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Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats.

Matzeu A, Martin-Fardon R.

Neuropharmacology. 2020 Mar 1;164:107906. doi: 10.1016/j.neuropharm.2019.107906. Epub 2019 Dec 4.


Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol-Seeking Behavior.

Kim JS, Martin-Fardon R.

Alcohol Clin Exp Res. 2020 Feb;44(2):354-367. doi: 10.1111/acer.14264. Epub 2020 Jan 2. Review.


Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala.

Suárez J, Khom S, Alén F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodríguez de Fonseca F, Roberto M.

Addict Biol. 2019 Jul 24:e12813. doi: 10.1111/adb.12813. [Epub ahead of print]


Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice.

Pavón FJ, Serrano A, Stouffer DG, Polis I, Roberto M, Cravatt BF, Martin-Fardon R, Rodríguez de Fonseca F, Parsons LH.

Addict Biol. 2019 Nov;24(6):1204-1215. doi: 10.1111/adb.12695. Epub 2018 Nov 13.


Exploring Sex Differences in the Attenuation of Ethanol Drinking by Naltrexone in Dependent Rats During Early and Protracted Abstinence.

Matzeu A, Terenius L, Martin-Fardon R.

Alcohol Clin Exp Res. 2018 Dec;42(12):2466-2478. doi: 10.1111/acer.13898. Epub 2018 Oct 28.


Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus.

Matzeu A, Martin-Fardon R.

Front Neurol. 2018 Aug 28;9:720. doi: 10.3389/fneur.2018.00720. eCollection 2018. Review.


Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake.

Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH.

Neuropsychopharmacology. 2018 Aug;43(9):1840-1850. doi: 10.1038/s41386-018-0055-3. Epub 2018 Apr 5.


Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats.

Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C.

Neuropsychopharmacology. 2018 Nov;43(12):2373-2382. doi: 10.1038/s41386-018-0054-4. Epub 2018 Apr 6.


Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle.

Gonzalez-Cuevas G, Martin-Fardon R, Kerr TM, Stouffer DG, Parsons LH, Hammell DC, Banks SL, Stinchcomb AL, Weiss F.

Neuropsychopharmacology. 2018 Sep;43(10):2036-2045. doi: 10.1038/s41386-018-0050-8. Epub 2018 Mar 22.


Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence.

Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R.

Neuropsychopharmacology. 2018 Apr;43(5):1010-1020. doi: 10.1038/npp.2017.250. Epub 2017 Oct 20.


Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility.

Natividad LA, Steinman MQ, Laredo SA, Irimia C, Polis IY, Lintz R, Buczynski MW, Martin-Fardon R, Roberto M, Parsons LH.

Addict Biol. 2018 Sep;23(5):1117-1129. doi: 10.1111/adb.12568. Epub 2017 Sep 22.


Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens.

Pavon FJ, Serrano A, Sidhpura N, Polis I, Stouffer D, de Fonseca FR, Cravatt BF, Martin-Fardon R, Parsons LH.

Addict Biol. 2018 Mar;23(2):723-734. doi: 10.1111/adb.12531. Epub 2017 Jun 29.


Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats.

de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O.

J Pharmacol Exp Ther. 2017 Sep;362(3):378-384. doi: 10.1124/jpet.117.241042. Epub 2017 Jun 23.


Differential role of hypothalamic orexin/hypocretin neurons in reward seeking motivated by cocaine versus palatable food.

Martin-Fardon R, Cauvi G, Kerr TM, Weiss F.

Addict Biol. 2018 Jan;23(1):6-15. doi: 10.1111/adb.12441. Epub 2016 Aug 24.


Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2.

Matzeu A, Kerr TM, Weiss F, Martin-Fardon R.

J Pharmacol Exp Ther. 2016 Nov;359(2):273-279. Epub 2016 Aug 18.


Perseveration of craving: effects of stimuli conditioned to drugs of abuse versus conventional reinforcers differing in demand.

Martin-Fardon R, Weiss F.

Addict Biol. 2017 Jul;22(4):923-932. doi: 10.1111/adb.12374. Epub 2016 Feb 10.


Transient inactivation of the posterior paraventricular nucleus of the thalamus blocks cocaine-seeking behavior.

Matzeu A, Weiss F, Martin-Fardon R.

Neurosci Lett. 2015 Nov 3;608:34-9. doi: 10.1016/j.neulet.2015.10.016. Epub 2015 Oct 9.


The paraventricular nucleus of the thalamus is differentially recruited by stimuli conditioned to the availability of cocaine versus palatable food.

Matzeu A, Cauvi G, Kerr TM, Weiss F, Martin-Fardon R.

Addict Biol. 2017 Jan;22(1):70-77. doi: 10.1111/adb.12280. Epub 2015 Jun 19.


MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats.

de Guglielmo G, Martin-Fardon R, Teshima K, Ciccocioppo R, Weiss F.

Addict Biol. 2015 Jul;20(4):643-51. doi: 10.1111/adb.12157. Epub 2014 Jun 16.


Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking.

Martin-Fardon R, Weiss F.

Neuroreport. 2014 May 7;25(7):485-8. doi: 10.1097/WNR.0000000000000120.


Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry?

Martin-Fardon R, Boutrel B.

Front Behav Neurosci. 2012 Nov 9;6:75. doi: 10.3389/fnbeh.2012.00075. eCollection 2012.


Effect of σ₁ receptor antagonism on ethanol and natural reward seeking.

Martin-Fardon R, Strong EM, Weiss F.

Neuroreport. 2012 Oct 3;23(14):809-13. doi: 10.1097/WNR.0b013e32835717c8.


Modification of anxiety-like behaviors by nociceptin/orphanin FQ (N/OFQ) and time-dependent changes in N/OFQ-NOP gene expression following ethanol withdrawal.

Aujla H, Cannarsa R, Romualdi P, Ciccocioppo R, Martin-Fardon R, Weiss F.

Addict Biol. 2013 May;18(3):467-79. doi: 10.1111/j.1369-1600.2012.00466.x. Epub 2012 Jul 15.


Modeling relapse in animals.

Martin-Fardon R, Weiss F.

Curr Top Behav Neurosci. 2013;13:403-32. doi: 10.1007/7854_2012_202. Review.


Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat.

Economidou D, Cippitelli A, Stopponi S, Braconi S, Clementi S, Ubaldi M, Martin-Fardon R, Weiss F, Massi M, Ciccocioppo R.

Alcohol Clin Exp Res. 2011 Apr;35(4):747-55. doi: 10.1111/j.1530-0277.2010.01392.x. Epub 2011 Jan 11.


Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence.

Sidhpura N, Weiss F, Martin-Fardon R.

Biol Psychiatry. 2010 May 1;67(9):804-11. doi: 10.1016/j.biopsych.2010.01.005. Epub 2010 Feb 26.


Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats.

Braconi S, Sidhpura N, Aujla H, Martin-Fardon R, Weiss F, Ciccocioppo R.

Alcohol Clin Exp Res. 2010 Mar 1;34(3):538-44. doi: 10.1111/j.1530-0277.2009.01119.x. Epub 2009 Dec 17.


Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin.

Martin-Fardon R, Zorrilla EP, Ciccocioppo R, Weiss F.

Brain Res. 2010 Feb 16;1314:145-61. doi: 10.1016/j.brainres.2009.12.027. Epub 2009 Dec 21. Review.


Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer.

Martin-Fardon R, Baptista MA, Dayas CV, Weiss F.

J Pharmacol Exp Ther. 2009 Jun;329(3):1084-90. doi: 10.1124/jpet.109.151357. Epub 2009 Mar 3.


Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.

Economidou D, Hansson AC, Weiss F, Terasmaa A, Sommer WH, Cippitelli A, Fedeli A, Martin-Fardon R, Massi M, Ciccocioppo R, Heilig M.

Biol Psychiatry. 2008 Aug 1;64(3):211-8. doi: 10.1016/j.biopsych.2008.02.004. Epub 2008 Mar 25.


The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking.

Martin-Fardon R, Ciccocioppo R, Aujla H, Weiss F.

Neuropsychopharmacology. 2008 Jul;33(8):1827-34. Epub 2007 Oct 24.


Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse.

Dayas CV, McGranahan TM, Martin-Fardon R, Weiss F.

Biol Psychiatry. 2008 Jan 15;63(2):152-7. Epub 2007 Jun 13. Erratum in: Biol Psychiatry. 2008 Mar 1;63(5):534.


Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior.

González-Cuevas G, Aujla H, Martin-Fardon R, López-Moreno JA, Navarro M, Weiss F.

Neuropsychopharmacology. 2007 Nov;32(11):2260-6. Epub 2007 Mar 28.


Differential effects of sigma1 receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward.

Martin-Fardon R, Maurice T, Aujla H, Bowen WD, Weiss F.

Neuropsychopharmacology. 2007 Sep;32(9):1967-73. Epub 2007 Jan 31.


Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.

Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73. Epub 2005 Dec 15.


Priming with BTCP, a dopamine reuptake blocker, reinstates cocaine-seeking and enhances cocaine cue-induced reinstatement.

Martin-Fardon R, Lorentz CU, Stuempfig ND, Weiss F.

Pharmacol Biochem Behav. 2005 Sep;82(1):46-54. Epub 2005 Aug 11.


Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats.

Dayas CV, Martin-Fardon R, Thorsell A, Weiss F.

Alcohol Alcohol. 2004 May-Jun;39(3):190-6.


Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking.

Ciccocioppo R, Martin-Fardon R, Weiss F.

Nat Neurosci. 2004 May;7(5):495-6. Epub 2004 Mar 28.


The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming.

Romieu P, Meunier J, Garcia D, Zozime N, Martin-Fardon R, Bowen WD, Maurice T.

Psychopharmacology (Berl). 2004 Sep;175(2):154-62. Epub 2004 Feb 25.


3-OH-pip-BTCP, a metabolite of the potent DA uptake blocker BTCP, exerts cocaine-like action in rats.

Martin-Fardon R, Lorentz CU, Kamenka JM, Weiss F.

Neuroreport. 2003 Dec 19;14(18):2439-44.


Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.

Romieu P, Martin-Fardon R, Bowen WD, Maurice T.

J Neurosci. 2003 May 1;23(9):3572-6.


Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone.

Ciccocioppo R, Lin D, Martin-Fardon R, Weiss F.

Psychopharmacology (Berl). 2003 Jul;168(1-2):208-215. doi: 10.1007/s00213-002-1380-z. Epub 2003 Mar 27.


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