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Items: 9


Therapeutic efficacy of LN-1-255 in combination with imipenem in severe infection caused by carbapenem-resistant Acinetobacter baumannii.

Vázquez-Ucha JC, Martínez-Guitián M, Maneiro M, Conde-Pérez K, Álvarez-Fraga L, Torrens G, Oliver A, Buynak JD, Bonomo RA, Bou G, González-Bello C, Poza M, Beceiro A.

Antimicrob Agents Chemother. 2019 Aug 5. pii: AAC.01092-19. doi: 10.1128/AAC.01092-19. [Epub ahead of print]


Challenging antimicrobial susceptibility and evolution of resistance (OXA-681) during treatment of a Pseudomonas aeruginosa ST175 clone long-term nosocomial infection.

Arca-Suárez J, Fraile-Ribot P, Vázquez-Ucha JC, Cabot G, Martínez-Guitián M, Lence E, González-Bello C, Beceiro A, Rodríguez-Iglesias M, Galán-Sánchez F, Bou G, Oliver A.

Antimicrob Agents Chemother. 2019 Aug 5. pii: AAC.01110-19. doi: 10.1128/AAC.01110-19. [Epub ahead of print]


Draft Genome Sequences of Two Epidemic OXA-48-Producing Klebsiella pneumoniae Clinical Strains Isolated during a Large Outbreak in Spain.

Gato E, Álvarez-Fraga L, Vallejo JA, Rumbo-Feal S, Martínez-Guitián M, Beceiro A, Poza M, Bou G, Pérez A.

Genome Announc. 2018 Mar 29;6(13). pii: e00026-18. doi: 10.1128/genomeA.00026-18.


Pneumonia infection in mice reveals the involvement of the feoA gene in the pathogenesis of Acinetobacter baumannii.

Álvarez-Fraga L, Vázquez-Ucha JC, Martínez-Guitián M, Vallejo JA, Bou G, Beceiro A, Poza M.

Virulence. 2018 Jan 1;9(1):496-509. doi: 10.1080/21505594.2017.1420451.


Activity of the β-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D β-Lactamases from Acinetobacter baumannii.

Vázquez-Ucha JC, Maneiro M, Martínez-Guitián M, Buynak J, Bethel CR, Bonomo RA, Bou G, Poza M, González-Bello C, Beceiro A.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01172-17. doi: 10.1128/AAC.01172-17. Print 2017 Nov.


Assessment of antivirulence activity of several d-amino acids against Acinetobacter baumannii and Pseudomonas aeruginosa.

Rumbo C, Vallejo JA, Cabral MP, Martínez-Guitián M, Pérez A, Beceiro A, Bou G.

J Antimicrob Chemother. 2016 Dec;71(12):3473-3481. Epub 2016 Sep 7.


Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii.

Martínez-Guitián M, Vázquez-Ucha JC, Odingo J, Parish T, Poza M, Waite RD, Bou G, Wareham DW, Beceiro A.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4375-9. doi: 10.1128/AAC.00510-16. Print 2016 Jul.


LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

Vallejo JA, Martínez-Guitián M, Vázquez-Ucha JC, González-Bello C, Poza M, Buynak JD, Bethel CR, Bonomo RA, Bou G, Beceiro A.

J Antimicrob Chemother. 2016 Aug;71(8):2171-80. doi: 10.1093/jac/dkw105. Epub 2016 Apr 28.


Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.

González-Bello C, Tizón L, Lence E, Otero JM, van Raaij MJ, Martinez-Guitian M, Beceiro A, Thompson P, Hawkins AR.

J Am Chem Soc. 2015 Jul 29;137(29):9333-43. doi: 10.1021/jacs.5b04080. Epub 2015 Jul 16.


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