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Items: 49


Dietary Vitamin E as a Protective Factor for Parkinson's Disease: Clinical and Experimental Evidence.

Schirinzi T, Martella G, Imbriani P, Di Lazzaro G, Franco D, Colona VL, Alwardat M, Sinibaldi Salimei P, Mercuri NB, Pierantozzi M, Pisani A.

Front Neurol. 2019 Feb 26;10:148. doi: 10.3389/fneur.2019.00148. eCollection 2019.


RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models.

Bonsi P, Ponterio G, Vanni V, Tassone A, Sciamanna G, Migliarini S, Martella G, Meringolo M, Dehay B, Doudnikoff E, Zachariou V, Goodchild RE, Mercuri NB, D'Amelio M, Pasqualetti M, Bezard E, Pisani A.

EMBO Mol Med. 2019 Jan;11(1). pii: e9283. doi: 10.15252/emmm.201809283.


Synaptic Plasticity Changes: Hallmark for Neurological and Psychiatric Disorders.

Martella G, Bonsi P, Johnson SW, Quartarone A.

Neural Plast. 2018 Oct 23;2018:9230704. doi: 10.1155/2018/9230704. eCollection 2018. No abstract available.


Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum.

Maltese M, Stanic J, Tassone A, Sciamanna G, Ponterio G, Vanni V, Martella G, Imbriani P, Bonsi P, Mercuri NB, Gardoni F, Pisani A.

Elife. 2018 Mar 5;7. pii: e33331. doi: 10.7554/eLife.33331.


The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum.

Martella G, Meringolo M, Trobiani L, De Jaco A, Pisani A, Bonsi P.

Eur J Neurosci. 2018 Mar;47(6):701-708. doi: 10.1111/ejn.13705. Epub 2017 Oct 4.


Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition.

Maltese M, Martella G, Imbriani P, Schuermans J, Billion K, Sciamanna G, Farook F, Ponterio G, Tassone A, Santoro M, Bonsi P, Pisani A, Goodchild RE.

Neurobiol Dis. 2017 Dec;108:128-139. doi: 10.1016/j.nbd.2017.08.007. Epub 2017 Aug 18.


Double hit mouse model of Parkinson's disease.

Schirinzi T, Martella G, Pisani A.

Oncotarget. 2016 Dec 6;7(49):80109-80110. doi: 10.18632/oncotarget.13460. No abstract available.


Outlining a Population "at Risk" of Parkinson's Disease: Evidence from a Case-Control Study.

Schirinzi T, Martella G, D'Elia A, Di Lazzaro G, Imbriani P, Madeo G, Monaco L, Maltese M, Pisani A.

Parkinsons Dis. 2016;2016:9646057. doi: 10.1155/2016/9646057. Epub 2016 Aug 29.


Early synaptic dysfunction in Parkinson's disease: Insights from animal models.

Schirinzi T, Madeo G, Martella G, Maltese M, Picconi B, Calabresi P, Pisani A.

Mov Disord. 2016 Jun;31(6):802-13. doi: 10.1002/mds.26620. Epub 2016 May 19. Review.


Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice.

Martella G, Madeo G, Maltese M, Vanni V, Puglisi F, Ferraro E, Schirinzi T, Valente EM, Bonanni L, Shen J, Mandolesi G, Mercuri NB, Bonsi P, Pisani A.

Neurobiol Dis. 2016 Jul;91:21-36. doi: 10.1016/j.nbd.2015.12.020. Epub 2016 Feb 23.


Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice.

Madeo G, Schirinzi T, Maltese M, Martella G, Rapino C, Fezza F, Mastrangelo N, Bonsi P, Maccarrone M, Pisani A.

Neuropharmacology. 2016 Feb;101:460-70. doi: 10.1016/j.neuropharm.2015.10.021. Epub 2015 Oct 20.


Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors.

Maltese M, Martella G, Madeo G, Fagiolo I, Tassone A, Ponterio G, Sciamanna G, Burbaud P, Conn PJ, Bonsi P, Pisani A.

Mov Disord. 2014 Nov;29(13):1655-65. doi: 10.1002/mds.26009. Epub 2014 Sep 4.


Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia.

Sciamanna G, Ponterio G, Tassone A, Maltese M, Madeo G, Martella G, Poli S, Schirinzi T, Bonsi P, Pisani A.

Neuropharmacology. 2014 Oct;85:440-50. doi: 10.1016/j.neuropharm.2014.06.013. Epub 2014 Jun 19.


Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia.

Martella G, Maltese M, Nisticò R, Schirinzi T, Madeo G, Sciamanna G, Ponterio G, Tassone A, Mandolesi G, Vanni V, Pignatelli M, Bonsi P, Pisani A.

Neurobiol Dis. 2014 May;65:124-32. doi: 10.1016/j.nbd.2014.01.016. Epub 2014 Feb 3.


PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity.

Madeo G, Schirinzi T, Martella G, Latagliata EC, Puglisi F, Shen J, Valente EM, Federici M, Mercuri NB, Puglisi-Allegra S, Bonsi P, Pisani A.

Mov Disord. 2014 Jan;29(1):41-53. doi: 10.1002/mds.25724. Epub 2013 Oct 25.


Cholinergic dysfunction alters synaptic integration between thalamostriatal and corticostriatal inputs in DYT1 dystonia.

Sciamanna G, Tassone A, Mandolesi G, Puglisi F, Ponterio G, Martella G, Madeo G, Bernardi G, Standaert DG, Bonsi P, Pisani A.

J Neurosci. 2012 Aug 29;32(35):11991-2004. doi: 10.1523/JNEUROSCI.0041-12.2012.


Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA.

Sciamanna G, Hollis R, Ball C, Martella G, Tassone A, Marshall A, Parsons D, Li X, Yokoi F, Zhang L, Li Y, Pisani A, Standaert DG.

Neurobiol Dis. 2012 Sep;47(3):416-27. doi: 10.1016/j.nbd.2012.04.015. Epub 2012 May 3.


Generation of a novel rodent model for DYT1 dystonia.

Grundmann K, Glöckle N, Martella G, Sciamanna G, Hauser TK, Yu L, Castaneda S, Pichler B, Fehrenbacher B, Schaller M, Nuscher B, Haass C, Hettich J, Yue Z, Nguyen HP, Pisani A, Riess O, Ott T.

Neurobiol Dis. 2012 Jul;47(1):61-74. doi: 10.1016/j.nbd.2012.03.024. Epub 2012 Mar 26.


Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia.

Sciamanna G, Tassone A, Martella G, Mandolesi G, Puglisi F, Cuomo D, Madeo G, Ponterio G, Standaert DG, Bonsi P, Pisani A.

PLoS One. 2011;6(9):e24261. doi: 10.1371/journal.pone.0024261. Epub 2011 Sep 2.


Experimental models of dystonia.

Tassone A, Sciamanna G, Bonsi P, Martella G, Pisani A.

Int Rev Neurobiol. 2011;98:551-72. doi: 10.1016/B978-0-12-381328-2.00020-1. Review.


Aberrant striatal synaptic plasticity in monogenic parkinsonisms.

Madeo G, Martella G, Schirinzi T, Ponterio G, Shen J, Bonsi P, Pisani A.

Neuroscience. 2012 Jun 1;211:126-35. doi: 10.1016/j.neuroscience.2011.07.065. Epub 2011 Aug 2. Review.


Centrality of striatal cholinergic transmission in Basal Ganglia function.

Bonsi P, Cuomo D, Martella G, Madeo G, Schirinzi T, Puglisi F, Ponterio G, Pisani A.

Front Neuroanat. 2011 Feb 7;5:6. doi: 10.3389/fnana.2011.00006. eCollection 2011.


Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease.

Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, Stefani A, Shen J, Pisani A, Bonsi P.

Neuroscience. 2011 Mar 17;177:240-51. doi: 10.1016/j.neuroscience.2010.12.057. Epub 2010 Dec 31.


Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine.

Napolitano F, Bonito-Oliva A, Federici M, Carta M, Errico F, Magara S, Martella G, Nisticò R, Centonze D, Pisani A, Gu HH, Mercuri NB, Usiello A.

J Neurosci. 2010 Aug 18;30(33):11043-56. doi: 10.1523/JNEUROSCI.1682-10.2010.


Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia.

Napolitano F, Pasqualetti M, Usiello A, Santini E, Pacini G, Sciamanna G, Errico F, Tassone A, Di Dato V, Martella G, Cuomo D, Fisone G, Bernardi G, Mandolesi G, Mercuri NB, Standaert DG, Pisani A.

Neurobiol Dis. 2010 Jun;38(3):434-45. doi: 10.1016/j.nbd.2010.03.003. Epub 2010 Mar 19.


R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14622-7. doi: 10.1073/pnas.0906334106. Epub 2009 Aug 10.


Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine.

Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A.

Brain. 2009 Sep;132(Pt 9):2336-49. doi: 10.1093/brain/awp194. Epub 2009 Jul 29.


Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment.

Cuomo D, Martella G, Barabino E, Platania P, Vita D, Madeo G, Selvam C, Goudet C, Oueslati N, Pin JP, Acher F, Pisani A, Beurrier C, Melon C, Kerkerian-Le Goff L, Gubellini P.

J Neurochem. 2009 May;109(4):1096-105. doi: 10.1111/j.1471-4159.2009.06036.x. Epub 2009 Mar 14.


Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.

Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J.

J Neurochem. 2009 Jul;110(2):613-21. doi: 10.1111/j.1471-4159.2009.06152.x. Epub 2009 May 5.


Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia.

Sciamanna G, Bonsi P, Tassone A, Cuomo D, Tscherter A, Viscomi MT, Martella G, Sharma N, Bernardi G, Standaert DG, Pisani A.

Neurobiol Dis. 2009 Apr;34(1):133-45. doi: 10.1016/j.nbd.2009.01.001. Epub 2009 Jan 13.


Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.

Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, Tscherter A, Kitada T, Bonsi P, Shen J, Pisani A.

Exp Neurol. 2009 Feb;215(2):388-96. doi: 10.1016/j.expneurol.2008.11.001. Epub 2008 Nov 21.


Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro.

Martella G, Bonsi P, Sciamanna G, Platania P, Madeo G, Tassone A, Cuomo D, Pisani A.

Epilepsia. 2009 Apr;50(4):702-10. doi: 10.1111/j.1528-1167.2008.01915.x. Epub 2008 Dec 4.


Antiepileptic drugs on calcium currents recorded from cortical and PAG neurons: therapeutic implications for migraine.

Martella G, Costa C, Pisani A, Cupini LM, Bernardi G, Calabresi P.

Cephalalgia. 2008 Dec;28(12):1315-26. doi: 10.1111/j.1468-2982.2008.01682.x. Epub 2008 Sep 2.


Mitochondrial toxins in Basal Ganglia disorders: from animal models to therapeutic strategies.

Bonsi P, Cuomo D, Martella G, Sciamanna G, Tolu M, Calabresi P, Bernardi G, Pisani A.

Curr Neuropharmacol. 2006 Jan;4(1):69-75.


Distinct roles of group I mGlu receptors in striatal function.

Bonsi P, Platania P, Martella G, Madeo G, Vita D, Tassone A, Bernardi G, Pisani A.

Neuropharmacology. 2008 Sep;55(4):392-5. doi: 10.1016/j.neuropharm.2008.05.020. Epub 2008 Jul 7. Review.


Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum.

Bonsi P, Martella G, Cuomo D, Platania P, Sciamanna G, Bernardi G, Wess J, Pisani A.

J Neurosci. 2008 Jun 11;28(24):6258-63. doi: 10.1523/JNEUROSCI.1678-08.2008.


Age-related functional changes of high-voltage-activated calcium channels in different neuronal subtypes of mouse striatum.

Martella G, Spadoni F, Sciamanna G, Tassone A, Bernardi G, Pisani A, Bonsi P.

Neuroscience. 2008 Mar 18;152(2):469-76. doi: 10.1016/j.neuroscience.2007.12.040. Epub 2008 Jan 9.


Rotenone enhances N-methyl-D-aspartate currents by activating a tyrosine kinase in rat dopamine neurons.

Wu YN, Martella G, Johnson SW.

Neuroreport. 2007 Nov 19;18(17):1813-6.


Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.

Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11441-6. Epub 2007 Jun 11.


Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia.

Pisani A, Martella G, Tscherter A, Bonsi P, Sharma N, Bernardi G, Standaert DG.

Neurobiol Dis. 2006 Nov;24(2):318-25. Epub 2006 Aug 28.


Neurotensin effects on N-type calcium currents among rat pallidal neurons: an electrophysiological and immunohistochemical study.

Martorana A, Martella G, D'Angelo V, Fusco FR, Spadoni F, Bernardi G, Stefani A.

Synapse. 2006 Oct;60(5):371-83.


Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.

Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Bernardi G, Shen J, Calabresi P.

Neurobiol Dis. 2006 Jul;23(1):54-60. Epub 2006 Apr 19.


Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia.

Costa C, Martella G, Picconi B, Prosperetti C, Pisani A, Di Filippo M, Pisani F, Bernardi G, Calabresi P.

Stroke. 2006 May;37(5):1319-26. Epub 2006 Mar 30.


Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity.

Martella G, De Persis C, Bonsi P, Natoli S, Cuomo D, Bernardi G, Calabresi P, Pisani A.

Epilepsia. 2005 May;46(5):624-35.


Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1.

Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J.

Neuron. 2005 Feb 17;45(4):489-96.


Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine.

Pisani A, Bonsi P, Martella G, De Persis C, Costa C, Pisani F, Bernardi G, Calabresi P.

Epilepsia. 2004 Jul;45(7):719-28.


Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.

Spadoni F, Martella G, Martorana A, Lavaroni F, D'Angelo V, Bernardi G, Stefani A.

Synapse. 2004 Mar 1;51(3):194-205.


Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons.

Spadoni F, Hainsworth AH, Mercuri NB, Caputi L, Martella G, Lavaroni F, Bernardi G, Stefani A.

Neuroreport. 2002 Jul 2;13(9):1167-70.


D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation.

Stefani A, Spadoni F, Martorana A, Lavaroni F, Martella G, Sancesario G, Bernardi G.

Eur J Neurosci. 2002 Mar;15(5):815-25.


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