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Items: 41

1.

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.

Probst G, Aubele DL, Bowers S, Dressen D, Garofalo AW, Hom RK, Konradi AW, Marugg JL, Mattson MN, Neitzel ML, Semko CM, Sham HL, Smith J, Sun M, Truong AP, Ye XM, Xu YZ, Dappen MS, Jagodzinski JJ, Keim PS, Peterson B, Latimer LH, Quincy D, Wu J, Goldbach E, Ness DK, Quinn KP, Sauer JM, Wong K, Zhang H, Zmolek W, Brigham EF, Kholodenko D, Hu K, Kwong GT, Lee M, Liao A, Motter RN, Sacayon P, Santiago P, Willits C, Bard F, Bova MP, Hemphill SS, Nguyen L, Ruslim L, Tanaka K, Tanaka P, Wallace W, Yednock TA, Basi GS.

J Med Chem. 2013 Jul 11;56(13):5261-74. doi: 10.1021/jm301741t. Epub 2013 Jun 20.

PMID:
23713656
2.

Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.

Neitzel ML, Aubele DL, Marugg JL, Jagodzinski JJ, Konradi AW, Pleiss MA, Szoke B, Zmolek W, Goldbach E, Quinn KP, Sauer JM, Brigham EF, Wallace W, Bova MP, Hemphill S, Basi G.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3715-20. doi: 10.1016/j.bmcl.2011.04.079. Epub 2011 May 1.

PMID:
21571529
3.

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.

Basi GS, Hemphill S, Brigham EF, Liao A, Aubele DL, Baker J, Barbour R, Bova M, Chen XH, Dappen MS, Eichenbaum T, Goldbach E, Hawkinson J, Lawler-Herbold R, Hu K, Hui T, Jagodzinski JJ, Keim PS, Kholodenko D, Latimer LH, Lee M, Marugg J, Mattson MN, McCauley S, Miller JL, Motter R, Mutter L, Neitzel ML, Ni H, Nguyen L, Quinn K, Ruslim L, Semko CM, Shapiro P, Smith J, Soriano F, Szoke B, Tanaka K, Tang P, Tucker JA, Ye XM, Yu M, Wu J, Xu YZ, Garofalo AW, Sauer JM, Konradi AW, Ness D, Shopp G, Pleiss MA, Freedman SB, Schenk D.

Alzheimers Res Ther. 2010 Dec 29;2(6):36. doi: 10.1186/alzrt60.

4.

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).

Ye XM, Konradi AW, Smith J, Aubele DL, Garofalo AW, Marugg J, Neitzel ML, Semko CM, Sham HL, Sun M, Truong AP, Wu J, Zhang H, Goldbach E, Sauer JM, Brigham EF, Bova M, Basi GS.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3502-6. doi: 10.1016/j.bmcl.2010.04.148. Epub 2010 May 6.

PMID:
20529683
5.

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.

Ye XM, Konradi AW, Smith J, Xu YZ, Dressen D, Garofalo AW, Marugg J, Sham HL, Truong AP, Jagodzinski J, Pleiss M, Zhang H, Goldbach E, Sauer JM, Brigham E, Bova M, Basi GS.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2195-9. doi: 10.1016/j.bmcl.2010.02.039. Epub 2010 Feb 13.

PMID:
20207136
6.

A rapid and reliable alternative to ISO 21528-1:2004 for detection of Enterobacteriaceae.

Joosten H, Marugg J, Stephan R, Klijn A, Jackson T, Iversen C.

Int J Food Microbiol. 2008 Jul 31;125(3):344-6. doi: 10.1016/j.ijfoodmicro.2008.04.003. Epub 2008 May 1.

PMID:
18547668
7.

Identification of gamma-secretase inhibitor potency determinants on presenilin.

Zhao B, Yu M, Neitzel M, Marugg J, Jagodzinski J, Lee M, Hu K, Schenk D, Yednock T, Basi G.

J Biol Chem. 2008 Feb 1;283(5):2927-38. Epub 2007 Nov 21.

8.

Identification of "Cronobacter" spp. (Enterobacter sakazakii).

Iversen C, Lehner A, Mullane N, Marugg J, Fanning S, Stephan R, Joosten H.

J Clin Microbiol. 2007 Nov;45(11):3814-6. Epub 2007 Sep 19.

9.

Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists.

Dressen D, Garofalo AW, Hawkinson J, Hom D, Jagodzinski J, Marugg JL, Neitzel ML, Pleiss MA, Szoke B, Tung JS, Wone DW, Wu J, Zhang H.

J Med Chem. 2007 Oct 18;50(21):5161-7. Epub 2007 Sep 19.

PMID:
17880055
11.

A simple and rapid cultural method for detection of Enterobacter sakazakii in environmental samples.

Guillaume-Gentil O, Sonnard V, Kandhai MC, Marugg JD, Joosten H.

J Food Prot. 2005 Jan;68(1):64-9.

PMID:
15690805
12.

Specialized roles of the two pathways for the synthesis of mannosylglycerate in osmoadaptation and thermoadaptation of Rhodothermus marinus.

Borges N, Marugg JD, Empadinhas N, da Costa MS, Santos H.

J Biol Chem. 2004 Mar 12;279(11):9892-8. Epub 2003 Dec 29.

13.

Reverse transcription-PCR analysis of bottled and natural mineral waters for the presence of noroviruses.

Lamothe GT, Putallaz T, Joosten H, Marugg JD.

Appl Environ Microbiol. 2003 Nov;69(11):6541-9.

14.

Osmotic adaptation of Thermus thermophilus RQ-1: lesson from a mutant deficient in synthesis of trehalose.

Silva Z, Alarico S, Nobre A, Horlacher R, Marugg J, Boos W, Mingote AI, da Costa MS.

J Bacteriol. 2003 Oct;185(20):5943-52.

15.

Comparison of media for enumeration of Clostridium perfringens from foods.

de Jong AE, Eijhusen GP, Brouwer-Post EJ, Grand M, Johansson T, Kärkkäinen T, Marugg J, in't Veld PH, Warmerdam FH, Wörner G, Zicavo A, Rombouts FM, Beumer RR.

J Microbiol Methods. 2003 Sep;54(3):359-66.

PMID:
12842482
16.

Genetic heterogeneity in Bacillus sporothermodurans as demonstrated by ribotyping and repetitive extragenic palindromic-PCR fingerprinting.

Guillaume-Gentil O, Scheldeman P, Marugg J, Herman L, Joosten H, Heyndrickx M.

Appl Environ Microbiol. 2002 Sep;68(9):4216-24.

17.

A siderophore peptide synthetase gene from plant-growth-promoting Pseudomonas putida WCS358.

Devescovi G, Aguilar C, Majolini MB, Marugg J, Weisbeek P, Venturi V.

Syst Appl Microbiol. 2001 Nov;24(3):321-30.

PMID:
11822666
18.

Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.

Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS.

J Biol Chem. 2001 Nov 23;276(47):43580-8. Epub 2001 Sep 18.

19.

Molecular and functional analyses of the metC gene of Lactococcus lactis, encoding cystathionine beta-lyase.

Fernández M, van Doesburg W, Rutten GA, Marugg JD, Alting AC, van Kranenburg R, Kuipers OP.

Appl Environ Microbiol. 2000 Jan;66(1):42-8.

20.

Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.

Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H.

J Biol Chem. 1999 Dec 10;274(50):35407-14.

21.

Characterization of the divergent sacBK and sacAR operons, involved in sucrose utilization by Lactococcus lactis.

Luesink EJ, Marugg JD, Kuipers OP, de Vos WM.

J Bacteriol. 1999 Mar;181(6):1924-6.

22.
23.

Molecular characterization of the plasmid-encoded eps gene cluster essential for exopolysaccharide biosynthesis in Lactococcus lactis.

van Kranenburg R, Marugg JD, van Swam II, Willem NJ, de Vos WM.

Mol Microbiol. 1997 Apr;24(2):387-97.

24.

Purification and characterization of enterocin 4, a bacteriocin produced by Enterococcus faecalis INIA 4.

Joosten HM, Nunez M, Devreese B, Van Beeumen J, Marugg JD.

Appl Environ Microbiol. 1996 Nov;62(11):4220-3.

25.
26.

Regulation of Proteolytic Enzyme Activity in Lactococcus lactis.

Meijer W, Marugg JD, Hugenholtz J.

Appl Environ Microbiol. 1996 Jan;62(1):156-61.

27.

Functional analysis of the pediocin operon of Pediococcus acidilactici PAC1.0: PedB is the immunity protein and PedD is the precursor processing enzyme.

Venema K, Kok J, Marugg JD, Toonen MY, Ledeboer AM, Venema G, Chikindas ML.

Mol Microbiol. 1995 Aug;17(3):515-22.

PMID:
8559070
28.

Medium-dependent regulation of proteinase gene expression in Lactococcus lactis: control of transcription initiation by specific dipeptides.

Marugg JD, Meijer W, van Kranenburg R, Laverman P, Bruinenberg PG, de Vos WM.

J Bacteriol. 1995 Jun;177(11):2982-9.

29.

Identification and characterization of the alpha-acetolactate synthase gene from Lactococcus lactis subsp. lactis biovar diacetylactis.

Marugg JD, Goelling D, Stahl U, Ledeboer AM, Toonen MY, Verhue WM, Verrips CT.

Appl Environ Microbiol. 1994 Apr;60(4):1390-4.

30.

Construction of a reshaped HMFG1 antibody and comparison of its fine specificity with that of the parent mouse antibody.

Verhoeyen ME, Saunders JA, Price MR, Marugg JD, Briggs S, Broderick EL, Eida SJ, Mooren AT, Badley RA.

Immunology. 1993 Mar;78(3):364-70.

31.

Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0.

Marugg JD, Gonzalez CF, Kunka BS, Ledeboer AM, Pucci MJ, Toonen MY, Walker SA, Zoetmulder LC, Vandenbergh PA.

Appl Environ Microbiol. 1992 Aug;58(8):2360-7.

32.
33.

Cloning and characterization of a gene encoding an outer membrane protein required for siderophore-mediated uptake of Fe3+ in Pseudomonas putida WCS358.

Marugg JD, de Weger LA, Nielander HB, Oorthuizen M, Recourt K, Lugtenberg B, van der Hofstad GA, Weisbeek PJ.

J Bacteriol. 1989 May;171(5):2819-26.

34.

Genetic organization and transcriptional analysis of a major gene cluster involved in siderophore biosynthesis in Pseudomonas putida WCS358.

Marugg JD, Nielander HB, Horrevoets AJ, van Megen I, van Genderen I, Weisbeek PJ.

J Bacteriol. 1988 Apr;170(4):1812-9.

36.

Use of a 1-hydroxybenzotriazole activated phosphorylating reagent towards the synthesis of short RNA fragments in solution.

de Vroom E, Fidder A, Marugg JE, van der Marel GA, van Boom JH.

Nucleic Acids Res. 1986 Jul 25;14(14):5885-900.

37.

Synthesis of nucleic acid methylphosphonates via the 1-hydroxybenzotriazole phosphotriester approach.

Marugg JE, de Vroom E, Dreef CE, Tromp M, van der Marel GA, van Boom JH.

Nucleic Acids Res. 1986 Mar 11;14(5):2171-85.

38.

Isolation and analysis of genes involved in siderophore biosynthesis in plant-growth-stimulating Pseudomonas putida WCS358.

Marugg JD, van Spanje M, Hoekstra WP, Schippers B, Weisbeek PJ.

J Bacteriol. 1985 Nov;164(2):563-70.

39.

Synthesis of phosphorothioate-containing DNA fragments by a modified hydroxybenzotriazole phosphotriester approach.

Marugg JE, van den Bergh C, Tromp M, van der Marel GA, van Zoest WJ, van Boom JH.

Nucleic Acids Res. 1984 Dec 11;12(23):9095-110.

40.

Polymer supported DNA synthesis using hydroxybenzotriazole activated phosphotriester intermediates.

Marugg JE, Piel N, McLaughlin LW, Tromp M, Veeneman GH, van der Marel GA, van Boom JH.

Nucleic Acids Res. 1984 Nov 26;12(22):8639-51.

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