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Items: 40

1.

Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway.

Ottis P, Palladino C, Thienger P, Britschgi A, Heichinger C, Berrera M, Julien-Laferriere A, Roudnicky F, Kam-Thong T, Bischoff JR, Martoglio B, Pettazzoni P.

ACS Chem Biol. 2019 Oct 18;14(10):2215-2223. doi: 10.1021/acschembio.9b00525. Epub 2019 Oct 8.

PMID:
31553577
2.

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.

Altmann E, Erbel P, Renatus M, Schaefer M, Schlierf A, Druet A, Kieffer L, Sorge M, Pfister K, Hassiepen U, Jones M, Ruedisser S, Ostermeier D, Martoglio B, Jefferson AB, Quancard J.

Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1294-1297. doi: 10.1002/anie.201608672. Epub 2016 Dec 16.

PMID:
27981705
3.

Targeted inhibition of the COP9 signalosome for treatment of cancer.

Schlierf A, Altmann E, Quancard J, Jefferson AB, Assenberg R, Renatus M, Jones M, Hassiepen U, Schaefer M, Kiffe M, Weiss A, Wiesmann C, Sedrani R, Eder J, Martoglio B.

Nat Commun. 2016 Oct 24;7:13166. doi: 10.1038/ncomms13166.

4.

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.

Beisner DR, Langerak P, Parker AE, Dahlberg C, Otero FJ, Sutton SE, Poirot L, Barnes W, Young MA, Niessen S, Wiltshire T, Bodendorf U, Martoglio B, Cravatt B, Cooke MP.

J Exp Med. 2013 Jan 14;210(1):23-30. doi: 10.1084/jem.20121072. Epub 2012 Dec 24.

5.

Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18.

Prod'homme V, Tomasec P, Cunningham C, Lemberg MK, Stanton RJ, McSharry BP, Wang EC, Cuff S, Martoglio B, Davison AJ, Braud VM, Wilkinson GW.

J Immunol. 2012 Mar 15;188(6):2794-804. doi: 10.4049/jimmunol.1102068. Epub 2012 Feb 15.

6.

The signal peptide of the mouse mammary tumor virus Rem protein is released from the endoplasmic reticulum membrane and accumulates in nucleoli.

Dultz E, Hildenbeutel M, Martoglio B, Hochman J, Dobberstein B, Kapp K.

J Biol Chem. 2008 Apr 11;283(15):9966-76. doi: 10.1074/jbc.M705712200. Epub 2008 Feb 12.

7.

A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate.

Hassiepen U, Eidhoff U, Meder G, Bulber JF, Hein A, Bodendorf U, Lorthiois E, Martoglio B.

Anal Biochem. 2007 Dec 15;371(2):201-7. Epub 2007 Aug 11.

PMID:
17869210
8.

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.

Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Lückerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO, Zörnig M.

Cell Death Differ. 2007 Sep;14(9):1678-87. Epub 2007 Jun 8.

9.

Aspartic proteases in drug discovery.

Eder J, Hommel U, Cumin F, Martoglio B, Gerhartz B.

Curr Pharm Des. 2007;13(3):271-85. Review.

PMID:
17313361
10.

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.

Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G, Martoglio B.

Nat Cell Biol. 2006 Aug;8(8):843-8. Epub 2006 Jul 9.

PMID:
16829952
11.

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Böhland C, Imhof A, Martoglio B, Teplow DB, Haass C.

Nat Cell Biol. 2006 Aug;8(8):894-6. Epub 2006 Jul 9.

12.

Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.

Dev KK, Chatterjee S, Osinde M, Stauffer D, Morgan H, Kobialko M, Dengler U, Rueeger H, Martoglio B, Rovelli G.

Eur J Pharmacol. 2006 Jul 1;540(1-3):10-7. Epub 2006 Apr 15.

PMID:
16697367
13.

Core protein of pestiviruses is processed at the C terminus by signal peptide peptidase.

Heimann M, Roman-Sosa G, Martoglio B, Thiel HJ, Rümenapf T.

J Virol. 2006 Feb;80(4):1915-21.

14.

Drosophila signal peptide peptidase is an essential protease for larval development.

Casso DJ, Tanda S, Biehs B, Martoglio B, Kornberg TB.

Genetics. 2005 May;170(1):139-48. Epub 2005 Feb 16.

15.

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.

Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B.

J Biol Chem. 2004 Dec 3;279(49):50790-8. Epub 2004 Sep 21.

16.

A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase.

Crawshaw SG, Martoglio B, Meacock SL, High S.

Biochem J. 2004 Nov 15;384(Pt 1):9-17.

18.

Intramembrane proteolysis and post-targeting functions of signal peptides.

Martoglio B.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1243-7. Review.

PMID:
14641034
19.

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs.

Martoglio B, Golde TE.

Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R201-6. Epub 2003 Sep 9. Review.

PMID:
12966028
20.

Analysis of polypeptides by sodium dodecyl sulfate-polyacrylamide gel electrophoresis alongside in vitro-generated reference peptides.

Lemberg MK, Martoglio B.

Anal Biochem. 2003 Aug 15;319(2):327-31. No abstract available.

PMID:
12871730
21.

Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E.

Bland FA, Lemberg MK, McMichael AJ, Martoglio B, Braud VM.

J Biol Chem. 2003 Sep 5;278(36):33747-52. Epub 2003 Jun 23.

22.

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.

Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B.

J Biol Chem. 2003 May 9;278(19):16528-33. Epub 2003 Mar 5.

23.

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.

Weihofen A, Martoglio B.

Trends Cell Biol. 2003 Feb;13(2):71-8. Review.

PMID:
12559757
24.

Protein folding during cotranslational translocation in the endoplasmic reticulum.

Kowarik M, Küng S, Martoglio B, Helenius A.

Mol Cell. 2002 Oct;10(4):769-78.

25.

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis.

Lemberg MK, Martoglio B.

Mol Cell. 2002 Oct;10(4):735-44.

26.

Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets.

McLauchlan J, Lemberg MK, Hope G, Martoglio B.

EMBO J. 2002 Aug 1;21(15):3980-8.

27.

Identification of signal peptide peptidase, a presenilin-type aspartic protease.

Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B.

Science. 2002 Jun 21;296(5576):2215-8.

28.

Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes.

Lemberg MK, Bland FA, Weihofen A, Braud VM, Martoglio B.

J Immunol. 2001 Dec 1;167(11):6441-6.

30.

Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4.

Schröder K, Martoglio B, Hofmann M, Hölscher C, Hartmann E, Prehn S, Rapoport TA, Dobberstein B.

EMBO J. 1999 Sep 1;18(17):4804-15. Erratum in: EMBO J 2002 Dec 16;21(24):6954.

31.

Signal sequences: more than just greasy peptides.

Martoglio B, Dobberstein B.

Trends Cell Biol. 1998 Oct;8(10):410-5. Review.

PMID:
9789330
32.

Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin.

Martoglio B, Graf R, Dobberstein B.

EMBO J. 1997 Nov 17;16(22):6636-45.

33.

Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta.

Zhao L, Helms JB, Brügger B, Harter C, Martoglio B, Graf R, Brunner J, Wieland FT.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4418-23.

34.

Snapshots of membrane-translocating proteins.

Martoglio B, Dobberstein B.

Trends Cell Biol. 1996 Apr;6(4):142-7.

PMID:
15157477
35.

Protein insertion into the endoplasmic reticulum of permeabilized cells.

Jadot M, Hofmann MW, Graf R, Quader H, Martoglio B.

FEBS Lett. 1995 Sep 4;371(2):145-8.

36.

Signal sequence processing in rough microsomes.

Lyko F, Martoglio B, Jungnickel B, Rapoport TA, Dobberstein B.

J Biol Chem. 1995 Aug 25;270(34):19873-8.

37.
38.

Protein insertion into the membrane of the endoplasmic reticulum: the architecture of the translocation site.

Martoglio B, Dobberstein B.

Cold Spring Harb Symp Quant Biol. 1995;60:41-5. Review. No abstract available.

PMID:
8824376
39.

Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence.

High S, Martoglio B, Görlich D, Andersen SS, Ashford AJ, Giner A, Hartmann E, Prehn S, Rapoport TA, Dobberstein B, et al.

J Biol Chem. 1993 Dec 15;268(35):26745-51.

40.

Mischarging Escherichia coli tRNAPhe with L-4'-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenylalanine, a photoactivatable analogue of phenylalanine.

Baldini G, Martoglio B, Schachenmann A, Zugliani C, Brunner J.

Biochemistry. 1988 Oct 4;27(20):7951-9.

PMID:
3061465

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