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Items: 40


Von Willebrand factor and ADAMTS13 impact on the outcome of Staphylococcus aureus sepsis.

Peetermans M, Meyers S, Liesenborghs L, Vanhoorelbeke K, De Meyer SF, Vandenbriele C, Lox M, Hoylaerts MF, Martinod K, Jacquemin M, Vanassche T, Verhamme P.

J Thromb Haemost. 2019 Nov 22. doi: 10.1111/jth.14686. [Epub ahead of print]


Extracellular DNA NET-Works With Dire Consequences for Health.

Sorvillo N, Cherpokova D, Martinod K, Wagner DD.

Circ Res. 2019 Aug 2;125(4):470-488. doi: 10.1161/CIRCRESAHA.119.314581. Epub 2019 Aug 1.


Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury.

Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD.

Circ Res. 2019 Aug 16;125(5):507-519. doi: 10.1161/CIRCRESAHA.118.314571. Epub 2019 Jun 28.


von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome.

Kraisin S, Verhenne S, Pham TT, Martinod K, Tersteeg C, Vandeputte N, Deckmyn H, Vanhoorelbeke K, Van den Steen PE, De Meyer SF.

J Thromb Haemost. 2019 Aug;17(8):1372-1383. doi: 10.1111/jth.14485. Epub 2019 Jun 12.


Neutrophil Extracellular Traps in Arterial and Venous Thrombosis.

Laridan E, Martinod K, De Meyer SF.

Semin Thromb Hemost. 2019 Feb;45(1):86-93. doi: 10.1055/s-0038-1677040. Epub 2019 Jan 11. Review.


Solid peripheral tumor leads to systemic inflammation, astrocyte activation and signs of behavioral despair in mice.

Demers M, Suidan GL, Andrews N, Martinod K, Cabral JE, Wagner DD.

PLoS One. 2018 Nov 15;13(11):e0207241. doi: 10.1371/journal.pone.0207241. eCollection 2018.


von Willebrand factor deficiency does not influence angiotensin II-induced abdominal aortic aneurysm formation in mice.

Portier I, Martinod K, Desender L, Vandeputte N, Deckmyn H, Vanhoorelbeke K, De Meyer SF.

Sci Rep. 2018 Nov 9;8(1):16645. doi: 10.1038/s41598-018-35029-8.


Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma.

Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD; National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators.

Sci Immunol. 2018 Aug 3;3(26). pii: eaao4747. doi: 10.1126/sciimmunol.aao4747.


What a drag: necrotic platelets induce remote neutrophil thrombi following ischemic gut injury.

Martinod K, Fuchs TA.

J Thromb Haemost. 2018 May;16(5):819-821. doi: 10.1111/jth.13989. No abstract available.


Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.

Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan8292. doi: 10.1126/scitranslmed.aan8292.


ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice.

Zitomersky NL, Demers M, Martinod K, Gallant M, Cifuni SM, Biswas A, Snapper S, Wagner DD.

TH Open. 2017 Jun;1(1):e11-e23. doi: 10.1055/s-0037-1603927.


Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice.

Witsch T, Martinod K, Sorvillo N, Portier I, De Meyer SF, Wagner DD.

J Am Heart Assoc. 2018 Jan 24;7(3). pii: e007004. doi: 10.1161/JAHA.117.007004.


Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients.

Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J.

J Thromb Haemost. 2018 Mar;16(3):508-518. doi: 10.1111/jth.13951. Epub 2018 Feb 7.


Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.

Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD.

PLoS One. 2017 Dec 13;12(12):e0188341. doi: 10.1371/journal.pone.0188341. eCollection 2017.


A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target.

Gavillet M, Martinod K, Renella R, Wagner DD, Williams DA.

Am J Hematol. 2018 Feb;93(2):269-276. doi: 10.1002/ajh.24970. Epub 2017 Dec 6.


White-tailed deer browse on an invasive shrub with extended leaf phenology meets assumptions of an apparent competition hypothesis.

Martinod KL, Gorchov DL.

AoB Plants. 2017 Feb 13;9(2):plx006. doi: 10.1093/aobpla/plx006. eCollection 2017 Mar.


Peptidylarginine deiminase 4 promotes age-related organ fibrosis.

Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD.

J Exp Med. 2017 Feb;214(2):439-458. doi: 10.1084/jem.20160530. Epub 2016 Dec 28.


Priming of neutrophils toward NETosis promotes tumor growth.

Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD.

Oncoimmunology. 2016 Feb 18;5(5):e1134073. doi: 10.1080/2162402X.2015.1134073. eCollection 2016 May.


OC-16 - Neutrophil extracellular traps and tissue factor-bearing microvesicles: a liaison dangereuse causing overt DIC in cancer patients?

Hell L, Thaler J, Martinod K, Ay C, Posch F, Wagner DD, Pabinger I.

Thromb Res. 2016 Apr;140 Suppl 1:S174-5. doi: 10.1016/S0049-3848(16)30133-5. Epub 2016 Apr 8.


Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.

Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A.

Science. 2016 Apr 22;352(6284):463-6. doi: 10.1126/science.aaf3926.


Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.

Martinod K, Witsch T, Farley K, Gallant M, Remold-O'Donnell E, Wagner DD.

J Thromb Haemost. 2016 Mar;14(3):551-8. doi: 10.1111/jth.13239. Epub 2016 Feb 5.


Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples.

Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA.

Am J Hematol. 2015 Dec;90(12):1155-8. doi: 10.1002/ajh.24185. Epub 2015 Oct 6.


Diabetes primes neutrophils to undergo NETosis, which impairs wound healing.

Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, Kahn CR, Wagner DD.

Nat Med. 2015 Jul;21(7):815-9. doi: 10.1038/nm.3887. Epub 2015 Jun 15.


P-selectin promotes neutrophil extracellular trap formation in mice.

Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD.

Blood. 2015 Jul 9;126(2):242-6. doi: 10.1182/blood-2015-01-624023. Epub 2015 May 15.


PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock.

Martinod K, Fuchs TA, Zitomersky NL, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD.

Blood. 2015 Mar 19;125(12):1948-56. doi: 10.1182/blood-2014-07-587709. Epub 2015 Jan 26.


Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM.

Nat Chem Biol. 2015 Mar;11(3):189-91. doi: 10.1038/nchembio.1735. Epub 2015 Jan 26.


Dietary omega-3 alpha-linolenic acid does not prevent venous thrombosis in mice.

Reiner MF, Martinod K, Stivala S, Savarese G, Camici GG, Lüscher TF, Wagner DD, Beer JH.

Thromb Haemost. 2015 Jan;113(1):177-84. doi: 10.1160/TH14-03-0200. Epub 2014 Sep 18.


Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins.

Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J.

J Immunol. 2014 Jun 1;192(11):5390-7. doi: 10.4049/jimmunol.1303296. Epub 2014 Apr 25.


Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development.

Savchenko AS, Martinod K, Seidman MA, Wong SL, Borissoff JI, Piazza G, Libby P, Goldhaber SZ, Mitchell RN, Wagner DD.

J Thromb Haemost. 2014 Jun;12(6):860-70. doi: 10.1111/jth.12571.


Thrombosis: tangled up in NETs.

Martinod K, Wagner DD.

Blood. 2014 May 1;123(18):2768-76. doi: 10.1182/blood-2013-10-463646. Epub 2013 Dec 23. Review.


VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice.

Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD.

Blood. 2014 Jan 2;123(1):141-8. doi: 10.1182/blood-2013-07-514992. Epub 2013 Nov 7.


Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.

Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BLJH.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):2032-2040. doi: 10.1161/ATVBAHA.113.301627. Epub 2013 Jul 1.


Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.

Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8674-9. doi: 10.1073/pnas.1301059110. Epub 2013 May 6.


Neutrophils release extracellular DNA traps during storage of red blood cell units.

Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD.

Transfusion. 2013 Dec;53(12):3210-6. doi: 10.1111/trf.12203. Epub 2013 Apr 8.


Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo.

Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN.

Blood. 2012 Nov 22;120(22):4421-31. doi: 10.1182/blood-2011-12-401133. Epub 2012 Sep 6.


Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.

Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81. doi: 10.1073/pnas.1200419109. Epub 2012 Jul 23.


Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.

Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD.

Blood. 2012 Jun 28;119(26):6335-43. doi: 10.1182/blood-2012-01-405183. Epub 2012 May 17.


Neutrophil extracellular traps promote deep vein thrombosis in mice.

Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD.

J Thromb Haemost. 2012 Jan;10(1):136-44. doi: 10.1111/j.1538-7836.2011.04544.x.


Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.

Gleissman H, Yang R, Martinod K, Lindskog M, Serhan CN, Johnsen JI, Kogner P.

FASEB J. 2010 Mar;24(3):906-15. doi: 10.1096/fj.09-137919. Epub 2009 Nov 4.


Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions.

Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M.

J Exp Med. 2009 Jan 16;206(1):15-23. doi: 10.1084/jem.20081880. Epub 2008 Dec 22.

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