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Items: 1 to 50 of 83

1.

Animal models for anti-emphysema drug discovery.

Gardi C, Stringa B, Martorana PA.

Expert Opin Drug Discov. 2015 Apr;10(4):399-410. doi: 10.1517/17460441.2015.1016871. Epub 2015 Feb 23. Review.

PMID:
25704258
2.

Downregulation of NOX4 expression by roflumilast N-oxide reduces markers of fibrosis in lung fibroblasts.

Vecchio D, Acquaviva A, Arezzini B, Tenor H, Martorana PA, Gardi C.

Mediators Inflamm. 2013;2013:745984. doi: 10.1155/2013/745984. Epub 2013 Aug 21.

3.

Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent.

Vecchio D, Arezzini B, Pecorelli A, Valacchi G, Martorana PA, Gardi C.

Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L704-13. doi: 10.1152/ajplung.00013.2009. Epub 2010 Feb 12.

4.

Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice.

Martorana PA, Lunghi B, Lucattelli M, De Cunto G, Beume R, Lungarella G.

BMC Pulm Med. 2008 Aug 28;8:17. doi: 10.1186/1471-2466-8-17.

5.

Testing of compounds in models of pulmonary emphysema.

Gardi C, Arezzini B, Martorana PA.

Curr Med Chem. 2008;15(8):803-808. Review.

PMID:
18393841
6.

The dual role of neutrophil elastase in lung destruction and repair.

Lungarella G, Cavarra E, Lucattelli M, Martorana PA.

Int J Biochem Cell Biol. 2008;40(6-7):1287-96. doi: 10.1016/j.biocel.2007.12.008. Epub 2007 Dec 24. Review.

PMID:
18243764
7.

Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase.

Schindler U, Strobel H, Schönafinger K, Linz W, Löhn M, Martorana PA, Rütten H, Schindler PW, Busch AE, Sohn M, Töpfer A, Pistorius A, Jannek C, Mülsch A.

Mol Pharmacol. 2006 Apr;69(4):1260-8. Epub 2005 Dec 6.

PMID:
16332991
8.

Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models.

Lucattelli M, Bartalesi B, Cavarra E, Fineschi S, Lunghi B, Martorana PA, Lungarella G.

Respir Res. 2005 Jul 26;6:83.

9.

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

Martorana PA, Beume R, Lucattelli M, Wollin L, Lungarella G.

Am J Respir Crit Care Med. 2005 Oct 1;172(7):848-53. Epub 2005 Jun 16.

PMID:
15961691
10.

Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants.

Bartalesi B, Cavarra E, Fineschi S, Lucattelli M, Lunghi B, Martorana PA, Lungarella G.

Eur Respir J. 2005 Jan;25(1):15-22.

11.

Collagen phagocytosis by lung alveolar macrophages in animal models of emphysema.

Lucattelli M, Cavarra E, de Santi MM, Tetley TD, Martorana PA, Lungarella G.

Eur Respir J. 2003 Nov;22(5):728-34.

12.

Platelet antiaggregatory effects and haemodynamic activity of two terfuroxan isomer pairs.

Cena C, Visentin S, Gasco A, Martorana PA, Fruttero R, Gasco A.

Farmaco. 2002 May;57(5):417-20.

PMID:
12058814
13.

Effects of cigarette smoke in mice with different levels of alpha(1)-proteinase inhibitor and sensitivity to oxidants.

Cavarra E, Bartalesi B, Lucattelli M, Fineschi S, Lunghi B, Gambelli F, Ortiz LA, Martorana PA, Lungarella G.

Am J Respir Crit Care Med. 2001 Sep 1;164(5):886-90.

PMID:
11549550
14.

Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress.

Cavarra E, Lucattelli M, Gambelli F, Bartalesi B, Fineschi S, Szarka A, Giannerini F, Martorana PA, Lungarella G.

Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L412-7.

15.

Genetic deficiency of alpha1-PI in mice influences lung responses to bleomycin.

Cavarra E, Martorana PA, Bartalesi B, Fineschi S, Gambelli F, Lucattelli M, Ortiz L, Lungarella G.

Eur Respir J. 2001 Mar;17(3):474-80.

16.

In vitro and in vivo vasodilating activity of nitroso derivatives gem -substituted with electron-withdrawing groups.

Di Stilo A, Medana C, Ferrarotti B, Gasco AL, Ghigo D, Bosia A, Martorana PA, Gasco A.

Pharmacol Res. 2000 Apr;41(4):469-74.

PMID:
10704272
17.

Ultrastructure of lung elastin and collagen in mouse models of spontaneous emphysema.

O'Donnell MD, O'Connor CM, FitzGerald MX, Lungarella G, Cavarra E, Martorana PA.

Matrix Biol. 1999 Aug;18(4):357-60.

PMID:
10517182
18.

Ramiprilat prevents the development of acute coronary endothelial dysfunction in the dog.

Martorana PA, Ruetten H, Goebel B, Koehl D, Roegner B, Schoelkens BA, Keil M.

Basic Res Cardiol. 1999 Aug;94(4):238-45.

PMID:
10505423
19.

Genetic deficiency in alpha 1 proteinase inhibitor (alpha 1 PI) associated with emphysema.

Martorana PA, Lungarella G.

Lab Anim Sci. 1998 Oct;48(5):460-2. No abstract available.

PMID:
10090058
20.

Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.

Cavarra E, Martorana PA, de Santi M, Bartalesi B, Cortese S, Gambelli F, Lungarella G.

Am J Respir Cell Mol Biol. 1999 Feb;20(2):264-9.

PMID:
9922217
21.

Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig.

Bowes J, Ruetten H, Martorana PA, Stockhausen H, Thiemermann C.

Eur J Pharmacol. 1998 Oct 23;359(2-3):143-50.

PMID:
9832385
22.

Coronary endothelial dysfunction after ischemia and reperfusion in the dog: a functional and morphological investigation.

Martorana PA, Goebel B, Ruetten H, Koehl D, Keil M.

Basic Res Cardiol. 1998 Aug;93(4):257-63.

PMID:
9782367
23.

Lung injury and degradation of extracellular matrix components by Aspergillus fumigatus serine proteinase.

Iadarola P, Lungarella G, Martorana PA, Viglio S, Guglielminetti M, Korzus E, Gorrini M, Cavarra E, Rossi A, Travis J, Luisetti M.

Exp Lung Res. 1998 May-Jun;24(3):233-51.

PMID:
9635248
24.

Characterisation of furoxancarbonitriles as a new class of vasodilators.

Gasco AM, Boschi D, Di Stilo A, Medana C, Gasco A, Martorana PA, Schönafinger K.

Arzneimittelforschung. 1998 Mar;48(3):212-8.

PMID:
9553676
25.

The effects of L-arginine on neointimal formation and vascular function following balloon injury in heritable hyperlipidaemic rabbits.

Greenlees C, Wadsworth RM, Martorana PA, Wainwright CL.

Cardiovasc Res. 1997 Aug;35(2):351-9.

PMID:
9349398
26.

Early induction of angiotensin I-converting enzyme in rat carotid artery after balloon injury.

Fernandez-Alfonso MS, Martorana PA, Licka I, van Even P, Trobisch D, Schölkens BA, Paul M.

Hypertension. 1997 Aug;30(2 Pt 1):272-7.

PMID:
9260992
27.

Neutrophils in beige mice secrete normal amounts of cathepsin G and a 46 kDa latent form of elastase that can be activated extracellularly by proteolytic activity.

Cavarra E, Martorana PA, Cortese S, Gambelli F, Di Simplicio P, Lungarella G.

Biol Chem. 1997 May;378(5):417-23.

PMID:
9191028
28.
29.

A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57 BL/6J mutants.

Keil M, Lungarella G, Cavarra E, van Even P, Martorana PA.

Lab Invest. 1996 Feb;74(2):353-62.

PMID:
8780155
30.

Role of kinins in myocardial ischemia.

Linz W, Martorana PA, Wiemer G, Wirth K, Schölkens BA.

EXS. 1996;76:231-41. Review. No abstract available.

PMID:
8805798
31.
32.

Cardiovascular actions of the furoxan CAS 1609, a novel nitric oxide donor.

Bohn H, Brendel J, Martorana PA, Schönafinger K.

Br J Pharmacol. 1995 Apr;114(8):1605-12.

33.

Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock.

Klemm P, Thiemermann C, Winklmaier G, Martorana PA, Henning R.

Br J Pharmacol. 1995 Jan;114(2):363-8.

34.

Antiischemic effects of pirsidomine, a new nitric oxide donor.

Martorana PA, Kettenbach B, Bohn H, Schönafinger K, Henning R.

Eur J Pharmacol. 1994 May 23;257(3):267-73.

PMID:
8088346
35.

Neutrophil lysosomal dysfunctions in mutant C57 Bl/6J mice: interstrain variations in content of lysosomal elastase, cathepsin G and their inhibitors.

Gardi C, Cavarra E, Calzoni P, Marcolongo P, de Santi M, Martorana PA, Lungarella G.

Biochem J. 1994 Apr 1;299 ( Pt 1):237-45.

36.

Cardiac collagen changes during the development of right ventricular hypertrophy in tight-skin mice with emphysema.

Gardi C, Martorana PA, Calzoni P, Cavarra E, Marcolongo P, de Santi MM, van Even P, Lungarella G.

Exp Mol Pathol. 1994 Apr;60(2):100-7.

PMID:
8070538
37.

[Reduction of infarct size and remodeling after ramipril].

Martorana PA, Linz W, Schölkens BA.

Z Kardiol. 1994;83 Suppl 4:63-4. German.

PMID:
7856282
38.

N-Acetylserotonin prevents the hypotension induced by bacterial lipopolysaccharides in the rat.

Klemm P, Ostrowski J, Morath T, Gruber C, Martorana PA, Henning R.

Eur J Pharmacol. 1993 Nov 30;250(1):R9-10.

PMID:
7509747
39.

Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia.

Scholz W, Albus U, Lang HJ, Linz W, Martorana PA, Englert HC, Schölkens BA.

Br J Pharmacol. 1993 Jun;109(2):562-8.

40.

The pallid mouse. A model of genetic alpha 1-antitrypsin deficiency.

Martorana PA, Brand T, Gardi C, van Even P, de Santi MM, Calzoni P, Marcolongo P, Lungarella G.

Lab Invest. 1993 Feb;68(2):233-41.

PMID:
8441253
41.

Pirsidomine, a novel nitric oxide donor, suppresses ischemic arrhythmias in anesthetized pigs.

Wainwright CL, Martorana PA.

J Cardiovasc Pharmacol. 1993;22 Suppl 7:S44-50.

PMID:
7504768
42.
43.

Lung collagen synthesis and deposition in tight-skin mice with genetic emphysema.

Gardi C, Martorana PA, Calzoni P, van Even P, de Santi MM, Cavarra E, Lungarella G.

Exp Mol Pathol. 1992 Apr;56(2):163-72.

PMID:
1587342
44.

The possible role of bradykinin in the antiischemic activity of ACE-inhibitors.

Martorana PA, Schölkens BA.

Agents Actions Suppl. 1992;38 ( Pt 3):98-102.

PMID:
1462888
45.

CAS 936, a novel syndnonimine with direct vasodilating and nitric oxide-donating properties: effects on isolated blood vessels.

Bohn H, Beyerle R, Martorana PA, Schönafinger K.

J Cardiovasc Pharmacol. 1991 Oct;18(4):522-7.

PMID:
1724528
46.

Does bradykinin play a role in the cardiac antiischemic effect of the ACE-inhibitors?

Martorana PA, Linz W, Schölkens BA.

Basic Res Cardiol. 1991 Jul-Aug;86(4):293-6. No abstract available.

PMID:
1958169
47.

Different evolution of emphysema in two strains of mice with similar serum antielastase deficit.

Gardi C, Martorana PA, de Santi MM, van Even P, Calzoni P, Lungarella G.

Ann N Y Acad Sci. 1991;624:329-30. No abstract available.

PMID:
2064237
48.

Development of cor pulmonale in tight-skin mice with genetic emphysema.

Martorana PA, Wilkinson M, de Santi MM, van Even P, Gardi C, Lungarella G.

Ann N Y Acad Sci. 1991;624:345-7. No abstract available.

PMID:
1829596
49.

[Nitric oxide dependence of the anti-thrombotic effect of sydnonimines in coronary arteries of swine].

Just M, Schönafinger K, Martorana PA.

Z Kardiol. 1991;80 Suppl 5:29-33. German.

PMID:
1776332
50.

Experimental cardiovascular benefits of angiotensin-converting enzyme inhibitors: beyond blood pressure reduction.

Schölkens BA, Linz W, Martorana PA.

J Cardiovasc Pharmacol. 1991;18 Suppl 2:S26-30. Review.

PMID:
1725038

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