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Items: 27


PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines.

Carrasco-Garcia E, Martinez-Lacaci I, Mayor-López L, Tristante E, Carballo-Santana M, García-Morales P, Ventero Martin MP, Fuentes-Baile M, Rodriguez-Lescure Á, Saceda M.

Cells. 2018 Sep 6;7(9). pii: E131. doi: 10.3390/cells7090131.


Autophagy regulates Selumetinib (AZD6244) induced-apoptosis in colorectal cancer cells.

Grasso S, Pereira GJS, Palmeira-Dos-Santos C, Calgarotto AK, Martínez-Lacaci I, Ferragut JA, Smaili SS, Bincoletto C.

Eur J Med Chem. 2016 Oct 21;122:611-618. doi: 10.1016/j.ejmech.2016.06.043. Epub 2016 Jul 9.


HGUE-C-1 is an atypical and novel colon carcinoma cell line.

Grasso S, Martínez-Lacaci I, Barberá VM, Castillejo A, Soto JL, Gallego-Plazas J, López-Riquelme N, García-Morales P, Mata-Balaguer T, Ferragut JA, Saceda M.

BMC Cancer. 2015 Apr 8;15:240. doi: 10.1186/s12885-015-1183-3.


Association of a characteristic membrane pattern of annexin A2 with high invasiveness and nodal status in colon adenocarcinoma.

Tristante E, Martínez CM, Jiménez S, Mora L, Carballo F, Martínez-Lacaci I, de Torre-Minguela C.

Transl Res. 2015 Aug;166(2):196-206. doi: 10.1016/j.trsl.2015.02.006. Epub 2015 Feb 28.


Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?

Mayor-López L, Tristante E, Carballo-Santana M, Carrasco-García E, Grasso S, García-Morales P, Saceda M, Luján J, García-Solano J, Carballo F, de Torre C, Martínez-Lacaci I.

Transl Oncol. 2014 Oct 24;7(5):590-604. doi: 10.1016/j.tranon.2014.08.001. eCollection 2014 Oct.


Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.

Grasso S, Tristante E, Saceda M, Carbonell P, Mayor-López L, Carballo-Santana M, Carrasco-García E, Rocamora-Reverte L, García-Morales P, Carballo F, Ferragut JA, Martínez-Lacaci I.

Neoplasia. 2014 Oct 23;16(10):845-60. doi: 10.1016/j.neo.2014.08.011. eCollection 2014 Oct.


Role of receptor tyrosine kinases and their ligands in glioblastoma.

Carrasco-García E, Saceda M, Martínez-Lacaci I.

Cells. 2014 Apr 4;3(2):199-235. doi: 10.3390/cells3020199.


Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines.

Balaguer TM, Gómez-Martínez A, García-Morales P, Lacueva J, Calpena R, Reverte LR, Riquelme NL, Martinez-Lacaci I, Ferragut JA, Saceda M.

BMC Mol Biol. 2012 Jul 30;13:25. doi: 10.1186/1471-2199-13-25.


Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.

Carrasco-García E, Saceda M, Grasso S, Rocamora-Reverte L, Conde M, Gómez-Martínez A, García-Morales P, Ferragut JA, Martínez-Lacaci I.

Exp Cell Res. 2011 Jun 10;317(10):1476-89. doi: 10.1016/j.yexcr.2011.03.015. Epub 2011 Apr 1.


Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells.

Castro-Galache MD, Menéndez-Gutiérrez MP, Carrasco Garcia E, Garcia-Morales P, Martinez-Lacaci I, Saceda M, Ferragut JA.

Int J Biochem Cell Biol. 2007;39(10):1877-85. Epub 2007 May 21.


Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines.

García-Morales P, Carrasco-García E, Ruiz-Rico P, Martínez-Mira R, Menéndez-Gutiérrez MP, Ferragut JA, Saceda M, Martínez-Lacaci I.

Oncogene. 2007 Nov 8;26(51):7185-93. Epub 2007 May 21.


Tumour cells resistance in cancer therapy.

Martínez-Lacaci I, García Morales P, Soto JL, Saceda M.

Clin Transl Oncol. 2007 Jan;9(1):13-20. Review.


Cyclin D3 is down-regulated by rapamycin in HER-2-overexpressing breast cancer cells.

García-Morales P, Hernando E, Carrasco-García E, Menéndez-Gutierrez MP, Saceda M, Martínez-Lacaci I.

Mol Cancer Ther. 2006 Sep;5(9):2172-81.


Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.

García-Morales P, Gómez-Martínez A, Carrato A, Martínez-Lacaci I, Barberá VM, Soto JL, Carrasco-García E, Menéndez-Gutierrez MP, Castro-Galache MD, Ferragut JA, Saceda M.

Mol Cancer Ther. 2005 Aug;4(8):1222-30.


Regulation of heparin-binding EGF-like growth factor expression in Ha-ras transformed human mammary epithelial cells.

Martínez-Lacaci I, De Santis M, Kannan S, Bianco C, Kim N, Wallace-Jones B, Wechselberger C, Ebert AD, Salomon DS.

J Cell Physiol. 2001 Feb;186(2):233-42.


RAS transformation causes sustained activation of epidermal growth factor receptor and elevation of mitogen-activated protein kinase in human mammary epithelial cells.

Martínez-Lacaci I, Kannan S, De Santis M, Bianco C, Kim N, Wallace-Jones B, Ebert AD, Wechselberger C, Salomon DS.

Int J Cancer. 2000 Oct 1;88(1):44-52.


Cripto-1-induced increase in vimentin expression is associated with enhanced migration of human Caski cervical carcinoma cells.

Ebert AD, Wechselberger C, Nees M, Clair T, Schaller G, Martinez-Lacaci I, Wallace-Jones B, Bianco C, Weitzel HK, Salomon DS.

Exp Cell Res. 2000 May 25;257(1):223-9.


Cripto-1 induces apoptosis in HC-11 mouse mammary epithelial cells.

De Santis ML, Martinez-Lacaci I, Bianco C, Seno M, Wallace-Jones B, Kim N, Ebert A, Wechselberger C, Salomon DS.

Cell Death Differ. 2000 Feb;7(2):189-96.


Expression and function of EGF-related peptides and their receptors in gynecological cancer--from basic science to therapy.

Ebert AD, Wechselberger C, Martinez-Lacaci I, Bianco C, Weitzel HK, Salomon DS.

J Recept Signal Transduct Res. 2000 Jan;20(1):1-46. Review.


Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells.

Ebert AD, Wechselberger C, Frank S, Wallace-Jones B, Seno M, Martinez-Lacaci I, Bianco C, De Santis M, Weitzel HK, Salomon DS.

Cancer Res. 1999 Sep 15;59(18):4502-5.


Cripto-1 indirectly stimulates the tyrosine phosphorylation of erb B-4 through a novel receptor.

Bianco C, Kannan S, De Santis M, Seno M, Tang CK, Martinez-Lacaci I, Kim N, Wallace-Jones B, Lippman ME, Ebert AD, Wechselberger C, Salomon DS.

J Biol Chem. 1999 Mar 26;274(13):8624-9.


Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and phosphatidylinositol 3'-kinase-dependent pathway.

De Santis ML, Kannan S, Smith GH, Seno M, Bianco C, Kim N, Martinez-Lacaci I, Wallace-Jones B, Salomon DS.

Cell Growth Differ. 1997 Dec;8(12):1257-66.


Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.

Kannan S, De Santis M, Lohmeyer M, Riese DJ 2nd, Smith GH, Hynes N, Seno M, Brandt R, Bianco C, Persico G, Kenney N, Normanno N, Martinez-Lacaci I, Ciardiello F, Stern DF, Gullick WJ, Salomon DS.

J Biol Chem. 1997 Feb 7;272(6):3330-5.


Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells.

Martinez-Lacaci I, Johnson GR, Salomon DS, Dickson RB.

J Cell Physiol. 1996 Dec;169(3):497-508.


Dual regulation of the epidermal growth factor family of growth factors in breast cancer by sex steroids and protein kinase C.

Martinez-Lacaci I, Dickson RB.

J Steroid Biochem Mol Biol. 1996 Jan;57(1-2):1-11. Review.


Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines.

Martínez-Lacaci I, Saceda M, Plowman GD, Johnson GR, Normanno N, Salomon DS, Dickson RB.

Endocrinology. 1995 Sep;136(9):3983-92.


Growth factors in breast cancer: mitogenesis to transformation.

Dickson RB, Johnson MD, Bano M, Shi E, Kurebayashi J, Ziff B, Martinez-Lacaci I, Amundadottir LT, Lippman ME.

J Steroid Biochem Mol Biol. 1992 Sep;43(1-3):69-78. Review.


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