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Items: 49


Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs.

Burke EE, Chenoweth JG, Shin JH, Collado-Torres L, Kim SK, Micali N, Wang Y, Colantuoni C, Straub RE, Hoeppner DJ, Chen HY, Sellers A, Shibbani K, Hamersky GR, Diaz Bustamante M, Phan BN, Ulrich WS, Valencia C, Jaishankar A, Price AJ, Rajpurohit A, Semick SA, B├╝rli RW, Barrow JC, Hiler DJ, Page SC, Martinowich K, Hyde TM, Kleinman JE, Berman KF, Apud JA, Cross AJ, Brandon NJ, Weinberger DR, Maher BJ, McKay RDG, Jaffe AE.

Nat Commun. 2020 Jan 23;11(1):462. doi: 10.1038/s41467-019-14266-z.


TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons.

Maynard KR, Kardian A, Hill JL, Mai Y, Barry B, Hallock HL, Jaffe AE, Martinowich K.

eNeuro. 2020 Feb 10;7(1). pii: ENEURO.0310-19.2019. doi: 10.1523/ENEURO.0310-19.2019. Print 2020 Jan/Feb.


Spatial transcriptomics: putting genome-wide expression on the map.

Maynard KR, Jaffe AE, Martinowich K.

Neuropsychopharmacology. 2020 Jan;45(1):232-233. doi: 10.1038/s41386-019-0484-7. No abstract available.


Manipulation of a genetically and spatially defined sub-population of BDNF-expressing neurons potentiates learned fear and decreases hippocampal-prefrontal synchrony in mice.

Hallock HL, Quillian HM 4th, Mai Y, Maynard KR, Hill JL, Martinowich K.

Neuropsychopharmacology. 2019 Dec;44(13):2239-2246. doi: 10.1038/s41386-019-0429-1. Epub 2019 Jun 6.


Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability.

Hill JL, Jimenez DV, Mai Y, Ren M, Hallock HL, Maynard KR, Chen HY, Hardy NF, Schloesser RJ, Maher BJ, Yang F, Martinowich K.

Brain Struct Funct. 2019 Jan;224(1):471-483. doi: 10.1007/s00429-018-1783-1. Epub 2018 Oct 30.


Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice.

McAllan L, Maynard KR, Kardian AS, Stayton AS, Fox SL, Stephenson EJ, Kinney CE, Alshibli NK, Gomes CK, Pierre JF, Puchowicz MA, Bridges D, Martinowich K, Han JC.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1168-E1184. doi: 10.1152/ajpendo.00205.2018. Epub 2018 Sep 25.


BDNF-TrkB signaling in oxytocin neurons contributes to maternal behavior.

Maynard KR, Hobbs JW, Phan BN, Gupta A, Rajpurohit S, Williams C, Rajpurohit A, Shin JH, Jaffe AE, Martinowich K.

Elife. 2018 Sep 7;7. pii: e33676. doi: 10.7554/eLife.33676.


Electroconvulsive seizures influence dendritic spine morphology and BDNF expression in a neuroendocrine model of depression.

Maynard KR, Hobbs JW, Rajpurohit SK, Martinowich K.

Brain Stimul. 2018 Jul - Aug;11(4):856-859. doi: 10.1016/j.brs.2018.04.003. Epub 2018 Apr 6.


Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.

Kolata SM, Nakao K, Jeevakumar V, Farmer-Alroth EL, Fujita Y, Bartley AF, Jiang SZ, Rompala GR, Sorge RE, Jimenez DV, Martinowich K, Mateo Y, Hashimoto K, Dobrunz LE, Nakazawa K.

Neuropsychopharmacology. 2018 May;43(6):1445-1456. doi: 10.1038/npp.2017.296. Epub 2017 Dec 6.


Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures.

Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, Hempstead BL, Martinowich K, Ann Wilson M, Baraban JM, Reti IM.

Neuropsychopharmacology. 2018 Apr;43(5):1088-1098. doi: 10.1038/npp.2017.252. Epub 2017 Oct 20.


BDNF at the synapse: why location matters.

Song M, Martinowich K, Lee FS.

Mol Psychiatry. 2017 Oct;22(10):1370-1375. doi: 10.1038/mp.2017.144. Epub 2017 Jul 25.


Bdnf mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus.

Maynard KR, Hobbs JW, Sukumar M, Kardian AS, Jimenez DV, Schloesser RJ, Martinowich K.

Brain Struct Funct. 2017 Sep;222(7):3295-3307. doi: 10.1007/s00429-017-1405-3. Epub 2017 Mar 21.


Loss of promoter IV-driven BDNF expression impacts oscillatory activity during sleep, sensory information processing and fear regulation.

Hill JL, Hardy NF, Jimenez DV, Maynard KR, Kardian AS, Pollock CJ, Schloesser RJ, Martinowich K.

Transl Psychiatry. 2016 Aug 23;6(8):e873. doi: 10.1038/tp.2016.153.


Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling.

Maynard KR, Hill JL, Calcaterra NE, Palko ME, Kardian A, Paredes D, Sukumar M, Adler BD, Jimenez DV, Schloesser RJ, Tessarollo L, Lu B, Martinowich K.

Neuropsychopharmacology. 2016 Jul;41(8):1943-55. doi: 10.1038/npp.2015.349. Epub 2015 Nov 16.


Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus.

Mou Z, Hyde TM, Lipska BK, Martinowich K, Wei P, Ong CJ, Hunter LA, Palaguachi GI, Morgun E, Teng R, Lai C, Condarco TA, Demidowich AP, Krause AJ, Marshall LJ, Haack K, Voruganti VS, Cole SA, Butte NF, Comuzzie AG, Nalls MA, Zonderman AB, Singleton AB, Evans MK, Martin B, Maudsley S, Tsao JW, Kleinman JE, Yanovski JA, Han JC.

Cell Rep. 2015 Nov 10;13(6):1073-1080. doi: 10.1016/j.celrep.2015.09.065. Epub 2015 Oct 29.


Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior.

Hill JL, Martinowich K.

Curr Opin Neurobiol. 2016 Feb;36:59-65. doi: 10.1016/j.conb.2015.10.001. Epub 2015 Oct 23. Review.


Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1.

Yuan Q, Yang F, Xiao Y, Tan S, Husain N, Ren M, Hu Z, Martinowich K, Ng JS, Kim PJ, Han W, Nagata KI, Weinberger DR, Je HS.

Biol Psychiatry. 2016 Aug 15;80(4):312-322. doi: 10.1016/j.biopsych.2015.08.019. Epub 2015 Aug 28.


Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression.

Schloesser RJ, Orvoen S, Jimenez DV, Hardy NF, Maynard KR, Sukumar M, Manji HK, Gardier AM, David DJ, Martinowich K.

Brain Stimul. 2015 Sep-Oct;8(5):862-7. doi: 10.1016/j.brs.2015.05.011. Epub 2015 Jun 9.


Rebound potentiation of inhibition in juvenile visual cortex requires vision-induced BDNF expression.

Gao M, Maynard KR, Chokshi V, Song L, Jacobs C, Wang H, Tran T, Martinowich K, Lee HK.

J Neurosci. 2014 Aug 6;34(32):10770-9. doi: 10.1523/JNEUROSCI.5454-13.2014.


Phasic dopamine neuron activity elicits unique mesofrontal plasticity in adolescence.

Mastwal S, Ye Y, Ren M, Jimenez DV, Martinowich K, Gerfen CR, Wang KH.

J Neurosci. 2014 Jul 16;34(29):9484-96. doi: 10.1523/JNEUROSCI.1114-14.2014.


Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance.

Sakata K, Martinowich K, Woo NH, Schloesser RJ, Jimenez DV, Ji Y, Shen L, Lu B.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15103-8. doi: 10.1073/pnas.1222872110. Epub 2013 Aug 26.


Rapid antidepressant effects: moving right along.

Martinowich K, Jimenez DV, Zarate CA Jr, Manji HK.

Mol Psychiatry. 2013 Aug;18(8):856-63. doi: 10.1038/mp.2013.55. Epub 2013 May 21.


Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome.

Han JC, Thurm A, Golden Williams C, Joseph LA, Zein WM, Brooks BP, Butman JA, Brady SM, Fuhr SR, Hicks MD, Huey AE, Hanish AE, Danley KM, Raygada MJ, Rennert OM, Martinowich K, Sharp SJ, Tsao JW, Swedo SE.

Cortex. 2013 Nov-Dec;49(10):2700-10. doi: 10.1016/j.cortex.2013.02.009. Epub 2013 Feb 19.


Atrophy of pyramidal neurons and increased stress-induced glutamate levels in CA3 following chronic suppression of adult neurogenesis.

Schloesser RJ, Jimenez DV, Hardy NF, Paredes D, Catlow BJ, Manji HK, McKay RD, Martinowich K.

Brain Struct Funct. 2014 May;219(3):1139-48. doi: 10.1007/s00429-013-0532-8. Epub 2013 Mar 13.


Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis.

Lehmann ML, Brachman RA, Martinowich K, Schloesser RJ, Herkenham M.

J Neurosci. 2013 Feb 13;33(7):2961-72. doi: 10.1523/JNEUROSCI.3878-12.2013.


Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder.

Tripp A, Oh H, Guilloux JP, Martinowich K, Lewis DA, Sibille E.

Am J Psychiatry. 2012 Nov;169(11):1194-202. doi: 10.1176/appi.ajp.2012.12020248.


Acetylcholinesterase inhibition ameliorates deficits in motivational drive.

Martinowich K, Cardinale KM, Schloesser RJ, Hsu M, Greig NH, Manji HK.

Behav Brain Funct. 2012 Mar 20;8:15. doi: 10.1186/1744-9081-8-15.


Mood-stabilizing drugs: mechanisms of action.

Schloesser RJ, Martinowich K, Manji HK.

Trends Neurosci. 2012 Jan;35(1):36-46. doi: 10.1016/j.tins.2011.11.009. Review.


Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping.

Martinowich K, Schloesser RJ, Lu Y, Jimenez DV, Paredes D, Greene JS, Greig NH, Manji HK, Lu B.

Biol Psychiatry. 2012 Jan 1;71(1):75-83. doi: 10.1016/j.biopsych.2011.08.014. Epub 2011 Oct 5.


Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression.

Guilloux JP, Douillard-Guilloux G, Kota R, Wang X, Gardier AM, Martinowich K, Tseng GC, Lewis DA, Sibille E.

Mol Psychiatry. 2012 Nov;17(11):1130-42. doi: 10.1038/mp.2011.113. Epub 2011 Sep 13.


TrkB as a potential synaptic and behavioral tag.

Lu Y, Ji Y, Ganesan S, Schloesser R, Martinowich K, Sun M, Mei F, Chao MV, Lu B.

J Neurosci. 2011 Aug 17;31(33):11762-71. doi: 10.1523/JNEUROSCI.2707-11.2011.


Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior.

Martinowich K, Schloesser RJ, Jimenez DV, Weinberger DR, Lu B.

Mol Brain. 2011 Mar 9;4:11. doi: 10.1186/1756-6606-4-11.


Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning.

Fritsch B, Reis J, Martinowich K, Schambra HM, Ji Y, Cohen LG, Lu B.

Neuron. 2010 Apr 29;66(2):198-204. doi: 10.1016/j.neuron.2010.03.035.


Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress.

Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M.

Mol Psychiatry. 2010 Dec;15(12):1152-63. doi: 10.1038/mp.2010.34. Epub 2010 Mar 23.


Bipolar disorder: from genes to behavior pathways.

Martinowich K, Schloesser RJ, Manji HK.

J Clin Invest. 2009 Apr;119(4):726-36. doi: 10.1172/JCI37703. Review.


Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response.

Schloesser RJ, Manji HK, Martinowich K.

Neuroreport. 2009 Apr 22;20(6):553-7. doi: 10.1097/WNR.0b013e3283293e59.


Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex.

Sakata K, Woo NH, Martinowich K, Greene JS, Schloesser RJ, Shen L, Lu B.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5942-7. doi: 10.1073/pnas.0811431106. Epub 2009 Mar 17.


Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Tao J, Hu K, Chang Q, Wu H, Sherman NE, Martinowich K, Klose RJ, Schanen C, Jaenisch R, Wang W, Sun YE.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7. doi: 10.1073/pnas.0811648106. Epub 2009 Feb 18.


Cell biology of BDNF and its relevance to schizophrenia.

Lu B, Martinowich K.

Novartis Found Symp. 2008;289:119-29; discussion 129-35, 193-5. Review.


Interaction between BDNF and serotonin: role in mood disorders.

Martinowich K, Lu B.

Neuropsychopharmacology. 2008 Jan;33(1):73-83. Epub 2007 Sep 19. Review.


New insights into BDNF function in depression and anxiety.

Martinowich K, Manji H, Lu B.

Nat Neurosci. 2007 Sep;10(9):1089-93. Review.


Coupling of cell migration with neurogenesis by proneural bHLH factors.

Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1319-24. Epub 2006 Jan 23.


Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action.

Du J, Machado-Vieira R, Maeng S, Martinowich K, Manji HK, Zarate CA Jr.

Drug Discov Today Ther Strateg. 2006 Winter;3(4):519-526.


DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.

Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE.

Development. 2005 Aug;132(15):3345-56.


A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis.

He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE.

Nat Neurosci. 2005 May;8(5):616-25. Epub 2005 Apr 24.


Distinct LIN-10 domains are required for its neuronal function, its epithelial function, and its synaptic localization.

Glodowski DR, Wright T, Martinowich K, Chang HC, Beach D, Rongo C.

Mol Biol Cell. 2005 Mar;16(3):1417-26. Epub 2005 Jan 12.


DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.

Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE.

Science. 2003 Oct 31;302(5646):890-3.


Making and repairing the mammalian brain--signaling toward neurogenesis and gliogenesis.

Sun YE, Martinowich K, Ge W.

Semin Cell Dev Biol. 2003 Jun;14(3):161-8. Review.


Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.

Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE.

J Neurosci Res. 2002 Sep 15;69(6):848-60.


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