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Items: 1 to 50 of 168

1.

Quantitative high-throughput screening using an organotypic model identifies compounds that inhibit ovarian cancer metastasis.

Kenny HA, Lal-Nag M, Shen M, Kara B, Nahotko DA, Wroblewski K, Fazal S, Chen S, Chiang CY, Chen YJ, Brimacombe KR, Marugan J, Ferrer M, Lengyel E.

Mol Cancer Ther. 2019 Sep 27. pii: molcanther.0052.2019. doi: 10.1158/1535-7163.MCT-19-0052. [Epub ahead of print]

PMID:
31562255
2.

Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.

Kaftanovskaya EM, Ng HH, Soula M, Rivas B, Myhr C, Ho BA, Cervantes BA, Shupe TD, Devarasetty M, Hu X, Xu X, Patnaik S, Wilson KJ, Barnaeva E, Ferrer M, Southall NT, Marugan JJ, Bishop CE, Agoulnik IU, Agoulnik AI.

FASEB J. 2019 Aug 16:fj201901046R. doi: 10.1096/fj.201901046R. [Epub ahead of print]

PMID:
31419161
3.

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.

Anantharajan J, Zhou H, Zhang L, Hotz T, Vincent MY, Blevins MA, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Baburajendran N, Lin G, Hung AW, Joy J, Patnaik S, Marugan J, Rudra P, Ghosh D, Hill J, Keller TH, Zhao R, Ford HL, Kang C.

Mol Cancer Ther. 2019 Sep;18(9):1484-1496. doi: 10.1158/1535-7163.MCT-18-1239. Epub 2019 Jul 8.

PMID:
31285279
4.

Novel Perovskite Materials for Thermal Water Splitting at Moderate Temperature.

Azcondo MT, Orfila M, Marugán J, Sanz R, Muñoz-Noval A, Salas-Colera E, Ritter C, García-Alvarado F, Amador U.

ChemSusChem. 2019 Sep 6;12(17):4029-4037. doi: 10.1002/cssc.201901484. Epub 2019 Aug 5.

PMID:
31282611
5.

δ-Tocopherol Effect on Endocytosis and Its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: A New Type of Drug Interaction?

Manthe RL, Rappaport JA, Long Y, Solomon M, Veluvolu V, Hildreth M, Gugutkov D, Marugan J, Zheng W, Muro S.

J Pharmacol Exp Ther. 2019 Sep;370(3):823-833. doi: 10.1124/jpet.119.257345. Epub 2019 May 17.

PMID:
31101681
6.

Evaluation of transformation products from chemical oxidation of micropollutants in wastewater by photoassisted generation of sulfate radicals.

Rodríguez-Chueca J, Garcia-Cañibano C, Sarro M, Encinas Á, Medana C, Fabbri D, Calza P, Marugán J.

Chemosphere. 2019 Jul;226:509-519. doi: 10.1016/j.chemosphere.2019.03.152. Epub 2019 Mar 28.

PMID:
30953896
7.

Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists.

Patnaik S, Basu D, Southall N, Dehdashti S, Wan KK, Zheng W, Ferrer M, Taylor M, Engel DA, Marugan JJ.

Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119. doi: 10.1016/j.bmcl.2019.02.027. Epub 2019 Feb 26.

PMID:
30852083
8.

Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy.

Fontelonga TM, Jordan B, Nunes AM, Barraza-Flores P, Bolden N, Wuebbles RD, Griner LM, Hu X, Ferrer M, Marugan J, Southall N, Burkin DJ.

Hum Mol Genet. 2019 Jul 1;28(13):2120-2132. doi: 10.1093/hmg/ddz044.

PMID:
30806670
9.

A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis.

Sharma G, Guardia CM, Roy A, Vassilev A, Saric A, Griner LN, Marugan J, Ferrer M, Bonifacino JS, DePamphilis ML.

Autophagy. 2019 Oct;15(10):1694-1718. doi: 10.1080/15548627.2019.1586257. Epub 2019 Mar 8.

PMID:
30806145
10.

Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus.

Morazzani EM, Compton JR, Leary DH, Berry AV, Hu X, Marugan JJ, Glass PJ, Legler PM.

Antiviral Res. 2019 Apr;164:106-122. doi: 10.1016/j.antiviral.2019.02.001. Epub 2019 Feb 10.

11.

A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha.

Sengupta N, Jović M, Barnaeva E, Kim DW, Hu X, Southall N, Dejmek M, Mejdrova I, Nencka R, Baumlova A, Chalupska D, Boura E, Ferrer M, Marugan J, Balla T.

J Lipid Res. 2019 Mar;60(3):683-693. doi: 10.1194/jlr.D090159. Epub 2019 Jan 9.

PMID:
30626625
12.

Assessment of full-scale tertiary wastewater treatment by UV-C based-AOPs: Removal or persistence of antibiotics and antibiotic resistance genes?

Rodríguez-Chueca J, Varella Della Giustina S, Rocha J, Fernandes T, Pablos C, Encinas Á, Barceló D, Rodríguez-Mozaz S, Manaia CM, Marugán J.

Sci Total Environ. 2019 Feb 20;652:1051-1061. doi: 10.1016/j.scitotenv.2018.10.223. Epub 2018 Oct 17.

PMID:
30586792
13.

Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.

Chiang N, Barnaeva E, Hu X, Marugan J, Southall N, Ferrer M, Serhan CN.

Cell Chem Biol. 2019 Feb 21;26(2):244-254.e4. doi: 10.1016/j.chembiol.2018.10.023. Epub 2018 Dec 13.

PMID:
30554914
14.

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.

Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS.

Sci Rep. 2018 Dec 7;8(1):17715. doi: 10.1038/s41598-018-36144-2.

15.

Risk factors for diarrhoea and malnutrition among children under the age of 5 years in the Tigray Region of Northern Ethiopia.

Wasihun AG, Dejene TA, Teferi M, Marugán J, Negash L, Yemane D, McGuigan KG.

PLoS One. 2018 Nov 26;13(11):e0207743. doi: 10.1371/journal.pone.0207743. eCollection 2018.

16.

Ensembl 2019.

Cunningham F, Achuthan P, Akanni W, Allen J, Amode MR, Armean IM, Bennett R, Bhai J, Billis K, Boddu S, Cummins C, Davidson C, Dodiya KJ, Gall A, Girón CG, Gil L, Grego T, Haggerty L, Haskell E, Hourlier T, Izuogu OG, Janacek SH, Juettemann T, Kay M, Laird MR, Lavidas I, Liu Z, Loveland JE, Marugán JC, Maurel T, McMahon AC, Moore B, Morales J, Mudge JM, Nuhn M, Ogeh D, Parker A, Parton A, Patricio M, Abdul Salam AI, Schmitt BM, Schuilenburg H, Sheppard D, Sparrow H, Stapleton E, Szuba M, Taylor K, Threadgold G, Thormann A, Vullo A, Walts B, Winterbottom A, Zadissa A, Chakiachvili M, Frankish A, Hunt SE, Kostadima M, Langridge N, Martin FJ, Muffato M, Perry E, Ruffier M, Staines DM, Trevanion SJ, Aken BL, Yates AD, Zerbino DR, Flicek P.

Nucleic Acids Res. 2019 Jan 8;47(D1):D745-D751. doi: 10.1093/nar/gky1113.

17.

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer.

Vilimas T, Wang AQ, Patnaik S, Hughes EA, Singleton MD, Knotts Z, Li D, Frankowski K, Schlomer JJ, Guerin TM, Springer S, Drennan C, Dextras C, Wang C, Gilbert D, Southall N, Ferrer M, Huang S, Kozlov S, Marugan J, Xu X, Rudloff U.

Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080. doi: 10.1007/s00280-018-3699-0. Epub 2018 Oct 10.

18.

Hybrid UV-C/microfiltration process in membrane photoreactor for wastewater disinfection.

Rodríguez-Chueca J, Mesones S, Marugán J.

Environ Sci Pollut Res Int. 2018 Oct 1. doi: 10.1007/s11356-018-3262-x. [Epub ahead of print]

PMID:
30276688
19.

Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease.

Vu M, Li R, Baskfield A, Lu B, Farkhondeh A, Gorshkov K, Motabar O, Beers J, Chen G, Zou J, Espejo-Mojica AJ, Rodríguez-López A, Alméciga-Díaz CJ, Barrera LA, Jiang X, Ory DS, Marugan JJ, Zheng W.

Orphanet J Rare Dis. 2018 Sep 17;13(1):152. doi: 10.1186/s13023-018-0886-3.

20.

Concomitant inactivation of Acanthamoeba spp. and Escherichia coli using suspended and immobilized TiO2.

Adán C, Magnet A, Fenoy S, Pablos C, Del Águila C, Marugán J.

Water Res. 2018 Nov 1;144:512-521. doi: 10.1016/j.watres.2018.07.060. Epub 2018 Jul 26.

PMID:
30081334
21.

Novel antimicrobial agents as alternative to chlorine with potential applications in the fruit and vegetable processing industry.

Pablos C, Romero A, de Diego A, Vargas C, Bascón I, Pérez-Rodríguez F, Marugán J.

Int J Food Microbiol. 2018 Nov 20;285:92-97. doi: 10.1016/j.ijfoodmicro.2018.07.029. Epub 2018 Jul 25.

PMID:
30071497
22.

Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.

Wilson KJ, Xiao J, Chen CZ, Huang Z, Agoulnik IU, Ferrer M, Southall N, Hu X, Zheng W, Xu X, Wang A, Myhr C, Barnaeva E, George ER, Agoulnik AI, Marugan JJ.

Eur J Med Chem. 2018 Aug 5;156:79-92. doi: 10.1016/j.ejmech.2018.06.008. Epub 2018 Jun 7.

23.

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.

Martinez NJ, Asawa RR, Cyr MG, Zakharov A, Urban DJ, Roth JS, Wallgren E, Klumpp-Thomas C, Coussens NP, Rai G, Yang SM, Hall MD, Marugan JJ, Simeonov A, Henderson MJ.

Sci Rep. 2018 Jun 21;8(1):9472. doi: 10.1038/s41598-018-27834-y.

24.

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.

Datta A, Kim H, McGee L, Johnson AE, Talwar S, Marugan J, Southall N, Hu X, Lal M, Mondal D, Ferrer M, Abdel-Mageed AB.

Sci Rep. 2018 May 25;8(1):8161. doi: 10.1038/s41598-018-26411-7.

25.

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, Lewandowska MA, Wen Y, Farley KI, Griner LM, Sultan J, Meng Z, Zhou M, Vilimas T, Powers AS, Kozlov S, Nagashima K, Quadri HS, Fang M, Long C, Khanolkar O, Chen W, Kang J, Huang H, Chow E, Goldberg E, Feldman C, Xi R, Kim HR, Sahagian G, Baserga SJ, Mazar A, Ferrer M, Zheng W, Shilatifard A, Aubé J, Rudloff U, Marugan JJ, Huang S.

Sci Transl Med. 2018 May 16;10(441). pii: eaap8307. doi: 10.1126/scitranslmed.aap8307.

26.

Intensification of UV-C tertiary treatment: Disinfection and removal of micropollutants by sulfate radical based Advanced Oxidation Processes.

Rodríguez-Chueca J, García-Cañibano C, Lepistö RJ, Encinas Á, Pellinen J, Marugán J.

J Hazard Mater. 2019 Jun 15;372:94-102. doi: 10.1016/j.jhazmat.2018.04.044. Epub 2018 Apr 21.

PMID:
29728280
27.

Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses.

Sima N, Li R, Huang W, Xu M, Beers J, Zou J, Titus S, Ottinger EA, Marugan JJ, Xie X, Zheng W.

Orphanet J Rare Dis. 2018 Apr 10;13(1):54. doi: 10.1186/s13023-018-0798-2.

28.

Micropollutants removal by full-scale UV-C/sulfate radical based Advanced Oxidation Processes.

Rodríguez-Chueca J, Laski E, García-Cañibano C, Martín de Vidales MJ, Encinas Á, Kuch B, Marugán J.

Sci Total Environ. 2018 Jul 15;630:1216-1225. doi: 10.1016/j.scitotenv.2018.02.279. Epub 2018 Mar 7.

PMID:
29554743
29.

Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

Rolt A, Le D, Hu Z, Wang AQ, Shah P, Singleton M, Hughes E, Dulcey AE, He S, Imamura M, Uchida T, Chayama K, Xu X, Marugan JJ, Liang TJ.

J Infect Dis. 2018 May 5;217(11):1761-1769. doi: 10.1093/infdis/jiy039.

30.

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.

Elife. 2017 Dec 26;6. pii: e29123. doi: 10.7554/eLife.29123.

31.

Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.

Neumann S, Eliseeva E, Boutin A, Barnaeva E, Ferrer M, Southall N, Kim D, Hu X, Morgan SJ, Marugan JJ, Gershengorn MC.

J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. doi: 10.1124/jpet.117.244095. Epub 2017 Oct 31.

32.

Synthesis, Characterization, and Photonic Efficiency of Novel Photocatalytic Niobium Oxide Materials.

Morais LA, Adán C, Araujo AS, Guedes APMA, Marugán J.

Glob Chall. 2017 Nov 2;1(9):1700066. doi: 10.1002/gch2.201700066. eCollection 2017 Dec 14.

33.

Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State.

Compton JR, Mickey MJ, Hu X, Marugan JJ, Legler PM.

Biochemistry. 2017 Nov 28;56(47):6221-6230. doi: 10.1021/acs.biochem.7b00746. Epub 2017 Nov 9.

PMID:
29064679
34.

A calibrated UV-LED based light source for water purification and characterisation of photocatalysis.

Sergejevs A, Clarke CT, Allsopp DWE, Marugan J, Jaroenworaluck A, Singhapong W, Manpetch P, Timmers R, Casado C, Bowen CR.

Photochem Photobiol Sci. 2017 Nov 8;16(11):1690-1699. doi: 10.1039/c7pp00269f.

PMID:
29034394
35.

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

Huang BX, Newcomer K, Kevala K, Barnaeva E, Zheng W, Hu X, Patnaik S, Southall N, Marugan J, Ferrer M, Kim HY.

Sci Rep. 2017 Sep 15;7(1):11673. doi: 10.1038/s41598-017-11870-1.

36.

Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290.

Kaftanovskaya EM, Soula M, Myhr C, Ho BA, Moore SN, Yoo C, Cervantes B, How J, Marugan J, Agoulnik IU, Agoulnik AI.

J Endocr Soc. 2017 Jun;1(6):712-725. doi: 10.1210/js.2017-00112. Epub 2017 May 8.

37.

Effects of natural antimicrobials on prevention and reduction of bacterial cross-contamination during the washing of ready-to-eat fresh-cut lettuce.

Pablos C, Fernández A, Thackeray A, Marugán J.

Food Sci Technol Int. 2017 Jul;23(5):403-414. doi: 10.1177/1082013217697851. Epub 2017 Mar 7.

PMID:
28675971
38.

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

He S, Li K, Lin B, Hu Z, Xiao J, Hu X, Wang AQ, Xu X, Ferrer M, Southall N, Zheng W, Aubé J, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

J Med Chem. 2017 Jul 27;60(14):6364-6383. doi: 10.1021/acs.jmedchem.7b00561. Epub 2017 Jul 13.

39.

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.

Li R, Hao J, Fujiwara H, Xu M, Yang S, Dai S, Long Y, Swaroop M, Li C, Vu M, Marugan JJ, Ory DS, Zheng W.

Assay Drug Dev Technol. 2017 May/Jun;15(4):154-166. doi: 10.1089/adt.2017.774.

40.

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.

Dai S, Dulcey AE, Hu X, Wassif CA, Porter FD, Austin CP, Ory DS, Marugan J, Zheng W.

Autophagy. 2017 Aug 3;13(8):1435-1451. doi: 10.1080/15548627.2017.1329081. Epub 2017 Jun 14.

41.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

Kocan M, Sarwar M, Ang SY, Xiao J, Marugan JJ, Hossain MA, Wang C, Hutchinson DS, Samuel CS, Agoulnik AI, Bathgate RAD, Summers RJ.

Sci Rep. 2017 Jun 7;7(1):2968. doi: 10.1038/s41598-017-02916-5.

42.

Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.

Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, Calvo R, Patnaik S, Wang W, King G, Samie M, Gao Q, Sahoo S, Sundaresan S, Keeley TM, Wang Y, Marugan J, Ferrer M, Samuelson LC, Merchant JL, Xu H.

Dev Cell. 2017 May 8;41(3):262-273.e6. doi: 10.1016/j.devcel.2017.04.003.

43.

Electrochemical Enhancement of Photocatalytic Disinfection on Aligned TiO₂ and Nitrogen Doped TiO₂ Nanotubes.

Pablos C, Marugán J, van Grieken R, Dunlop PSM, Hamilton JWJ, Dionysiou DD, Byrne JA.

Molecules. 2017 Apr 28;22(5). pii: E704. doi: 10.3390/molecules22050704.

44.

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Sarathy A, Wuebbles RD, Fontelonga TM, Tarchione AR, Mathews Griner LA, Heredia DJ, Nunes AM, Duan S, Brewer PD, Van Ry T, Hennig GW, Gould TW, Dulcey AE, Wang A, Xu X, Chen CZ, Hu X, Zheng W, Southall N, Ferrer M, Marugan J, Burkin DJ.

Mol Ther. 2017 Jun 7;25(6):1395-1407. doi: 10.1016/j.ymthe.2017.03.022. Epub 2017 Apr 5.

45.

ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice.

Abera MB, Xiao J, Nofziger J, Titus S, Southall N, Zheng W, Moritz KE, Ferrer M, Cherry JJ, Androphy EJ, Wang A, Xu X, Austin C, Fischbeck KH, Marugan JJ, Burnett BG.

JCI Insight. 2016 Nov 17;1(19):e88427. doi: 10.1172/jci.insight.88427.

46.

Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1.

Agoulnik AI, Agoulnik IU, Hu X, Marugan J.

Br J Pharmacol. 2017 May;174(10):977-989. doi: 10.1111/bph.13656. Epub 2016 Nov 30. Review.

47.

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.

Lee JW, Huang BX, Kwon H, Rashid MA, Kharebava G, Desai A, Patnaik S, Marugan J, Kim HY.

Nat Commun. 2016 Oct 19;7:13123. doi: 10.1038/ncomms13123.

48.

Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease.

Jang DS, Ye W, Guimei T, Solomon M, Southall N, Hu X, Marugan J, Ferrer M, Maegawa GH.

J Neurosci Res. 2016 Nov;94(11):1231-45. doi: 10.1002/jnr.23875.

49.

Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.

Estrada LD, Chamorro D, Yañez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, Zanlungo S, Inestrosa NC, Alvarez AR.

J Alzheimers Dis. 2016 Oct 4;54(3):1193-1205.

PMID:
27567806
50.

Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.

Long Y, Xu M, Li R, Dai S, Beers J, Chen G, Soheilian F, Baxa U, Wang M, Marugan JJ, Muro S, Li Z, Brady R, Zheng W.

Stem Cells Transl Med. 2016 Dec;5(12):1644-1655. Epub 2016 Aug 2.

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