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Items: 1 to 50 of 73

1.

Targeting the PI3K/Akt/mTOR-pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases.

Ippen FM, Grosch JK, Subramanian M, Kuter BM, Liederer BM, Plise EG, Mora JL, Nayyar N, Schmidt SP, Giobbie-Hurder A, Martinez-Lage M, Carter SL, Cahill DP, Wakimoto H, Brastianos PK.

Neuro Oncol. 2019 Jun 7. pii: noz105. doi: 10.1093/neuonc/noz105. [Epub ahead of print]

PMID:
31173106
2.

Functional characterization of two enhancers located downstream FOXP2.

Torres-Ruiz R, Benítez-Burraco A, Martínez-Lage M, Rodríguez-Perales S, García-Bellido P.

BMC Med Genet. 2019 May 2;20(1):65. doi: 10.1186/s12881-019-0810-2.

3.

Transcriptome signatures associated with meningioma progression.

Viaene AN, Zhang B, Martinez-Lage M, Xiang C, Tosi U, Thawani JP, Gungor B, Zhu Y, Roccograndi L, Zhang L, Bailey RL, Storm PB, O'Rourke DM, Resnick AC, Grady MS, Dahmane N.

Acta Neuropathol Commun. 2019 Apr 30;7(1):67. doi: 10.1186/s40478-019-0690-x.

4.

Treatment-Induced Brain Tissue Necrosis: A Clinical Challenge in Neuro-Oncology.

Winter SF, Loebel F, Loeffler J, Batchelor TT, Martinez-Lage M, Vajkoczy P, Dietrich J.

Neuro Oncol. 2019 Mar 4. pii: noz048. doi: 10.1093/neuonc/noz048. [Epub ahead of print]

PMID:
30828724
5.

The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases.

Ippen FM, Alvarez-Breckenridge CA, Kuter BM, Fink AL, Bihun IV, Lastrapes M, Penson T, Schmidt SP, Wojtkiewicz GR, Ning J, Subramanian M, Giobbie-Hurder A, Martinez-Lage M, Carter SL, Cahill DP, Wakimoto H, Brastianos PK.

Clin Cancer Res. 2019 Jun 1;25(11):3374-3383. doi: 10.1158/1078-0432.CCR-18-3049. Epub 2019 Feb 22.

PMID:
30796030
6.

MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas.

Nayyar N, White MD, Gill CM, Lastrapes M, Bertalan M, Kaplan A, D'Andrea MR, Bihun I, Kaneb A, Dietrich J, Ferry JA, Martinez-Lage M, Giobbie-Hurder A, Borger DR, Rodriguez FJ, Frosch MP, Batchelor E, Hoang K, Kuter B, Fortin S, Holdhoff M, Cahill DP, Carter S, Brastianos PK, Batchelor TT.

Blood Adv. 2019 Feb 12;3(3):375-383. doi: 10.1182/bloodadvances.2018027672.

7.

Increase of pseudoprogression and other treatment related effects in low-grade glioma patients treated with proton radiation and temozolomide.

Dworkin M, Mehan W, Niemierko A, Kamran SC, Lamba N, Dietrich J, Martinez-Lage M, Oh KS, Batchelor TT, Wen PY, Loeffler JS, Shih HA.

J Neurooncol. 2019 Mar;142(1):69-77. doi: 10.1007/s11060-018-03063-1. Epub 2018 Nov 28.

PMID:
30488294
8.

A Clinical Rule for Preoperative Prediction of BRAF Mutation Status in Craniopharyngiomas.

Fujio S, Juratli TA, Arita K, Hirano H, Nagano Y, Takajo T, Yoshimoto K, Bihun IV, Kaplan AB, Nayyar N, Fink AL, Bertalan MS, Tummala SS, Curry WT Jr, Jones PS, Martinez-Lage M, Cahill DP, Barker FG 2nd, Brastianos PK.

Neurosurgery. 2018 Nov 27. doi: 10.1093/neuros/nyy569. [Epub ahead of print]

PMID:
30481321
9.

CRISPR/Cas9 for Cancer Therapy: Hopes and Challenges.

Martinez-Lage M, Puig-Serra P, Menendez P, Torres-Ruiz R, Rodriguez-Perales S.

Biomedicines. 2018 Nov 12;6(4). pii: E105. doi: 10.3390/biomedicines6040105. Review.

10.

Primary diffuse large B-cell lymphoma of the CNS: a rare case of spontaneous remission.

Debonera F, Nasta S, Martinez-Lage M, Schuster SJ, Tsai DE.

Int J Hematol Oncol. 2017 Nov;6(3):69-73. doi: 10.2217/ijh-2017-0009. Epub 2017 Nov 20.

11.

DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome.

Juratli TA, McCabe D, Nayyar N, Williams EA, Silverman IM, Tummala SS, Fink AL, Baig A, Martinez-Lage M, Selig MK, Bihun IV, Shankar GM, Penson T, Lastrapes M, Daubner D, Meinhardt M, Hennig S, Kaplan AB, Fujio S, Kuter BM, Bertalan MS, Miller JJ, Batten JM, Ely HA, Christiansen J, Baretton GB, Stemmer-Rachamimov AO, Santagata S, Rivera MN, Barker FG 2nd, Schackert G, Wakimoto H, Iafrate AJ, Carter SL, Cahill DP, Brastianos PK.

Acta Neuropathol. 2018 Nov;136(5):779-792. doi: 10.1007/s00401-018-1899-7. Epub 2018 Aug 19.

PMID:
30123936
12.

Case 5-2018: A Man with Confusion after Stem-Cell Transplantation.

El-Jawahri AR, El Khoury JB, Martinez-Lage M.

N Engl J Med. 2018 Jun 28;378(26):2545. doi: 10.1056/NEJMc1806522. No abstract available.

PMID:
29949493
13.

Neuropathology Education Using Social Media.

Nix JS, Gardner JM, Costa F, Soares AL, Rodriguez FJ, Moore B, Martinez-Lage M, Ahlawat S, Gokden M, Anthony DC.

J Neuropathol Exp Neurol. 2018 Jun 1;77(6):454-460. doi: 10.1093/jnen/nly025.

PMID:
29788115
14.

The role of proton beam therapy in central neurocytoma: A single-institution experience.

Kang KH, Schapira E, Niemierko A, Martinez-Lage M, Bussière MR, Yock TI, Loeffler JS, Butler WE, Carter BS, Shih HA.

Pract Radiat Oncol. 2018 Sep - Oct;8(5):e305-e311. doi: 10.1016/j.prro.2018.02.005. Epub 2018 Feb 16.

PMID:
29706302
15.

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.

Filbin MG, Tirosh I, Hovestadt V, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, van Galen P, Bonal DM, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popović M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein BE, Suvà ML.

Science. 2018 Apr 20;360(6386):331-335. doi: 10.1126/science.aao4750.

16.

Thyroidosis Mistaken for Thyroid Cancer.

Crawford AR, Martinez-Lage M, Kim CS.

JAMA Otolaryngol Head Neck Surg. 2018 Jun 1;144(6):540-541. doi: 10.1001/jamaoto.2018.0066. No abstract available.

PMID:
29621377
17.

In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C.

Neuro Oncol. 2018 Jul 5;20(8):1068-1079. doi: 10.1093/neuonc/noy033.

PMID:
29617843
18.

Practical Implications of the Updated WHO Classification of Brain Tumors.

Martinez-Lage M, Sahm F.

Semin Neurol. 2018 Feb;38(1):11-18. doi: 10.1055/s-0038-1641162. Epub 2018 Mar 16. Review.

PMID:
29548047
19.

Case 5-2018: A 63-Year-Old Man with Confusion after Stem-Cell Transplantation.

El-Jawahri AR, Schaefer PW, El Khoury JB, Martinez-Lage M.

N Engl J Med. 2018 Feb 15;378(7):659-669. doi: 10.1056/NEJMcpc1707556. No abstract available.

PMID:
29443669
20.

Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy.

Talos DM, Jacobs LM, Gourmaud S, Coto CA, Sun H, Lim KC, Lucas TH, Davis KA, Martinez-Lage M, Jensen FE.

Ann Neurol. 2018 Feb;83(2):311-327. doi: 10.1002/ana.25149. Epub 2018 Feb 15.

21.

Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas.

Juratli TA, Thiede C, Koerner MVA, Tummala SS, Daubner D, Shankar GM, Williams EA, Martinez-Lage M, Soucek S, Robel K, Penson T, Krause M, Appold S, Meinhardt M, Pinzer T, Miller JJ, Krex D, Ely HA, Silverman IM, Christiansen J, Schackert G, Wakimoto H, Kirsch M, Brastianos PK, Cahill DP.

Oncotarget. 2017 Nov 24;8(65):109228-109237. doi: 10.18632/oncotarget.22650. eCollection 2017 Dec 12.

22.

CRISPR/Cas9 Technology: Applications and Human Disease Modeling.

Martinez-Lage M, Torres-Ruiz R, Rodriguez-Perales S.

Prog Mol Biol Transl Sci. 2017;152:23-48. doi: 10.1016/bs.pmbts.2017.09.002. Epub 2017 Oct 31.

PMID:
29150003
23.

Folate receptor overexpression can be visualized in real time during pituitary adenoma endoscopic transsphenoidal surgery with near-infrared imaging.

Lee JYK, Cho SS, Zeh R, Pierce JT, Martinez-Lage M, Adappa ND, Palmer JN, Newman JG, Learned KO, White C, Kharlip J, Snyder P, Low PS, Singhal S, Grady MS.

J Neurosurg. 2018 Aug;129(2):390-403. doi: 10.3171/2017.2.JNS163191. Epub 2017 Aug 25.

PMID:
28841122
24.

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV.

Sci Transl Med. 2017 Jul 19;9(399). pii: eaaa0984. doi: 10.1126/scitranslmed.aaa0984.

25.

19-Year-Old Male with Headaches and a Possible Seizure.

Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M.

Brain Pathol. 2017 Jul;27(4):557-558. doi: 10.1111/bpa.12529. No abstract available.

PMID:
28585383
26.

Efficient Recreation of t(11;22) EWSR1-FLI1+ in Human Stem Cells Using CRISPR/Cas9.

Torres-Ruiz R, Martinez-Lage M, Martin MC, Garcia A, Bueno C, Castaño J, Ramirez JC, Menendez P, Cigudosa JC, Rodriguez-Perales S.

Stem Cell Reports. 2017 May 9;8(5):1408-1420. doi: 10.1016/j.stemcr.2017.04.014.

27.

In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index.

Bakas S, Akbari H, Pisapia J, Martinez-Lage M, Rozycki M, Rathore S, Dahmane N, O'Rourke DM, Davatzikos C.

Clin Cancer Res. 2017 Aug 15;23(16):4724-4734. doi: 10.1158/1078-0432.CCR-16-1871. Epub 2017 Apr 20.

28.

Near-infrared fluorescent image-guided surgery for intracranial meningioma.

Lee JYK, Pierce JT, Thawani JP, Zeh R, Nie S, Martinez-Lage M, Singhal S.

J Neurosurg. 2018 Feb;128(2):380-390. doi: 10.3171/2016.10.JNS161636. Epub 2017 Apr 7.

PMID:
28387632
29.

Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery.

Lee JY, Thawani JP, Pierce J, Zeh R, Martinez-Lage M, Chanin M, Venegas O, Nims S, Learned K, Keating J, Singhal S.

Neurosurgery. 2016 Dec;79(6):856-871.

30.

Population-based MRI atlases of spatial distribution are specific to patient and tumor characteristics in glioblastoma.

Bilello M, Akbari H, Da X, Pisapia JM, Mohan S, Wolf RL, O'Rourke DM, Martinez-Lage M, Davatzikos C.

Neuroimage Clin. 2016 Mar 12;12:34-40. doi: 10.1016/j.nicl.2016.03.007. eCollection 2016.

31.

Prevalence of clinically silent corticotroph macroadenomas.

Guttenberg KB, Mayson SE, Sawan C, Kharlip J, Lee JY, Martinez-Lage M, Loevner LA, Ewanichak J, Grady MS, Snyder PJ.

Clin Endocrinol (Oxf). 2016 Dec;85(6):874-880. doi: 10.1111/cen.13146. Epub 2016 Jul 27.

PMID:
27346850
32.

Synovial-type giant cell tumors of the axial spine.

Nayak NR, Richard CE, Martinez-Lage M, Smith H, Malhotra NR.

J Neurosurg Sci. 2017 Feb;61(1):106-109. Epub 2016 Feb 11. Review. No abstract available.

PMID:
26868266
33.

Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma.

Akbari H, Macyszyn L, Da X, Bilello M, Wolf RL, Martinez-Lage M, Biros G, Alonso-Basanta M, OʼRourke DM, Davatzikos C.

Neurosurgery. 2016 Apr;78(4):572-80. doi: 10.1227/NEU.0000000000001202.

34.

Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients.

Evans SM, Putt M, Yang XY, Lustig RA, Martinez-Lage M, Williams D, Desai A, Wolf R, Brem S, Koch CJ.

J Neurooncol. 2016 Apr;127(2):391-400. doi: 10.1007/s11060-015-2051-3. Epub 2016 Jan 8.

35.

Differentiating Tumor Progression from Pseudoprogression in Patients with Glioblastomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI.

Wang S, Martinez-Lage M, Sakai Y, Chawla S, Kim SG, Alonso-Basanta M, Lustig RA, Brem S, Mohan S, Wolf RL, Desai A, Poptani H.

AJNR Am J Neuroradiol. 2016 Jan;37(1):28-36. doi: 10.3174/ajnr.A4474. Epub 2015 Oct 8.

36.

Lateral Transorbital Endoscopic Access to the Hippocampus, Amygdala, and Entorhinal Cortex: Initial Clinical Experience.

Chen HI, Bohman LE, Emery L, Martinez-Lage M, Richardson AG, Davis KA, Pollard JR, Litt B, Gausas RE, Lucas TH.

ORL J Otorhinolaryngol Relat Spec. 2015;77(6):321-32. doi: 10.1159/000438762. Epub 2015 Sep 30.

37.

Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques.

Macyszyn L, Akbari H, Pisapia JM, Da X, Attiah M, Pigrish V, Bi Y, Pal S, Davuluri RV, Roccograndi L, Dahmane N, Martinez-Lage M, Biros G, Wolf RL, Bilello M, O'Rourke DM, Davatzikos C.

Neuro Oncol. 2016 Mar;18(3):417-25. doi: 10.1093/neuonc/nov127. Epub 2015 Jul 16.

38.

Factors associated with increased survival after surgical resection of glioblastoma in octogenarians.

Abdullah KG, Ramayya A, Thawani JP, Macyszyn L, Martinez-Lage M, O'Rourke DM, Brem S.

PLoS One. 2015 May 15;10(5):e0127202. doi: 10.1371/journal.pone.0127202. eCollection 2015.

39.

Management of an expansile orbital mass: Plexiform neurofibroma decompression by orbitozygomatic approach.

Kovatch KJ, Purkey MT, Martinez-Lage M, Gausas RE, Loevner LA, Grady MS, O'Malley BW Jr, Rassekh CH.

Laryngoscope. 2015 Nov;125(11):2457-60. doi: 10.1002/lary.25232. Epub 2015 May 9.

PMID:
25960281
40.

Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma.

Walsh AM, Kapoor GS, Buonato JM, Mathew LK, Bi Y, Davuluri RV, Martinez-Lage M, Simon MC, O'Rourke DM, Lazzara MJ.

Mol Cancer Res. 2015 Aug;13(8):1227-37. doi: 10.1158/1541-7786.MCR-14-0183-T. Epub 2015 May 1.

41.

Microvesicles as a Biomarker for Tumor Progression versus Treatment Effect in Radiation/Temozolomide-Treated Glioblastoma Patients.

Koch CJ, Lustig RA, Yang XY, Jenkins WT, Wolf RL, Martinez-Lage M, Desai A, Williams D, Evans SM.

Transl Oncol. 2014 Dec;7(6):752-8. doi: 10.1016/j.tranon.2014.10.004.

42.

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.

Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, Martinez-Lage M, Santi M, Storm PB, Lee JY, Palmer JN, Adappa ND, Scott RM, Dunn IF, Laws ER Jr, Stewart C, Ligon KL, Hoang MP, Van Hummelen P, Hahn WC, Louis DN, Resnick AC, Kieran MW, Getz G, Santagata S.

Nat Genet. 2014 Feb;46(2):161-5. doi: 10.1038/ng.2868. Epub 2014 Jan 12.

43.

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.

Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS.

Acta Neuropathol Commun. 2013 Jul 11;1:36. doi: 10.1186/2051-5960-1-36.

44.

Mega-epsilon waves on 12-lead ECG--just another case of arrhythmogenic right ventricular dysplasia/cardiomyopathy?

Khaji A, Zhang L, Kowey P, Martinez-Lage M, Kocovic D.

J Electrocardiol. 2013 Nov-Dec;46(6):524-7. doi: 10.1016/j.jelectrocard.2013.08.007. Epub 2013 Sep 7.

PMID:
24016846
45.

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.

Abedalthagafi M, Phillips JJ, Kim GE, Mueller S, Haas-Kogen DA, Marshall RE, Croul SE, Santi MR, Cheng J, Zhou S, Sullivan LM, Martinez-Lage M, Judkins AR, Perry A.

Mod Pathol. 2013 Nov;26(11):1425-32. doi: 10.1038/modpathol.2013.90. Epub 2013 Jun 14.

46.

PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.

Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A.

Brain Pathol. 2013 Sep;23(5):565-73. doi: 10.1111/bpa.12043. Epub 2013 Mar 18.

47.

Dry Beriberi and Wernicke's encephalopathy following gastric lap band surgery.

Becker DA, Ingala EE, Martinez-Lage M, Price RS, Galetta SL.

J Clin Neurosci. 2012 Jul;19(7):1050-2. doi: 10.1016/j.jocn.2011.11.006. Epub 2012 Apr 22.

PMID:
22525460
48.

TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation.

Martinez-Lage M, Molina-Porcel L, Falcone D, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ.

Acta Neuropathol. 2012 Aug;124(2):285-91.

49.

Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis.

Martinez-Hernandez E, Horvath J, Shiloh-Malawsky Y, Sangha N, Martinez-Lage M, Dalmau J.

Neurology. 2011 Aug 9;77(6):589-93. doi: 10.1212/WNL.0b013e318228c136. Epub 2011 Jul 27.

50.

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.

Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL 3rd, Brooks WS, Halliday GM, Kril JJ, Gearing M, Beach TG, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Pickering-Brown SM, Snowden J, van Swieten JC, Heutink P, Seelaar H, Murrell JR, Ghetti B, Spina S, Grafman J, Kaye JA, Woltjer RL, Mesulam M, Bigio E, Lladó A, Miller BL, Alzualde A, Moreno F, Rohrer JD, Mackenzie IR, Feldman HH, Hamilton RL, Cruts M, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bird TD, Cairns NJ, Goate A, Frosch MP, Riederer PF, Bogdanovic N, Lee VM, Trojanowski JQ, Van Deerlin VM.

Arch Neurol. 2011 Apr;68(4):488-97. doi: 10.1001/archneurol.2011.53.

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