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Probing the dynamic properties of two sites simultaneously in a protein-protein interaction process: a SDSL-EPR study.

Le Breton N, Longhi S, Rockenbauer A, Guigliarelli B, Marque SRA, Belle V, Martinho M.

Phys Chem Chem Phys. 2019 Oct 7. doi: 10.1039/c9cp04660g. [Epub ahead of print]


Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects.

Barbier P, Zejneli O, Martinho M, Lasorsa A, Belle V, Smet-Nocca C, Tsvetkov PO, Devred F, Landrieu I.

Front Aging Neurosci. 2019 Aug 7;11:204. doi: 10.3389/fnagi.2019.00204. eCollection 2019.


The Hunt for the Closed Conformation of the Fruit-Ripening Enzyme 1-Aminocyclopropane-1-carboxylic Oxidase: A Combined Electron Paramagnetic Resonance and Molecular Dynamics Study.

Fournier E, Tachon S, Fowler NJ, Gerbaud G, Mansuelle P, Dorlet P, de Visser SP, Belle V, Simaan AJ, Martinho M.

Chemistry. 2019 Aug 19. doi: 10.1002/chem.201903003. [Epub ahead of print]


Chemical Modification of 1-Aminocyclopropane Carboxylic Acid (ACC) Oxidase: Cysteine Mutational Analysis, Characterization, and Bioconjugation with a Nitroxide Spin Label.

Tachon S, Fournier E, Decroos C, Mansuelle P, Etienne E, Maresca M, Martinho M, Belle V, Tron T, Simaan AJ.

Mol Biotechnol. 2019 Sep;61(9):650-662. doi: 10.1007/s12033-019-00191-5.


Assessment of Drug Interaction Potential Between the Hepatitis C Virus Direct-Acting Antiviral Agents Elbasvir/Grazoprevir and the Nucleotide Analog Reverse-Transcriptase Inhibitor Tenofovir Disoproxil Fumarate.

Feng HP, Guo Z, Caro L, Talaty JE, Mangin E, Panebianco D, Fandozzi C, Zhu Y, Marshall W, Huang X, Hanley WD, Jumes P, Valesky R, Martinho M, Butterton JR, Iwamoto M, Yeh WW.

Clin Pharmacol Drug Dev. 2019 Oct;8(7):962-970. doi: 10.1002/cpdd.701. Epub 2019 Jun 7.


Pharmacokinetic Interactions Between the Fixed-Dose Combinations of Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine and Elbasvir/Grazoprevir in Healthy Adult Participants.

Feng HP, Guo Z, Fandozzi C, Panebianco D, Caro L, Wolford D, Dreyer DP, Valesky R, Martinho M, Rizk ML, Iwamoto M, Yeh WW.

Clin Pharmacol Drug Dev. 2019 Oct;8(7):952-961. doi: 10.1002/cpdd.702. Epub 2019 Jun 7.


Pharmacokinetic Interactions between the Hepatitis C Virus Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, and Darunavir in Healthy Volunteers.

Feng HP, Caro L, Fandozzi C, Chu X, Guo Z, Talaty J, Panebianco D, Dunnington K, Du L, Hanley WD, Fraser IP, Mitselos A, Denef JF, De Lepeleire I, de Hoon JN, Vandermeulen C, Marshall WL, Jumes P, Huang X, Martinho M, Valesky R, Butterton JR, Iwamoto M, Yeh WW.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02142-18. doi: 10.1128/AAC.02142-18. Print 2019 Apr.


Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges.

Martinho M, Allegro D, Huvent I, Chabaud C, Etienne E, Kovacic H, Guigliarelli B, Peyrot V, Landrieu I, Belle V, Barbier P.

Sci Rep. 2018 Sep 14;8(1):13846. doi: 10.1038/s41598-018-32096-9.


No Pharmacokinetic Interactions Between Elbasvir or Grazoprevir and Methadone in Participants Receiving Maintenance Opioid Agonist Therapy.

Feng HP, Guo Z, Caro L, Marshall WL, Liu F, Panebianco D, Vaddady P, Reitmann C, Jumes P, Wolford D, Fraser I, Valesky R, Martinho M, Butterton JR, Iwamoto M, Webster L, Yeh WW.

Clin Transl Sci. 2018 Nov;11(6):553-561. doi: 10.1111/cts.12564. Epub 2018 Jul 24.


No Pharmacokinetic Interactions Between Elbasvir or Grazoprevir and Buprenorphine/Naloxone in Healthy Participants and Participants Receiving Stable Opioid Agonist Therapy.

Feng HP, Guo Z, Caro L, Marshall WL, Liu F, Panebianco D, Vaddady P, Barbour A, Reitmann C, Jumes P, Gilmartin J, Wolford D, Valesky R, Martinho M, Butterton JR, Iwamoto M, Fraser I, Webster L, Yeh WW.

Clin Transl Sci. 2018 Nov;11(6):562-572. doi: 10.1111/cts.12565. Epub 2018 Jul 24.


Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.

Khalilieh S, Hussain A, Montgomery D, Levine V, Shaw PM, Bodrug I, Mekokishvili L, Bailey-Smith C, Glasgow XS, Cheng A, Martinho M, Iwamoto M.

Br J Clin Pharmacol. 2018 Oct;84(10):2292-2302. doi: 10.1111/bcp.13670. Epub 2018 Jul 31.


Effect of clinical information and previous exam execution on observer agreement and reliability in the analysis of hysteroscopic video-recordings.

Martinho MSL, da Costa Santos CMN, Silva Carvalho JLM, Bernardes JFMAL.

Arch Gynecol Obstet. 2018 Feb;297(2):393-400. doi: 10.1007/s00404-017-4614-3. Epub 2017 Dec 7.


Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group.

van Rooij D, Anagnostou E, Arango C, Auzias G, Behrmann M, Busatto GF, Calderoni S, Daly E, Deruelle C, Di Martino A, Dinstein I, Duran FLS, Durston S, Ecker C, Fair D, Fedor J, Fitzgerald J, Freitag CM, Gallagher L, Gori I, Haar S, Hoekstra L, Jahanshad N, Jalbrzikowski M, Janssen J, Lerch J, Luna B, Martinho MM, McGrath J, Muratori F, Murphy CM, Murphy DGM, O'Hearn K, Oranje B, Parellada M, Retico A, Rosa P, Rubia K, Shook D, Taylor M, Thompson PM, Tosetti M, Wallace GL, Zhou F, Buitelaar JK.

Am J Psychiatry. 2018 Apr 1;175(4):359-369. doi: 10.1176/appi.ajp.2017.17010100. Epub 2017 Nov 17.


A novel platform for distributed and remote real-time monitoring of animal model behavior in a bioterium.

Manso A, Martinho M, Silva H, Cabrita A, Banganho A, Machado G, Macedo M.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:3728-3731. doi: 10.1109/EMBC.2017.8037667.


Update on medical treatment of uterine fibroids.

Faustino F, Martinho M, Reis J, Águas F.

Eur J Obstet Gynecol Reprod Biol. 2017 Sep;216:61-68. doi: 10.1016/j.ejogrb.2017.06.047. Epub 2017 Jul 8. Review.


Characterization of Cu(II)-reconstituted ACC Oxidase using experimental and theoretical approaches.

El Bakkali-Tahéri N, Tachon S, Orio M, Bertaina S, Martinho M, Robert V, Réglier M, Tron T, Dorlet P, Simaan AJ.

Arch Biochem Biophys. 2017 Jun 1;623-624:31-41. doi: 10.1016/ Epub 2017 May 15.


Evaluation of the electric field in the brain during transcranial direct current stimulation: A sensitivity analysis.

Santos L, Martinho M, Salvador R, Wenger C, Fernandes SR, Ripolles O, Ruffini G, Miranda PC.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1778-1781. doi: 10.1109/EMBC.2016.7591062.


Oxoiron(IV) Tetramethylcyclam Complexes with Axial Carboxylate Ligands: Effect of Tethering the Carboxylate on Reactivity.

Bigelow JO, England J, Klein JE, Farquhar ER, Frisch JR, Martinho M, Mandal D, Münck E, Shaik S, Que L Jr.

Inorg Chem. 2017 Mar 20;56(6):3287-3301. doi: 10.1021/acs.inorgchem.6b02659. Epub 2017 Mar 3.


SimLabel: a graphical user interface to simulate continuous wave EPR spectra from site-directed spin labeling experiments.

Etienne E, Le Breton N, Martinho M, Mileo E, Belle V.

Magn Reson Chem. 2017 Aug;55(8):714-719. doi: 10.1002/mrc.4578. Epub 2017 Feb 16.


Laparoscopic management of ureteral endometriosis: A systematic review.

Cavaco-Gomes J, Martinho M, Gilabert-Aguilar J, Gilabert-Estélles J.

Eur J Obstet Gynecol Reprod Biol. 2017 Mar;210:94-101. doi: 10.1016/j.ejogrb.2016.12.011. Epub 2016 Dec 12. Review.


Dimerization interface and dynamic properties of yeast IF1 revealed by Site-Directed Spin Labeling EPR spectroscopy.

Le Breton N, Adrianaivomananjaona T, Gerbaud G, Etienne E, Bisetto E, Dautant A, Guigliarelli B, Haraux F, Martinho M, Belle V.

Biochim Biophys Acta. 2016 Jan;1857(1):89-97. doi: 10.1016/j.bbabio.2015.10.010. Epub 2015 Oct 28.


Temperature Effect on Ionic Current and ssDNA Transport through Nanopores.

Payet L, Martinho M, Merstorf C, Pastoriza-Gallego M, Pelta J, Viasnoff V, Auvray L, Muthukumar M, Mathé J.

Biophys J. 2015 Oct 20;109(8):1600-7. doi: 10.1016/j.bpj.2015.08.043.


Exploring intrinsically disordered proteins using site-directed spin labeling electron paramagnetic resonance spectroscopy.

Le Breton N, Martinho M, Mileo E, Etienne E, Gerbaud G, Guigliarelli B, Belle V.

Front Mol Biosci. 2015 May 19;2:21. doi: 10.3389/fmolb.2015.00021. eCollection 2015. Review.


[Decision making satisfaction in health scale: instrument adapted and validated to Portuguese].

Martinho MJ, Martins MM, Angelo M.

Rev Bras Enferm. 2014 Nov-Dec;67(6):891-7. doi: 10.1590/0034-7167.2014670605. Epub 2014 Dec 1. Portuguese.


Nurses' attitudes regarding the importance of families in pediatric nursing care.

Angelo M, Cruz AC, Mekitarian FF, Santos CC, Martinho MJ, Martins MM.

Rev Esc Enferm USP. 2014 Aug;48 Spec No:74-9. doi: 10.1590/S0080-623420140000600011. Epub 2014 Aug 1. English, Portuguese.


An Ultra-Stable Oxoiron(IV) Complex and Its Blue Conjugate Base.

England J, Bigelow JO, Van Heuvelen KM, Farquhar ER, Martinho M, Meier KK, Frisch JR, Münck E, Que L Jr.

Chem Sci. 2014 Mar 1;5(3):1204-1215.


[Scale of conflict in health care decision-making: an instrument adapted and validated for the Portuguese language].

Martinho MJ, da Silva MM, Angelo M.

Rev Esc Enferm USP. 2013 Jun;47(3):576-83. Portuguese.


Diversification of EPR signatures in Site Directed Spin Labeling using a β-phosphorylated nitroxide.

Le Breton N, Martinho M, Kabytaev K, Topin J, Mileo E, Blocquel D, Habchi J, Longhi S, Rockenbauer A, Golebiowski J, Guigliarelli B, Marque SR, Belle V.

Phys Chem Chem Phys. 2014 Mar 7;16(9):4202-9. doi: 10.1039/c3cp54816c.


The Absence of a Clinically Significant Effect of Food on the Single Dose Pharmacokinetics of Vorapaxar, a PAR-1 Antagonist, in Healthy Adult Subjects.

Behm MO, Kosoglou T, Miltenburg AM, Li J, Statkevich P, Johnson-Levonas AO, Martinho M, Fackler P.

Clin Pharmacol Drug Dev. 2013 Oct;2(4):310-5. doi: 10.1002/cpdd.38.


Enlarging the panoply of site-directed spin labeling electron paramagnetic resonance (SDSL-EPR): sensitive and selective spin-labeling of tyrosine using an isoindoline-based nitroxide.

Mileo E, Etienne E, Martinho M, Lebrun R, Roubaud V, Tordo P, Gontero B, Guigliarelli B, Marque SR, Belle V.

Bioconjug Chem. 2013 Jun 19;24(6):1110-7. doi: 10.1021/bc4000542. Epub 2013 May 22.


Assessing induced folding within the intrinsically disordered C-terminal domain of the Henipavirus nucleoproteins by site-directed spin labeling EPR spectroscopy.

Martinho M, Habchi J, El Habre Z, Nesme L, Guigliarelli B, Belle V, Longhi S.

J Biomol Struct Dyn. 2013;31(5):453-71. doi: 10.1080/07391102.2012.706068. Epub 2012 Aug 13.


A new solid oral tablet formulation of posaconazole: a randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers.

Krishna G, Ma L, Martinho M, Preston RA, O'Mara E.

J Antimicrob Chemother. 2012 Nov;67(11):2725-30. doi: 10.1093/jac/dks268. Epub 2012 Jul 24.


Monitoring structural transitions in IDPs by site-directed spin labeling EPR spectroscopy.

Habchi J, Martinho M, Gruet A, Guigliarelli B, Longhi S, Belle V.

Methods Mol Biol. 2012;895:361-86. doi: 10.1007/978-1-61779-927-3_21.


Single-dose phase I study to evaluate the pharmacokinetics of posaconazole in new tablet and capsule formulations relative to oral suspension.

Krishna G, Ma L, Martinho M, O'Mara E.

Antimicrob Agents Chemother. 2012 Aug;56(8):4196-201. doi: 10.1128/AAC.00222-12. Epub 2012 May 21.


Thermal unfolding of proteins probed at the single molecule level using nanopores.

Payet L, Martinho M, Pastoriza-Gallego M, Betton JM, Auvray L, Pelta J, Mathé J.

Anal Chem. 2012 May 1;84(9):4071-6. doi: 10.1021/ac300129e. Epub 2012 Apr 18.


Vorapaxar, an oral PAR-1 receptor antagonist, does not affect the pharmacokinetics and pharmacodynamics of warfarin.

Kosoglou T, Zhu Y, Xuan F, Black L, Johnson-Levonas AO, Martinho M, Statkevich P, Cutler DL.

Eur J Clin Pharmacol. 2012 Nov;68(11):1509-16. doi: 10.1007/s00228-012-1271-0. Epub 2012 Apr 5.


[Attitudes of nurses towards families: validation of the scale Families' Importance in Nursing Care--Nurses Attitudes].

Oliveira Pda C, Fernandes HI, Vilar AI, Figueiredo MH, Ferreira MM, Martinho MJ, Figueiredo Mdo C, Andrade LM, de Carvalho JC, Martins MM.

Rev Esc Enferm USP. 2011 Dec;45(6):1331-7. Portuguese.


Effect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers.

Krishna G, Ma L, Prasad P, Moton A, Martinho M, O'Mara E.

Expert Opin Drug Metab Toxicol. 2012 Jan;8(1):1-10. doi: 10.1517/17425255.2012.639360. Epub 2011 Dec 19.


Tyrosine-targeted spin labeling and EPR spectroscopy: an alternative strategy for studying structural transitions in proteins.

Lorenzi M, Puppo C, Lebrun R, Lignon S, Roubaud V, Martinho M, Mileo E, Tordo P, Marque SR, Gontero B, Guigliarelli B, Belle V.

Angew Chem Int Ed Engl. 2011 Sep 19;50(39):9108-11. doi: 10.1002/anie.201102539. Epub 2011 Aug 24. No abstract available.


Dividing to unveil protein microheterogeneities: traveling wave ion mobility study.

Halgand F, Habchi J, Cravello L, Martinho M, Guigliarelli B, Longhi S.

Anal Chem. 2011 Oct 1;83(19):7306-15. doi: 10.1021/ac200994c. Epub 2011 Aug 29.


Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.

Krishna G, Ma L, Martinho M, Prasad P, Wahl J, Tavakkol A.

Antimicrob Agents Chemother. 2011 Sep;55(9):4424-6. doi: 10.1128/AAC.01302-10. Epub 2011 Jul 11.


Primary adenocarcinoma of the fallopian tube presenting as hydrosalpinx.

Melo A, Fernandes AS, Costa A, Paiva V, Martinho M.

J Obstet Gynaecol. 2011 Jul;31(5):455-7. doi: 10.3109/01443615.2011.569778. No abstract available.


DNA translocation and unzipping through a nanopore: some geometrical effects.

Muzard J, Martinho M, Mathé J, Bockelmann U, Viasnoff V.

Biophys J. 2010 May 19;98(10):2170-8. doi: 10.1016/j.bpj.2010.01.041.


Skin concentrations and pharmacokinetics of posaconazole after oral administration.

Krishna G, Beresford E, Ma L, Vickery D, Martinho M, Yu X, Komjathy S, Tavakkol A.

Antimicrob Agents Chemother. 2010 May;54(5):1807-10. doi: 10.1128/AAC.01616-09. Epub 2010 Mar 1.


Activation of dioxygen by a mononuclear non-heme iron complex: characterization of a Fe(III)(OOH) intermediate.

Martinho M, Blain G, Banse F.

Dalton Trans. 2010 Feb 14;39(6):1630-4. doi: 10.1039/b918061c. Epub 2009 Dec 15.


Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center.

Vu VV, Emerson JP, Martinho M, Kim YS, Münck E, Park MH, Que L Jr.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14814-9. doi: 10.1073/pnas.0904553106. Epub 2009 Aug 19.


Effects of oral posaconazole on the pharmacokinetics of atazanavir alone and with ritonavir or with efavirenz in healthy adult volunteers.

Krishna G, Moton A, Ma L, Martinho M, Seiberling M, McLeod J.

J Acquir Immune Defic Syndr. 2009 Aug 1;51(4):437-44.


Characterization of two distinct adducts in the reaction of a nonheme diiron(II) complex with O2.

Frisch JR, Vu VV, Martinho M, Münck E, Que L Jr.

Inorg Chem. 2009 Sep 7;48(17):8325-36. doi: 10.1021/ic900961k.


A synthetic high-spin oxoiron(IV) complex: generation, spectroscopic characterization, and reactivity.

England J, Martinho M, Farquhar ER, Frisch JR, Bominaar EL, Münck E, Que L Jr.

Angew Chem Int Ed Engl. 2009;48(20):3622-6. doi: 10.1002/anie.200900863.


Mössbauer and DFT study of the ferromagnetically coupled diiron(IV) precursor to a complex with an Fe(IV)(2)O(2) diamond core.

Martinho M, Xue G, Fiedler AT, Que L Jr, Bominaar EL, Münck E.

J Am Chem Soc. 2009 Apr 29;131(16):5823-30. doi: 10.1021/ja8098917.

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