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Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: An in vitro and in vivo study in aortic stenosis.

Matilla L, Ibarrola J, Arrieta V, Garcia-Peña A, Martinez-Martinez E, Sádaba R, Alvarez V, Navarro A, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Bayes-Genis A, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2019 Jul 8. pii: CS20190475. doi: 10.1042/CS20190475. [Epub ahead of print]


Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition.

Ibarrola J, Matilla L, Martínez-Martínez E, Gueret A, Fernández-Celis A, Henry JP, Nicol L, Jaisser F, Mulder P, Ouvrard-Pascaud A, López-Andrés N.

Sci Rep. 2019 Jul 3;9(1):9607. doi: 10.1038/s41598-019-46119-6.


The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction.

Marín-Royo G, Ortega-Hernández A, Martínez-Martínez E, Jurado-López R, Luaces M, Islas F, Gómez-Garre D, Delgado-Valero B, Lagunas E, Ramchandani B, García-Bouza M, Nieto ML, Cachofeiro V.

Sci Rep. 2019 Jan 24;9(1):444. doi: 10.1038/s41598-018-36914-y.


CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation.

Martínez-Martínez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, López B, Fernández-Celis A, Querejeta R, Santamaria E, Fernández-Irigoyen J, Rábago G, Moreno MU, Jaisser F, Díez J, González A, López-Andrés N.

Hypertension. 2019 Mar;73(3):602-611. doi: 10.1161/HYPERTENSIONAHA.118.11874.


More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases.

Buonafine M, Martinez-Martinez E, Jaisser F.

Clin Sci (Lond). 2018 May 8;132(9):909-923. doi: 10.1042/CS20171592. Print 2018 May 16. Review.


Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12.

Ibarrola J, Sadaba R, Martinez-Martinez E, Garcia-Peña A, Arrieta V, Alvarez V, Fernández-Celis A, Gainza A, Cachofeiro V, Santamaria E, Fernandez-Irigoyen J, Jaisser F, Lopez-Andres N.

Sci Rep. 2018 May 1;8(1):6801. doi: 10.1038/s41598-018-25068-6.


Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage.

Ibarrola J, Arrieta V, Sádaba R, Martinez-Martinez E, Garcia-Peña A, Alvarez V, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Cachofeiro V, Zalba G, Fay R, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2018 Jul 18;132(13):1471-1485. doi: 10.1042/CS20171389. Print 2018 Jul 18.


A role for fumarate hydratase in mediating oxidative effects of galectin-3 in human cardiac fibroblasts.

Ibarrola J, Sádaba R, Garcia-Peña A, Arrieta V, Martinez-Martinez E, Alvarez V, Fernández-Celis A, Gainza A, Santamaría E, Fernández-Irigoyen J, Cachofeiro V, Fay R, Rossignol P, López-Andrés N.

Int J Cardiol. 2018 May 1;258:217-223. doi: 10.1016/j.ijcard.2017.12.103.


Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity.

Marín-Royo G, Gallardo I, Martínez-Martínez E, Gutiérrez B, Jurado-López R, López-Andrés N, Gutiérrez-Tenorio J, Rial E, Bartolomé MAV, Nieto ML, Cachofeiro V.

Dis Model Mech. 2018 Feb 5;11(2). pii: dmm032086. doi: 10.1242/dmm.032086.


Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation.

Buonafine M, Martínez-Martínez E, Amador C, Gravez B, Ibarrola J, Fernández-Celis A, El Moghrabi S, Rossignol P, López-Andrés N, Jaisser F.

J Mol Cell Cardiol. 2018 Feb;115:32-38. doi: 10.1016/j.yjmcc.2017.12.011. Epub 2017 Dec 28.


The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity.

Gutiérrez-Tenorio J, Marín-Royo G, Martínez-Martínez E, Martín R, Miana M, López-Andrés N, Jurado-López R, Gallardo I, Luaces M, San Román JA, González-Amor M, Salaices M, Nieto ML, Cachofeiro V.

Sci Rep. 2017 Dec 1;7(1):16802. doi: 10.1038/s41598-017-17103-9.


Aldosterone Target NGAL (Neutrophil Gelatinase-Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NFκB Pathway.

Martínez-Martínez E, Buonafine M, Boukhalfa I, Ibarrola J, Fernández-Celis A, Kolkhof P, Rossignol P, Girerd N, Mulder P, López-Andrés N, Ouvrard-Pascaud A, Jaisser F.

Hypertension. 2017 Dec;70(6):1148-1156. doi: 10.1161/HYPERTENSIONAHA.117.09791. Epub 2017 Oct 23.


The endothelial αENaC contributes to vascular endothelial function in vivo.

Tarjus A, Maase M, Jeggle P, Martinez-Martinez E, Fassot C, Loufrani L, Henrion D, Hansen PBL, Kusche-Vihrog K, Jaisser F.

PLoS One. 2017 Sep 26;12(9):e0185319. doi: 10.1371/journal.pone.0185319. eCollection 2017.


Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts.

Martínez-Martínez E, Ibarrola J, Fernández-Celis A, Santamaria E, Fernández-Irigoyen J, Rossignol P, Jaisser F, López-Andrés N.

Sci Rep. 2017 Sep 22;7(1):12192. doi: 10.1038/s41598-017-12305-7.


The impact of obesity in the cardiac lipidome and its consequences in the cardiac damage observed in obese rats.

Marín-Royo G, Martínez-Martínez E, Gutiérrez B, Jurado-López R, Gallardo I, Montero O, Bartolomé MV, San Román JA, Salaices M, Nieto ML, Cachofeiro V.

Clin Investig Arterioscler. 2018 Jan - Feb;30(1):10-20. doi: 10.1016/j.arteri.2017.07.004. Epub 2017 Aug 30. English, Spanish.


Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats.

Martínez-Martínez E, Ibarrola J, Fernández-Celis A, Calvier L, Leroy C, Cachofeiro V, Rossignol P, López-Andrés N.

J Hypertens. 2018 Feb;36(2):368-376. doi: 10.1097/HJH.0000000000001545.


Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model.

Ibarrola J, Martínez-Martínez E, Sádaba JR, Arrieta V, García-Peña A, Álvarez V, Fernández-Celis A, Gainza A, Rossignol P, Cachofeiro Ramos V, López-Andrés N.

Int J Mol Sci. 2017 Jul 31;18(8). pii: E1664. doi: 10.3390/ijms18081664.


Differential proteomics reveals S100-A11 as a key factor in aldosterone-induced collagen expression in human cardiac fibroblasts.

Martínez-Martínez E, Ibarrola J, Lachén-Montes M, Fernández-Celis A, Jaisser F, Santamaría E, Fernández-Irigoyen J, López-Andrés N.

J Proteomics. 2017 Aug 23;166:93-100. doi: 10.1016/j.jprot.2017.07.011. Epub 2017 Jul 22.


Interferon-γ Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.

Nagy E, Lei Y, Martínez-Martínez E, Body SC, Schlotter F, Creager M, Assmann A, Khabbaz K, Libby P, Hansson GK, Aikawa E.

Am J Pathol. 2017 Jun;187(6):1413-1425. doi: 10.1016/j.ajpath.2017.02.012. Epub 2017 Apr 19.


A role for galectin-3 in the development of early molecular alterations in short-term aortic stenosis.

Arrieta V, Martinez-Martinez E, Ibarrola J, Alvarez V, Sádaba R, Garcia-Peña A, Fernández-Celis A, Cachofeiro V, Rossignol P, López-Andrés N.

Clin Sci (Lond). 2017 May 1;131(10):935-949. doi: 10.1042/CS20170145. Epub 2017 Mar 30.


Evaluating the significance of wetland restoration scenarios on phosphorus removal.

Daneshvar F, Nejadhashemi AP, Adhikari U, Elahi B, Abouali M, Herman MR, Martinez-Martinez E, Calappi TJ, Rohn BG.

J Environ Manage. 2017 May 1;192:184-196. doi: 10.1016/j.jenvman.2017.01.059. Epub 2017 Feb 2.


Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose.

Brianza-Padilla M, Carbó R, Arana JC, Vázquez-Palacios G, Ballinas-Verdugo MA, Cardoso-Saldaña GC, Palacio AG, Juárez-Vicuña Y, Sánchez F, Martínez-Martínez E, Huang F, Sánchez-Muñoz F, Bojalil R.

Biomed Res Int. 2016;2016:2489479. doi: 10.1155/2016/2489479. Epub 2016 Nov 24.


Galectin-3 Blockade Reduces Renal Fibrosis in Two Normotensive Experimental Models of Renal Damage.

Martinez-Martinez E, Ibarrola J, Calvier L, Fernandez-Celis A, Leroy C, Cachofeiro V, Rossignol P, Lopez-Andres N.

PLoS One. 2016 Nov 9;11(11):e0166272. doi: 10.1371/journal.pone.0166272. eCollection 2016.


Role for Galectin-3 in Calcific Aortic Valve Stenosis.

Sádaba JR, Martínez-Martínez E, Arrieta V, Álvarez V, Fernández-Celis A, Ibarrola J, Melero A, Rossignol P, Cachofeiro V, López-Andrés N.

J Am Heart Assoc. 2016 Nov 4;5(11). pii: e004360.


CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3β signaling pathway.

Martínez-Martínez E, Martín-Ruiz A, Martín P, Calvo V, Provencio M, García JM.

Oncotarget. 2016 Oct 18;7(42):68781-68791. doi: 10.18632/oncotarget.11968.


Spontaneous Cannabinoid Receptor 2 (CB2) Expression in the Cochlea of Adult Albino Rat and Its Up-Regulation after Cisplatin Treatment.

Martín-Saldaña S, Trinidad A, Ramil E, Sánchez-López AJ, Coronado MJ, Martínez-Martínez E, García JM, García-Berrocal JR, Ramírez-Camacho R.

PLoS One. 2016 Aug 26;11(8):e0161954. doi: 10.1371/journal.pone.0161954. eCollection 2016.


Stereological Quantification of Cell-Cycle Kinetics and Mobilization of Epithelial Stem Cells during Wound Healing.

Martínez-Martínez E, Uribe-Querol E, Galván-Hernández CI, Gutiérrez-Ospina G.

Methods Mol Biol. 2016;1453:93-107. doi: 10.1007/978-1-4939-3786-8_11.


High levels of circulating TNFR1 increase the risk of all-cause mortality and progression of renal disease in type 2 diabetic nephropathy.

Fernández-Juárez G, Villacorta Perez J, Luño Fernández JL, Martinez-Martinez E, Cachofeiro V, Barrio Lucia V, Tato Ribera AM, Mendez Abreu A, Cordon A, Oliva Dominguez JA, Praga Terente M.

Nephrology (Carlton). 2017 May;22(5):354-360. doi: 10.1111/nep.12781.


Galectin-3 inhibition prevents adipose tissue remodelling in obesity.

Martínez-Martínez E, Calvier L, Rossignol P, Rousseau E, Fernández-Celis A, Jurado-López R, Laville M, Cachofeiro V, López-Andrés N.

Int J Obes (Lond). 2016 Jun;40(6):1034-8. doi: 10.1038/ijo.2016.19. Epub 2016 Feb 8.


Extracellular vesicles in cardiovascular calcification: expanding current paradigms.

Krohn JB, Hutcheson JD, Martínez-Martínez E, Aikawa E.

J Physiol. 2016 Jun 1;594(11):2895-903. doi: 10.1113/JP271338. Review.


Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.

Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):525-33. doi: 10.1161/ATVBAHA.115.307009. Epub 2016 Jan 21.


The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.

Martínez-Martínez E, Rodríguez C, Galán M, Miana M, Jurado-López R, Bartolomé MV, Luaces M, Islas F, Martínez-González J, López-Andrés N, Cachofeiro V.

J Mol Cell Cardiol. 2016 Mar;92:96-104. doi: 10.1016/j.yjmcc.2016.01.012. Epub 2016 Jan 15.


Galectin-3 Participates in Cardiovascular Remodeling Associated With Obesity.

Martínez-Martínez E, López-Ándres N, Jurado-López R, Rousseau E, Bartolomé MV, Fernández-Celis A, Rossignol P, Islas F, Antequera A, Prieto S, Luaces M, Cachofeiro V.

Hypertension. 2015 Nov;66(5):961-9. doi: 10.1161/HYPERTENSIONAHA.115.06032. Epub 2015 Sep 8.


Galectin-3 blockade inhibits cardiac inflammation and fibrosis in experimental hyperaldosteronism and hypertension.

Martínez-Martínez E, Calvier L, Fernández-Celis A, Rousseau E, Jurado-López R, Rossoni LV, Jaisser F, Zannad F, Rossignol P, Cachofeiro V, López-Andrés N.

Hypertension. 2015 Oct;66(4):767-75. doi: 10.1161/HYPERTENSIONAHA.115.05876. Epub 2015 Aug 3.


The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats.

Miana M, Galán M, Martínez-Martínez E, Varona S, Jurado-López R, Bausa-Miranda B, Antequera A, Luaces M, Martínez-González J, Rodríguez C, Cachofeiro V.

Dis Model Mech. 2015 Jun;8(6):543-51. doi: 10.1242/dmm.020107. Epub 2015 Apr 7.


Neutrophil Gelatinase-Associated Lipocalin, a Novel Mineralocorticoid Biotarget, Mediates Vascular Profibrotic Effects of Mineralocorticoids.

Tarjus A, Martínez-Martínez E, Amador C, Latouche C, El Moghrabi S, Berger T, Mak TW, Fay R, Farman N, Rossignol P, Zannad F, López-Andrés N, Jaisser F.

Hypertension. 2015 Jul;66(1):158-66. doi: 10.1161/HYPERTENSIONAHA.115.05431. Epub 2015 May 18.


Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation.

Martínez-Martínez E, Cachofeiro V, Rousseau E, Álvarez V, Calvier L, Fernández-Celis A, Leroy C, Miana M, Jurado-López R, Briones AM, Jaisser F, Zannad F, Rossignol P, López-Andrés N.

Mol Cell Endocrinol. 2015 Aug 15;411:20-7. doi: 10.1016/j.mce.2015.04.007. Epub 2015 Apr 17.


Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival.

Martínez-Martínez E, Gómez I, Martín P, Sánchez A, Román L, Tejerina E, Bonilla F, Merino AG, de Herreros AG, Provencio M, García JM.

Oncoscience. 2015 Feb 9;2(2):131-41. eCollection 2015.


The impact of galectin-3 inhibition on aldosterone-induced cardiac and renal injuries.

Calvier L, Martinez-Martinez E, Miana M, Cachofeiro V, Rousseau E, Sádaba JR, Zannad F, Rossignol P, López-Andrés N.

JACC Heart Fail. 2015 Jan;3(1):59-67. doi: 10.1016/j.jchf.2014.08.002. Epub 2014 Nov 11.


Leptin, a mediator of cardiac damage associated with obesity.

Martínez-Martínez E, Jurado-López R, Cervantes-Escalera P, Cachofeiro V, Miana M.

Horm Mol Biol Clin Investig. 2014 Apr;18(1):3-14. doi: 10.1515/hmbci-2013-0060. Review.


Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer.

Murase R, Kawamura R, Singer E, Pakdel A, Sarma P, Judkins J, Elwakeel E, Dayal S, Martinez-Martinez E, Amere M, Gujjar R, Mahadevan A, Desprez PY, McAllister SD.

Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.


Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity.

Martínez-Martínez E, Jurado-López R, Valero-Muñoz M, Bartolomé MV, Ballesteros S, Luaces M, Briones AM, López-Andrés N, Miana M, Cachofeiro V.

J Hypertens. 2014 May;32(5):1104-14; discussion 1114. doi: 10.1097/HJH.0000000000000149.


The potential role of leptin in the vascular remodeling associated with obesity.

Martínez-Martínez E, Miana M, Jurado-López R, Bartolomé MV, Souza Neto FV, Salaices M, López-Andrés N, Cachofeiro V.

Int J Obes (Lond). 2014 Dec;38(12):1565-72. doi: 10.1038/ijo.2014.37. Epub 2014 Mar 3.


Modeling the hydrological significance of wetland restoration scenarios.

Martinez-Martinez E, Nejadhashemi AP, Woznicki SA, Love BJ.

J Environ Manage. 2014 Jan 15;133:121-34. doi: 10.1016/j.jenvman.2013.11.046. Epub 2013 Dec 25.


A role for soluble ST2 in vascular remodeling associated with obesity in rats.

Martínez-Martínez E, Miana M, Jurado-López R, Rousseau E, Rossignol P, Zannad F, Cachofeiro V, López-Andrés N.

PLoS One. 2013 Nov 12;8(11):e79176. doi: 10.1371/journal.pone.0079176. eCollection 2013.


Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.

Guijarro-Muñoz I, Sánchez A, Martínez-Martínez E, García JM, Salas C, Provencio M, Alvarez-Vallina L, Sanz L.

Med Oncol. 2013;30(2):572. doi: 10.1007/s12032-013-0572-1. Epub 2013 Apr 12.


Shifts in developmental timing, and not increased levels of experience-dependent neuronal activity, promote barrel expansion in the primary somatosensory cortex of rats enucleated at birth.

Fetter-Pruneda I, Geovannini-Acuña H, Santiago C, Ibarrarán-Viniegra AS, Martínez-Martínez E, Sandoval-Velasco M, Uribe-Figueroa L, Padilla-Cortés P, Mercado-Célis G, Gutiérrez-Ospina G.

PLoS One. 2013;8(1):e54940. doi: 10.1371/journal.pone.0054940. Epub 2013 Jan 25.


Relevance of vascular peroxisome proliferator-activated receptor γ coactivator-1α to molecular alterations in atherosclerosis.

Valero-Muñoz M, Martín-Fernández B, Ballesteros S, Martínez-Martínez E, Blanco-Rivero J, Balfagón G, Cachofeiro V, Lahera V, de las Heras N.

Exp Physiol. 2013 May;98(5):999-1008. doi: 10.1113/expphysiol.2012.070557. Epub 2013 Jan 18.


The impact of bariatric surgery on renal and cardiac functions in morbidly obese patients.

Luaces M, Martínez-Martínez E, Medina M, Miana M, González N, Fernández-Pérez C, Cachofeiro V.

Nephrol Dial Transplant. 2012 Dec;27 Suppl 4:iv53-7. doi: 10.1093/ndt/gfs529.


Health research funding in Mexico: the need for a long-term agenda.

Martínez-Martínez E, Zaragoza ML, Solano E, Figueroa B, Zúñiga P, Laclette JP.

PLoS One. 2012;7(12):e51195. doi: 10.1371/journal.pone.0051195. Epub 2012 Dec 10.

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