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Items: 41


The cell wall regulates dynamics and size of plasma-membrane nanodomains in Arabidopsis.

McKenna JF, Rolfe DJ, Webb SED, Tolmie AF, Botchway SW, Martin-Fernandez ML, Hawes C, Runions J.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12857-12862. doi: 10.1073/pnas.1819077116. Epub 2019 Jun 10.


A Brief History of Single-Particle Tracking of the Epidermal Growth Factor Receptor.

Clarke DT, Martin-Fernandez ML.

Methods Protoc. 2019 Jan 30;2(1). pii: E12. doi: 10.3390/mps2010012. Review.


Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer.

Martin-Fernandez ML, Clarke DT, Roberts SK, Zanetti-Domingues LC, Gervasio FL.

Cells. 2019 Apr 5;8(4). pii: E316. doi: 10.3390/cells8040316. Review.


The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity.

Elbediwy A, Zhang Y, Cobbaut M, Riou P, Tan RS, Roberts SK, Tynan C, George R, Kjaer S, Martin-Fernandez ML, Thompson BJ, McDonald NQ, Parker PJ.

J Cell Sci. 2019 Apr 25;132(8). pii: jcs223743. doi: 10.1242/jcs.223743.


Solid immersion microscopy images cells under cryogenic conditions with 12 nm resolution.

Wang L, Bateman B, Zanetti-Domingues LC, Moores AN, Astbury S, Spindloe C, Darrow MC, Romano M, Needham SR, Beis K, Rolfe DJ, Clarke DT, Martin-Fernandez ML.

Commun Biol. 2019 Feb 21;2:74. doi: 10.1038/s42003-019-0317-6. eCollection 2019.


The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.

Zanetti-Domingues LC, Korovesis D, Needham SR, Tynan CJ, Sagawa S, Roberts SK, Kuzmanic A, Ortiz-Zapater E, Jain P, Roovers RC, Lajevardipour A, van Bergen En Henegouwen PMP, Santis G, Clayton AHA, Clarke DT, Gervasio FL, Shan Y, Shaw DE, Rolfe DJ, Parker PJ, Martin-Fernandez ML.

Nat Commun. 2018 Oct 18;9(1):4325. doi: 10.1038/s41467-018-06632-0.


Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface.

Claus J, Patel G, Autore F, Colomba A, Weitsman G, Soliman TN, Roberts S, Zanetti-Domingues LC, Hirsch M, Collu F, George R, Ortiz-Zapater E, Barber PR, Vojnovic B, Yarden Y, Martin-Fernandez ML, Cameron A, Fraternali F, Ng T, Parker PJ.

Elife. 2018 May 1;7. pii: e32271. doi: 10.7554/eLife.32271.


EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.

Needham SR, Roberts SK, Arkhipov A, Mysore VP, Tynan CJ, Zanetti-Domingues LC, Kim ET, Losasso V, Korovesis D, Hirsch M, Rolfe DJ, Clarke DT, Winn MD, Lajevardipour A, Clayton AH, Pike LJ, Perani M, Parker PJ, Shan Y, Shaw DE, Martin-Fernandez ML.

Nat Commun. 2016 Oct 31;7:13307. doi: 10.1038/ncomms13307.


A tale of the epidermal growth factor receptor: The quest for structural resolution on cells.

Tynan CJ, Lo Schiavo V, Zanetti-Domingues L, Needham SR, Roberts SK, Hirsch M, Rolfe DJ, Korovesis D, Clarke DT, Martin-Fernandez ML.

Methods. 2016 Feb 15;95:86-93. doi: 10.1016/j.ymeth.2015.10.009. Epub 2015 Oct 17. Review.


Determining the geometry of oligomers of the human epidermal growth factor family on cells with <10 nm resolution.

Needham SR, Zanetti-Domingues LC, Scherer KM, Hirsch M, Rolfe DJ, Roberts SK, Martin-Fernandez ML, Clarke DT, Tynan CJ.

Biochem Soc Trans. 2015 Jun;43(3):309-14. doi: 10.1042/BST20140318. Review.


Nanometric molecular separation measurements by single molecule photobleaching.

Webb SE, Hirsch M, Needham SR, Coles BC, Scherer KM, Roberts SK, Zanetti-Domingues LC, Tynan CJ, Martin-Fernandez ML, Rolfe DJ.

Methods. 2015 Oct 15;88:76-80. doi: 10.1016/j.ymeth.2015.05.009. Epub 2015 May 14.


Determining the geometry of oligomers of the human epidermal growth factor family on cells with 7 nm resolution.

Zanetti-Domingues LC, Hirsch M, Tynan CJ, Rolfe DJ, Boyadzhiev TV, Scherer KM, Clarke DT, Martin-Fernandez ML, Needham SR.

Prog Biophys Mol Biol. 2015 Sep;118(3):139-52. doi: 10.1016/j.pbiomolbio.2015.04.002. Epub 2015 Apr 18. Review.


Effect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM.

Coban O, Zanetti-Dominguez LC, Matthews DR, Rolfe DJ, Weitsman G, Barber PR, Barbeau J, Devauges V, Kampmeier F, Winn M, Vojnovic B, Parker PJ, Lidke KA, Lidke DS, Ameer-Beg SM, Martin-Fernandez ML, Ng T.

Biophys J. 2015 Mar 10;108(5):1013-26. doi: 10.1016/j.bpj.2015.01.005.


The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T.

Sci Signal. 2014 Aug 19;7(339):ra78. doi: 10.1126/scisignal.2005157.


Structure-function relationships and supramolecular organization of the EGFR (epidermal growth factor receptor) on the cell surface.

Needham SR, Zanetti-Domingues LC, Hirsch M, Rolfe DJ, Tynan CJ, Roberts SK, Martin-Fernandez ML, Clarke DT.

Biochem Soc Trans. 2014 Feb;42(1):114-9. doi: 10.1042/BST20130236. Review.


A 'pocket guide' to total internal reflection fluorescence.

Martin-Fernandez ML, Tynan CJ, Webb SE.

J Microsc. 2013 Oct;252(1):16-22. doi: 10.1111/jmi.12070. Epub 2013 Jul 24. Review.


Measuring EGFR separations on cells with ~10 nm resolution via fluorophore localization imaging with photobleaching.

Needham SR, Hirsch M, Rolfe DJ, Clarke DT, Zanetti-Domingues LC, Wareham R, Martin-Fernandez ML.

PLoS One. 2013 May 1;8(5):e62331. doi: 10.1371/journal.pone.0062331. Print 2013.


A stochastic model for electron multiplication charge-coupled devices--from theory to practice.

Hirsch M, Wareham RJ, Martin-Fernandez ML, Hobson MP, Rolfe DJ.

PLoS One. 2013;8(1):e53671. doi: 10.1371/journal.pone.0053671. Epub 2013 Jan 31.


Single molecule fluorescence detection and tracking in mammalian cells: the state-of-the-art and future perspectives.

Martin-Fernandez ML, Clarke DT.

Int J Mol Sci. 2012 Nov 13;13(11):14742-65. doi: 10.3390/ijms131114742. Review.


A systematic investigation of differential effects of cell culture substrates on the extent of artifacts in single-molecule tracking.

Zanetti-Domingues LC, Martin-Fernandez ML, Needham SR, Rolfe DJ, Clarke DT.

PLoS One. 2012;7(9):e45655. doi: 10.1371/journal.pone.0045655. Epub 2012 Sep 25.


Cell wall constrains lateral diffusion of plant plasma-membrane proteins.

Martinière A, Lavagi I, Nageswaran G, Rolfe DJ, Maneta-Peyret L, Luu DT, Botchway SW, Webb SE, Mongrand S, Maurel C, Martin-Fernandez ML, Kleine-Vehn J, Friml J, Moreau P, Runions J.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12805-10. doi: 10.1073/pnas.1202040109. Epub 2012 Jun 11.


Multicolour single molecule imaging in cells with near infra-red dyes.

Tynan CJ, Clarke DT, Coles BC, Rolfe DJ, Martin-Fernandez ML, Webb SE.

PLoS One. 2012;7(4):e36265. doi: 10.1371/journal.pone.0036265. Epub 2012 Apr 25.


Multicolour single molecule imaging on cells using a supercontinuum source.

Webb SE, Zanetti-Domingues L, Coles BC, Rolfe DJ, Wareham RJ, Martin-Fernandez ML.

Biomed Opt Express. 2012 Mar 1;3(3):400-6. doi: 10.1364/BOE.3.000400. Epub 2012 Feb 2.


Investigating extracellular in situ EGFR structure and conformational changes using FRET microscopy.

Roberts SK, Tynan CJ, Winn M, Martin-Fernandez ML.

Biochem Soc Trans. 2012 Feb;40(1):189-94. doi: 10.1042/BST20110632.


Human epidermal growth factor receptor (HER1) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry.

Martin-Fernandez ML.

Biochem Soc Trans. 2012 Feb;40(1):184-8. doi: 10.1042/BST20110692.


Optics clustered to output unique solutions: a multi-laser facility for combined single molecule and ensemble microscopy.

Clarke DT, Botchway SW, Coles BC, Needham SR, Roberts SK, Rolfe DJ, Tynan CJ, Ward AD, Webb SE, Yadav R, Zanetti-Domingues L, Martin-Fernandez ML.

Rev Sci Instrum. 2011 Sep;82(9):093705. doi: 10.1063/1.3635536.


Automated multidimensional single molecule fluorescence microscopy feature detection and tracking.

Rolfe DJ, McLachlan CI, Hirsch M, Needham SR, Tynan CJ, Webb SE, Martin-Fernandez ML, Hobson MP.

Eur Biophys J. 2011 Oct;40(10):1167-86. doi: 10.1007/s00249-011-0747-7. Epub 2011 Sep 18.


Subcellular and single-molecule imaging of plant fluorescent proteins using total internal reflection fluorescence microscopy (TIRFM).

Vizcay-Barrena G, Webb SE, Martin-Fernandez ML, Wilson ZA.

J Exp Bot. 2011 Nov;62(15):5419-28. doi: 10.1093/jxb/err212. Epub 2011 Aug 23.


CAR modulates E-cadherin dynamics in the presence of adenovirus type 5.

Hussain F, Morton PE, Snippe M, Sullivan J, Farmer C, Martin-Fernandez ML, Parsons M, Santis G.

PLoS One. 2011;6(8):e23056. doi: 10.1371/journal.pone.0023056. Epub 2011 Aug 5.


Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry.

Tynan CJ, Roberts SK, Rolfe DJ, Clarke DT, Loeffler HH, Kästner J, Winn MD, Parker PJ, Martin-Fernandez ML.

Mol Cell Biol. 2011 Jun;31(11):2241-52. doi: 10.1128/MCB.01431-10. Epub 2011 Mar 28.


Focal adhesions are sites of integrin extension.

Askari JA, Tynan CJ, Webb SE, Martin-Fernandez ML, Ballestrem C, Humphries MJ.

J Cell Biol. 2010 Mar 22;188(6):891-903. doi: 10.1083/jcb.200907174. Epub 2010 Mar 15.


Self-association of calcium-binding protein S100A4 and metastasis.

Ismail TM, Zhang S, Fernig DG, Gross S, Martin-Fernandez ML, See V, Tozawa K, Tynan CJ, Wang G, Wilkinson MC, Rudland PS, Barraclough R.

J Biol Chem. 2010 Jan 8;285(2):914-22. doi: 10.1074/jbc.M109.010892. Epub 2009 Nov 16.


Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics.

Kästner J, Loeffler HH, Roberts SK, Martin-Fernandez ML, Winn MD.

J Struct Biol. 2009 Aug;167(2):117-28. doi: 10.1016/j.jsb.2009.04.007. Epub 2009 May 3.


Simultaneous widefield single molecule orientation and FRET microscopy in cells.

Webb SE, Rolfe DJ, Needham SR, Roberts SK, Clarke DT, McLachlan CI, Hobson MP, Martin-Fernandez ML.

Opt Express. 2008 Dec 8;16(25):20258-65.


Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells.

Webb SE, Roberts SK, Needham SR, Tynan CJ, Rolfe DJ, Winn MD, Clarke DT, Barraclough R, Martin-Fernandez ML.

Biophys J. 2008 Feb 1;94(3):803-19. Epub 2007 Sep 21.


Multidimensional single-molecule imaging in live cells using total-internal-reflection fluorescence microscopy.

Webb SE, Needham SR, Roberts SK, Martin-Fernandez ML.

Opt Lett. 2006 Jul 15;31(14):2157-9.


Real-time studies of the interactions between epidermal growth factor and its receptor during endocytic trafficking.

Martin-Fernandez ML, Clarke DT, Tobin MJ, Jones GR.

Cell Mol Biol (Noisy-le-grand). 2000 Sep;46(6):1103-12.


Time-resolved X-ray diffraction studies of myosin head movements in live frog sartorius muscle during isometric and isotonic contractions.

Martin-Fernandez ML, Bordas J, Diakun G, Harries J, Lowy J, Mant GR, Svensson A, Towns-Andrews E.

J Muscle Res Cell Motil. 1994 Jun;15(3):319-48.


Two-dimensional time-resolved X-ray diffraction studies of live isometrically contracting frog sartorius muscle.

Bordas J, Diakun GP, Diaz FG, Harries JE, Lewis RA, Lowy J, Mant GR, Martin-Fernandez ML, Towns-Andrews E.

J Muscle Res Cell Motil. 1993 Jun;14(3):311-24.


A comparative study of the supramolecular structure of frog sartorius and dorsal semitendinosus muscle.

Harries JE, Martin-Fernandez ML, Diakun GP, Mant GR, Bordas J.

J Struct Biol. 1991 Jun;106(3):264-71.


Two-dimensional time resolved X-ray diffraction of muscle: recent results.

Bordas J, Diakun GP, Harries JE, Lewis RA, Mant GR, Martin-Fernandez ML, Towns-Andrews E.

Adv Biophys. 1991;27:15-33. Review.


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