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Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes.

Martinez SE, Bauman JD, Das K, Arnold E.

Protein Sci. 2019 Mar;28(3):587-597. doi: 10.1002/pro.3559. Epub 2018 Dec 22.


NextGen Voices: Quality mentoring.

Segal L, Agarwal D, Isaacson KJ, Oehmke TB, Kumar B, Chen JS, Cusimano JM, Negi S, Tiper I, Bakermans AJ, Jensen MM, Sanganyado E, Zaidi SS, Romero-Molina C, Martínez SE, Anderson SM, Santos GM, De Lella Ezcurra AL, Farragher J, Sharma V, Duncan G, Dutton-Regester K, Kim SA, Yu S, Schwendimann BA, Reichardt JKV, Halder A, Dennis AF, Ellwanger JH, Chiu YH, Kerman BE.

Science. 2018 Oct 5;362(6410):22-24. doi: 10.1126/science.aav5914. No abstract available.


Effects of low-level laser therapy on bone healing and signs of pain in dogs following tibial plateau leveling osteotomy.

Kennedy KC, Martinez SA, Martinez SE, Tucker RL, Davies NM.

Am J Vet Res. 2018 Aug;79(8):893-904. doi: 10.2460/ajvr.79.8.893.


Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids.

Novaes JT, Lillico R, Sayre CL, Nagabushnam K, Majeed M, Chen Y, Ho EA, Oliveira ALP, Martinez SE, Alrushaid S, Davies NM, Lakowski TM.

Pharmaceutics. 2017 Oct 12;9(4). pii: E45. doi: 10.3390/pharmaceutics9040045.


Pharmacokinetic Analysis of an Oral Multicomponent Joint Dietary Supplement (Phycox®) in Dogs.

Martinez SE, Lillico R, Lakowski TM, Martinez SA, Davies NM.

Pharmaceutics. 2017 Aug 18;9(3). pii: E30. doi: 10.3390/pharmaceutics9030030.


[Reversible posterior leukoencephalopathy syndrome].

Martínez SE, García Contreras ML, Manzella DJ, Brugnolo MR, Raab LA, Dobarro M.

Medicina (B Aires). 2017;77(3):233. Spanish. No abstract available.


Stereospecific pharmacokinetic characterization of liquiritigenin in the rat.

Alrushaid S, Davies NM, Martinez SE, Sayre CL.

Res Pharm Sci. 2017 Jun;12(3):176-186. doi: 10.4103/1735-5362.207197.


Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.

Das K, Martinez SE, Arnold E.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00224-17. doi: 10.1128/AAC.00224-17. Print 2017 Jun.


Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice.

Alrushaid S, Davies NM, Martinez SE, Sayre CL.

Res Pharm Sci. 2016 Oct;11(5):355-365.


Calebin A: Analytical Development for Pharmacokinetics Study, Elucidation of Pharmacological Activities and Content Analysis of Natural Health Products.

Oliveira AL, Martinez SE, Nagabushnam K, Majeed M, Alrushaid S, Sayre CL, Davies NM.

J Pharm Pharm Sci. 2015;18(4):494-514.


Pre-Clinical Pharmacokinetic and Pharmacodynamic Characterization of Selected Chiral Flavonoids: Pinocembrin and Pinostrobin.

Sayre CL, Alrushaid S, Martinez SE, Anderson HD, Davies NM.

J Pharm Pharm Sci. 2015;18(4):368-95.


Enantiospecific pharmacokinetics of isoxanthohumol and its metabolite 8-prenylnaringenin in the rat.

Martinez SE, Davies NM.

Mol Nutr Food Res. 2015 Sep;59(9):1674-89. doi: 10.1002/mnfr.201500118. Epub 2015 Jul 1.


Preclinical Pharmacokinetics and Pharmacodynamics and Content Analysis of Gnetol in Foodstuffs.

Remsberg CM, Martinez SE, Akinwumi BC, Anderson HD, Takemoto JK, Sayre CL, Davies NM.

Phytother Res. 2015 Aug;29(8):1168-79. doi: 10.1002/ptr.5363. Epub 2015 May 4.


Polymorphisms rs12998 and rs5780218 in KiSS1 suppressor metastasis gene in Mexican patients with breast cancer.

Quevedo EG, Aguilar GM, Aguilar LA, Rubio SA, Martínez SE, Rodríguez IP, Corona JS, Morán MI, Gómez RC, Moguel MC.

Dis Markers. 2015;2015:365845. doi: 10.1155/2015/365845. Epub 2015 Feb 24.


Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.

Balzarini J, Das K, Bernatchez JA, Martinez SE, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Vande Voorde J, Liekens S, Naesens L, Götte M, Maguire AR, Arnold E.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3475-80. doi: 10.1073/pnas.1420233112. Epub 2015 Mar 2.


Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.

Das K, Martinez SE, Bandwar RP, Arnold E.

Nucleic Acids Res. 2014 Jul;42(12):8125-37. doi: 10.1093/nar/gku487. Epub 2014 May 31.


Pharmacometrics of 3-methoxypterostilbene: a component of traditional chinese medicinal plants.

Martinez SE, Sayre CL, Davies NM.

Evid Based Complement Alternat Med. 2013;2013:261468. doi: 10.1155/2013/261468. Epub 2013 Apr 16.


Chiral analytical method development and application to pre-clinical pharmacokinetics of pinocembrin.

Sayre CL, Takemoto JK, Martinez SE, Davies NM.

Biomed Chromatogr. 2013 Jun;27(6):681-4. doi: 10.1002/bmc.2853. Epub 2012 Dec 5.


Stereospecific analytical method development and preliminary in vivo pharmacokinetic characterization of pinostrobin in the rat.

Sayre CL, Zhang Y, Martinez SE, Takemoto JK, Davies NM.

Biomed Chromatogr. 2013 May;27(5):548-50. doi: 10.1002/bmc.2834. Epub 2012 Oct 15.


Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)-b-poly(DL-lactic acid) micelle nanocarriers: characterization and effects on pharmacokinetics in rat serum and urine.

Mohamed EA, Zhao Y, Meshali MM, Remsberg CM, Borg TM, Foda AM, Takemoto JK, Sayre CL, Martinez SE, Davies NM, Forrest ML.

J Pharm Sci. 2012 Oct;101(10):3787-98. doi: 10.1002/jps.23265. Epub 2012 Jul 17.


Hyperuricemic renal failure in nonhematologic solid tumors: a case report and review of the literature.

Saini N, Pyo Lee K, Jha S, Patel S, Bonthu N, Kansagra A, Bhatia A, Martinez SE, Patel J, Altamimi S, Ghotb S.

Case Rep Med. 2012;2012:314056. doi: 10.1155/2012/314056. Epub 2012 May 27.


Analysis of 3-methoxypterostilbene in biological fluids by high-performance liquid chromatography: application to pre-clinical pharmacokinetics.

Martinez SE, Sayre CL, Davies NM.

Biomed Chromatogr. 2013 Jan;27(1):67-72. doi: 10.1002/bmc.2749. Epub 2012 May 22.


Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: a review.

Joya X, Friguls B, Ortigosa S, Papaseit E, Martínez SE, Manich A, Garcia-Algar O, Pacifici R, Vall O, Pichini S.

J Pharm Biomed Anal. 2012 Oct;69:209-22. doi: 10.1016/j.jpba.2012.01.006. Epub 2012 Jan 16. Review.


HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.

Das K, Martinez SE, Bauman JD, Arnold E.

Nat Struct Mol Biol. 2012 Jan 22;19(2):253-9. doi: 10.1038/nsmb.2223.


Pharmacokinetics of oral rufinamide in dogs.

Wright HM, Chen AV, Martinez SE, Davies NM.

J Vet Pharmacol Ther. 2012 Dec;35(6):529-33. doi: 10.1111/j.1365-2885.2011.01353.x. Epub 2011 Dec 2.


High-performance liquid chromatographic analysis of lacosamide in canine serum using ultraviolet detection: application to pre-clinical pharmacokinetics in dogs.

Martinez SE, Bowen KA, Remsberg CM, Takemoto JK, Wright HM, Chen-Allen AV, Davies NM.

Biomed Chromatogr. 2012 May;26(5):606-9. doi: 10.1002/bmc.1704. Epub 2011 Sep 6.


Silver sub-nanoclusters electrocatalyze ethanol oxidation and provide protection against ethanol toxicity in cultured mammalian cells.

Selva J, Martínez SE, Buceta D, Rodríguez-Vázquez MJ, Blanco MC, López-Quintela MA, Egea G.

J Am Chem Soc. 2010 May 26;132(20):6947-54. doi: 10.1021/ja907988s.


The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change.

Martinez SE, Heikaus CC, Klevit RE, Beavo JA.

J Biol Chem. 2008 Sep 19;283(38):25913-9. doi: 10.1074/jbc.M802891200. Epub 2008 Jul 9.


Novel molecular targets for the prevention of fetal alcohol syndrome.

Martínez SE, Egea G.

Recent Pat CNS Drug Discov. 2007 Jan;2(1):23-35. Review.


Variable actin dynamics requirement for the exit of different cargo from the trans-Golgi network.

Lázaro-Diéguez F, Colonna C, Cortegano M, Calvo M, Martínez SE, Egea G.

FEBS Lett. 2007 Aug 7;581(20):3875-81. Epub 2007 Jul 17.


Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.

Fernández-Ulibarri I, Vilella M, Lázaro-Diéguez F, Sarri E, Martínez SE, Jiménez N, Claro E, Mérida I, Burger KN, Egea G.

Mol Biol Cell. 2007 Sep;18(9):3250-63. Epub 2007 Jun 13.


Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol.

Martínez SE, Lázaro-Diéguez F, Selva J, Calvo F, Piqueras JR, Crespo P, Claro E, Egea G.

J Neurochem. 2007 Aug;102(4):1044-52. Epub 2007 Apr 17.


MAPK interacts with XGef and is required for CPEB activation during meiosis in Xenopus oocytes.

Keady BT, Kuo P, Martínez SE, Yuan L, Hake LE.

J Cell Sci. 2007 Mar 15;120(Pt 6):1093-103.


Genetic diversity of the IL-4, IL-4 receptor and IL-13 loci in mestizos in the general population and in patients with asthma from three subpopulations in Mexico.

López KI, Martínez SE, Moguel MC, Romero LT, Figueroa CS, Pacheco GV, Ibarra B, Corona JS.

Int J Immunogenet. 2007 Feb;34(1):27-33.


EcoRI polymorphism of the metastasis-suppressor gene NME1 in Mexican patients with breast cancer.

Rubio SA, Martinez SE, Corona JS, Ruiz AP, Rincon AE, Lagunas IA, Camacho JG, Moguel MC.

Breast Cancer Res Treat. 2006 Mar;96(2):159-61. Epub 2005 Nov 30.


Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization.

Martinez SE, Bruder S, Schultz A, Zheng N, Schultz JE, Beavo JA, Linder JU.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3082-7. Epub 2005 Feb 11.


The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites.

Bruder S, Linder JU, Martinez SE, Zheng N, Beavo JA, Schultz JE.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3088-92. Epub 2005 Feb 11.


XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.

Martínez SE, Yuan L, Lacza C, Ransom H, Mahon GM, Whitehead IP, Hake LE.

Mol Biol Cell. 2005 Mar;16(3):1152-64. Epub 2005 Jan 5.


Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase.

Huang D, Hinds TR, Martinez SE, Doneanu C, Beavo JA.

J Biol Chem. 2004 Nov 12;279(46):48143-51. Epub 2004 Aug 25.


Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A.

Wu AY, Tang XB, Martinez SE, Ikeda K, Beavo JA.

J Biol Chem. 2004 Sep 3;279(36):37928-38. Epub 2004 Jun 21.


The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina.

Martras S, Alvarez R, Martínez SE, Torres D, Gallego O, Duester G, Farrés J, de Lera AR, Parés X.

Eur J Biochem. 2004 May;271(9):1660-70.


Prevalence of dementia and Alzheimer's disease in elders of nursing homes and a senior center of Durango City, Mexico.

Alvarado-Esquivel C, Hernández-Alvarado AB, Tapia-Rodríguez RO, Guerrero-Iturbe A, Rodríguez-Corral K, Martínez SE.

BMC Psychiatry. 2004 Feb 18;4:3.


GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides.

Martinez SE, Beavo JA, Hol WG.

Mol Interv. 2002 Sep;2(5):317-23. Review.


Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract.

Vaglenova J, Martínez SE, Porté S, Duester G, Farrés J, Parés X.

Eur J Biochem. 2003 Jun;270(12):2652-62.


The GAFa domains of rod cGMP-phosphodiesterase 6 determine the selectivity of the enzyme dimerization.

Muradov KG, Boyd KK, Martinez SE, Beavo JA, Artemyev NO.

J Biol Chem. 2003 Mar 21;278(12):10594-601. Epub 2003 Jan 16.


The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.

Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13260-5. Epub 2002 Sep 23.


Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and retinoid metabolism.

Martínez SE, Vaglenova J, Sabrià J, Martínez MC, Farrés J, Parés X.

Eur J Biochem. 2001 Oct;268(19):5045-56.

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