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Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of nonalcoholic steatohepatitis.

Duparc T, Briand F, Trenteseaux C, Merian J, Combes G, Najib S, Sulpice T, Martinez LO.

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G508-G517. doi: 10.1152/ajpgi.00139.2019. Epub 2019 Aug 28.


Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.

Cabou C, Honorato P, Briceño L, Ghezali L, Duparc T, León M, Combes G, Frayssinhes L, Fournel A, Abot A, Masri B, Parada N, Aguilera V, Aguayo C, Knauf C, González M, Radojkovic C, Martinez LO.

Acta Physiol (Oxf). 2019 Jul;226(3):e13268. doi: 10.1111/apha.13268. Epub 2019 Apr 4.


Common p2y13 polymorphisms are associated with plasma inhibitory factor 1 and lipoprotein(a) concentrations, heart rate and body fat mass: The GENES study.

Verdier C, Ruidavets JB, Genoux A, Combes G, Bongard V, Taraszkiewicz D, Galinier M, Elbaz M, Ferrières J, Martinez LO, Perret B.

Arch Cardiovasc Dis. 2019 Feb;112(2):124-134. doi: 10.1016/j.acvd.2018.09.003. Epub 2018 Dec 29.


Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y12 receptor.

Garcia C, Maurel-Ribes A, Nauze M, N'Guyen D, Martinez LO, Payrastre B, Sénard JM, Galés C, Pons V.

Cell Mol Life Sci. 2019 Feb;76(3):561-576. doi: 10.1007/s00018-018-2960-3. Epub 2018 Nov 7.


Characterization of immortalized human dermal microvascular endothelial cells (HMEC-1) for the study of HDL functionality.

Muñoz-Vega M, Massó F, Páez A, Carreón-Torres E, Cabrera-Fuentes HA, Fragoso JM, Pérez-Hernández N, Martinez LO, Najib S, Vargas-Alarcón G, Pérez-Méndez Ó.

Lipids Health Dis. 2018 Mar 9;17(1):44. doi: 10.1186/s12944-018-0695-7.


Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans.

Hoeke G, Nahon KJ, Bakker LEH, Norkauer SSC, Dinnes DLM, Kockx M, Lichtenstein L, Drettwan D, Reifel-Miller A, Coskun T, Pagel P, Romijn FPHTM, Cobbaert CM, Jazet IM, Martinez LO, Kritharides L, Berbée JFP, Boon MR, Rensen PCN.

J Clin Lipidol. 2017 Jul - Aug;11(4):920-928.e2. doi: 10.1016/j.jacl.2017.04.117. Epub 2017 May 3.


PI3Kβ Plays a Key Role in Apolipoprotein A-I-Induced Endothelial Cell Proliferation Through Activation of the Ecto-F1-ATPase/P2Y1 Receptors.

Castaing-Berthou A, Malet N, Radojkovic C, Cabou C, Gayral S, Martinez LO, Laffargue M.

Cell Physiol Biochem. 2017;42(2):579-593. doi: 10.1159/000477607. Epub 2017 Jun 5.


Serum inhibitory factor 1, high-density lipoprotein and cardiovascular diseases.

Martinez LO, Genoux A, Ferrières J, Duparc T, Perret B.

Curr Opin Lipidol. 2017 Aug;28(4):337-346. doi: 10.1097/MOL.0000000000000434. Review.


Ectopic adenine nucleotide translocase activity controls extracellular ADP levels and regulates the F1-ATPase-mediated HDL endocytosis pathway on hepatocytes.

Cardouat G, Duparc T, Fried S, Perret B, Najib S, Martinez LO.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):832-841. doi: 10.1016/j.bbalip.2017.05.005. Epub 2017 May 11.


A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.

Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD.

Nat Med. 2017 Jan;23(1):107-113. doi: 10.1038/nm.4236. Epub 2016 Nov 28.


Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study.

Genoux A, Lichtenstein L, Ferrières J, Duparc T, Bongard V, Vervueren PL, Combes G, Taraszkiewicz D, Elbaz M, Galinier M, Nassar B, Ruidavets JB, Perret B, Martinez LO.

BMC Med. 2016 Aug 23;14(1):125. doi: 10.1186/s12916-016-0672-9.


RNY-derived small RNAs as a signature of coronary artery disease.

Repetto E, Lichtenstein L, Hizir Z, Tekaya N, Benahmed M, Ruidavets JB, Zaragosi LE, Perret B, Bouchareychas L, Genoux A, Lotte R, Ruimy R, Ferrières J, Barbry P, Martinez LO, Trabucchi M.

BMC Med. 2015 Oct 8;13:259. doi: 10.1186/s12916-015-0489-y.


Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport.

Lichtenstein L, Serhan N, Espinosa-Delgado S, Fabre A, Annema W, Tietge UJ, Robaye B, Boeynaems JM, Laffargue M, Perret B, Martinez LO.

Cardiovasc Res. 2015 May 1;106(2):314-23. doi: 10.1093/cvr/cvv109. Epub 2015 Mar 13.


Apolipoprotein A-I enhances proliferation of human endothelial progenitor cells and promotes angiogenesis through the cell surface ATP synthase.

González-Pecchi V, Valdés S, Pons V, Honorato P, Martinez LO, Lamperti L, Aguayo C, Radojkovic C.

Microvasc Res. 2015 Mar;98:9-15. doi: 10.1016/j.mvr.2014.11.003. Epub 2014 Nov 8.


Ecto-F1-ATPase/P2Y pathways in metabolic and vascular functions of high density lipoproteins.

Martinez LO, Najib S, Perret B, Cabou C, Lichtenstein L.

Atherosclerosis. 2015 Jan;238(1):89-100. doi: 10.1016/j.atherosclerosis.2014.11.017. Epub 2014 Nov 20. Review.


Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.

Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M.

J Exp Med. 2014 Aug 25;211(9):1779-92. doi: 10.1084/jem.20131276. Epub 2014 Jul 29.


Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport.

Lichtenstein L, Serhan N, Annema W, Combes G, Robaye B, Boeynaems JM, Perret B, Tietge UJF, Laffargue M, Martinez LO.

Nutr Metab (Lond). 2013 Nov 6;10(1):67. doi: 10.1186/1743-7075-10-67.


Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.

Gayral S, Garnotel R, Castaing-Berthou A, Blaise S, Fougerat A, Berge E, Montheil A, Malet N, Wymann MP, Maurice P, Debelle L, Martiny L, Martinez LO, Pshezhetsky AV, Duca L, Laffargue M.

Cardiovasc Res. 2014 Apr 1;102(1):118-27. doi: 10.1093/cvr/cvt336. Epub 2013 Dec 19.


Targeting high-density lipoproteins: update on a promising therapy.

Verdier C, Martinez LO, Ferrières J, Elbaz M, Genoux A, Perret B.

Arch Cardiovasc Dis. 2013 Nov;106(11):601-11. doi: 10.1016/j.acvd.2013.06.052. Epub 2013 Sep 25.


Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.

Pons V, Serhan N, Gayral S, Malaval C, Nauze M, Malet N, Laffargue M, Galés C, Martinez LO.

Cell Mol Life Sci. 2014 May;71(9):1775-88. doi: 10.1007/s00018-013-1471-5. Epub 2013 Sep 13.


Association of hepatic lipase -514T allele with coronary artery disease and ankle-brachial index, dependence on the lipoprotein phenotype: the GENES study.

Verdier C, Ruidavets JB, Bongard V, Taraszkiewicz D, Martinez LO, Elbaz M, Ferrières J, Perret B.

PLoS One. 2013 Jul 9;8(7):e67805. doi: 10.1371/journal.pone.0067805. Print 2013.


Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study.

Genoux A, Ruidavets JB, Ferrières J, Combes G, Lichtenstein L, Pons V, Laffargue M, Taraszkiewicz D, Carrié D, Elbaz M, Perret B, Martinez LO.

J Lipid Res. 2013 Sep;54(9):2550-8. doi: 10.1194/jlr.P036335. Epub 2013 Jun 21.


Chronic pharmacological activation of P2Y13 receptor in mice decreases HDL-cholesterol level by increasing hepatic HDL uptake and bile acid secretion.

Serhan N, Cabou C, Verdier C, Lichtenstein L, Malet N, Perret B, Laffargue M, Martinez LO.

Biochim Biophys Acta. 2013 Apr;1831(4):719-25. doi: 10.1016/j.bbalip.2012.12.006. Epub 2012 Dec 20.


Identification of the F1-ATPase at the cell surface of colonic epithelial cells: role in mediating cell proliferation.

Kowalski-Chauvel A, Najib S, Tikhonova IG, Huc L, Lopez F, Martinez LO, Cohen-Jonathan-Moyal E, Ferrand A, Seva C.

J Biol Chem. 2012 Nov 30;287(49):41458-68. doi: 10.1074/jbc.M112.382465. Epub 2012 Oct 10.


Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration.

Fougerat A, Smirnova NF, Gayral S, Malet N, Hirsch E, Wymann MP, Perret B, Martinez LO, Douillon M, Laffargue M.

Br J Pharmacol. 2012 Jul;166(5):1643-53. doi: 10.1111/j.1476-5381.2012.01866.x.


Mitochondrial inhibitory factor 1 (IF1) is present in human serum and is positively correlated with HDL-cholesterol.

Genoux A, Pons V, Radojkovic C, Roux-Dalvai F, Combes G, Rolland C, Malet N, Monsarrat B, Lopez F, Ruidavets JB, Perret B, Martinez LO.

PLoS One. 2011;6(9):e23949. doi: 10.1371/journal.pone.0023949. Epub 2011 Sep 14.


Ecto-F₁-ATPase: a moonlighting protein complex and an unexpected apoA-I receptor.

Vantourout P, Radojkovic C, Lichtenstein L, Pons V, Champagne E, Martinez LO.

World J Gastroenterol. 2010 Dec 21;16(47):5925-35. Review.


P2Y13 receptor is critical for reverse cholesterol transport.

Fabre AC, Malaval C, Ben Addi A, Verdier C, Pons V, Serhan N, Lichtenstein L, Combes G, Huby T, Briand F, Collet X, Nijstad N, Tietge UJ, Robaye B, Perret B, Boeynaems JM, Martinez LO.

Hepatology. 2010 Oct;52(4):1477-83. doi: 10.1002/hep.23897.


F1-adenosine triphosphatase displays properties characteristic of an antigen presentation molecule for Vgamma9Vdelta2 T cells.

Mookerjee-Basu J, Vantourout P, Martinez LO, Perret B, Collet X, Périgaud C, Peyrottes S, Champagne E.

J Immunol. 2010 Jun 15;184(12):6920-8. doi: 10.4049/jimmunol.0904024. Epub 2010 May 7.


Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen.

Vantourout P, Mookerjee-Basu J, Rolland C, Pont F, Martin H, Davrinche C, Martinez LO, Perret B, Collet X, Périgaud C, Peyrottes S, Champagne E.

J Immunol. 2009 Sep 15;183(6):3848-57. doi: 10.4049/jimmunol.0901085. Epub 2009 Aug 26.


Stimulation of cell surface F1-ATPase activity by apolipoprotein A-I inhibits endothelial cell apoptosis and promotes proliferation.

Radojkovic C, Genoux A, Pons V, Combes G, de Jonge H, Champagne E, Rolland C, Perret B, Collet X, Tercé F, Martinez LO.

Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1125-30. doi: 10.1161/ATVBAHA.109.187997. Epub 2009 Apr 16.


RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes.

Malaval C, Laffargue M, Barbaras R, Rolland C, Peres C, Champagne E, Perret B, Tercé F, Collet X, Martinez LO.

Cell Signal. 2009 Jan;21(1):120-7. doi: 10.1016/j.cellsig.2008.09.016. Epub 2008 Oct 7.


Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism.

Lyly A, Marjavaara SK, Kyttälä A, Uusi-Rauva K, Luiro K, Kopra O, Martinez LO, Tanhuanpää K, Kalkkinen N, Suomalainen A, Jauhiainen M, Jalanko A.

Hum Mol Genet. 2008 May 15;17(10):1406-17. doi: 10.1093/hmg/ddn028. Epub 2008 Feb 1.


Ecto-F1-ATPase and MHC-class I close association on cell membranes.

Vantourout P, Martinez LO, Fabre A, Collet X, Champagne E.

Mol Immunol. 2008 Jan;45(2):485-92. Epub 2007 Jul 23.


Cell surface adenylate kinase activity regulates the F(1)-ATPase/P2Y (13)-mediated HDL endocytosis pathway on human hepatocytes.

Fabre AC, Vantourout P, Champagne E, Tercé F, Rolland C, Perret B, Collet X, Barbaras R, Martinez LO.

Cell Mol Life Sci. 2006 Dec;63(23):2829-37.


Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunological functions.

Champagne E, Martinez LO, Collet X, Barbaras R.

Curr Opin Lipidol. 2006 Jun;17(3):279-84. Review.


Role of apolipoproteins in gammadelta and NKT cell-mediated innate immunity.

Champagne E, Martinez LO, Vantourout P, Collet X, Barbaras R.

Immunol Res. 2005;33(3):241-55. Review.


The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosis.

Jacquet S, Malaval C, Martinez LO, Sak K, Rolland C, Perez C, Nauze M, Champagne E, Tercé F, Gachet C, Perret B, Collet X, Boeynaems JM, Barbaras R.

Cell Mol Life Sci. 2005 Nov;62(21):2508-15.


Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I.

Scotet E, Martinez LO, Grant E, Barbaras R, Jenö P, Guiraud M, Monsarrat B, Saulquin X, Maillet S, Estève JP, Lopez F, Perret B, Collet X, Bonneville M, Champagne E.

Immunity. 2005 Jan;22(1):71-80.


New insight on the molecular mechanisms of high-density lipoprotein cellular interactions.

Martinez LO, Jacquet S, Tercé F, Collet X, Perret B, Barbaras R.

Cell Mol Life Sci. 2004 Sep;61(18):2343-60. Review.


ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.

Wang N, Lan D, Gerbod-Giannone M, Linsel-Nitschke P, Jehle AW, Chen W, Martinez LO, Tall AR.

J Biol Chem. 2003 Oct 31;278(44):42906-12. Epub 2003 Aug 12.


Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I.

Martinez LO, Agerholm-Larsen B, Wang N, Chen W, Tall AR.

J Biol Chem. 2003 Sep 26;278(39):37368-74. Epub 2003 Jul 17.


Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis.

Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezón E, Champagne E, Pineau T, Georgeaud V, Walker JE, Tercé F, Collet X, Perret B, Barbaras R.

Nature. 2003 Jan 2;421(6918):75-9.


A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.

Wang N, Chen W, Linsel-Nitschke P, Martinez LO, Agerholm-Larsen B, Silver DL, Tall AR.

J Clin Invest. 2003 Jan;111(1):99-107.


World Health Organization--basic radiographic system (WHO-BRS) unit: experimental clinical evaluation.

Viamonte M, Martinez LO, Hanson G, McLeod TF, Balanag P, Matczynski M, Ireland W, Telleria R, Penny P.

Clin Radiol. 1990 May;41(5):321-5.


Empty right iliac fossa.

Martinez LO, Friedland JT, Silberman MR.

South Med J. 1985 Aug;78(8):958-61.


Charcoal-containing empyema complicating treatment for overdose.

Justiniani FR, Hippalgaonkar R, Martinez LO.

Chest. 1985 Mar;87(3):404-5.


Thickening of the posterior wall of the bronchus intermedius in right lung pneumonia.

Martinez LO, Esserman L.

Br J Radiol. 1984 Dec;57(684):1073-6.


Diagnosis of polar hypertrophy of the kidney revisited.

Martinez LO, Francis DA, Schilling KJ, Cohen BM.

Mt Sinai J Med. 1984 Dec;51(6):697-701. No abstract available.


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