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Items: 1 to 50 of 123

1.

Automated Live-Cell Imaging of Synapses in Rat and Human Neuronal Cultures.

Green MV, Pengo T, Raybuck JD, Naqvi T, McMullan HM, Hawkinson JE, Marron Fernandez de Velasco E, Muntean BS, Martemyanov KA, Satterfield R, Young SM Jr, Thayer SA.

Front Cell Neurosci. 2019 Oct 17;13:467. doi: 10.3389/fncel.2019.00467. eCollection 2019.

2.

Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling.

Muntean BS, Dao MT, Martemyanov KA.

Cell Rep. 2019 Oct 22;29(4):946-960.e2. doi: 10.1016/j.celrep.2019.09.034.

3.

Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome.

Xu L, Bolch SN, Santiago CP, Dyka FM, Akil O, Lobanova ES, Wang Y, Martemyanov KA, Hauswirth WW, Smith WC, Handa JT, Blackshaw S, Ash JD, Dinculescu A.

J Pathol. 2019 Oct 18. doi: 10.1002/path.5360. [Epub ahead of print]

PMID:
31625146
4.

NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control.

Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA.

PLoS Biol. 2019 Oct 10;17(10):e3000477. doi: 10.1371/journal.pbio.3000477. eCollection 2019 Oct.

5.

Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling.

Cirnaru MD, Melis C, Fanutza T, Naphade S, Tshilenge KT, Muntean BS, Martemyanov KA, Plotkin JL, Ellerby LM, Ehrlich ME.

eNeuro. 2019 Oct 10;6(5). pii: ENEURO.0305-19.2019. doi: 10.1523/ENEURO.0305-19.2019. Print 2019 Sep/Oct.

6.

Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology.

Dunn HA, Orlandi C, Martemyanov KA.

Pharmacol Rev. 2019 Oct;71(4):503-519. doi: 10.1124/pr.119.018044. Review.

PMID:
31515243
7.

ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior.

Dunn HA, Zucca S, Dao M, Orlandi C, Martemyanov KA.

Mol Psychiatry. 2019 Sep 4. doi: 10.1038/s41380-019-0512-3. [Epub ahead of print]

PMID:
31485013
8.

Genetic behavioral screen identifies an orphan anti-opioid system.

Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA.

Science. 2019 Sep 20;365(6459):1267-1273. doi: 10.1126/science.aau2078. Epub 2019 Aug 15.

PMID:
31416932
9.

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling.

Xu ZX, Tan JW, Xu H, Hill CJ, Ostrovskaya O, Martemyanov KA, Xu B.

Nat Commun. 2019 Aug 9;10(1):3622. doi: 10.1038/s41467-019-11575-1.

10.

The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.

Song C, Orlandi C, Sutton LP, Martemyanov KA.

J Biol Chem. 2019 Aug 30;294(35):13145-13157. doi: 10.1074/jbc.RA119.007533. Epub 2019 Jul 16.

PMID:
31311860
11.

Live cell optical assay for precise characterization of receptors coupling to Gα12.

Masuho I, Skamangas NK, Martemyanov KA.

Basic Clin Pharmacol Toxicol. 2019 Mar 27. doi: 10.1111/bcpt.13228. [Epub ahead of print]

PMID:
30916867
12.

GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.

Itakura T, Webster A, Chintala SK, Wang Y, Gonzalez JM Jr, Tan JC, Vranka JA, Acott T, Craft CM, Sibug Saber ME, Jeong S, Stamer WD, Martemyanov KA, Fini ME.

J Ocul Pharmacol Ther. 2019 May;35(4):203-215. doi: 10.1089/jop.2018.0135. Epub 2019 Mar 18.

PMID:
30855200
13.

Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y.

Sci Rep. 2019 Mar 9;9(1):4523. doi: 10.1038/s41598-018-37932-6.

14.

Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors.

Orlandi C, Sutton LP, Muntean BS, Song C, Martemyanov KA.

Neuropsychopharmacology. 2019 Feb;44(3):642-653. doi: 10.1038/s41386-018-0238-y. Epub 2018 Oct 11.

PMID:
30546127
15.

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.

Patil DN, Rangarajan ES, Novick SJ, Pascal BD, Kojetin DJ, Griffin PR, Izard T, Martemyanov KA.

Elife. 2018 Dec 12;7. pii: e42150. doi: 10.7554/eLife.42150.

16.

Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7.

Ostrovskaya OI, Orlandi C, Fajardo-Serrano A, Young SM Jr, Lujan R, Martemyanov KA.

J Neurosci. 2018 Nov 14;38(46):10002-10015. doi: 10.1523/JNEUROSCI.1378-18.2018. Epub 2018 Oct 12.

17.

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses.

Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J.

Neuron. 2018 Oct 10;100(1):201-215.e9. doi: 10.1016/j.neuron.2018.08.038. Epub 2018 Oct 2.

18.

Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.

Orlandi C, Omori Y, Wang Y, Cao Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA.

Cell Rep. 2018 Oct 2;25(1):130-145.e5. doi: 10.1016/j.celrep.2018.08.068.

19.

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.

Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA.

Cell Rep. 2018 Jul 24;24(4):1081-1084. doi: 10.1016/j.celrep.2018.07.031. No abstract available.

20.

Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling.

Masuho I, Chavali S, Muntean BS, Skamangas NK, Simonyan K, Patil DN, Kramer GM, Ozelius L, Babu MM, Martemyanov KA.

Cell Rep. 2018 Jul 17;24(3):557-568.e5. doi: 10.1016/j.celrep.2018.06.080.

21.

Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum.

Song C, Anderson GR, Sutton LP, Dao M, Martemyanov KA.

J Neurosci. 2018 Aug 8;38(32):7120-7131. doi: 10.1523/JNEUROSCI.0493-18.2018. Epub 2018 Jul 13.

22.

Correction: The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart.

Kulkarni K, Xie X, Marron Fernandez de Velasco E, Anderson A, Martemyanov KA, Wickman K, Tolkacheva EG.

PLoS One. 2018 Jul 6;13(7):e0200553. doi: 10.1371/journal.pone.0200553. eCollection 2018.

23.

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K.

Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.

24.

Making useful gadgets with miniaturized G proteins.

Martemyanov KA, Garcia-Marcos M.

J Biol Chem. 2018 May 11;293(19):7474-7475. doi: 10.1074/jbc.H118.002879.

25.

Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans.

Dunn HA, Patil DN, Cao Y, Orlandi C, Martemyanov KA.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):5022-5027. doi: 10.1073/pnas.1722498115. Epub 2018 Apr 23.

26.

The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart.

Kulkarni K, Xie X, Marron Fernandez de Velasco E, Anderson A, Martemyanov KA, Wickman K, Tolkacheva EG.

PLoS One. 2018 Apr 18;13(4):e0193798. doi: 10.1371/journal.pone.0193798. eCollection 2018. Erratum in: PLoS One. 2018 Jul 6;13(7):e0200553.

27.

A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex.

Muntean BS, Patil DN, Madoux F, Fossetta J, Scampavia L, Spicer TP, Martemyanov KA.

Assay Drug Dev Technol. 2018 Apr;16(3):150-161. doi: 10.1089/adt.2017.839.

28.

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.

Marcott PF, Gong S, Donthamsetti P, Grinnell SG, Nelson MN, Newman AH, Birnbaumer L, Martemyanov KA, Javitch JA, Ford CP.

Neuron. 2018 May 2;98(3):575-587.e4. doi: 10.1016/j.neuron.2018.03.038. Epub 2018 Apr 12.

29.

Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders.

Spicer TP, Hubbs C, Vaissiere T, Collia D, Rojas C, Kilinc M, Vick K, Madoux F, Baillargeon P, Shumate J, Martemyanov KA, Page DT, Puthanveettil S, Hodder P, Davis R, Miller CA, Scampavia L, Rumbaugh G.

Mol Neuropsychiatry. 2018 Feb;3(3):141-150. doi: 10.1159/000481731. Epub 2017 Nov 17.

30.

LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.

Sarria I, Cao Y, Wang Y, Ingram NT, Orlandi C, Kamasawa N, Kolesnikov AV, Pahlberg J, Kefalov VJ, Sampath AP, Martemyanov KA.

Cell Rep. 2018 Mar 27;22(13):3562-3573. doi: 10.1016/j.celrep.2018.03.008.

31.

Orphan receptor GPR158 controls stress-induced depression.

Sutton LP, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JDW, Renner KJ, Young SM Jr, Xu B, Kwon H, Martemyanov KA.

Elife. 2018 Feb 8;7. pii: e33273. doi: 10.7554/eLife.33273.

32.

Expression and relevance of the G protein-gated K+ channel in the mouse ventricle.

Anderson A, Kulkarni K, Marron Fernandez de Velasco E, Carlblom N, Xia Z, Nakano A, Martemyanov KA, Tolkacheva EG, Wickman K.

Sci Rep. 2018 Jan 19;8(1):1192. doi: 10.1038/s41598-018-19719-x.

33.

RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.

Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y.

Sci Rep. 2018 Jan 12;8(1):653. doi: 10.1038/s41598-017-18851-4. Erratum in: Sci Rep. 2019 Mar 9;9(1):4523.

34.

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.

Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA.

Cell Rep. 2018 Jan 2;22(1):255-268. doi: 10.1016/j.celrep.2017.12.022. Erratum in: Cell Rep. 2018 Jul 24;24(4):1081-1084.

35.

Pharmacogenomics of GPCR Drug Targets.

Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM.

Cell. 2018 Jan 11;172(1-2):41-54.e19. doi: 10.1016/j.cell.2017.11.033. Epub 2017 Dec 14.

36.

Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila.

Himmelreich S, Masuho I, Berry JA, MacMullen C, Skamangas NK, Martemyanov KA, Davis RL.

Cell Rep. 2017 Nov 21;21(8):2074-2081. doi: 10.1016/j.celrep.2017.10.108.

37.

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.

Carmon KS, Gong X, Yi J, Wu L, Thomas A, Moore CM, Masuho I, Timson DJ, Martemyanov KA, Liu QJ.

J Biol Chem. 2017 Sep 8;292(36):14989-15001. doi: 10.1074/jbc.M117.786798. Epub 2017 Jul 24.

38.

The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.

Martemyanov KA, Sampath AP.

Annu Rev Vis Sci. 2017 Sep 15;3:25-51. doi: 10.1146/annurev-vision-102016-061338. Epub 2017 Jul 17. Review.

39.

LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells.

Neuillé M, Cao Y, Caplette R, Guerrero-Given D, Thomas C, Kamasawa N, Sahel JA, Hamel CP, Audo I, Picaud S, Martemyanov KA, Zeitz C.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1768-1778. doi: 10.1167/iovs.16-20745.

40.

The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.

Wang Y, Fehlhaber KE, Sarria I, Cao Y, Ingram NT, Guerrero-Given D, Throesch B, Baldwin K, Kamasawa N, Ohtsuka T, Sampath AP, Martemyanov KA.

Neuron. 2017 Mar 22;93(6):1359-1374.e6. doi: 10.1016/j.neuron.2017.02.021. Epub 2017 Mar 2.

41.

Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans.

Lohmann K, Masuho I, Patil DN, Baumann H, Hebert E, Steinrücke S, Trujillano D, Skamangas NK, Dobricic V, Hüning I, Gillessen-Kaesbach G, Westenberger A, Savic-Pavicevic D, Münchau A, Oprea G, Klein C, Rolfs A, Martemyanov KA.

Hum Mol Genet. 2017 Mar 15;26(6):1078-1086. doi: 10.1093/hmg/ddx018.

42.

Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex.

Aguado C, Orlandi C, Fajardo-Serrano A, Gil-Minguez M, Martemyanov KA, Luján R.

Front Neuroanat. 2016 Nov 30;10:114. eCollection 2016.

43.

NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.

Xie K, Colgan LA, Dao MT, Muntean BS, Sutton LP, Orlandi C, Boye SL, Boye SE, Shih CC, Li Y, Xu B, Smith RG, Yasuda R, Martemyanov KA.

Curr Biol. 2016 Nov 21;26(22):2992-3003. doi: 10.1016/j.cub.2016.09.010. Epub 2016 Oct 20.

44.

G Protein-Gated K+ Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning.

Victoria NC, Marron Fernandez de Velasco E, Ostrovskaya O, Metzger S, Xia Z, Kotecki L, Benneyworth MA, Zink AN, Martemyanov KA, Wickman K.

Biol Psychiatry. 2016 Nov 15;80(10):796-806. doi: 10.1016/j.biopsych.2015.10.004. Epub 2015 Nov 10.

45.

GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition.

Shamseldin HE, Masuho I, Alenizi A, Alyamani S, Patil DN, Ibrahim N, Martemyanov KA, Alkuraya FS.

Genome Biol. 2016 Sep 27;17(1):195.

46.

Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.

Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K.

Sci Signal. 2016 Jul 26;9(438):ra74. doi: 10.1126/scisignal.aag0245.

47.

Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia.

Masuho I, Fang M, Geng C, Zhang J, Jiang H, Özgul RK, Yılmaz DY, Yalnızoğlu D, Yüksel D, Yarrow A, Myers A, Burn SC, Crotwell PL, Padilla-Lopez S, Dursun A, Martemyanov KA, Kruer MC.

Neurol Genet. 2016 May 12;2(3):e78. doi: 10.1212/NXG.0000000000000078. eCollection 2016 Jun. No abstract available.

48.

Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.

Sarria I, Orlandi C, McCall MA, Gregg RG, Martemyanov KA.

J Neurosci. 2016 Mar 9;36(10):2915-25. doi: 10.1523/JNEUROSCI.3833-15.2016.

49.

Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.

Tayou J, Wang Q, Jang GF, Pronin AN, Orlandi C, Martemyanov KA, Crabb JW, Slepak VZ.

J Biol Chem. 2016 Apr 22;291(17):9133-47. doi: 10.1074/jbc.M115.694075. Epub 2016 Feb 19.

50.

The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go.

Xu Y, Orlandi C, Cao Y, Yang S, Choi CI, Pagadala V, Birnbaumer L, Martemyanov KA, Vardi N.

Sci Rep. 2016 Feb 17;6:20940. doi: 10.1038/srep20940.

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