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Items: 40


The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage.

Jeong E, Brady OA, Martina JA, Pirooznia M, Tunc I, Puertollano R.

Elife. 2018 Dec 6;7. pii: e40856. doi: 10.7554/eLife.40856.


Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply.

Zhang H, Yan S, Khambu B, Ma F, Li Y, Chen X, Martina JA, Puertollano R, Li Y, Chalasani N, Yin XM.

Autophagy. 2018;14(10):1779-1795. doi: 10.1080/15548627.2018.1490850. Epub 2018 Jul 25.


Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress.

Martina JA, Puertollano R.

J Biol Chem. 2018 Aug 10;293(32):12525-12534. doi: 10.1074/jbc.RA118.003471. Epub 2018 Jun 26.


TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.

Willett R, Martina JA, Zewe JP, Wills R, Hammond GRV, Puertollano R.

Nat Commun. 2017 Nov 17;8(1):1580. doi: 10.1038/s41467-017-01871-z.


Emerging roles for TFEB in the immune response and inflammation.

Brady OA, Martina JA, Puertollano R.

Autophagy. 2018;14(2):181-189. doi: 10.1080/15548627.2017.1313943. Epub 2017 Jul 24.


The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z.

Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2.


TFEB and TFE3: The art of multi-tasking under stress conditions.

Martina JA, Puertollano R.

Transcription. 2017 Jan;8(1):48-54. doi: 10.1080/21541264.2016.1264353. Epub 2016 Nov 28.


TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.

Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A, Puertollano R.

Autophagy. 2016 Aug 2;12(8):1240-58. doi: 10.1080/15548627.2016.1179405. Epub 2016 May 12.


TFEB and TFE3 are novel components of the integrated stress response.

Martina JA, Diab HI, Brady OA, Puertollano R.

EMBO J. 2016 Mar 1;35(5):479-95. doi: 10.15252/embj.201593428. Epub 2016 Jan 25.


Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis.

Martina JA, Diab HI, Li H, Puertollano R.

Cell Mol Life Sci. 2014 Jul;71(13):2483-97. doi: 10.1007/s00018-014-1565-8. Epub 2014 Jan 30. Review.


The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.

Martina JA, Diab HI, Lishu L, Jeong-A L, Patange S, Raben N, Puertollano R.

Sci Signal. 2014 Jan 21;7(309):ra9. doi: 10.1126/scisignal.2004754.


RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis.

Martina JA, Puertollano R.

Autophagy. 2013 Jun 1;9(6):928-30. doi: 10.4161/auto.24371. Epub 2013 Mar 22.


Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.

Martina JA, Puertollano R.

J Cell Biol. 2013 Feb 18;200(4):475-91. doi: 10.1083/jcb.201209135. Epub 2013 Feb 11.


Melanoregulin is stably targeted to the melanosome membrane by palmitoylation.

Wu XS, Martina JA, Hammer JA 3rd.

Biochem Biophys Res Commun. 2012 Sep 21;426(2):209-14. doi: 10.1016/j.bbrc.2012.08.064. Epub 2012 Aug 23.


MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

Martina JA, Chen Y, Gucek M, Puertollano R.

Autophagy. 2012 Jun;8(6):903-14. doi: 10.4161/auto.19653. Epub 2012 May 11.


Transcriptional activation of lysosomal exocytosis promotes cellular clearance.

Medina DL, Fraldi A, Bouche V, Annunziata F, Mansueto G, Spampanato C, Puri C, Pignata A, Martina JA, Sardiello M, Palmieri M, Polishchuk R, Puertollano R, Ballabio A.

Dev Cell. 2011 Sep 13;21(3):421-30. doi: 10.1016/j.devcel.2011.07.016. Epub 2011 Sep 1.


Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.

Martina JA, Wu XS, Catalfamo M, Sakamoto T, Yi C, Hammer JA 3rd.

Cell Immunol. 2011;271(2):267-79. doi: 10.1016/j.cellimm.2011.07.004. Epub 2011 Jul 24.


Two modes of lytic granule fusion during degranulation by natural killer cells.

Liu D, Martina JA, Wu XS, Hammer JA 3rd, Long EO.

Immunol Cell Biol. 2011 Aug;89(6):728-38. doi: 10.1038/icb.2010.167. Epub 2011 Apr 12.


LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV.

Vergarajauregui S, Martina JA, Puertollano R.

J Cell Sci. 2011 Feb 1;124(Pt 3):459-68. doi: 10.1242/jcs.076240. Epub 2011 Jan 11.


Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1.

Vergarajauregui S, Martina JA, Puertollano R.

J Biol Chem. 2009 Dec 25;284(52):36357-66. doi: 10.1074/jbc.M109.047241. Epub 2009 Oct 28.


The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway.

Martina JA, Lelouvier B, Puertollano R.

Traffic. 2009 Aug;10(8):1143-56. doi: 10.1111/j.1600-0854.2009.00935.x. Epub 2009 Apr 29.


Modulation of GalT1 and SialT1 sub-Golgi localization by SialT2 expression reveals an organellar level of glycolipid synthesis control.

Uliana AS, Crespo PM, Martina JA, Daniotti JL, Maccioni HJ.

J Biol Chem. 2006 Oct 27;281(43):32852-60. Epub 2006 Sep 1.


EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling.

Salvucci O, de la Luz Sierra M, Martina JA, McCormick PJ, Tosato G.

Blood. 2006 Nov 1;108(9):2914-22. Epub 2006 Jul 13.


Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.

Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G.

Mol Biol Cell. 2005 Nov;16(11):5356-72. Epub 2005 Sep 14.


Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments.

McCormick PJ, Martina JA, Bonifacino JS.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):7910-5. Epub 2005 May 23.


Polycystic liver disease is a disorder of cotranslational protein processing.

Drenth JP, Martina JA, van de Kerkhof R, Bonifacino JS, Jansen JB.

Trends Mol Med. 2005 Jan;11(1):37-42. Review.


Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex.

Gwynn B, Martina JA, Bonifacino JS, Sviderskaya EV, Lamoreux ML, Bennett DC, Moriyama K, Huizing M, Helip-Wooley A, Gahl WA, Webb LS, Lambert AJ, Peters LL.

Blood. 2004 Nov 15;104(10):3181-9. Epub 2004 Jul 20.


Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease.

Drenth JP, Martina JA, Te Morsche RH, Jansen JB, Bonifacino JS.

Gastroenterology. 2004 Jun;126(7):1819-27.


Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes.

Janvier K, Kato Y, Boehm M, Rose JR, Martina JA, Kim BY, Venkatesan S, Bonifacino JS.

J Cell Biol. 2003 Dec 22;163(6):1281-90.


BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4.

Martina JA, Moriyama K, Bonifacino JS.

J Biol Chem. 2003 Aug 1;278(31):29376-84. Epub 2003 May 19.


Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.

Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS.

J Cell Biol. 2001 May 28;153(5):1111-20.


GM1 synthase depends on N-glycosylation for enzyme activity and trafficking to the Golgi complex.

Martina JA, Daniotti JL, Maccioni HJ.

Neurochem Res. 2000 May;25(5):725-31.


GM3 alpha2,8-sialyltransferase (GD3 synthase): protein characterization and sub-golgi location in CHO-K1 cells.

Daniotti JL, Martina JA, Giraudo CG, Zurita AR, Maccioni HJ.

J Neurochem. 2000 Apr;74(4):1711-20.


Organization of ganglioside synthesis in the Golgi apparatus.

Maccioni HJ, Daniotti JL, Martina JA.

Biochim Biophys Acta. 1999 Feb 25;1437(2):101-18. Review. No abstract available.


Expression of beta 1-4 N-acetylgalactosaminyltransferase gene in the developing rat brain and retina: mRNA, protein immunoreactivity and enzyme activity.

Daniotti JL, Rosales Fritz VM, Martina JA, Furukawa K, Maccioni HJ.

Neurochem Int. 1997 Jul;31(1):11-9.


Compartmental organization of ganglioside synthesis in the Golgi complex.

Maccioni HJ, Rosales Fritz V, Maxzúd MK, Daniotti JL, Martina JA.

Biocell. 1996 Dec;20(3):279-86. Review. No abstract available.


UDP-sugar pyrophosphatase of rat retina: subcellular localization and topography.

Martina JA, Maccioni HJ.

J Neurosci Res. 1996 Nov 15;46(4):485-91.


A UDP-sugar pyrophosphatase is developmentally regulated in the rat retina.

Martina JA, Daniotti JL, Maccioni HJ.

J Neurochem. 1995 Mar;64(3):1274-80.


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