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Items: 37

1.

Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.

Roels S, Costa OR, Tersey SA, Stangé G, De Smet D, Balti EV, Gillard P, Keymeulen B, Ling Z, Pipeleers DG, Gorus FK, Mirmira RG, Martens GA.

J Clin Endocrinol Metab. 2019 Feb 1;104(2):451-460. doi: 10.1210/jc.2017-02520.

2.

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65.

Costa OR, Verhaeghen K, Roels S, Stangé G, Ling Z, Pipeleers D, Gorus FK, Martens GA.

PLoS One. 2018 Mar 8;13(3):e0193670. doi: 10.1371/journal.pone.0193670. eCollection 2018.

3.

Circulating microRNA-375 as biomarker of pancreatic beta cell death and protection of beta cell mass by cytoprotective compounds.

Song I, Roels S, Martens GA, Bouwens L.

PLoS One. 2017 Oct 17;12(10):e0186480. doi: 10.1371/journal.pone.0186480. eCollection 2017.

4.

CD99 as surface anchor for human islet endocrine cell purification.

Martens GA, De Punt V, Stangé G.

J Tissue Eng Regen Med. 2018 Jan;12(1):e171-e176. doi: 10.1002/term.2329. Epub 2017 Jan 27.

PMID:
27687889
5.

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage.

De Groef S, Renmans D, Cai Y, Leuckx G, Roels S, Staels W, Gradwohl G, Baeyens L, Heremans Y, Martens GA, De Leu N, Sojoodi M, Van de Casteele M, Heimberg H.

Cell Death Dis. 2016 Jun 23;7(6):e2272. doi: 10.1038/cddis.2016.171.

6.

Development of an Enhanced Sensitivity Bead-Based Immunoassay for Real-Time In Vivo Detection of Pancreatic β-Cell Death.

Costa OR, Stangé G, Verhaeghen K, Brackeva B, Nonneman E, Hampe CS, Ling Z, Pipeleers D, Gorus FK, Martens GA.

Endocrinology. 2015 Dec;156(12):4755-60. doi: 10.1210/en.2015-1636. Epub 2015 Oct 2.

7.

Quantitative proteomics of rat and human pancreatic beta cells.

Brackeva B, Kramer G, Vissers JP, Martens GA.

Data Brief. 2015 Mar 10;3:234-9. doi: 10.1016/j.dib.2015.02.019. eCollection 2015 Jun.

8.

Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells.

Martens GA.

J Diabetes Res. 2015;2015:549818. doi: 10.1155/2015/549818. Epub 2015 May 10.

9.

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients.

Ling Z, De Pauw P, Jacobs-Tulleneers-Thevissen D, Mao R, Gillard P, Hampe CS, Martens GA, In't Veld P, Lernmark Å, Keymeulen B, Gorus F, Pipeleers D.

J Clin Endocrinol Metab. 2015 Jun;100(6):2314-21. doi: 10.1210/jc.2015-1216. Epub 2015 Mar 27.

10.

Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.

Brackeva B, De Punt V, Kramer G, Costa O, Verhaeghen K, Stangé G, Sadones J, Xavier C, Aerts JM, Gorus FK, Martens GA.

J Proteomics. 2015 Mar 18;117:156-67. doi: 10.1016/j.jprot.2015.01.009. Epub 2015 Jan 29.

PMID:
25638021
11.

Glucose regulates rat beta cell number through age-dependent effects on beta cell survival and proliferation.

Assefa Z, Lavens A, Steyaert C, Stangé G, Martens GA, Ling Z, Hellemans K, Pipeleers D.

PLoS One. 2014 Jan 9;9(1):e85174. doi: 10.1371/journal.pone.0085174. eCollection 2014.

12.

Functional characteristics of neonatal rat β cells with distinct markers.

Martens GA, Motté E, Kramer G, Stangé G, Gaarn LW, Hellemans K, Nielsen JH, Aerts JM, Ling Z, Pipeleers D.

J Mol Endocrinol. 2013 Dec 19;52(1):11-28. doi: 10.1530/JME-13-0106. Print 2014 Feb.

PMID:
24049066
13.

Potential of protein phosphatase inhibitor 1 as biomarker of pancreatic β-cell injury in vitro and in vivo.

Jiang L, Brackeva B, Ling Z, Kramer G, Aerts JM, Schuit F, Keymeulen B, Pipeleers D, Gorus F, Martens GA.

Diabetes. 2013 Aug;62(8):2683-8. doi: 10.2337/db12-1507. Epub 2013 Apr 4.

14.

Evaluation of the INS-1 832/13 cell line as a beta-cell based screening system to assess pollutant effects on beta-cell function.

Hectors TL, Vanparys C, Pereira-Fernandes A, Martens GA, Blust R.

PLoS One. 2013;8(3):e60030. doi: 10.1371/journal.pone.0060030. Epub 2013 Mar 21.

15.

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.

Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ.

J Autoimmun. 2013 Jun;43:1-9. doi: 10.1016/j.jaut.2013.01.013. Epub 2013 Mar 13.

16.

LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro.

Jiang L, Brackeva B, Stangé G, Verhaeghen K, Costa O, Couillard-Després S, Rotheneichner P, Aigner L, Van Schravendijk C, Pipeleers D, Ling Z, Gorus F, Martens GA.

J Proteomics. 2013 Mar 27;80:268-80. doi: 10.1016/j.jprot.2012.12.031. Epub 2013 Jan 19.

PMID:
23337804
17.

Enzymatic pyruvate measurement by Cobas 6000 open channel assay.

Van den Bossche D, Schiettecatte J, Vekens E, De Smet D, Gorus FK, Martens GA.

Clin Lab. 2012;58(9-10):1091-5.

PMID:
23163130
18.

Homozygosity for aquaporin 7 G264V in three unrelated children with hyperglyceroluria and a mild platelet secretion defect.

Goubau C, Jaeken J, Levtchenko EN, Thys C, Di Michele M, Martens GA, Gerlo E, De Vos R, Buyse GM, Goemans N, Van Geet C, Freson K.

Genet Med. 2013 Jan;15(1):55-63. doi: 10.1038/gim.2012.90. Epub 2012 Aug 16.

PMID:
22899094
19.

Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.

Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de Casteele M, Ling Z, Pipeleers D, Ravassard P, Nielsen F, Ferrer J, Heimberg H.

PLoS One. 2012;7(5):e37055. doi: 10.1371/journal.pone.0037055. Epub 2012 May 14.

20.

Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.

Martens GA, Jiang L, Hellemans KH, Stangé G, Heimberg H, Nielsen FC, Sand O, Van Helden J, Van Lommel L, Schuit F, Gorus FK, Pipeleers DG.

PLoS One. 2011;6(9):e24134. doi: 10.1371/journal.pone.0024134. Epub 2011 Sep 2. Erratum in: PLoS One. 2012;7(1). doi: 10.1371/annotation/a91571a6-acbb-456f-bcc5-f4a431e28516. PLoS One. 2012;7(1). doi:10.1371/annotation/13c6d084-a8fd-4019-a3cf-12a0d8abe309.. Van Lommel, Leentje [added], Schuit, Frans [added]. PLoS One. 2012;7(1). doi:10.1371/annotation/4aae21a9-e176-4feb-9f15-103b265d3335. PLoS One. 2012;7(1). doi:10.1371/annotation/7aa0ff33-5660-4b56-889a-4b86a273d522.

21.

Convulsions and apnoea in a patient infected with New Delhi metallo-β-lactamase-1 Escherichia coli treated with colistin.

Spapen HD, Honore PM, Gregoire N, Gobin P, de Regt J, Martens GA, Pierard D, Couet W.

J Infect. 2011 Dec;63(6):468-70. doi: 10.1016/j.jinf.2011.07.008. Epub 2011 Jul 23.

PMID:
21798284
22.

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function.

Hectors TL, Vanparys C, van der Ven K, Martens GA, Jorens PG, Van Gaal LF, Covaci A, De Coen W, Blust R.

Diabetologia. 2011 Jun;54(6):1273-90. doi: 10.1007/s00125-011-2109-5. Epub 2011 Mar 27. Review.

PMID:
21442161
23.

Protein markers for insulin-producing beta cells with higher glucose sensitivity.

Martens GA, Jiang L, Verhaeghen K, Connolly JB, Geromanos SG, Stangé G, Van Oudenhove L, Devreese B, Hellemans KH, Ling Z, Van Schravendijk C, Pipeleers DG, Vissers JP, Gorus FK.

PLoS One. 2010 Dec 6;5(12):e14214. doi: 10.1371/journal.pone.0014214.

24.

Use of likelihood ratios improves interpretation of laboratory testing for pulmonary sarcoidosis.

De Smet D, Martens GA, Berghe BV, Meysman M, Heylen O, Gorus FK, De Waele M.

Am J Clin Pathol. 2010 Dec;134(6):939-47. doi: 10.1309/AJCPNC7STHG0FWMP.

PMID:
21088158
25.

Plasma protein binding of luciferase substrates influences sensitivity and accuracy of bioluminescence imaging.

Keyaerts M, Heneweer C, Gainkam LO, Caveliers V, Beattie BJ, Martens GA, Vanhove C, Bossuyt A, Blasberg RG, Lahoutte T.

Mol Imaging Biol. 2011 Feb;13(1):59-66. doi: 10.1007/s11307-010-0325-x.

PMID:
20383591
26.

Use of the Cell-Dyn Sapphire hematology analyzer for automated counting of blood cells in body fluids.

De Smet D, Van Moer G, Martens GA, Nanos N, Smet L, Jochmans K, De Waele M.

Am J Clin Pathol. 2010 Feb;133(2):291-9. doi: 10.1309/AJCPY7J7OLASZAPC.

PMID:
20093239
27.

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.

Hellemans KH, Hannaert JC, Denys B, Steffensen KR, Raemdonck C, Martens GA, Van Veldhoven PP, Gustafsson JA, Pipeleers D.

PLoS One. 2009 Sep 29;4(9):e7266. doi: 10.1371/journal.pone.0007266.

28.

Automated validation of clinical laboratory test results: do we get what we expect?

De Smet D, Nanos N, Martens GA, Smet L, Damiaens S, Van Moer G, De Pauw A, Jochmans K, De Waele M.

Clin Chem Lab Med. 2009;47(3):379-80. doi: 10.1515/CCLM.2009.079. No abstract available.

PMID:
19327109
29.

Glucose, regulator of survival and phenotype of pancreatic beta cells.

Martens GA, Pipeleers D.

Vitam Horm. 2009;80:507-39. doi: 10.1016/S0083-6729(08)00617-1. Review.

PMID:
19251048
30.

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.

El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D, van Obberghen E.

Diabetes. 2008 Oct;57(10):2708-17. doi: 10.2337/db07-1614. Epub 2008 Jun 30.

31.

Homocysteine measurement by Vitros Microtip homocysteine assay.

Martens GA, De Nayer J, De Smet D, Couck P, Gorus F, Gerlo E.

Clin Chem Lab Med. 2008;46(2):283-6. doi: 10.1515/CCLM.2008.054.

PMID:
18324911
32.

Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release.

Martens GA, Vervoort A, Van de Casteele M, Stangé G, Hellemans K, Van Thi HV, Schuit F, Pipeleers D.

J Biol Chem. 2007 Jul 20;282(29):21134-44. Epub 2007 May 9.

33.

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M.

Br J Pharmacol. 2007 Apr;150(8):1031-43. Epub 2007 Mar 5.

34.

Glycemic control of apoptosis in the pancreatic beta cell: danger of extremes?

Martens GA, Van de Casteele M.

Antioxid Redox Signal. 2007 Mar;9(3):309-17. Review.

PMID:
17184175
35.

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M.

Free Radic Biol Med. 2007 Jan 1;42(1):64-78. Epub 2006 Sep 27.

PMID:
17157194
36.

Metabolic activation of glucose low-responsive beta-cells by glyceraldehyde correlates with their biosynthetic activation in lower glucose concentration range but not at high glucose.

Martens GA, Wang Q, Kerckhofs K, Stangé G, Ling Z, Pipeleers D.

Endocrinology. 2006 Nov;147(11):5196-204. Epub 2006 Aug 17.

PMID:
16916947
37.

Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells.

Martens GA, Cai Y, Hinke S, Stangé G, Van de Casteele M, Pipeleers D.

J Biol Chem. 2005 May 27;280(21):20389-96. Epub 2005 Mar 17.

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