.1111/jgh.14594. Epub 2019 Jan 21. Review. No abstract available.


Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.

Inuzuka T, Ueda Y, Arasawa S, Takeda H, Matsumoto T, Osaki Y, Uemoto S, Seno H, Marusawa H.

Sci Rep. 2018 Dec 24;8(1):18070. doi: 10.1038/s41598-018-36093-w.


Comparative proteomics of Helicobacter pylori strains reveals geographical features rather than genomic variations.

Sugiyama N, Miyake S, Lin MH, Wakabayashi M, Marusawa H, Nishiumi S, Yoshida M, Ishihama Y.

Genes Cells. 2019 Feb;24(2):139-150. doi: 10.1111/gtc.12662. Epub 2019 Jan 20.


Accelerated Progression of Hepatocellular Carcinoma during Immunosuppressive Therapy with Abatacept for Rheumatoid Arthritis.

Yoshiji S, Takahashi K, Sawada K, Mishima M, Eso Y, Morita M, Takai A, Marusawa H, Ueda Y, Mimori T, Seno H.

Intern Med. 2019 Jan 1;58(1):67-71. doi: 10.2169/internalmedicine.0843-18. Epub 2018 Aug 24.


Ultrasound-guided microfoam sclerotherapy with polidocanol for symptomatic giant hepatic cyst: Initial experience.

Eso Y, Furuta A, Takai A, Takahashi K, Ueda Y, Marusawa H, Seno H.

Hepatol Res. 2018 Nov;48(12):1055-1063. doi: 10.1111/hepr.13202. Epub 2018 Jul 10.


The use of hepatitis B immunoglobulin with or without hepatitis B vaccine to prevent de novo hepatitis B in pediatric recipients of anti-HBc-positive livers.

Yamashiki N, Yoshizawa A, Ueda Y, Kaido T, Okajima H, Marusawa H, Seno H, Uemoto S.

Pediatr Transplant. 2018 Aug;22(5):e13227. doi: 10.1111/petr.13227. Epub 2018 May 15.


Genetic features of multicentric/multifocal intramucosal gastric carcinoma.

Mizuguchi A, Takai A, Shimizu T, Matsumoto T, Kumagai K, Miyamoto S, Seno H, Marusawa H.

Int J Cancer. 2018 Oct 15;143(8):1923-1934. doi: 10.1002/ijc.31578. Epub 2018 Jul 3.


Novel approaches for molecular targeted therapy against hepatocellular carcinoma.

Eso Y, Marusawa H.

Hepatol Res. 2018 Jul;48(8):597-607. doi: 10.1111/hepr.13181. Epub 2018 May 17. Review.


Long-term Prognosis and Recurrence of Primary Sclerosing Cholangitis After Liver Transplantation: A Single-Center Experience.

Ueda Y, Kaido T, Okajima H, Hata K, Anazawa T, Yoshizawa A, Yagi S, Taura K, Masui T, Yamashiki N, Haga H, Nagao M, Marusawa H, Seno H, Uemoto S.

Transplant Direct. 2017 Nov 20;3(12):e334. doi: 10.1097/TXD.0000000000000751. eCollection 2017 Dec.


Association of Mac-2-binding protein glycosylation isomer level with nutritional status in chronic liver disease.

Eso Y, Takai A, Taura K, Takahashi K, Ueda Y, Marusawa H, Seno H.

J Gastroenterol Hepatol. 2018 Feb 22. doi: 10.1111/jgh.14130. [Epub ahead of print]


Hepatitis C Treatment with Sofosbuvir and Ledipasvir Accompanied by Immediate Improvement in Hemoglobin A1c.

Ikeda A, Ikeda K, Takai A, Takahashi K, Ueda Y, Marusawa H, Seno H, Inagaki N, Kokuryu H.

Digestion. 2017 Nov;96(4):228-230. doi: 10.1159/000484237. Epub 2017 Oct 30.


Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.

Nosaka T, Naito T, Hiramatsu K, Ohtani M, Nemoto T, Marusawa H, Ma N, Hiraku Y, Kawanishi S, Yamashita T, Kaneko S, Nakamoto Y.

PLoS One. 2017 Oct 2;12(10):e0185442. doi: 10.1371/journal.pone.0185442. eCollection 2017.


Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma.

Matsumoto T, Takai A, Eso Y, Kinoshita K, Manabe T, Seno H, Chiba T, Marusawa H.

Cancer Res. 2017 Nov 15;77(22):6131-6143. doi: 10.1158/0008-5472.CAN-17-1800. Epub 2017 Sep 26.


Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing.

Takeda H, Ueda Y, Inuzuka T, Yamashita Y, Osaki Y, Nasu A, Umeda M, Takemura R, Seno H, Sekine A, Marusawa H.

Sci Rep. 2017 Mar 31;7:45605. doi: 10.1038/srep45605.


Helicobacter pylori-Mediated Genetic Instability and Gastric Carcinogenesis.

Shimizu T, Chiba T, Marusawa H.

Curr Top Microbiol Immunol. 2017;400:305-323. doi: 10.1007/978-3-319-50520-6_13. Review.


Corrigendum: Modelling mutational landscapes of human cancers in vitro.

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J.

Sci Rep. 2017 Jan 16;7:40898. doi: 10.1038/srep40898. No abstract available.


Activation of TNF-α-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B.

Matsumoto T, Takahashi K, Inuzuka T, Kim SK, Kurosaki T, Kawakami S, Chiba T, Seno H, Marusawa H.

Antiviral Res. 2017 Mar;139:138-145. doi: 10.1016/j.antiviral.2017.01.004. Epub 2017 Jan 5.


Sonazoid-enhanced ultrasonography guidance improves the quality of pathological diagnosis in the biopsy of focal hepatic lesions.

Eso Y, Takai A, Takeda H, Matsumoto T, Lee M, Inuzuka T, Takahashi K, Ueda Y, Marusawa H, Seno H.

Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1462-1467.


Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis.

Takeda H, Takai A, Inuzuka T, Marusawa H.

J Gastroenterol. 2017 Jan;52(1):26-38. doi: 10.1007/s00535-016-1273-2. Epub 2016 Oct 6. Review.


TERT promoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma.

Ki Kim S, Ueda Y, Hatano E, Kakiuchi N, Takeda H, Goto T, Shimizu T, Yoshida K, Ikura Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Uemoto S, Chiba T, Ogawa S, Marusawa H.

Int J Cancer. 2016 Dec 1;139(11):2512-8. doi: 10.1002/ijc.30379. Epub 2016 Aug 29.


MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.

Eso Y, Takai A, Matsumoto T, Inuzuka T, Horie T, Ono K, Uemoto S, Lee K, Edelmann W, Chiba T, Marusawa H.

Cancer Res. 2016 Aug 1;76(15):4383-93. doi: 10.1158/0008-5472.CAN-15-2926. Epub 2016 Jun 3.


[Treatment for hepatitis C before and after liver transplantation].

Ueda Y, Marusawa H.

Nihon Rinsho. 2015 Dec;73 Suppl 9:306-10. Japanese. No abstract available.


Long-term efficacy of hepatitis B vaccination as post-transplant prophylaxis in hepatitis B surface antigen (HBsAg) positive recipients and HBsAg negative recipients of anti-hepatitis B core positive grafts.

Yoshizawa A, Yamashiki N, Ueda Y, Kaido T, Okajima H, Marusawa H, Chiba T, Uemoto S.

Hepatol Res. 2016 May;46(6):541-51. doi: 10.1111/hepr.12586. Epub 2015 Oct 8.


Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer.

Shimizu T, Marusawa H, Watanabe N, Chiba T.

Gastroenterol Clin North Am. 2015 Sep;44(3):625-38. doi: 10.1016/j.gtc.2015.05.011. Epub 2015 Jul 7. Review.


Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations.

Sawai Y, Kodama Y, Shimizu T, Ota Y, Maruno T, Eso Y, Kurita A, Shiokawa M, Tsuji Y, Uza N, Matsumoto Y, Masui T, Uemoto S, Marusawa H, Chiba T.

Cancer Res. 2015 Aug 15;75(16):3292-301. doi: 10.1158/0008-5472.CAN-14-3028. Epub 2015 Jun 25.


Exploring the Mechanisms of Gastrointestinal Cancer Development Using Deep Sequencing Analysis.

Matsumoto T, Shimizu T, Takai A, Marusawa H.

Cancers (Basel). 2015 Jun 15;7(2):1037-51. doi: 10.3390/cancers7020823. Review.


Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis.

Matsumoto T, Shimizu T, Nishijima N, Ikeda A, Eso Y, Matsumoto Y, Chiba T, Marusawa H.

Carcinogenesis. 2015 Aug;36(8):904-13. doi: 10.1093/carcin/bgv065. Epub 2015 May 12.


Comprehensive characterization of hepatitis B virus-associated multifocal hepatocellular carcinoma using a multi-omics strategy.

Takeda H, Takai A, Marusawa H.

Ann Transl Med. 2015 Jan;3(1):3. doi: 10.3978/j.issn.2305-5839.2014.12.10. No abstract available.


Education and imaging. Gastrointestinal: Recurrent pancreatitis due to pancreatic arteriovenous malformation.

Lee M, Marusawa H, Yamashita Y.

J Gastroenterol Hepatol. 2015 Jan;30(1):2. doi: 10.1111/jgh.12815. No abstract available.


Mouse models of hepatitis B virus infection comprising host-virus immunologic interactions.

Inuzuka T, Takahashi K, Chiba T, Marusawa H.

Pathogens. 2014 Apr 23;3(2):377-89. doi: 10.3390/pathogens3020377. Review.


The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA.

Shimizu Y, Nishitsuji H, Marusawa H, Ujino S, Takaku H, Shimotohno K.

J Biol Chem. 2014 Sep 19;289(38):26226-38. doi: 10.1074/jbc.M114.563221. Epub 2014 Aug 6.


Reactivation from occult HBV carrier status is characterized by low genetic heterogeneity with the wild-type or G1896A variant prevalence.

Inuzuka T, Ueda Y, Morimura H, Fujii Y, Umeda M, Kou T, Osaki Y, Uemoto S, Chiba T, Marusawa H.

J Hepatol. 2014 Sep;61(3):492-501. doi: 10.1016/j.jhep.2014.04.033. Epub 2014 May 4.


Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection.

Shimizu T, Marusawa H, Matsumoto Y, Inuzuka T, Ikeda A, Fujii Y, Minamiguchi S, Miyamoto S, Kou T, Sakai Y, Crabtree JE, Chiba T.

Gastroenterology. 2014 Aug;147(2):407-17.e3. doi: 10.1053/j.gastro.2014.04.036. Epub 2014 Apr 29.


Modelling mutational landscapes of human cancers in vitro.

Olivier M, Weninger A, Ardin M, Huskova H, Castells X, Vallée MP, McKay J, Nedelko T, Muehlbauer KR, Marusawa H, Alexander J, Hazelwood L, Byrnes G, Hollstein M, Zavadil J.

Sci Rep. 2014 Mar 27;4:4482. doi: 10.1038/srep04482. Erratum in: Sci Rep. 2017 Jan 16;7:40898.


Characteristics of hepatocellular carcinoma with stem/progenitor cell phenotypes.

Lee M, Marusawa H, Chiba T.

Gastroenterology. 2014 Feb;146(2):579-81. doi: 10.1053/j.gastro.2013.12.009. Epub 2013 Dec 17. No abstract available.


MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.

Nat Commun. 2013;4:2883. doi: 10.1038/ncomms3883.


Novel mouse models of hepatocarcinogenesis with stepwise accumulation of genetic alterations.

Kim SK, Marusawa H, Eso Y, Chiba T, Kudo M.

Dig Dis. 2013;31(5-6):454-8. doi: 10.1159/000355244. Epub 2013 Nov 21. Review.


Chronic rejection associated with antiviral therapy for recurrent hepatitis C after living-donor liver transplantation.

Ueda Y, Kaido T, Ito T, Ogawa K, Yoshizawa A, Fujimoto Y, Mori A, Miyagawa-Hayashino A, Haga H, Marusawa H, Chiba T, Uemoto S.

Transplantation. 2014 Feb 15;97(3):344-50. doi: 10.1097/01.TP.0000435702.61642.0a.


Leptin receptor somatic mutations are frequent in HCV-infected cirrhotic liver and associated with hepatocellular carcinoma.

Ikeda A, Shimizu T, Matsumoto Y, Fujii Y, Eso Y, Inuzuka T, Mizuguchi A, Shimizu K, Hatano E, Uemoto S, Chiba T, Marusawa H.

Gastroenterology. 2014 Jan;146(1):222-32.e35. doi: 10.1053/j.gastro.2013.09.025. Epub 2013 Sep 19.


Interleukin-1 and tumor necrosis factor-α trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID).

Watashi K, Liang G, Iwamoto M, Marusawa H, Uchida N, Daito T, Kitamura K, Muramatsu M, Ohashi H, Kiyohara T, Suzuki R, Li J, Tong S, Tanaka Y, Murata K, Aizaki H, Wakita T.

J Biol Chem. 2013 Nov 1;288(44):31715-27. doi: 10.1074/jbc.M113.501122. Epub 2013 Sep 11.


Dynamics of defective hepatitis C virus clones in reinfected liver grafts in liver transplant recipients: ultradeep sequencing analysis.

Ohtsuru S, Ueda Y, Marusawa H, Inuzuka T, Nishijima N, Nasu A, Shimizu K, Koike K, Uemoto S, Chiba T.

J Clin Microbiol. 2013 Nov;51(11):3645-52. doi: 10.1128/JCM.00676-13. Epub 2013 Aug 28.


Inflammation and gastrointestinal cancer: an overview.

Marusawa H, Jenkins BJ.

Cancer Lett. 2014 Apr 10;345(2):153-6. doi: 10.1016/j.canlet.2013.08.025. Epub 2013 Aug 24. Review.


A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.

Kim SK, Nasu A, Komori J, Shimizu T, Matsumoto Y, Minaki Y, Kohno K, Shimizu K, Uemoto S, Chiba T, Marusawa H.

Int J Cancer. 2014 Mar 1;134(5):1067-76. doi: 10.1002/ijc.28445. Epub 2013 Sep 16.


Landscape of genetic aberrations detected in human colorectal cancers.

Goto T, Marusawa H, Chiba T.

Gastroenterology. 2013 Sep;145(3):686-8. doi: 10.1053/j.gastro.2013.07.029. Epub 2013 Jul 25. No abstract available.


Enhanced expression of activation-induced cytidine deaminase in human gastric mucosa infected by Helicobacter pylori and its decrease following eradication.

Nagata N, Akiyama J, Marusawa H, Shimbo T, Liu Y, Igari T, Nakashima R, Watanabe H, Uemura N, Chiba T.

J Gastroenterol. 2014 Mar;49(3):427-35. doi: 10.1007/s00535-013-0808-z. Epub 2013 Apr 18.


Platelet plays a role in the pathogenesis of hepatitis B virus-related hepatocellular carcinoma.

Eso Y, Marusawa H, Chiba T.

Gastroenterology. 2013 May;144(5):1140-2. doi: 10.1053/j.gastro.2013.03.034. Epub 2013 Mar 22. No abstract available.


Pretransplant serum hepatitis C virus RNA levels predict response to antiviral treatment after living donor liver transplantation.

Ueda Y, Kaido T, Ogura Y, Ogawa K, Yoshizawa A, Hata K, Fujimoto Y, Miyagawa-Hayashino A, Haga H, Marusawa H, Teramukai S, Uemoto S, Chiba T.

PLoS One. 2013;8(3):e58380. doi: 10.1371/journal.pone.0058380. Epub 2013 Mar 7. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/1601274b-def0-4970-8e61-62e657c2d1ae.

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