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Items: 1 to 50 of 422

1.

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages.

Lipus A, Janosz E, Ackermann M, Hetzel M, Dahlke J, Buchegger T, Wunderlich S, Martin U, Cathomen T, Schambach A, Moritz T, Lachmann N.

Int J Mol Sci. 2020 Apr 3;21(7). pii: E2481. doi: 10.3390/ijms21072481.

2.

Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab.

Jackson DJ, Korn S, Mathur SK, Barker P, Meka VG, Martin UJ, Zangrilli JG.

Drug Saf. 2020 Apr 2. doi: 10.1007/s40264-020-00926-3. [Epub ahead of print] Review.

PMID:
32242310
3.

Generation of an induced pluripotent stem cell line (MHHi018-A) from a patient with Cystic Fibrosis carrying p.Asn1303Lys (N1303K) mutation.

Merkert S, Schubert M, Haase A, Janssens HM, Scholte B, Lachmann N, Göhring G, Martin U.

Stem Cell Res. 2020 Mar 25;44:101744. doi: 10.1016/j.scr.2020.101744. [Epub ahead of print]

4.

Blood Eosinophil Counts in Clinical Trials for Chronic Obstructive Pulmonary Disease.

Singh D, Bafadhel M, Brightling CE, Sciurba FC, Curtis JL, Martinez FJ, Pasquale CB, Merrill DD, Metzdorf N, Petruzzelli S, Tal-Singer R, Compton C, Rennard S, Martin UJ; COPD Foundation Eosinophil Working Group.

Am J Respir Crit Care Med. 2020 Mar 18. doi: 10.1164/rccm.201912-2384PP. [Epub ahead of print]

PMID:
32186896
5.

Nonadherence to antihypertensive medications is related to pill burden in apparent treatment-resistant hypertensive individuals.

Lawson AJ, Hameed MA, Brown R, Cappuccio FP, George S, Hinton T, Kapil V, Lenart J, Lobo MD, Martin U, Menon M, Nightingale A, Rylance PB, Webb DJ, Dasgupta I.

J Hypertens. 2020 Mar 5. doi: 10.1097/HJH.0000000000002398. [Epub ahead of print]

PMID:
32141970
6.

Onset of Effect, Changes in Airflow Obstruction and Lung Volume, and Health-Related Quality of Life Improvements with Benralizumab for Patients with Severe Eosinophilic Asthma: Phase IIIb Randomized, Controlled Trial (SOLANA).

Panettieri RA Jr, Welte T, Shenoy KV, Korn S, Jandl M, Kerwin EM, Feijoo R, Barker P, Olsson RF, Martin UJ; SOLANA Study Investigators.

J Asthma Allergy. 2020 Feb 17;13:115-126. doi: 10.2147/JAA.S240044. eCollection 2020. Erratum in: J Asthma Allergy. 2020 Mar 13;13:135.

7.

Generation of three induced pluripotent stem cell lines (MHHi012-A, MHHi013-A, MHHi014-A) from a family with Loeys-Dietz syndrome carrying a heterozygous p.M253I (c.759G>A) mutation in the TGFBR1 gene.

Pongpamorn P, Dahlmann J, Haase A, Ebeling CT, Merkert S, Göhring G, Lachmann N, Martens A, Haverich A, Martin U, Olmer R.

Stem Cell Res. 2020 Mar;43:101707. doi: 10.1016/j.scr.2020.101707. Epub 2020 Feb 4.

8.

Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Improves Lung Function versus Monotherapies in GOLD Category A Patients with COPD: Pooled Data from the Phase III PINNACLE Studies.

Martinez FJ, Rabe KF, Lipworth BJ, Arora S, Jenkins M, Martin UJ, Reisner C.

Int J Chron Obstruct Pulmon Dis. 2020 Jan 9;15:99-106. doi: 10.2147/COPD.S229794. eCollection 2020.

9.

Efficacy And Safety Of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler (GFF MDI) Formulated Using Co-Suspension Delivery Technology In Chinese Patients With COPD.

Chen R, Zhong N, Wang HY, Zhao L, Mei X, Qin Z, Huang J, Assam PN, Maes A, Siddiqui S, Martin UJ, Reisner C.

Int J Chron Obstruct Pulmon Dis. 2020 Jan 8;15:43-56. doi: 10.2147/COPD.S223638. eCollection 2020.

10.

Bayesian smoothed small-areas analysis of urban inequalities in fertility across 1999-2013.

León-Gómez BB, Gotsens M, Marí-Dell'Olmo M, Domínguez-Berjón MF, Luque-Fernandez MÁ, Martin U, Rodríguez-Sanz M, Pérez G.

Fertil Res Pract. 2019 Dec 21;5:17. doi: 10.1186/s40738-019-0066-8. eCollection 2019.

11.

Two-year integrated steroid-sparing analysis and safety of benralizumab for severe asthma.

Bourdin A, Shaw D, Menzies-Gow A, FitzGerald JM, Bleecker ER, Busse WW, Ferguson GT, Brooks L, Barker P, Gil EG, Martin UJ.

J Asthma. 2019 Dec 26:1-9. doi: 10.1080/02770903.2019.1705333. [Epub ahead of print]

PMID:
31859541
12.

Two-Year Integrated Efficacy And Safety Analysis Of Benralizumab In Severe Asthma.

FitzGerald JM, Bleecker ER, Bourdin A, Busse WW, Ferguson GT, Brooks L, Barker P, Martin UJ.

J Asthma Allergy. 2019 Dec 9;12:401-413. doi: 10.2147/JAA.S227170. eCollection 2019.

13.

Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential.

Sahabian A, Sgodda M, Naujok O, Dettmer R, Dahlmann J, Manstein F, Cantz T, Zweigerdt R, Martin U, Olmer R.

Cells. 2019 Dec 4;8(12). pii: E1571. doi: 10.3390/cells8121571.

14.

Generation of a NKX2.1 - p63 double transgenic knock-in reporter cell line from human induced pluripotent stem cells (MHHi006-A-4).

Drick N, Sahabian A, Pongpamorn P, Merkert S, Göhring G, Welte T, Martin U, Olmer R.

Stem Cell Res. 2020 Jan;42:101659. doi: 10.1016/j.scr.2019.101659. Epub 2019 Nov 19.

15.

[Online surveys and the false illusion of the large n. On a survey on euthanasia among medical practitioners].

Utzet M, Martin U.

Gac Sanit. 2019 Nov 19. pii: S0213-9111(19)30221-3. doi: 10.1016/j.gaceta.2019.07.009. [Epub ahead of print] Spanish.

16.

Single-Use Autoinjector Functionality And Reliability For At-Home Administration Of Benralizumab For Patients With Severe Asthma: GRECO Trial Results.

Ferguson GT, Cole J, Aurivillius M, Roussel P, Barker P, Martin UJ; GRECO study investigators.

J Asthma Allergy. 2019 Oct 23;12:363-373. doi: 10.2147/JAA.S224266. eCollection 2019.

17.

Decline in fertility induced by economic recession in Spain.

Puig-Barrachina V, Rodríguez-Sanz M, Domínguez-Berjón MF, Martín U, Luque MÁ, Ruiz M, Perez G.

Gac Sanit. 2019 Oct 19. pii: S0213-9111(19)30155-4. doi: 10.1016/j.gaceta.2019.05.011. [Epub ahead of print]

18.

Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture.

Halloin C, Schwanke K, Löbel W, Franke A, Szepes M, Biswanath S, Wunderlich S, Merkert S, Weber N, Osten F, de la Roche J, Polten F, Christoph Wollert K, Kraft T, Fischer M, Martin U, Gruh I, Kempf H, Zweigerdt R.

Stem Cell Reports. 2019 Oct 8;13(4):775. doi: 10.1016/j.stemcr.2019.09.001. No abstract available.

19.

Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial.

Menzies-Gow A, Corren J, Bel EH, Maspero J, Heaney LG, Gurnell M, Wessman P, Martin UJ, Siddiqui S, Garcia Gil E.

ERJ Open Res. 2019 Sep 25;5(3). pii: 00009-2019. doi: 10.1183/23120541.00009-2019. eCollection 2019 Jul.

20.

Predicting response to benralizumab in chronic obstructive pulmonary disease: analyses of GALATHEA and TERRANOVA studies.

Criner GJ, Celli BR, Singh D, Agusti A, Papi A, Jison M, Makulova N, Shih VH, Brooks L, Barker P, Martin UJ, Newbold P.

Lancet Respir Med. 2020 Feb;8(2):158-170. doi: 10.1016/S2213-2600(19)30338-8. Epub 2019 Sep 28.

PMID:
31575508
21.

[Socioeconomic inequalities in health among the elderly population in Spain].

Machón M, Mosquera I, Larrañaga I, Martín U, Vergara I; por el Grupo de Determinantes Sociales de la Salud de la Sociedad Española de Epidemiología.

Gac Sanit. 2019 Sep 25. pii: S0213-9111(19)30178-5. doi: 10.1016/j.gaceta.2019.06.008. [Epub ahead of print] Review. Spanish.

22.

Comparison of autoinjector with accessorized prefilled syringe for benralizumab pharmacokinetic exposure: AMES trial results.

Martin UJ, Fuhr R, Forte P, Barker P, Axley MJ, Aurivillius M, Yan L, Roskos L.

J Asthma. 2019 Sep 20:1-9. doi: 10.1080/02770903.2019.1663428. [Epub ahead of print]

PMID:
31539289
23.

Generation of a CFTR knock-in reporter cell line (MHHi006-A-1) from a human induced pluripotent stem cell line.

Engels L, Olmer R, de la Roche J, Göhring G, Ulrich S, Haller R, Martin U, Merkert S.

Stem Cell Res. 2019 Oct;40:101542. doi: 10.1016/j.scr.2019.101542. Epub 2019 Aug 20.

24.

Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture.

Halloin C, Schwanke K, Löbel W, Franke A, Szepes M, Biswanath S, Wunderlich S, Merkert S, Weber N, Osten F, de la Roche J, Polten F, Christoph Wollert K, Kraft T, Fischer M, Martin U, Gruh I, Kempf H, Zweigerdt R.

Stem Cell Reports. 2019 Aug 13;13(2):366-379. doi: 10.1016/j.stemcr.2019.06.004. Epub 2019 Jul 25. Erratum in: Stem Cell Reports. 2019 Oct 8;13(4):775.

25.

Generation of a NKX2.1 knock-in reporter cell line from human induced pluripotent stem cells (MHHi006-A-2).

Olmer R, Dahlmann J, Merkert S, Baus S, Göhring G, Martin U.

Stem Cell Res. 2019 Aug;39:101492. doi: 10.1016/j.scr.2019.101492. Epub 2019 Jun 28.

26.

A Randomized, Double-Blind, Double-Dummy Study of Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Relative to Umeclidinium/Vilanterol Dry Powder Inhaler in COPD.

Maltais F, Ferguson GT, Feldman GJ, Deslee G, Bourdin A, Fjällbrant H, Siwek-Posłuszna A, Jenkins MA, Martin UJ.

Adv Ther. 2019 Sep;36(9):2434-2449. doi: 10.1007/s12325-019-01015-3. Epub 2019 Jul 2.

PMID:
31267366
27.

Sputum Streptococcus pneumoniae is reduced in COPD following treatment with benralizumab.

George L, Wright A, Mistry V, Sutcliffe A, Chachi L, Haldar K, Ramsheh MY, Richardson M, van der Merwe R, Martin U, Newbold P, Brightling CE.

Int J Chron Obstruct Pulmon Dis. 2019 Jun 5;14:1177-1185. doi: 10.2147/COPD.S198302. eCollection 2019.

28.

[Erratum to: Study protocol on the effect of the economic crisis on mortality and reproductive health and health inequalities in Spain].

Pérez G, Gotsens M, Palència L, Marí-Dell'Olmo M, Domínguez-Berjón MF, Rodríguez-Sanz M, Puig V, Bartoll X, Gandarillas A, Martín U, Bacigalupe A, Díez E, Ruiz M, Esnaola S, Calvo M, Sánchez P, Luque Fernández MÁ, Borrell C.

Gac Sanit. 2019 Sep - Oct;33(5):496. doi: 10.1016/j.gaceta.2019.05.001. Epub 2019 Jun 5. Spanish. No abstract available.

29.

[Corrigendum to: Contextual indicators to assess social determinants of health and the Spanish economic recession].

Cabrera-León A, Daponte-Codina A, Mateo I, Arroyo-Borrell E, Bartoll X, Bravo MJ, Domínguez-Berjón MF, Renart G, Álvarez-Dardet C, Marí-Dell'Olmo M, Bolívar-Muñoz J, Saez M, Escribà-Agüir V, Palència L, López MJ, Saurina C, Puig V, Martín U, Gotsens M, Borrell C, Serra-Saurina L, Sordo L, Bacigalupe A, Rodríguez-Sanz M, Pérez G, Espelt A, Ruiz M, Bernal M.

Gac Sanit. 2019 Sep - Oct;33(5):497. doi: 10.1016/j.gaceta.2019.04.001. Epub 2019 May 20. Spanish. No abstract available.

30.

Benralizumab for the Prevention of COPD Exacerbations.

Criner GJ, Celli BR, Brightling CE, Agusti A, Papi A, Singh D, Sin DD, Vogelmeier CF, Sciurba FC, Bafadhel M, Backer V, Kato M, Ramírez-Venegas A, Wei YF, Bjermer L, Shih VH, Jison M, O'Quinn S, Makulova N, Newbold P, Goldman M, Martin UJ; GALATHEA Study Investigators; TERRANOVA Study Investigators.

N Engl J Med. 2019 Sep 12;381(11):1023-1034. doi: 10.1056/NEJMoa1905248. Epub 2019 May 20.

PMID:
31112385
31.

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.

Merkert S, Schubert M, Olmer R, Engels L, Radetzki S, Veltman M, Scholte BJ, Zöllner J, Pedemonte N, Galietta LJV, von Kries JP, Martin U.

Stem Cell Reports. 2019 Jun 11;12(6):1389-1403. doi: 10.1016/j.stemcr.2019.04.014. Epub 2019 May 9.

32.

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization.

Leung WH, Gay J, Martin U, Garrett TE, Horton HM, Certo MT, Blazar BR, Morgan RA, Gregory PD, Jarjour J, Astrakhan A.

JCI Insight. 2019 Apr 30;5. pii: 124430. doi: 10.1172/jci.insight.124430.

33.

Development of a methotrexate educational guide/information/monitoring booklet for inflammatory arthritis.

Martin U, O'Gradaig D, Nolan DF, Sheehy C.

Musculoskeletal Care. 2019 Jun;17(2):234-241. doi: 10.1002/msc.1398. Epub 2019 Apr 17.

PMID:
30993834
34.

Explanation in mathematical conversations: an empirical investigation.

Pease A, Aberdein A, Martin U.

Philos Trans A Math Phys Eng Sci. 2019 Mar 11;377(2140):20180159. doi: 10.1098/rsta.2018.0159.

35.

Defining the relationship between arm and leg blood pressure readings: a systematic review and meta-analysis.

Sheppard JP, Albasri A, Franssen M, Fletcher B, Pealing L, Roberts N, Obeid A, Pucci M, McManus RJ, Martin U; British and Irish Hypertension Society.

J Hypertens. 2019 Apr;37(4):660-670. doi: 10.1097/HJH.0000000000001958.

PMID:
30817444
36.

GMP-compatible manufacturing of three iPS cell lines from human peripheral blood.

Haase A, Glienke W, Engels L, Göhring G, Esser R, Arseniev L, Martin U.

Stem Cell Res. 2019 Mar;35:101394. doi: 10.1016/j.scr.2019.101394. Epub 2019 Feb 11.

37.

Schedules for Self-monitoring Blood Pressure: A Systematic Review.

Hodgkinson JA, Stevens R, Grant S, Mant J, Bray EP, Hobbs FDR, Martin U, Schwartz C, McCartney D, O'Mahony R, Perera-Salazar R, Roberts N, Stevens S, Williams B, McManus RJ.

Am J Hypertens. 2019 Mar 16;32(4):350-364. doi: 10.1093/ajh/hpy185.

38.

[Social inequalities in health among the elderly population: review of indicators used in Spain].

Mosquera I, Machón M, Vergara I, Larrañaga I, Martín U; por el Grupo de Determinantes Sociales de la Salud de la Sociedad Española de Epidemiología.

Gac Sanit. 2019 Jan 18. pii: S0213-9111(18)30248-6. doi: 10.1016/j.gaceta.2018.11.002. [Epub ahead of print] Review. Spanish.

39.

Defining the relationship between arm and leg blood pressure readings: a systematic review and meta-analysis.

Sheppard JP, Albasri A, Franssen M, Fletcher B, Pealing L, Roberts N, Obeid A, Pucci M, McManus RJ, Martin U; British and Irish Hypertension Society.

J Hypertens. 2018 Dec 11. doi: 10.1097/HJH.0000000000001958. [Epub ahead of print]

PMID:
30585948
40.

Author Correction: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG.

Nat Commun. 2018 Dec 19;9(1):5398. doi: 10.1038/s41467-018-07917-0.

41.

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.

Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin AR, Brinkert K, Schott JW, Haake K, Kühnel MP, Glage S, Figueiredo C, Jonigk D, Sewald K, Schambach A, Wronski S, Moritz T, Martin U, Zweigerdt R, Munder A, Lachmann N.

Nat Commun. 2018 Nov 30;9(1):5088. doi: 10.1038/s41467-018-07570-7.

42.

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial.

Busse WW, Bleecker ER, FitzGerald JM, Ferguson GT, Barker P, Sproule S, Olsson RF, Martin UJ, Goldman M; BORA study investigators.

Lancet Respir Med. 2019 Jan;7(1):46-59. doi: 10.1016/S2213-2600(18)30406-5. Epub 2018 Nov 8. Erratum in: Lancet Respir Med. 2019 Jan;7(1):e1.

PMID:
30416083
43.

Corrigendum to "Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice" Journal of Molecular and Cellular Cardiology 122 (2018) 114-124.

Froese N, Wang H, Zwadlo C, Wang Y, Grund A, Gigina A, Hofmann M, Kilian K, Scharf G, Korf-Klingebiel M, Melchert A, Signorini MER, Halloin C, Zweigerdt R, Martin U, Gruh I, Wollert KC, Geffers R, Bauersachs J, Heineke J.

J Mol Cell Cardiol. 2018 Dec;125:205. doi: 10.1016/j.yjmcc.2018.11.003. Epub 2018 Nov 7. No abstract available.

PMID:
30414408
44.

Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension.

Sheppard JP, Stevens S, Stevens R, Martin U, Mant J, Hobbs FDR, McManus RJ.

JAMA Intern Med. 2018 Dec 1;178(12):1626-1634. doi: 10.1001/jamainternmed.2018.4684.

45.

Improved lung function and patient-reported outcomes with co-suspension delivery technology glycopyrrolate/formoterol fumarate metered dose inhaler in COPD: a randomized Phase III study conducted in Asia, Europe, and the USA.

Lipworth BJ, Collier DJ, Gon Y, Zhong N, Nishi K, Chen R, Arora S, Maes A, Siddiqui S, Reisner C, Martin UJ.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 26;13:2969-2984. doi: 10.2147/COPD.S171835. eCollection 2018.

46.
47.

A randomized study using functional respiratory imaging to characterize bronchodilator effects of glycopyrrolate/formoterol fumarate delivered by a metered dose inhaler using co-suspension delivery technology in patients with COPD.

De Backer W, De Backer J, Vos W, Verlinden I, Van Holsbeke C, Clukers J, Hajian B, Siddiqui S, Jenkins M, Reisner C, Martin UJ.

Int J Chron Obstruct Pulmon Dis. 2018 Aug 30;13:2673-2684. doi: 10.2147/COPD.S171707. eCollection 2018.

48.
49.

Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice.

Froese N, Wang H, Zwadlo C, Wang Y, Grund A, Gigina A, Hofmann M, Kilian K, Scharf G, Korf-Klingebiel M, Melchert A, Signorini MER, Halloin C, Zweigerdt R, Martin U, Gruh I, Wollert KC, Geffers R, Bauersachs J, Heineke J.

J Mol Cell Cardiol. 2018 Sep;122:114-124. doi: 10.1016/j.yjmcc.2018.08.011. Epub 2018 Aug 14. Erratum in: J Mol Cell Cardiol. 2018 Dec;125:205.

PMID:
30118791
50.

A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial.

Mukhtar O, Cheriyan J, Cockcroft JR, Collier D, Coulson JM, Dasgupta I, Faconti L, Glover M, Heagerty AM, Khong TK, Lip GYH, Mander AP, Marchong MN, Martin U, McDonnell BJ, McEniery CM, Padmanabhan S, Saxena M, Sever PJ, Shiel JI, Wych J, Chowienczyk PJ, Wilkinson IB.

Am Heart J. 2018 Oct;204:102-108. doi: 10.1016/j.ahj.2018.05.006. Epub 2018 May 20.

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