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Items: 42


2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype.

O'Neill S, Porter RK, McNamee N, Martinez VG, O'Driscoll L.

Sci Rep. 2019 Mar 7;9(1):3788. doi: 10.1038/s41598-019-39789-9.


Immunomodulatory effects of soluble CD5 on experimental tumor models.

Simões IT, Aranda F, Carreras E, Andrés MV, Casadó-Llombart S, Martinez VG, Lozano F.

Oncotarget. 2017 Nov 20;8(64):108156-108169. doi: 10.18632/oncotarget.22564. eCollection 2017 Dec 8.


Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles.

Martinez VG, O'Neill S, Salimu J, Breslin S, Clayton A, Crown J, O'Driscoll L.

Oncoimmunology. 2017 Aug 11;6(12):e1362530. doi: 10.1080/2162402X.2017.1362530. eCollection 2017.


Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.

Martinez VG, Ontoria-Oviedo I, Ricardo CP, Harding SE, Sacedon R, Varas A, Zapata A, Sepulveda P, Vicente A.

Stem Cell Res Ther. 2017 Sep 29;8(1):208. doi: 10.1186/s13287-017-0659-2.


BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer.

Martínez VG, Rubio C, Martínez-Fernández M, Segovia C, López-Calderón F, Garín MI, Teijeira A, Munera-Maravilla E, Varas A, Sacedón R, Guerrero F, Villacampa F, de la Rosa F, Castellano D, López-Collazo E, Paramio JM, Vicente Á, Dueñas M.

Clin Cancer Res. 2017 Dec 1;23(23):7388-7399. doi: 10.1158/1078-0432.CCR-17-1004. Epub 2017 Sep 19.


Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer.

Martinez VG, Crown J, Porter RK, O'Driscoll L.

Int J Cancer. 2017 Jun 15;140(12):2771-2784. doi: 10.1002/ijc.30705.


Characterization of human fibroblastic reticular cells as potential immunotherapeutic tools.

Valencia J, Jiménez E, Martínez VG, Del Amo BG, Hidalgo L, Entrena A, Fernández-Sevilla LM, Del Río F, Varas A, Vicente Á, Sacedón R.

Cytotherapy. 2017 May;19(5):640-653. doi: 10.1016/j.jcyt.2017.01.010. Epub 2017 Mar 2.


CD6 modulates thymocyte selection and peripheral T cell homeostasis.

Orta-Mascaró M, Consuegra-Fernández M, Carreras E, Roncagalli R, Carreras-Sureda A, Alvarez P, Girard L, Simões I, Martínez-Florensa M, Aranda F, Merino R, Martínez VG, Vicente R, Merino J, Sarukhan A, Malissen M, Malissen B, Lozano F.

J Exp Med. 2016 Jul 25;213(8):1387-97. doi: 10.1084/jem.20151785. Epub 2016 Jul 4.


miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity.

O'Brien K, Lowry MC, Corcoran C, Martinez VG, Daly M, Rani S, Gallagher WM, Radomski MW, MacLeod RA, O'Driscoll L.

Oncotarget. 2015 Oct 20;6(32):32774-89. doi: 10.18632/oncotarget.5192.


Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes.

Varas A, Valencia J, Lavocat F, Martínez VG, Thiam NN, Hidalgo L, Fernández-Sevilla LM, Sacedón R, Vicente A, Miossec P.

Arthritis Res Ther. 2015 Jul 28;17:192. doi: 10.1186/s13075-015-0710-6.


The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.

Martínez VG, Sacedón R, Hidalgo L, Valencia J, Fernández-Sevilla LM, Hernández-López C, Vicente A, Varas A.

PLoS One. 2015 Jun 25;10(6):e0131453. doi: 10.1371/journal.pone.0131453. eCollection 2015.


A discrete population of IFN λ-expressing BDCA3hi dendritic cells is present in human thymus.

Martínez VG, Canseco NM, Hidalgo L, Valencia J, Entrena A, Fernández-Sevilla LM, Hernández-López C, Sacedón R, Vicente A, Varas A.

Immunol Cell Biol. 2015 Aug;93(7):673-8. doi: 10.1038/icb.2015.22. Epub 2015 Mar 10.


Neuromedin U: a multifunctional neuropeptide with pleiotropic roles.

Martinez VG, O'Driscoll L.

Clin Chem. 2015 Mar;61(3):471-82. doi: 10.1373/clinchem.2014.231753. Epub 2015 Jan 20. Review.


Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-γ production by CD4+ T cells.

Valencia J, Martínez VG, Hidalgo L, Hernández-López C, Canseco NM, Vicente A, Varas A, Sacedón R.

Immunol Lett. 2014 Nov;162(1 Pt A):188-99. doi: 10.1016/j.imlet.2014.08.015. Epub 2014 Sep 6.


Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.

Robson NC, Hidalgo L, Mc Alpine T, Wei H, Martínez VG, Entrena A, Melen GJ, MacDonald AS, Phythian-Adams A, Sacedón R, Maraskovsky E, Cebon J, Ramírez M, Vicente A, Varas A.

Cancer Res. 2014 Sep 15;74(18):5019-5031. doi: 10.1158/0008-5472.CAN-13-2845. Epub 2014 Jul 18.


Modulation of CD6 function through interaction with Galectin-1 and -3.

Escoda-Ferran C, Carrasco E, Caballero-Baños M, Miró-Julià C, Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Liu FT, Lozano F.

FEBS Lett. 2014 Aug 25;588(17):2805-13. doi: 10.1016/j.febslet.2014.05.064. Epub 2014 Jun 16.


The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression.

Martinez VG, Escoda-Ferran C, Tadeu Simões I, Arai S, Orta Mascaró M, Carreras E, Martínez-Florensa M, Yelamos J, Miyazaki T, Lozano F.

Cell Mol Immunol. 2014 Jul;11(4):343-54. doi: 10.1038/cmi.2014.12. Epub 2014 Mar 3.


Autocrine activation of canonical BMP signaling regulates PD-L1 and PD-L2 expression in human dendritic cells.

Martínez VG, Hidalgo L, Valencia J, Hernández-López C, Entrena A, del Amo BG, Zapata AG, Vicente A, Sacedón R, Varas A.

Eur J Immunol. 2014 Apr;44(4):1031-8. doi: 10.1002/eji.201343693. Epub 2014 Feb 16.


Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses.

Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, Alberola-Ila J, Ramos-Casals M, Soldevila G, Raman C, Merino J, Merino R, Engel P, Lozano F.

PLoS One. 2014 Jan 15;9(1):e84895. doi: 10.1371/journal.pone.0084895. eCollection 2014.


Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6.

Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F.

J Infect Dis. 2014 Apr 1;209(7):1077-86. doi: 10.1093/infdis/jit624. Epub 2013 Nov 21.


Identification of functionally relevant phoshorylatable serine clusters in the cytoplasmic region of the human CD6 lymphocyte surface receptor.

Bonet L, Farnós M, Martínez-Florensa M, Martínez VG, Lozano F.

FEBS Lett. 2013 Jul 11;587(14):2205-13. doi: 10.1016/j.febslet.2013.05.043. Epub 2013 May 24.


Expression of BMPRIA on human thymic NK cell precursors: role of BMP signaling in intrathymic NK cell development.

Hidalgo L, Martínez VG, Valencia J, Hernández-López C, Vázquez MN, Nuñez JR, Zapata AG, Sacedón R, Varas A, Vicente A.

Blood. 2012 Feb 23;119(8):1861-71. doi: 10.1182/blood-2011-07-370650. Epub 2011 Dec 30.


Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer.

Barron N, Keenan J, Gammell P, Martinez VG, Freeman A, Masters JR, Clynes M.

Prostate. 2012 Aug 1;72(11):1193-9. doi: 10.1002/pros.22469. Epub 2011 Dec 7.


Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features.

Valencia J, Hernández-López C, Martínez VG, Hidalgo L, Zapata AG, Vicente Á, Varas A, Sacedón R.

J Immunol. 2011 Oct 15;187(8):4129-39. doi: 10.4049/jimmunol.1101243. Epub 2011 Sep 14.


The conserved scavenger receptor cysteine-rich superfamily in therapy and diagnosis.

Martínez VG, Moestrup SK, Holmskov U, Mollenhauer J, Lozano F.

Pharmacol Rev. 2011 Dec;63(4):967-1000. doi: 10.1124/pr.111.004523. Epub 2011 Aug 31. Review.


Molecular and functional characterization of mouse S5D-SRCRB: a new group B member of the scavenger receptor cysteine-rich superfamily.

Miró-Julià C, Roselló S, Martínez VG, Fink DR, Escoda-Ferran C, Padilla O, Vázquez-Echeverría C, Espinal-Marin P, Pujades C, García-Pardo A, Vila J, Serra-Pagès C, Holmskov U, Yélamos J, Lozano F.

J Immunol. 2011 Feb 15;186(4):2344-54. doi: 10.4049/jimmunol.1000840. Epub 2011 Jan 7.


The canonical BMP signaling pathway is involved in human monocyte-derived dendritic cell maturation.

Martínez VG, Hernández-López C, Valencia J, Hidalgo L, Entrena A, Zapata AG, Vicente A, Sacedón R, Varas A.

Immunol Cell Biol. 2011 Jul;89(5):610-8. doi: 10.1038/icb.2010.135. Epub 2010 Nov 23.


Physician counseling of pregnant women about active and secondhand smoking in Argentina.

Mejia R, Martinez VG, Gregorich SE, Pérez-Stable EJ.

Acta Obstet Gynecol Scand. 2010;89(4):490-5. doi: 10.3109/00016341003739567.


The CXCL12/CXCR4 pair in aged human thymus.

Hernández-López C, Varas A, Sacedón R, Martínez VG, Hidalgo L, Valencia J, Zapata AG, Vicente A.

Neuroimmunomodulation. 2010;17(3):217-20. doi: 10.1159/000258728. Epub 2010 Feb 4.


Filamin B plays a key role in vascular endothelial growth factor-induced endothelial cell motility through its interaction with Rac-1 and Vav-2.

Del Valle-Pérez B, Martínez VG, Lacasa-Salavert C, Figueras A, Shapiro SS, Takafuta T, Casanovas O, Capellà G, Ventura F, Viñals F.

J Biol Chem. 2010 Apr 2;285(14):10748-60. doi: 10.1074/jbc.M109.062984. Epub 2010 Jan 28.


Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors.

Valencia J, Hernández-López C, Martínez VG, Hidalgo L, Zapata AG, Vicente A, Varas A, Sacedón R.

J Leukoc Biol. 2010 Mar;87(3):405-14. doi: 10.1189/jlb.0509344. Epub 2009 Dec 1.


Interplay between BMP4 and IL-7 in human intrathymic precursor cells.

Varas A, Sacedón R, Hidalgo L, Martínez VG, Valencia J, Cejalvo T, Zapata A, Hernández-López C, Vicente A.

Cell Cycle. 2009 Dec 15;8(24):4119-26. Epub 2009 Dec 21.


An unusual way of diagnosing sickle-cell disease.

Berend K, de Martinez VG, Schnog JJ.

Am J Hematol. 2009 Jun;84(6):371. doi: 10.1002/ajh.21299. No abstract available.


CXCL12/CXCR4 signaling promotes human thymic dendritic cell survival regulating the Bcl-2/Bax ratio.

Hernández-López C, Valencia J, Hidalgo L, Martínez VG, Zapata AG, Sacedón R, Varas A, Vicente A.

Immunol Lett. 2008 Oct 30;120(1-2):72-8. doi: 10.1016/j.imlet.2008.07.006. Epub 2008 Aug 8.


Effects of nerve injury and segmental regeneration on the cellular correlates of neural morphallaxis.

Martinez VG, Manson JM, Zoran MJ.

J Exp Zool B Mol Dev Evol. 2008 Sep 15;310(6):520-33. doi: 10.1002/jez.b.21224.


Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling.

Varas A, Hernández-López C, Valencia J, Mattavelli S, Martínez VG, Hidalgo L, Gutiérrez-Frías C, Zapata AG, Sacedón R, Vicente A.

J Leukoc Biol. 2008 Jun;83(6):1476-83. doi: 10.1189/jlb.1107792. Epub 2008 Mar 11.


CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance.

Martinez VG, O'Connor R, Liang Y, Clynes M.

Br J Cancer. 2008 Feb 12;98(3):564-70. doi: 10.1038/sj.bjc.6604195. Epub 2008 Jan 22.


Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved.

Martinez VG, Williams KJ, Stratford IJ, Clynes M, O'Connor R.

Toxicol In Vitro. 2008 Apr;22(3):582-8. doi: 10.1016/j.tiv.2007.11.017. Epub 2007 Dec 7.


Age-related changes in climbing behavior and neural circuit physiology in Drosophila.

Martinez VG, Javadi CS, Ngo E, Ngo L, Lagow RD, Zhang B.

Dev Neurobiol. 2007 May;67(6):778-91.


Galectin-1, a cell adhesion modulator, induces apoptosis of rat Leydig cells in vitro.

Martinez VG, Pellizzari EH, Díaz ES, Cigorraga SB, Lustig L, Denduchis B, Wolfenstein-Todel C, Iglesias MM.

Glycobiology. 2004 Feb;14(2):127-37. Epub 2003 Nov 24.


Mapping of the Prostaglandin-Endoperoxide Synthase 2 (PTGS2) gene to porcine chromosome 9 and bovine chromosome 16 by linkage analysis using novel PCR-RFLP.

Gladney CD, Martinez VG, Brumbaugh KA, DeGroot BJ, Linville RC, Oommen AM, Huebinger RM, Messer LA, Allan MF, Pomp D.

J Anim Sci. 1999 Mar;77(3):787-8. No abstract available.


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