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Items: 36

1.

A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia.

Marín-Ramos NI, Balabasquer M, Ortega-Nogales FJ, Torrecillas IR, Gil-Ordóñez A, Marcos-Ramiro B, Aguilar-Garrido P, Cushman I, Romero A, Medrano FJ, Gajate C, Mollinedo F, Philips MR, Campillo M, Gallardo M, Martín-Fontecha M, López-Rodríguez ML, Ortega-Gutiérrez S.

J Med Chem. 2019 Jul 11;62(13):6035-6046. doi: 10.1021/acs.jmedchem.9b00145. Epub 2019 Jun 19.

PMID:
31181882
2.

Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination.

Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-García Á, Martín-Fontecha M, Pérez-Cerdá F, Sánchez-Gómez MV, Ortega-Gutiérrez S, Brown JM, Hsu KL, Cravatt B, Matute C, Mato S.

Biochem Pharmacol. 2018 Nov;157:189-201. doi: 10.1016/j.bcp.2018.07.042. Epub 2018 Aug 1.

PMID:
30075103
3.

Monoacylglycerol lipase (MAGL) as a promising therapeutic target.

Gil-Ordóñez A, Martín-Fontecha M, Ortega-Gutiérrez S, López-Rodríguez ML.

Biochem Pharmacol. 2018 Nov;157:18-32. doi: 10.1016/j.bcp.2018.07.036. Epub 2018 Jul 27. Review.

PMID:
30059673
4.

Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5-HT1A Receptor in Native Cells of the Immune System.

Hernández-Torres G, Enríquez-Palacios E, Mecha M, Feliú A, Rueda-Zubiaurre A, Angelina A, Martín-Cruz L, Martín-Fontecha M, Palomares O, Guaza C, Peña-Cabrera E, López-Rodríguez ML, Ortega-Gutiérrez S.

Bioconjug Chem. 2018 Jun 20;29(6):2021-2027. doi: 10.1021/acs.bioconjchem.8b00228. Epub 2018 May 14.

PMID:
29733594
5.

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes.

Camicia F, Celentano AM, Johns ME, Chan JD, Maldonado L, Vaca H, Di Siervi N, Kamentezky L, Gamo AM, Ortega-Gutierrez S, Martin-Fontecha M, Davio C, Marchant JS, Rosenzvit MC.

PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006267. doi: 10.1371/journal.pntd.0006267. eCollection 2018 Feb.

6.

A Fluorescent Probe to Unravel Functional Features of Cannabinoid Receptor CB1 in Human Blood and Tonsil Immune System Cells.

Martín-Fontecha M, Angelina A, Rückert B, Rueda-Zubiaurre A, Martín-Cruz L, van de Veen W, Akdis M, Ortega-Gutiérrez S, López-Rodríguez ML, Akdis CA, Palomares O.

Bioconjug Chem. 2018 Feb 21;29(2):382-389. doi: 10.1021/acs.bioconjchem.7b00680. Epub 2018 Jan 22.

PMID:
29314831
7.

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells.

Palomares O, Akdis M, Martín-Fontecha M, Akdis CA.

Immunol Rev. 2017 Jul;278(1):219-236. doi: 10.1111/imr.12555. Review.

PMID:
28658547
8.

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors.

Artola M, Ruíz-Avila LB, Ramírez-Aportela E, Martínez RF, Araujo-Bazán L, Vázquez-Villa H, Martín-Fontecha M, Oliva MA, Martín-Galiano AJ, Chacón P, López-Rodríguez ML, Andreu JM, Huecas S.

Chem Sci. 2017 Feb 1;8(2):1525-1534. doi: 10.1039/c6sc03792e. Epub 2016 Oct 21.

9.

Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma.

Rodriguez-Perez N, Schiavi E, Frei R, Ferstl R, Wawrzyniak P, Smolinska S, Sokolowska M, Sievi NA, Kohler M, Schmid-Grendelmeier P, Michalovich D, Simpson KD, Hessel EM, Jutel M, Martin-Fontecha M, Palomares O, Akdis CA, O'Mahony L.

Allergy. 2017 Nov;72(11):1744-1752. doi: 10.1111/all.13180. Epub 2017 May 10.

10.

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

González-Vera JA, Medina RA, Martín-Fontecha M, Gonzalez A, de la Fuente T, Vázquez-Villa H, García-Cárceles J, Botta J, McCormick PJ, Benhamú B, Pardo L, López-Rodríguez ML.

Sci Rep. 2017 Jan 24;7:41293. doi: 10.1038/srep41293.

11.

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

Marín-Ramos NI, Piñar C, Vázquez-Villa H, Martín-Fontecha M, González Á, Canales Á, Algar S, Mayo PP, Jiménez-Barbero J, Gajate C, Mollinedo F, Pardo L, Ortega-Gutiérrez S, Viso A, López-Rodríguez ML.

Chemistry. 2017 Jan 31;23(7):1676-1685. doi: 10.1002/chem.201604905. Epub 2016 Dec 27.

PMID:
27885731
12.

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.

Gamo AM, González-Vera JA, Rueda-Zubiaurre A, Alonso D, Vázquez-Villa H, Martín-Couce L, Palomares Ó, López JA, Martín-Fontecha M, Benhamú B, López-Rodríguez ML, Ortega-Gutiérrez S.

Chemistry. 2016 Jan 22;22(4):1313-21. doi: 10.1002/chem.201503101. Epub 2015 Nov 12.

PMID:
26560738
13.

Auranofin efficacy against MDR Streptococcus pneumoniae and Staphylococcus aureus infections.

Aguinagalde L, Díez-Martínez R, Yuste J, Royo I, Gil C, Lasa Í, Martín-Fontecha M, Marín-Ramos NI, Ardanuy C, Liñares J, García P, García E, Sánchez-Puelles JM.

J Antimicrob Chemother. 2015 Sep;70(9):2608-17. doi: 10.1093/jac/dkv163. Epub 2015 Jul 4.

PMID:
26142477
14.

New inhibitors of angiogenesis with antitumor activity in vivo.

Marín-Ramos NI, Alonso D, Ortega-Gutiérrez S, Ortega-Nogales FJ, Balabasquer M, Vázquez-Villa H, Andradas C, Blasco-Benito S, Pérez-Gómez E, Canales Á, Jiménez-Barbero J, Marquina A, del Prado JM, Sánchez C, Martín-Fontecha M, López-Rodríguez ML.

J Med Chem. 2015 May 14;58(9):3757-66. doi: 10.1021/jm5019252. Epub 2015 May 4.

PMID:
25906180
15.

Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action.

Artola M, Ruiz-Avila LB, Vergoñós A, Huecas S, Araujo-Bazán L, Martín-Fontecha M, Vázquez-Villa H, Turrado C, Ramírez-Aportela E, Hoegl A, Nodwell M, Barasoain I, Chacón P, Sieber SA, Andreu JM, López-Rodríguez ML.

ACS Chem Biol. 2015 Mar 20;10(3):834-43. doi: 10.1021/cb500974d. Epub 2014 Dec 30.

PMID:
25486266
16.

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

Medina RA, Vázquez-Villa H, Gómez-Tamayo JC, Benhamú B, Martín-Fontecha M, de la Fuente T, Caltabiano G, Hedlund PB, Pardo L, López-Rodríguez ML.

J Med Chem. 2014 Aug 14;57(15):6879-84. doi: 10.1021/jm500880c. Epub 2014 Aug 5.

PMID:
25073094
17.

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β.

Palomares O, Martín-Fontecha M, Lauener R, Traidl-Hoffmann C, Cavkaytar O, Akdis M, Akdis CA.

Genes Immun. 2014 Dec;15(8):511-20. doi: 10.1038/gene.2014.45. Epub 2014 Jul 24. Review.

PMID:
25056447
18.

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Benhamú B, Martín-Fontecha M, Vázquez-Villa H, Pardo L, López-Rodríguez ML.

J Med Chem. 2014 Sep 11;57(17):7160-81. doi: 10.1021/jm5003952. Epub 2014 Jun 3. Review.

PMID:
24850589
19.

The expression of cannabinoid receptor 1 is significantly increased in atopic patients.

Martín-Fontecha M, Eiwegger T, Jartti T, Rueda-Zubiaurre A, Tiringer K, Stepanow J, Puhakka T, Rückert B, Ortega-Gutiérrez S, López-Rodríguez ML, Akdis M, Akdis CA, Palomares O.

J Allergy Clin Immunol. 2014 Mar;133(3):926-9.e2. doi: 10.1016/j.jaci.2013.12.1032. Epub 2014 Jan 31. No abstract available.

PMID:
24486070
20.

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

Valhondo M, Marco I, Martín-Fontecha M, Vázquez-Villa H, Ramos JA, Berkels R, Lauterbach T, Benhamú B, López-Rodríguez ML.

J Med Chem. 2013 Oct 24;56(20):7851-61. doi: 10.1021/jm400766k. Epub 2013 Oct 8.

PMID:
24050112
21.

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

Ruiz-Avila LB, Huecas S, Artola M, Vergoñós A, Ramírez-Aportela E, Cercenado E, Barasoain I, Vázquez-Villa H, Martín-Fontecha M, Chacón P, López-Rodríguez ML, Andreu JM.

ACS Chem Biol. 2013 Sep 20;8(9):2072-83. doi: 10.1021/cb400208z. Epub 2013 Jul 31.

PMID:
23855511
22.

Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade.

Bellocchio L, Soria-Gómez E, Quarta C, Metna-Laurent M, Cardinal P, Binder E, Cannich A, Delamarre A, Häring M, Martín-Fontecha M, Vega D, Leste-Lasserre T, Bartsch D, Monory K, Lutz B, Chaouloff F, Pagotto U, Guzman M, Cota D, Marsicano G.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4786-91. doi: 10.1073/pnas.1218573110. Epub 2013 Mar 4.

23.

Chemical probes for the recognition of cannabinoid receptors in native systems.

Martín-Couce L, Martín-Fontecha M, Palomares O, Mestre L, Cordomí A, Hernangomez M, Palma S, Pardo L, Guaza C, López-Rodríguez ML, Ortega-Gutiérrez S.

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6896-9. doi: 10.1002/anie.201200467. Epub 2012 Jun 11.

PMID:
22689411
24.

Mitochondrial CB₁ receptors regulate neuronal energy metabolism.

Bénard G, Massa F, Puente N, Lourenço J, Bellocchio L, Soria-Gómez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutiérrez S, Martín-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, López-Rodríguez ML, Grandes P, Rossignol R, Marsicano G.

Nat Neurosci. 2012 Mar 4;15(4):558-64. doi: 10.1038/nn.3053.

PMID:
22388959
25.

Targeting the assembly of bacterial cell division protein FtsZ with small molecules.

Schaffner-Barbero C, Martín-Fontecha M, Chacón P, Andreu JM.

ACS Chem Biol. 2012 Feb 17;7(2):269-77. doi: 10.1021/cb2003626. Epub 2011 Nov 15. Review.

PMID:
22047077
26.

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

Marco I, Valhondo M, Martín-Fontecha M, Vázquez-Villa H, Del Río J, Planas A, Sagredo O, Ramos JA, Torrecillas IR, Pardo L, Frechilla D, Benhamú B, López-Rodríguez ML.

J Med Chem. 2011 Dec 8;54(23):7986-99. doi: 10.1021/jm2007886. Epub 2011 Nov 11.

PMID:
22029386
27.

Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors.

Martín-Couce L, Martín-Fontecha M, Capolicchio S, López-Rodríguez ML, Ortega-Gutiérrez S.

J Med Chem. 2011 Jul 28;54(14):5265-9. doi: 10.1021/jm2004392. Epub 2011 Jun 27.

PMID:
21675776
28.

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

Alonso D, Vázquez-Villa H, Gamo AM, Martínez-Esperón MF, Tortosa M, Viso A, Fernández de la Pradilla R, Junquera E, Aicart E, Martín-Fontecha M, Benhamú B, López-Rodríguez ML, Ortega-Gutiérrez S.

ACS Med Chem Lett. 2010 May 14;1(6):249-53. doi: 10.1021/ml100053y. eCollection 2010 Sep 9.

29.

SmI2-mediated 3-exo-trig cyclization of β,γ-unsaturated carbonyl compounds: diastereoselective synthesis of cyclopropanols.

Martin-Fontecha M, Agarrabeitia AR, Ortiz MJ, Armesto D.

Org Lett. 2010 Sep 17;12(18):4082-5. doi: 10.1021/ol101666m.

PMID:
20707351
30.

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

de la Fuente T, Martín-Fontecha M, Sallander J, Benhamú B, Campillo M, Medina RA, Pellissier LP, Claeysen S, Dumuis A, Pardo L, López-Rodríguez ML.

J Med Chem. 2010 Feb 11;53(3):1357-69. doi: 10.1021/jm901672k.

PMID:
20078106
31.

Remarkable observations on triplet-sensitized reactions. the di-pi-methane rearrangement of acyclic 1,4-dienes in the triplet excited state.

Armesto D, Ortiz MJ, Agarrabeitia AR, Martin-Fontecha M, El-Boulifi N, Duran-Sampedro G, Enma D.

Org Lett. 2009 Sep 17;11(18):4148-51. doi: 10.1021/ol901636z.

PMID:
19685921
32.

Novel oxa-di-pi-methane and Norrish type I reactions in the S2 (pi,pi*) excited state of a series of beta,gamma-unsaturated ketones.

Armesto D, Ortiz MJ, Agarrabeitia AR, Martín-Fontecha M.

Org Lett. 2005 Jun 23;7(13):2687-90.

PMID:
15957922
33.

Influence of electron-donor sensitizers on SET-promoted photochemical reactions of beta,gamma-unsaturated aldehydes.

Armesto D, Ortiz MJ, Agarrabeitia AR, Martin-Fontecha M.

Org Lett. 2004 Jun 24;6(13):2261-4.

PMID:
15200335
34.
35.

Photochemical reactivity of 1-substituted-1-aza-1,4-dienes promoted by electron-acceptor sensitizers. Di-pi-methane rearrangements and alternative reactions via radical-cation intermediates.

Armesto D, Ortiz MJ, Agarrabeitia AR, Aparicio-Lara S, Martin-Fontecha M, Liras M, Martinez-Alcazar MP.

J Org Chem. 2002 Dec 27;67(26):9397-405.

PMID:
12492344
36.

Di-pi-methane reactions promoted by SET from electron-donor sensitizers.

Armesto D, Ortiz MJ, Agarrabeitia AR, Martin-Fontecha M.

J Am Chem Soc. 2001 Oct 10;123(40):9920-1. No abstract available.

PMID:
11583566

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