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Items: 1 to 50 of 58

1.

Multiple cancer pathways regulate telomere protection.

Bejarano L, Bosso G, Louzame J, Serrano R, Gómez-Casero E, Martínez-Torrecuadrada J, Martínez S, Blanco-Aparicio C, Pastor J, Blasco MA.

EMBO Mol Med. 2019 Jul;11(7):e10292. doi: 10.15252/emmm.201910292. Epub 2019 Jun 13.

2.

Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination.

Lennon S, Oweida A, Milner D, Phan AV, Bhatia S, Van Court B, Darragh L, Mueller AC, Raben D, Martínez-Torrecuadrada JL, Pitts TM, Somerset H, Jordan KR, Hansen KC, Williams J, Messersmith WA, Schulick RD, Owens P, Goodman KA, Karam SD.

Clin Cancer Res. 2019 Jun 1;25(11):3352-3365. doi: 10.1158/1078-0432.CCR-18-2811. Epub 2019 Apr 3.

PMID:
30944125
3.

Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy.

Garaulet G, Pérez-Chacon G, Alarcón H, Alfranca A, Mulero F, Martínez-Torrecuadrada J, Zapata JM, Rodríguez A.

Cancer Gene Ther. 2019 Jul;26(7-8):216-233. doi: 10.1038/s41417-018-0076-4. Epub 2019 Jan 9.

PMID:
30622324
4.

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity.

Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G, Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L.

Nat Commun. 2018 Nov 15;9(1):4809. doi: 10.1038/s41467-018-07195-w.

5.

MT1-MMP as a PET Imaging Biomarker for Pancreas Cancer Management.

Morcillo MÁ, García de Lucas Á, Oteo M, Romero E, Magro N, Ibáñez M, Martínez A, Garaulet G, Arroyo AG, López-Casas PP, Hidalgo M, Mulero F, Martínez-Torrecuadrada J.

Contrast Media Mol Imaging. 2018 Aug 26;2018:8382148. doi: 10.1155/2018/8382148. eCollection 2018.

6.

Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.

Toledo RA, Garralda E, Mitsi M, Pons T, Monsech J, Vega E, Otero Á, Albarran MI, Baños N, Durán Y, Bonilla V, Sarno F, Camacho-Artacho M, Sanchez-Perez T, Perea S, Álvarez R, De Martino A, Lietha D, Blanco-Aparicio C, Cubillo A, Domínguez O, Martínez-Torrecuadrada JL, Hidalgo M.

Clin Cancer Res. 2018 Aug 1;24(15):3550-3559. doi: 10.1158/1078-0432.CCR-18-0103. Epub 2018 Mar 27.

7.

Display of the Albumin-Binding Domain in the Envelope Improves Lentiviral Vector Bioavailability.

Garaulet G, Lazcano JJ, Alarcón H, de Frutos S, Martínez-Torrecuadrada JL, Rodríguez A.

Hum Gene Ther Methods. 2017 Dec;28(6):340-351. doi: 10.1089/hgtb.2017.057.

PMID:
29160106
8.

Modulation of telomere protection by the PI3K/AKT pathway.

Méndez-Pertuz M, Martínez P, Blanco-Aparicio C, Gómez-Casero E, Belen García A, Martínez-Torrecuadrada J, Palafox M, Cortés J, Serra V, Pastor J, Blasco MA.

Nat Commun. 2017 Nov 2;8(1):1278. doi: 10.1038/s41467-017-01329-2.

9.

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.

Olmeda D, Cerezo-Wallis D, Riveiro-Falkenbach E, Pennacchi PC, Contreras-Alcalde M, Ibarz N, Cifdaloz M, Catena X, Calvo TG, Cañón E, Alonso-Curbelo D, Suarez J, Osterloh L, Graña O, Mulero F, Megías D, Cañamero M, Martínez-Torrecuadrada JL, Mondal C, Di Martino J, Lora D, Martinez-Corral I, Bravo-Cordero JJ, Muñoz J, Puig S, Ortiz-Romero P, Rodriguez-Peralto JL, Ortega S, Soengas MS.

Nature. 2017 Jun 28;546(7660):676-680. doi: 10.1038/nature22977.

10.

Sinusoidal ephrin receptor EPHB4 controls hematopoietic progenitor cell mobilization from bone marrow.

Kwak H, Salvucci O, Weigert R, Martinez-Torrecuadrada JL, Henkemeyer M, Poulos MG, Butler JM, Tosato G.

J Clin Invest. 2016 Dec 1;126(12):4554-4568. doi: 10.1172/JCI87848. Epub 2016 Nov 7.

11.

Molecular Architecture of Full-length TRF1 Favors Its Interaction with DNA.

Boskovic J, Martinez-Gago J, Mendez-Pertuz M, Buscato A, Martinez-Torrecuadrada JL, Blasco MA.

J Biol Chem. 2016 Oct 7;291(41):21829-21835. Epub 2016 Aug 25.

12.

Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.

de Lucas AG, Schuhmacher AJ, Oteo M, Romero E, Cámara JA, de Martino A, Arroyo AG, Morcillo MÁ, Squatrito M, Martinez-Torrecuadrada JL, Mulero F.

PLoS One. 2016 Jul 27;11(7):e0158634. doi: 10.1371/journal.pone.0158634. eCollection 2016.

13.

Changes in the folding landscape of the WW domain provide a molecular mechanism for an inherited genetic syndrome.

Pucheta-Martinez E, D'Amelio N, Lelli M, Martinez-Torrecuadrada JL, Sudol M, Saladino G, Gervasio FL.

Sci Rep. 2016 Jul 26;6:30293. doi: 10.1038/srep30293.

14.

EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells.

Krusche B, Ottone C, Clements MP, Johnstone ER, Goetsch K, Lieven H, Mota SG, Singh P, Khadayate S, Ashraf A, Davies T, Pollard SM, De Paola V, Roncaroli F, Martinez-Torrecuadrada J, Bertone P, Parrinello S.

Elife. 2016 Jun 28;5. pii: e14845. doi: 10.7554/eLife.14845.

15.

An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase.

Pucheta-Martínez E, Saladino G, Morando MA, Martinez-Torrecuadrada J, Lelli M, Sutto L, D'Amelio N, Gervasio FL.

Sci Rep. 2016 Apr 11;6:24235. doi: 10.1038/srep24235.

16.

Towards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational Dynamics.

Lovera S, Morando M, Pucheta-Martinez E, Martinez-Torrecuadrada JL, Saladino G, Gervasio FL.

PLoS Comput Biol. 2015 Nov 25;11(11):e1004578. doi: 10.1371/journal.pcbi.1004578. eCollection 2015 Nov.

17.

CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma.

Martín-Moreno AM, Roncador G, Maestre L, Mata E, Jiménez S, Martínez-Torrecuadrada JL, Reyes-García AI, Rubio C, Tomás JF, Estévez M, Pulford K, Piris MA, García JF.

PLoS One. 2015 Jun 12;10(6):e0125203. doi: 10.1371/journal.pone.0125203. eCollection 2015.

18.

NOTCH pathway inactivation promotes bladder cancer progression.

Maraver A, Fernandez-Marcos PJ, Cash TP, Mendez-Pertuz M, Dueñas M, Maietta P, Martinelli P, Muñoz-Martin M, Martínez-Fernández M, Cañamero M, Roncador G, Martinez-Torrecuadrada JL, Grivas D, de la Pompa JL, Valencia A, Paramio JM, Real FX, Serrano M.

J Clin Invest. 2015 Feb;125(2):824-30. doi: 10.1172/JCI78185. Epub 2015 Jan 9.

19.

The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins.

Barreira M, Fabbiano S, Couceiro JR, Torreira E, Martínez-Torrecuadrada JL, Montoya G, Llorca O, Bustelo XR.

Sci Signal. 2014 Apr 15;7(321):ra35. doi: 10.1126/scisignal.2004993.

PMID:
24736456
20.

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies.

Sánchez-Martín D, Martínez-Torrecuadrada J, Teesalu T, Sugahara KN, Alvarez-Cienfuegos A, Ximénez-Embún P, Fernández-Periáñez R, Martín MT, Molina-Privado I, Ruppen-Cañás I, Blanco-Toribio A, Cañamero M, Cuesta AM, Compte M, Kremer L, Bellas C, Alonso-Camino V, Guijarro-Muñoz I, Sanz L, Ruoslahti E, Alvarez-Vallina L.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13791-6. doi: 10.1073/pnas.1300013110. Epub 2013 Aug 5.

21.

SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms.

Montes-Moreno S, Ramos-Medina R, Martínez-López A, Barrionuevo Cornejo C, Parra Cubillos A, Quintana-Truyenque S, Rodriguez Pinilla SM, Pajares R, Sanchez-Verde L, Martinez-Torrecuadrada J, Roncador G, Piris MA.

Blood. 2013 Jan 24;121(4):643-7. doi: 10.1182/blood-2012-08-447599. Epub 2012 Nov 19.

PMID:
23165482
22.

BCL7A protein expression in normal and malignant lymphoid tissues.

Ramos-Medina R, Montes-Moreno S, Maestre L, Cañamero M, Rodríguez-Pinilla M, Martínez-Torrecuadrada J, Piris MÁ, Majid A, Dyer MJ, Pulford K, Roncador G.

Br J Haematol. 2013 Jan;160(1):106-9. doi: 10.1111/bjh.12080. Epub 2012 Oct 9. No abstract available.

PMID:
23043359
23.

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth.

Abéngozar MA, de Frutos S, Ferreiro S, Soriano J, Perez-Martinez M, Olmeda D, Marenchino M, Cañamero M, Ortega S, Megias D, Rodriguez A, Martínez-Torrecuadrada JL.

Blood. 2012 May 10;119(19):4565-76. doi: 10.1182/blood-2011-09-380006. Epub 2012 Mar 23.

PMID:
22446484
24.

Differential protein expression on the cell surface of colorectal cancer cells associated to tumor metastasis.

Luque-García JL, Martínez-Torrecuadrada JL, Epifano C, Cañamero M, Babel I, Casal JI.

Proteomics. 2010 Mar;10(5):940-52. doi: 10.1002/pmic.200900441.

PMID:
20049862
25.

Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays.

Babel I, Barderas R, Díaz-Uriarte R, Martínez-Torrecuadrada JL, Sánchez-Carbayo M, Casal JI.

Mol Cell Proteomics. 2009 Oct;8(10):2382-95. doi: 10.1074/mcp.M800596-MCP200. Epub 2009 Jul 28.

26.

Identification of MNDA as a new marker for nodal marginal zone lymphoma.

Kanellis G, Roncador G, Arribas A, Mollejo M, Montes-Moreno S, Maestre L, Campos-Martin Y, Ríos Gonzalez JL, Martinez-Torrecuadrada JL, Sanchez-Verde L, Pajares R, Cigudosa JC, Martin MC, Piris MA.

Leukemia. 2009 Oct;23(10):1847-57. doi: 10.1038/leu.2009.108. Epub 2009 May 28.

PMID:
19474799
27.

Differential phosphorylation patterns between the Cyclin-A2/CDK2 complex and their monomers.

Casado-Vela J, Martínez-Torrecuadrada JL, Casal JI.

Protein Expr Purif. 2009 Jul;66(1):15-21. doi: 10.1016/j.pep.2009.02.007. Epub 2009 Feb 20.

PMID:
19233286
28.

Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis.

Martínez-Torrecuadrada JL, Cheung LH, López-Serra P, Barderas R, Cañamero M, Ferreiro S, Rosenblum MG, Casal JI.

Mol Cancer Ther. 2008 Apr;7(4):862-73. doi: 10.1158/1535-7163.MCT-07-0394.

29.

Designing antibodies for the inhibition of gastrin activity in tumoral cell lines.

Barderas R, Shochat S, Timmerman P, Hollestelle MJ, Martínez-Torrecuadrada JL, Höppener JW, Altschuh D, Meloen R, Casal JI.

Int J Cancer. 2008 May 15;122(10):2351-9. doi: 10.1002/ijc.23395.

30.

Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas.

Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA.

Blood. 2008 Jan 1;111(1):351-8. Epub 2007 Sep 26.

PMID:
17898315
31.

Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis.

Madoz-Gúrpide J, López-Serra P, Martínez-Torrecuadrada JL, Sánchez L, Lombardía L, Casal JI.

Mol Cell Proteomics. 2006 Aug;5(8):1471-83. Epub 2006 May 29.

32.

A fast mutagenesis procedure to recover soluble and functional scFvs containing amber stop codons from synthetic and semisynthetic antibody libraries.

Barderas R, Shochat S, Martínez-Torrecuadrada J, Altschuh D, Meloen R, Ignacio Casal J.

J Immunol Methods. 2006 May 30;312(1-2):182-9. Epub 2006 Apr 21.

PMID:
16674972
33.

Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation.

Martínez-Torrecuadrada J, Cifuentes G, López-Serra P, Saenz P, Martínez A, Casal JI.

Clin Cancer Res. 2005 Sep 1;11(17):6280-90.

34.

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level.

Roncador G, Brown PJ, Maestre L, Hue S, Martínez-Torrecuadrada JL, Ling KL, Pratap S, Toms C, Fox BC, Cerundolo V, Powrie F, Banham AH.

Eur J Immunol. 2005 Jun;35(6):1681-91.

35.

An efficient expression system for the production of functionally active human LKB1.

Martínez-Torrecuadrada JL, Romero S, Núñez A, Alfonso P, Sánchez-Céspedes M, Casal JI.

J Biotechnol. 2005 Jan 12;115(1):23-34.

PMID:
15607222
36.

Structure-dependent efficacy of infectious bursal disease virus (IBDV) recombinant vaccines.

Martinez-Torrecuadrada JL, Saubi N, Pagès-Manté A, Castón JR, Espuña E, Casal JI.

Vaccine. 2003 Jul 4;21(23):3342-50.

PMID:
12804866
37.

Structure-dependent efficacy of infectious bursal disease virus (IBDV) recombinant vaccines.

Martinez-Torrecuadrada JL, Saubi N, Pagès-Manté A, Castón JR, Espuña E, Casal JI.

Vaccine. 2003 May 16;21(17-18):1952-60.

PMID:
12706682
38.

Identification of immunogenic hot spots within plum pox potyvirus capsid protein for efficient antigen presentation.

Fernández-Fernández MR, Martínez-Torrecuadrada JL, Roncal F, Domínguez E, García JA.

J Virol. 2002 Dec;76(24):12646-53.

39.

Characterization of the immune response to canine parvovirus induced by vaccination with chimaeric plant viruses.

Nicholas BL, Brennan FR, Martinez-Torrecuadrada JL, Casal JI, Hamilton WD, Wakelin D.

Vaccine. 2002 Jun 21;20(21-22):2727-34.

PMID:
12034099
40.

C terminus of infectious bursal disease virus major capsid protein VP2 is involved in definition of the T number for capsid assembly.

Castón JR, Martínez-Torrecuadrada JL, Maraver A, Lombardo E, Rodríguez JF, Casal JI, Carrascosa JL.

J Virol. 2001 Nov;75(22):10815-28.

41.

Definition of neutralizing sites on African horse sickness virus serotype 4 VP2 at the level of peptides.

Martínez-Torrecuadrada JL, Langeveld JP, Meloen RH, Casal JI.

J Gen Virol. 2001 Oct;82(Pt 10):2415-24.

PMID:
11562535
42.

Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus.

Langeveld JP, Brennan FR, Martínez-Torrecuadrada JL, Jones TD, Boshuizen RS, Vela C, Casal JI, Kamstrup S, Dalsgaard K, Meloen RH, Bendig MM, Hamilton WD.

Vaccine. 2001 Jun 14;19(27):3661-70.

PMID:
11395200
43.

Characterisation of a protective linear B cell epitope against feline parvoviruses.

Langeveld JP, Martinez-Torrecuadrada J, Boshuizen RS, Meloen RH, Ignacio Casal J.

Vaccine. 2001 Mar 21;19(17-19):2352-60.

PMID:
11257360
44.

High-yield expression of a viral peptide vaccine in transgenic plants.

Gil F, Brun A, Wigdorovitz A, Catalá R, Martínez-Torrecuadrada JL, Casal I, Salinas J, Borca MV, Escribano JM.

FEBS Lett. 2001 Jan 12;488(1-2):13-7.

45.

Different architectures in the assembly of infectious bursal disease virus capsid proteins expressed in insect cells.

Martinez-Torrecuadrada JL, Castón JR, Castro M, Carrascosa JL, Rodriguez JF, Casal JI.

Virology. 2000 Dec 20;278(2):322-31.

46.

Antigenic properties and diagnostic potential of baculovirus-expressed infectious bursal disease virus proteins VPX and VP3.

Martínez-Torrecuadrada JL, Lázaro B, Rodriguez JF, Casal JI.

Clin Diagn Lab Immunol. 2000 Jul;7(4):645-51.

47.

Minor displacements in the insertion site provoke major differences in the induction of antibody responses by chimeric parvovirus-like particles.

Rueda P, Hurtado A, del Barrio M, Martínez-Torrecuadrada JL, Kamstrup S, Leclerc C, Casal JI.

Virology. 1999 Oct 10;263(1):89-99.

48.

Engineering parvovirus-like particles for the induction of B-cell, CD4(+) and CTL responses.

Rueda P, Martínez-Torrecuadrada JL, Sarraseca J, Sedlik C, del Barrio M, Hurtado A, Leclerc C, Casal JI.

Vaccine. 1999 Sep;18(3-4):325-32.

PMID:
10506659
49.

Pathogenesis of African horse sickness: ultrastructural study of the capillaries in experimental infection.

Gómez-Villamandos JC, Sánchez C, Carrasco L, Laviada MM, Bautista MJ, Martínez-Torrecuadrada J, Sánchez-Vizcaíno JM, Sierra MA.

J Comp Pathol. 1999 Aug;121(2):101-16.

PMID:
10405303
50.

The role of pulmonary intravascular macrophages in the pathogenesis of African horse sickness.

Carrasco L, Sánchez C, Gómez-Villamandos JC, Laviada MD, Bautista MJ, Martínez-Torrecuadrada J, Sánchez-Vizcaíno JM, Sierra MA.

J Comp Pathol. 1999 Jul;121(1):25-38.

PMID:
10373291

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