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ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis.

Scambler T, Jarosz-Griffiths HH, Lara-Reyna S, Pathak S, Wong C, Holbrook J, Martinon F, Savic S, Peckham D, McDermott MF.

Elife. 2019 Sep 18;8. pii: e49248. doi: 10.7554/eLife.49248.


Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.

Lara-Reyna S, Scambler T, Holbrook J, Wong C, Jarosz-Griffiths HH, Martinon F, Savic S, Peckham D, McDermott MF.

Front Immunol. 2019 Aug 2;10:1789. doi: 10.3389/fimmu.2019.01789. eCollection 2019.


NK cell immune responses differ after prime and boost vaccination.

Palgen JL, Tchitchek N, Huot N, Elhmouzi-Younes J, Lefebvre C, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Hocini H, Cosma A, Müller-Trutwin M, Lévy Y, Le Grand R, Beignon AS.

J Leukoc Biol. 2019 May;105(5):1055-1073. doi: 10.1002/JLB.4A1018-391RR. Epub 2019 Feb 22.


Gasdermin D opens the way for NETs.

Spel L, Martinon F.

Nat Rev Rheumatol. 2018 Dec;14(12):690-692. doi: 10.1038/s41584-018-0124-3. No abstract available.


Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis.

Järver P, Dondalska A, Poux C, Sandberg A, Bergenstråhle J, Sköld AE, Dereuddre-Bosquet N, Martinon F, Pålsson S, Zaghloul E, Brodin D, Sander B, Lennox KA, Behlke MA, El-Andaloussi S, Lehtiö J, Lundeberg J, LeGrand R, Spetz AL.

Sci Rep. 2018 Oct 26;8(1):15841. doi: 10.1038/s41598-018-33960-4.


A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate.

Jamilloux Y, Lagrange B, Di Micco A, Bourdonnay E, Provost A, Tallant R, Henry T, Martinon F.

J Biol Chem. 2018 Aug 10;293(32):12563-12575. doi: 10.1074/jbc.RA117.000435. Epub 2018 Jun 21.


Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine.

Rosenbaum P, Tchitchek N, Joly C, Stimmer L, Hocini H, Dereuddre-Bosquet N, Beignon AS, Chapon C, Levy Y, Le Grand R, Martinon F.

Front Immunol. 2018 Apr 25;9:870. doi: 10.3389/fimmu.2018.00870. eCollection 2018.


Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection.

Roques P, Thiberville SD, Dupuis-Maguiraga L, Lum FM, Labadie K, Martinon F, Gras G, Lebon P, Ng LFP, de Lamballerie X, Le Grand R.

Viruses. 2018 May 17;10(5). pii: E268. doi: 10.3390/v10050268.


Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response.

Palgen JL, Tchitchek N, Elhmouzi-Younes J, Delandre S, Namet I, Rosenbaum P, Dereuddre-Bosquet N, Martinon F, Cosma A, Lévy Y, Le Grand R, Beignon AS.

Sci Rep. 2018 Feb 15;8(1):3087. doi: 10.1038/s41598-018-21222-2.


Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation.

Castelblanco M, Lugrin J, Ehirchiou D, Nasi S, Ishii I, So A, Martinon F, Busso N.

J Biol Chem. 2018 Feb 16;293(7):2546-2557. doi: 10.1074/jbc.M117.806869. Epub 2017 Dec 26.


The AIM2 inflammasome: Sensor of pathogens and cellular perturbations.

Lugrin J, Martinon F.

Immunol Rev. 2018 Jan;281(1):99-114. doi: 10.1111/imr.12618. Review.


Detection of ASC Oligomerization by Western Blotting.

Lugrin J, Martinon F.

Bio Protoc. 2017 May 20;7(10). pii: e2292. doi: 10.21769/BioProtoc.2292.


Inflammation in gout: mechanisms and therapeutic targets.

So AK, Martinon F.

Nat Rev Rheumatol. 2017 Nov;13(11):639-647. doi: 10.1038/nrrheum.2017.155. Epub 2017 Sep 28. Review.


Inflammation initiated by stressed organelles.

Martinon F.

Joint Bone Spine. 2018 Jul;85(4):423-428. doi: 10.1016/j.jbspin.2017.06.005. Epub 2017 Jul 10.


Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques.

Todorova B, Adam L, Culina S, Boisgard R, Martinon F, Cosma A, Ustav M, Kortulewski T, Le Grand R, Chapon C.

Sci Rep. 2017 Jun 23;7(1):4122. doi: 10.1038/s41598-017-04547-2.


IRE1 gives weight to obesity-associated inflammation.

Bujisic B, Martinon F.

Nat Immunol. 2017 Apr 18;18(5):479-480. doi: 10.1038/ni.3725. No abstract available.


Sublingual Priming with a HIV gp41-Based Subunit Vaccine Elicits Mucosal Antibodies and Persistent B Memory Responses in Non-Human Primates.

Bekri S, Bourdely P, Luci C, Dereuddre-Bosquet N, Su B, Martinon F, Braud VM, Luque I, Mateo PL, Crespillo S, Conejero-Lara F, Moog C, Le Grand R, Anjuère F.

Front Immunol. 2017 Feb 1;8:63. doi: 10.3389/fimmu.2017.00063. eCollection 2017.


Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.

Bujisic B, De Gassart A, Tallant R, Demaria O, Zaffalon L, Chelbi S, Gilliet M, Bertoni F, Martinon F.

Blood. 2017 Apr 27;129(17):2420-2428. doi: 10.1182/blood-2016-09-741348. Epub 2017 Feb 6.


Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome.

Cheung MS, Theodoropoulou K, Lugrin J, Martinon F, Busso N, Hofer M.

J Immunol. 2017 Mar 1;198(5):2063-2069. doi: 10.4049/jimmunol.1600760. Epub 2017 Jan 30.


Translating the anticancer properties of eEF2K.

De Gassart A, Martinon F.

Cell Cycle. 2017 Feb 16;16(4):299-300. doi: 10.1080/15384101.2016.1254974. Epub 2016 Nov 10. No abstract available.


Pharmacological eEF2K activation promotes cell death and inhibits cancer progression.

De Gassart A, Demaria O, Panes R, Zaffalon L, Ryazanov AG, Gilliet M, Martinon F.

EMBO Rep. 2016 Oct;17(10):1471-1484. Epub 2016 Aug 29.


AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity.

Di Micco A, Frera G, Lugrin J, Jamilloux Y, Hsu ET, Tardivel A, De Gassart A, Zaffalon L, Bujisic B, Siegert S, Quadroni M, Broz P, Henry T, Hrycyna CA, Martinon F.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4671-80. doi: 10.1073/pnas.1602419113. Epub 2016 Jul 26.


Raptor hunted by caspases.

Martin R, Thome M, Martinon F, Fasel N.

Cell Death Dis. 2016 Jun 2;7(6):e2242. doi: 10.1038/cddis.2016.153. No abstract available.


Cell-Free Assay for Inflammasome Activation.

Jamilloux Y, Martinon F.

Methods Mol Biol. 2016;1417:207-15. doi: 10.1007/978-1-4939-3566-6_14.


An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.

De Gassart A, Bujisic B, Zaffalon L, Decosterd LA, Di Micco A, Frera G, Tallant R, Martinon F.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E117-26. doi: 10.1073/pnas.1514076113. Epub 2015 Dec 29.


Intradermal injection of an anti-Langerin-HIVGag fusion vaccine targets epidermal Langerhans cells in nonhuman primates and can be tracked in vivo.

Salabert N, Todorova B, Martinon F, Boisgard R, Zurawski G, Zurawski S, Dereuddre-Bosquet N, Cosma A, Kortulewski T, Banchereau J, Levy Y, Le Grand R, Chapon C.

Eur J Immunol. 2016 Mar;46(3):689-700. doi: 10.1002/eji.201545465. Epub 2016 Jan 19.


STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.

Demaria O, De Gassart A, Coso S, Gestermann N, Di Domizio J, Flatz L, Gaide O, Michielin O, Hwu P, Petrova TV, Martinon F, Modlin RL, Speiser DE, Gilliet M.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15408-13. doi: 10.1073/pnas.1512832112. Epub 2015 Nov 25.


Pyroptosis: Caspase-11 Unlocks the Gates of Death.

de Gassart A, Martinon F.

Immunity. 2015 Nov 17;43(5):835-7. doi: 10.1016/j.immuni.2015.10.024.


Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo.

Flamar AL, Contreras V, Zurawski S, Montes M, Dereuddre-Bosquet N, Martinon F, Banchereau J, Le Grand R, Zurawski G, Levy Y.

PLoS One. 2015 Sep 25;10(9):e0135513. doi: 10.1371/journal.pone.0135513. eCollection 2015.


Identification of skin immune cells in non-human primates.

Adam L, Rosenbaum P, Cosma A, Le Grand R, Martinon F.

J Immunol Methods. 2015 Nov;426:42-9. doi: 10.1016/j.jim.2015.07.010. Epub 2015 Jul 26.


HIV specific responses induced in nonhuman primates with ANRS HIV-Lipo-5 vaccine combined with rMVA-HIV prime or boost immunizations.

Dereuddre-Bosquet N, Baron ML, Contreras V, Gosse L, Mangeot I, Martinon F, Yousfi R, Clayette P, Levy Y, Le Grand R; Vaccine Research Institute.

Vaccine. 2015 May 11;33(20):2354-9. doi: 10.1016/j.vaccine.2015.03.032. Epub 2015 Apr 1.


Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.

Ives A, Nomura J, Martinon F, Roger T, LeRoy D, Miner JN, Simon G, Busso N, So A.

Nat Commun. 2015 Mar 24;6:6555. doi: 10.1038/ncomms7555.


Pathogenesis of adult-onset Still's disease: new insights from the juvenile counterpart.

Jamilloux Y, Gerfaud-Valentin M, Martinon F, Belot A, Henry T, Sève P.

Immunol Res. 2015 Feb;61(1-2):53-62. doi: 10.1007/s12026-014-8561-9. Review.


New players driving inflammation in monogenic autoinflammatory diseases.

Martinon F, Aksentijevich I.

Nat Rev Rheumatol. 2015 Jan;11(1):11-20. doi: 10.1038/nrrheum.2014.158. Epub 2014 Sep 23. Review.


Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses.

Epaulard O, Adam L, Poux C, Zurawski G, Salabert N, Rosenbaum P, Dereuddre-Bosquet N, Zurawski S, Flamar AL, Oh S, Romain G, Chapon C, Banchereau J, Lévy Y, Le Grand R, Martinon F.

J Immunol. 2014 Sep 1;193(5):2416-26. doi: 10.4049/jimmunol.1303339. Epub 2014 Jul 23.


Electroporation-mediated intradermal delivery of DNA vaccines in nonhuman primates.

Adam L, Le Grand R, Martinon F.

Methods Mol Biol. 2014;1121:309-13. doi: 10.1007/978-1-4614-9632-8_27.


Crystal structure of NLRC4 reveals its autoinhibition mechanism.

Hu Z, Yan C, Liu P, Huang Z, Ma R, Zhang C, Wang R, Zhang Y, Martinon F, Miao D, Deng H, Wang J, Chang J, Chai J.

Science. 2013 Jul 12;341(6142):172-5. doi: 10.1126/science.1236381. Epub 2013 Jun 13.


Did cholera toxin finally get caught?

Martinon F, van der Goot FG.

Cell Host Microbe. 2013 May 15;13(5):501-503. doi: 10.1016/j.chom.2013.04.014.


Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques.

Borggren M, Vinner L, Andresen BS, Grevstad B, Repits J, Melchers M, Elvang TL, Sanders RW, Martinon F, Dereuddre-Bosquet N, Bowles EJ, Stewart-Jones G, Biswas P, Scarlatti G, Jansson M, Heyndrickx L, Grand RL, Fomsgaard A.

Vaccines (Basel). 2013 Jul 19;1(3):305-27. doi: 10.3390/vaccines1030305.


The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses.

Martinon F.

Microbes Infect. 2012 Nov;14(14):1293-300. doi: 10.1016/j.micinf.2012.07.005. Epub 2012 Jul 16. Review.


Targeting endoplasmic reticulum signaling pathways in cancer.

Martinon F.

Acta Oncol. 2012 Sep;51(7):822-30. doi: 10.3109/0284186X.2012.689113. Epub 2012 Jun 11. Review.


CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates.

Romain G, van Gulck E, Epaulard O, Oh S, Li D, Zurawski G, Zurawski S, Cosma A, Adam L, Chapon C, Todorova B, Banchereau J, Dereuddre-Bosquet N, Vanham G, Le Grand R, Martinon F.

Eur J Immunol. 2012 Aug;42(8):2019-30. doi: 10.1002/eji.201242478. Epub 2012 Jul 4.


Dangerous liaisons: mitochondrial DNA meets the NLRP3 inflammasome.

Martinon F.

Immunity. 2012 Mar 23;36(3):313-5. doi: 10.1016/j.immuni.2012.03.005.


The unfolded protein response: integrating stress signals through the stress sensor IRE1α.

Hetz C, Martinon F, Rodriguez D, Glimcher LH.

Physiol Rev. 2011 Oct;91(4):1219-43. doi: 10.1152/physrev.00001.2011. Review.


Editorial overview.

Glimcher LH, Martinon F, Modlin RL.

Curr Opin Immunol. 2011 Feb;23(1):1-2. doi: 10.1016/j.coi.2010.12.001. Epub 2010 Dec 23. No abstract available.


Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum.

Martinon F, Glimcher LH.

Curr Opin Immunol. 2011 Feb;23(1):35-40. doi: 10.1016/j.coi.2010.10.016. Epub 2010 Nov 18. Review.


Update on biology: uric acid and the activation of immune and inflammatory cells.

Martinon F.

Curr Rheumatol Rep. 2010 Apr;12(2):135-41. doi: 10.1007/s11926-010-0092-3. Review.


TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

Martinon F, Chen X, Lee AH, Glimcher LH.

Nat Immunol. 2010 May;11(5):411-8. doi: 10.1038/ni.1857. Epub 2010 Mar 28.


Signaling by ROS drives inflammasome activation.

Martinon F.

Eur J Immunol. 2010 Mar;40(3):616-9. doi: 10.1002/eji.200940168. Review.


Mechanisms of uric acid crystal-mediated autoinflammation.

Martinon F.

Immunol Rev. 2010 Jan;233(1):218-32. doi: 10.1111/j.0105-2896.2009.00860.x. Review.


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