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Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria.

Teruel-Montoya R, Luengo-Gil G, Vallejo F, Yuste JE, Bohdan N, García-Barberá N, Espín S, Martínez C, Espín JC, Vicente V, Martínez-Martínez I.

Sci Rep. 2019 Mar 5;9(1):3611. doi: 10.1038/s41598-019-40453-5.


Effectiveness of a Hand Hygiene Program at Child Care Centers: A Cluster Randomized Trial.

Azor-Martinez E, Yui-Hifume R, Muñoz-Vico FJ, Jimenez-Noguera E, Strizzi JM, Martinez-Martinez I, Garcia-Fernandez L, Seijas-Vazquez ML, Torres-Alegre P, Fernández-Campos MA, Gimenez-Sanchez F.

Pediatrics. 2018 Nov;142(5). pii: e20181245. doi: 10.1542/peds.2018-1245. Epub 2018 Oct 8.


Variability of defensin genes from a Mexican endemic Triatominae: Triatoma (Meccus) pallidipennis (Hemiptera: Reduviidae).

Díaz-Garrido P, Sepúlveda-Robles O, Martínez-Martínez I, Espinoza B.

Biosci Rep. 2018 Sep 28;38(5). pii: BSR20180988. doi: 10.1042/BSR20180988. Print 2018 Oct 31.


Defects of splicing in antithrombin deficiency.

de la Morena-Barrio ME, López-Gálvez R, Martínez-Martínez I, Asenjo S, Sevivas TS, López MF, Wypasek E, Entrena L, Vicente V, Corral J.

Res Pract Thromb Haemost. 2017 Jul 14;1(2):216-222. doi: 10.1002/rth2.12025. eCollection 2017 Oct.


Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities.

Águila S, Izaguirre G, Martínez-Martínez I, Vicente V, Olson ST, Corral J.

J Biol Chem. 2017 Oct 6;292(40):16513-16520. doi: 10.1074/jbc.M117.787325. Epub 2017 Jul 25.


Severe Thrombophilia in Idiopathic Fatal Pulmonary Embolism.

Martínez-Martínez I.

EBioMedicine. 2017 Mar;17:13-14. doi: 10.1016/j.ebiom.2017.02.016. Epub 2017 Feb 20. No abstract available.


Identification of a new potential mechanism responsible for severe bleeding in myeloma: immunoglobulins bind the heparin binding domain of antithrombin activating this endogenous anticoagulant.

Martínez-Martínez I, González-Porras JR, Cebeira MJ, de Arriba F, Espín S, Bohdan N, Corrales FJ, Corral J, Vicente V.

Haematologica. 2016 Oct;101(10):e423-e426. Epub 2016 Jun 16. No abstract available.


Heparanase Activates Antithrombin through the Binding to Its Heparin Binding Site.

Bohdan N, Espín S, Águila S, Teruel-Montoya R, Vicente V, Corral J, Martínez-Martínez I.

PLoS One. 2016 Jun 20;11(6):e0157834. doi: 10.1371/journal.pone.0157834. eCollection 2016.


Antithrombin controls tumor migration, invasion and angiogenesis by inhibition of enteropeptidase.

Luengo-Gil G, Calvo MI, Martín-Villar E, Águila S, Bohdan N, Antón AI, Espín S, Ayala de la Peña F, Vicente V, Corral J, Quintanilla M, Martínez-Martínez I.

Sci Rep. 2016 Jun 8;6:27544. doi: 10.1038/srep27544.


Hypoglycosylation is a common finding in antithrombin deficiency in the absence of a SERPINC1 gene defect.

de la Morena-Barrio ME, Martínez-Martínez I, de Cos C, Wypasek E, Roldán V, Undas A, van Scherpenzeel M, Lefeber DJ, Toderici M, Sevivas T, España F, Jaeken J, Corral J, Vicente V.

J Thromb Haemost. 2016 Aug;14(8):1549-60. doi: 10.1111/jth.13372. Epub 2016 Jun 29.


Antithrombin Dublin (p.Val30Glu): a relatively common variant with moderate thrombosis risk of causing transient antithrombin deficiency.

Navarro-Fernández J, de la Morena-Barrio ME, Padilla J, Miñano A, Bohdan N, Águila S, Martínez-Martínez I, Sevivas TS, de Cos C, Fernández-Mosteirín N, Llamas P, Asenjo S, Medina P, Souto JC, Overvad K, Kristensen SR, Corral J, Vicente V.

Thromb Haemost. 2016 Jul 4;116(1):146-54. doi: 10.1160/TH15-11-0871. Epub 2016 Apr 21.


Quantum stochastic walks on networks for decision-making.

Martínez-Martínez I, Sánchez-Burillo E.

Sci Rep. 2016 Mar 31;6:23812. doi: 10.1038/srep23812.


A new method to quantify β-antithrombin glycoform in plasma reveals increased levels during the acute stroke event.

de la Morena-Barrio ME, García A, Martínez-Martínez I, Miñano A, Padilla J, Navarro-Fernández J, Roldán V, Águila S, Iniesta JA, Corral J, Vicente V.

Thromb Res. 2015 Sep;136(3):634-41. doi: 10.1016/j.thromres.2015.06.039. Epub 2015 Jul 6.


An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets.

Sánchez Guiu IM, Martínez-Martinez I, Martínez C, Navarro-Fernandez J, García-Candel F, Ferrer-Marín F, Vicente V, Watson SP, Andrews RK, Gardiner EE, Lozano ML, Rivera J.

Thromb Haemost. 2015 Aug;114(2):313-24. doi: 10.1160/TH14-11-0945. Epub 2015 May 21.


Increased N-glycosylation efficiency by generation of an aromatic sequon on N135 of antithrombin.

Aguila S, Martínez-Martínez I, Dichiara G, Gutiérrez-Gallego R, Navarro-Fernández J, Vicente V, Corral J.

PLoS One. 2014 Dec 8;9(12):e114454. doi: 10.1371/journal.pone.0114454. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0122177.


Role of the C-sheet in the maturation of N-glycans on antithrombin: functional relevance of pleiotropic mutations.

Aguila S, Navarro-Fernández J, Bohdan N, Gutiérrez-Gallego R, de la Morena-Barrio ME, Vicente V, Corral J, Martínez-Martínez I.

J Thromb Haemost. 2014 Jul;12(7):1131-40. doi: 10.1111/jth.12606. Epub 2014 Jun 19.


GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients.

de la Morena-Barrio ME, Hernández-Caselles T, Corral J, García-López R, Martínez-Martínez I, Pérez-Dueñas B, Altisent C, Sevivas T, Kristensen SR, Guillén-Navarro E, Miñano A, Vicente V, Jaeken J, Lozano ML.

Orphanet J Rare Dis. 2013 Oct 20;8:170. doi: 10.1186/1750-1172-8-170.


[Standardization of Dot-ELISA for detection of anti-Trypanosoma cruzi antibodies, compared to ELISA and Western blot].

Cervantes-Landín AY, Martínez-Martínez I, Reyes PA, Shabib M, Espinoza-Gutiérrez B.

Enferm Infecc Microbiol Clin. 2014 Jun-Jul;32(6):363-8. doi: 10.1016/j.eimc.2013.05.006. Epub 2013 Jul 25. Spanish.


Identification of potential oviductal factors responsible for zona pellucida hardening and monospermy during fertilization in mammals.

Mondéjar I, Martínez-Martínez I, Avilés M, Coy P.

Biol Reprod. 2013 Sep 27;89(3):67. doi: 10.1095/biolreprod.113.111385. Print 2013 Sep.


Identification of antithrombin-modulating genes. Role of LARGE, a gene encoding a bifunctional glycosyltransferase, in the secretion of proteins?

de la Morena-Barrio ME, Buil A, Antón AI, Martínez-Martínez I, Miñano A, Gutiérrez-Gallego R, Navarro-Fernández J, Aguila S, Souto JC, Vicente V, Soria JM, Corral J.

PLoS One. 2013 May 21;8(5):e64998. doi: 10.1371/journal.pone.0064998. Print 2013.


Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a.

Teruel R, Martínez-Martínez I, Guerrero JA, González-Conejero R, de la Morena-Barrio ME, Salloum-Asfar S, Arroyo AB, Águila S, García-Barberá N, Miñano A, Vicente V, Corral J, Martínez C.

J Biomed Sci. 2013 May 16;20:29. doi: 10.1186/1423-0127-20-29.


Compound heterozygosity involving Antithrombin Cambridge II (p.Ala416Ser) in antithrombin deficiency.

Águila S, Martínez-Martínez I, Collado M, Llamas P, Antón AI, Martínez-Redondo C, Padilla J, Miñano A, de la Morena-Barrio ME, Garcia-Avello Á, Vicente V, Corral J.

Thromb Haemost. 2013 Mar;109(3):556-8. doi: 10.1160/TH12-09-0707. Epub 2013 Jan 17. No abstract available.


Congenital disorder of glycosylation (PMM2-CDG) in a patient with antithrombin deficiency and severe thrombophilia.

de la Morena-Barrio ME, Sevivas TS, Martinez-Martinez I, Miñano A, Vicente V, Jaeken J, Corral J.

J Thromb Haemost. 2012 Dec;10(12):2625-7. doi: 10.1111/jth.12031. No abstract available.


Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.

Martínez-Martínez I, Johnson DJ, Yamasaki M, Navarro-Fernández J, Ordóñez A, Vicente V, Huntington JA, Corral J.

J Thromb Haemost. 2012 Sep;10(9):1859-66. doi: 10.1111/j.1538-7836.2012.04839.x.


Protective role of antithrombin in mouse models of liver injury.

Guerrero JA, Teruel R, Martínez C, Arcas I, Martínez-Martínez I, de la Morena-Barrio ME, Vicente V, Corral J.

J Hepatol. 2012 Nov;57(5):980-6. doi: 10.1016/j.jhep.2012.06.023. Epub 2012 Jun 26.


In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity.

Navarro-Fernández J, Pérez-Sánchez H, Martínez-Martínez I, Meliciani I, Guerrero JA, Vicente V, Corral J, Wenzel W.

J Med Chem. 2012 Jul 26;55(14):6403-12. doi: 10.1021/jm300621j. Epub 2012 Jul 17.


Amelioration of the severity of heparin-binding antithrombin mutations by posttranslational mosaicism.

Martínez-Martínez I, Navarro-Fernández J, Østergaard A, Gutiérrez-Gallego R, Padilla J, Bohdan N, Miñano A, Pascual C, Martínez C, de la Morena-Barrio ME, Aguila S, Pedersen S, Kristensen SR, Vicente V, Corral J.

Blood. 2012 Jul 26;120(4):900-4. doi: 10.1182/blood-2012-01-406207. Epub 2012 Apr 12.


The infective polymerization of conformationally unstable antithrombin mutants may play a role in the clinical severity of antithrombin deficiency.

Martínez-Martínez I, Navarro-Fernández J, Aguila S, Miñano A, Bohdan N, De La Morena-Barrio ME, Ordóñez A, Martínez C, Vicente V, Corral J.

Mol Med. 2012 Jul 18;18:762-70. doi: 10.2119/molmed.2012.00017.


Regulatory regions of SERPINC1 gene: identification of the first mutation associated with antithrombin deficiency.

de la Morena-Barrio ME, Antón AI, Martínez-Martínez I, Padilla J, Miñano A, Navarro-Fernández J, Águila S, López MF, Fontcuberta J, Vicente V, Corral J.

Thromb Haemost. 2012 Mar;107(3):430-7. doi: 10.1160/TH11-10-0701. Epub 2012 Jan 11.


[A Trypanosoma cruzi infection without serologic evidence].

Blum-Domínguez S, Espinoza B, Martínez-Martínez I, Maldonado-Velázquez G, Tamay-Segovia P.

Rev Med Inst Mex Seguro Soc. 2011 Sep-Oct;49(5):537-9. Spanish.


Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome.

Teruel R, Pérez-Sánchez C, Corral J, Herranz MT, Pérez-Andreu V, Saiz E, García-Barberá N, Martínez-Martínez I, Roldán V, Vicente V, López-Pedrera C, Martínez C.

J Thromb Haemost. 2011 Oct;9(10):1985-92. doi: 10.1111/j.1538-7836.2011.04451.x.


Potential role of miRNAs in developmental haemostasis.

Teruel R, Corral J, Pérez-Andreu V, Martínez-Martínez I, Vicente V, Martínez C.

PLoS One. 2011 Mar 9;6(3):e17648. doi: 10.1371/journal.pone.0017648.


Rare homozygous status of P43 β1-tubulin polymorphism causes alterations in platelet ultrastructure.

Navarro-Núñez L, Teruel R, Antón AI, Nurden P, Martínez-Martínez I, Lozano ML, Rivera J, Corral J, Mezzano D, Vicente V, Martinez C.

Thromb Haemost. 2011 May;105(5):855-63. doi: 10.1160/TH10-08-0536. Epub 2011 Mar 8.


Heparin affinity of factor VIIa: implications on the physiological inhibition by antithrombin and clearance of recombinant factor VIIa.

Martínez-Martínez I, Ordóñez A, Pedersen S, de la Morena-Barrio ME, Navarro-Fernández J, Kristensen SR, Miñano A, Padilla J, Vicente V, Corral J.

Thromb Res. 2011 Feb;127(2):154-60. doi: 10.1016/j.thromres.2010.11.008. Epub 2010 Dec 3.


Increased levels of citrullinated antithrombin in plasma of patients with rheumatoid arthritis and colorectal adenocarcinoma determined by a newly developed ELISA using a specific monoclonal antibody.

Ordóñez A, Yélamos J, Pedersen S, Miñano A, Conesa-Zamora P, Kristensen SR, Stender MT, Thorlacius-Ussing O, Martínez-Martínez I, Vicente V, Corral J.

Thromb Haemost. 2010 Dec;104(6):1143-9. doi: 10.1160/TH10-05-0297. Epub 2010 Sep 13.


Antithrombin Murcia (K241E) causing antithrombin deficiency: a possible role for altered glycosylation.

Martínez-Martínez I, Ordóñez A, Navarro-Fernández J, Pérez-Lara A, Gutiérrez-Gallego R, Giraldo R, Martínez C, Llop E, Vicente V, Corral J.

Haematologica. 2010 Aug;95(8):1358-65. doi: 10.3324/haematol.2009.015487. Epub 2010 Apr 30.


Effect of citrullination on the function and conformation of antithrombin.

Ordóñez A, Martínez-Martínez I, Corrales FJ, Miqueo C, Miñano A, Vicente V, Corral J.

FEBS J. 2009 Nov;276(22):6763-72. doi: 10.1111/j.1742-4658.2009.07391.x. Epub 2009 Oct 16.


Effects of acrolein, a natural occurring aldehyde, on the anticoagulant serpin antithrombin.

Martínez-Martínez I, Ordóñez A, Guerrero JA, Pedersen S, Miñano A, Teruel R, Velázquez L, Kristensen SR, Vicente V, Corral J.

FEBS Lett. 2009 Oct 6;583(19):3165-70. doi: 10.1016/j.febslet.2009.07.062. Epub 2009 Sep 1.


Hyperglycaemia impairs antithrombin secretion: possible contribution to the thrombotic risk of diabetes.

Hernández-Espinosa D, Ordóñez A, Miñano A, Martínez-Martínez I, Vicente V, Corral J.

Thromb Res. 2009 Sep;124(4):483-9. doi: 10.1016/j.thromres.2009.05.020. Epub 2009 Jul 2.


Dexamethasone induces a heat-stress response that ameliorates the conformational consequences on antithrombin of L-asparaginase treatment.

Hernández-Espinosa D, Miñano A, Ordóñez A, Mota R, Martínez-Martínez I, Vicente V, Corral J.

J Thromb Haemost. 2009 Jul;7(7):1128-33. doi: 10.1111/j.1538-7836.2009.03449.x. Epub 2009 Apr 27.


Characterization of a novel thermostable carboxylesterase from Geobacillus kaustophilus HTA426 shows the existence of a new carboxylesterase family.

Montoro-García S, Martínez-Martínez I, Navarro-Fernández J, Takami H, García-Carmona F, Sánchez-Ferrer A.

J Bacteriol. 2009 May;191(9):3076-85. doi: 10.1128/JB.01060-08. Epub 2009 Mar 20.


Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels.

Antón AI, Teruel R, Corral J, Miñano A, Martínez-Martínez I, Ordóñez A, Vicente V, Sánchez-Vega B.

Haematologica. 2009 Apr;94(4):589-92. doi: 10.3324/haematol.2008.000604. Epub 2009 Feb 19.


Extension of the Job Demands-Resources model in the prediction of burnout and engagement among teachers over time.

Lorente Prieto L, Salanova Soria M, Martínez Martínez I, Schaufeli W.

Psicothema. 2008 Aug;20(3):354-60.


S-adenosylhomocysteine hydrolase from Corynebacterium glutamicum: cloning, overexpression, purification, and biochemical characterization.

Lozada-Ramírez JD, Martínez-Martínez I, Sánchez-Ferrer A, García-Carmona F.

J Mol Microbiol Biotechnol. 2008;15(4):277-86. doi: 10.1159/000115846. Epub 2008 Feb 4.


Production of the apoptotic cellular mediator 4-Methylthio-2-oxobutyric acid by using an enzymatic stirred tank reactor with in situ product removal.

García-García M, Martínez-Martínez I, Sánchez-Ferrer A, García-Carmona F.

Biotechnol Prog. 2008 Jan-Feb;24(1):187-91. Epub 2007 Dec 20.


Characterization of a new rhamnogalacturonan acetyl esterase from Bacillus halodurans C-125 with a new putative carbohydrate binding domain.

Navarro-Fernández J, Martínez-Martínez I, Montoro-García S, García-Carmona F, Takami H, Sánchez-Ferrer A.

J Bacteriol. 2008 Feb;190(4):1375-82. Epub 2007 Dec 14.


Cloning, overexpression, purification, and characterization of S-adenosylhomocysteine hydrolase from Corynebacterium efficiens YS-314.

Lozada-Ramírez JD, Martínez-Martínez I, García-Carmona F, Sánchez-Ferrer A.

Biotechnol Prog. 2008 Jan-Feb;24(1):120-7. Epub 2007 Nov 23.


Implication of a mutation in the flavin binding site on the specific activity and substrate specificity of glycine oxidase from Bacillus subtilis produced by directed evolution.

Martínez-Martínez I, Navarro-Fernández J, García-Carmona F, Sánchez-Ferrer A.

J Biotechnol. 2008 Jan 1;133(1):1-8. Epub 2007 Aug 3.


YesT: a new rhamnogalacturonan acetyl esterase from Bacillus subtilis.

Martínez-Martínez I, Navarro-Fernández J, Daniel Lozada-Ramírez J, García-Carmona F, Sánchez-Ferrer A.

Proteins. 2008 Apr;71(1):379-88.


Characterization and structural modeling of a novel thermostable glycine oxidase from Geobacillus kaustophilus HTA426.

Martínez-Martínez I, Navarro-Fernández J, García-Carmona F, Takami H, Sánchez-Ferrer A.

Proteins. 2008 Mar;70(4):1429-41.


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