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Items: 37

1.

Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.

Diaz-Ruiz A, Lanasa M, Garcia J, Mora H, Fan F, Martin-Montalvo A, Di Francesco A, Calvo-Rubio M, Salvador-Pascual A, Aon MA, Fishbein KW, Pearson KJ, Villalba JM, Navas P, Bernier M, de Cabo R.

Aging Cell. 2018 Apr 28:e12767. doi: 10.1111/acel.12767. [Epub ahead of print]

2.

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.

Cobo-Vuilleumier N, Lorenzo PI, Rodríguez NG, Herrera Gómez IG, Fuente-Martin E, López-Noriega L, Mellado-Gil JM, Romero-Zerbo SY, Baquié M, Lachaud CC, Stifter K, Perdomo G, Bugliani M, De Tata V, Bosco D, Parnaud G, Pozo D, Hmadcha A, Florido JP, Toscano MG, de Haan P, Schoonjans K, Sánchez Palazón L, Marchetti P, Schirmbeck R, Martín-Montalvo A, Meda P, Soria B, Bermúdez-Silva FJ, St-Onge L, Gauthier BR.

Nat Commun. 2018 Apr 16;9(1):1488. doi: 10.1038/s41467-018-03943-0.

3.

The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.

Mellado-Gil JM, Fuente-Martín E, Lorenzo PI, Cobo-Vuilleumier N, López-Noriega L, Martín-Montalvo A, Gómez IGH, Ceballos-Chávez M, Gómez-Jaramillo L, Campos-Caro A, Romero-Zerbo SY, Rodríguez-Comas J, Servitja JM, Rojo-Martinez G, Hmadcha A, Soria B, Bugliani M, Marchetti P, Bérmudez-Silva FJ, Reyes JC, Aguilar-Diosdado M, Gauthier BR.

Cell Death Dis. 2018 Feb 15;9(3):279. doi: 10.1038/s41419-018-0272-z.

4.

Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice.

López-Noriega L, Cobo-Vuilleumier N, Narbona-Pérez ÁJ, Araujo-Garrido JL, Lorenzo PI, Mellado-Gil JM, Moreno JC, Gauthier BR, Martín-Montalvo A.

Br J Pharmacol. 2017 Nov;174(21):3795-3810. doi: 10.1111/bph.13975. Epub 2017 Sep 20.

PMID:
28800677
5.

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

Mercken EM, Capri M, Carboneau BA, Conte M, Heidler J, Santoro A, Martin-Montalvo A, Gonzalez-Freire M, Khraiwesh H, González-Reyes JA, Moaddel R, Zhang Y, Becker KG, Villalba JM, Mattison JA, Wittig I, Franceschi C, de Cabo R.

NPJ Aging Mech Dis. 2017 May 5;3:8. doi: 10.1038/s41514-017-0009-8. eCollection 2017.

6.

Balanced CoQ6 biosynthesis is required for lifespan and mitophagy in yeast.

González-Mariscal I, Martín-Montalvo A, Ojeda-González C, Rodríguez-Eguren A, Gutiérrez-Ríos P, Navas P, Santos-Ocaña C.

Microb Cell. 2017 Feb 3;4(2):38-51. doi: 10.15698/mic2017.02.556.

7.

Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors.

Martin-Montalvo A, Lorenzo PI, López-Noriega L, Gauthier BR.

Expert Opin Ther Targets. 2017 Jan;21(1):77-89. Epub 2016 Nov 18. Review.

PMID:
27841034
8.

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.

Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD.

Cancer Cell. 2016 Jul 11;30(1):136-146. doi: 10.1016/j.ccell.2016.06.005.

9.

Cytochrome b5 reductase and the control of lipid metabolism and healthspan.

Martin-Montalvo A, Sun Y, Diaz-Ruiz A, Ali A, Gutierrez V, Palacios HH, Curtis J, Siendones E, Ariza J, Abulwerdi GA, Sun X, Wang AX, Pearson KJ, Fishbein KW, Spencer RG, Wang M, Han X, Scheibye-Knudsen M, Baur JA, Shertzer HG, Navas P, Villalba JM, Zou S, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2016 May 12;2:16006. doi: 10.1038/npjamd.2016.6. eCollection 2016.

10.

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence.

Noren Hooten N, Martin-Montalvo A, Dluzen DF, Zhang Y, Bernier M, Zonderman AB, Becker KG, Gorospe M, de Cabo R, Evans MK.

Aging Cell. 2016 Jun;15(3):572-81. doi: 10.1111/acel.12469. Epub 2016 Mar 17.

11.

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.

Mellado-Gil JM, Jiménez-Moreno CM, Martin-Montalvo A, Alvarez-Mercado AI, Fuente-Martin E, Cobo-Vuilleumier N, Lorenzo PI, Bru-Tari E, Herrera-Gómez Ide G, López-Noriega L, Pérez-Florido J, Santoyo-López J, Spyrantis A, Meda P, Boehm BO, Quesada I, Gauthier BR.

Diabetologia. 2016 Apr;59(4):755-65. doi: 10.1007/s00125-016-3864-0. Epub 2016 Jan 26.

12.

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet.

Lorenzo PI, Fuente-Martín E, Brun T, Cobo-Vuilleumier N, Jimenez-Moreno CM, G Herrera Gomez I, López Noriega L, Mellado-Gil JM, Martin-Montalvo A, Soria B, Gauthier BR.

Sci Rep. 2015 Oct 27;5:15672. doi: 10.1038/srep15672.

13.

A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors.

Jimenez-Moreno CM, Herrera-Gomez IG, Lopez-Noriega L, Lorenzo PI, Cobo-Vuilleumier N, Fuente-Martin E, Mellado-Gil JM, Parnaud G, Bosco D, Gauthier BR, Martin-Montalvo A.

Curr Gene Ther. 2015;15(4):436-46.

14.

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P.

Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009.

15.

The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us.

González-Mariscal I, García-Testón E, Padilla S, Martín-Montalvo A, Pomares Viciana T, Vazquez-Fonseca L, Gandolfo Domínguez P, Santos-Ocaña C.

Mol Syndromol. 2014 Jul;5(3-4):107-18. doi: 10.1159/000362897.

16.

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.

Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R.

Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16.

17.

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet.

Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, de Cabo R.

Cell Rep. 2014 Mar 13;6(5):836-43. doi: 10.1016/j.celrep.2014.01.031. Epub 2014 Feb 27.

18.

Regulation of coenzyme Q biosynthesis in yeast: a new complex in the block.

González-Mariscal I, García-Testón E, Padilla S, Martín-Montalvo A, Pomares-Viciana T, Vazquez-Fonseca L, Gandolfo-Domínguez P, Santos-Ocaña C.

IUBMB Life. 2014 Feb;66(2):63-70. doi: 10.1002/iub.1243. Epub 2014 Jan 27. Review.

19.

Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.

Siendones E, SantaCruz-Calvo S, Martín-Montalvo A, Cascajo MV, Ariza J, López-Lluch G, Villalba JM, Acquaviva-Bourdain C, Roze E, Bernier M, de Cabo R, Navas P.

Antioxid Redox Signal. 2014 Oct 20;21(12):1708-25. doi: 10.1089/ars.2013.5479. Epub 2014 Feb 28.

20.

Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.

Okun E, Griffioen KJ, Rothman S, Wan R, Cong WN, De Cabo R, Martin-Montalvo A, Levette A, Maudsley S, Martin B, Arumugam TV, Mattson MP.

Brain Behav Immun. 2014 Feb;36:90-100. doi: 10.1016/j.bbi.2013.10.013. Epub 2013 Oct 18.

21.

Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R.

Cell Metab. 2013 Oct 1;18(4):533-45. doi: 10.1016/j.cmet.2013.09.004.

22.

Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells.

Lee-Chang C, Bodogai M, Martin-Montalvo A, Wejksza K, Sanghvi M, Moaddel R, de Cabo R, Biragyn A.

J Immunol. 2013 Oct 15;191(8):4141-51. doi: 10.4049/jimmunol.1300606. Epub 2013 Sep 16.

23.

The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.

Martín-Montalvo A, González-Mariscal I, Pomares-Viciana T, Padilla-López S, Ballesteros M, Vazquez-Fonseca L, Gandolfo P, Brautigan DL, Navas P, Santos-Ocaña C.

J Biol Chem. 2013 Sep 27;288(39):28126-37. doi: 10.1074/jbc.M113.474494. Epub 2013 Aug 12.

24.

Metformin improves healthspan and lifespan in mice.

Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R.

Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192.

25.

Mitochondrial metabolic reprogramming induced by calorie restriction.

Martin-Montalvo A, de Cabo R.

Antioxid Redox Signal. 2013 Jul 20;19(3):310-20. doi: 10.1089/ars.2012.4866. Epub 2012 Oct 15. Review.

26.

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA.

Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003.

27.

SRT1720 improves survival and healthspan of obese mice.

Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R.

Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Erratum in: Sci Rep. 2013;3():1131.

28.

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.

Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD.

Sci Transl Med. 2012 Mar 7;4(124):124ra27. doi: 10.1126/scitranslmed.3003293. Epub 2012 Feb 8.

29.

Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p.

Martín-Montalvo A, González-Mariscal I, Padilla S, Ballesteros M, Brautigan DL, Navas P, Santos-Ocaña C.

Biochem J. 2011 Nov 15;440(1):107-14. doi: 10.1042/BJ20101422.

PMID:
21812761
30.

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.

Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI.

Cell Metab. 2011 Aug 3;14(2):184-95. doi: 10.1016/j.cmet.2011.06.009. Erratum in: Cell Metab. 2011 Oct 5;14(4):567.

31.

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.

Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R.

J Biol Chem. 2011 Jun 3;286(22):19270-9. doi: 10.1074/jbc.M110.200311. Epub 2011 Apr 5.

32.

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.

Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD.

Sci Transl Med. 2011 Feb 16;3(70):70ra13. doi: 10.1126/scitranslmed.3001845.

33.

NRF2, cancer and calorie restriction.

Martín-Montalvo A, Villalba JM, Navas P, de Cabo R.

Oncogene. 2011 Feb 3;30(5):505-20. doi: 10.1038/onc.2010.492. Epub 2010 Nov 8. Review.

34.

Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha.

Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR.

Bioorg Med Chem. 2010 Feb;18(3):1103-10. doi: 10.1016/j.bmc.2009.12.056. Epub 2010 Jan 4.

35.

Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae.

Padilla-López S, Jiménez-Hidalgo M, Martín-Montalvo A, Clarke CF, Navas P, Santos-Ocaña C.

Biochim Biophys Acta. 2009 Jun;1788(6):1238-48. doi: 10.1016/j.bbamem.2009.03.018. Epub 2009 Apr 2.

36.

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.

Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P.

Aging Cell. 2009 Apr;8(2):140-51. doi: 10.1111/j.1474-9726.2009.00461.x. Epub 2009 Feb 23.

37.

Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis.

Padilla S, Tran UC, Jiménez-Hidalgo M, López-Martín JM, Martín-Montalvo A, Clarke CF, Navas P, Santos-Ocaña C.

Cell Mol Life Sci. 2009 Jan;66(1):173-86. doi: 10.1007/s00018-008-8547-7.

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