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Items: 31

1.

Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study.

Banerjee S, Oza AM, Birrer MJ, Hamilton EP, Hasan J, Leary A, Moore KN, Mackowiak-Matejczyk B, Pikiel J, Ray-Coquard I, Trask P, Lin K, Schuth E, Vaze A, Choi Y, Marsters JC, Maslyar DJ, Lemahieu V, Wang Y, Humke EW, Liu JF.

Ann Oncol. 2018 Apr 1;29(4):917-923. doi: 10.1093/annonc/mdy023.

PMID:
29401246
2.

Discovery and preclinical development of vismodegib.

Gould SE, Low JA, Marsters JC Jr, Robarge K, Rubin LL, de Sauvage FJ, Sutherlin DP, Wong H, Yauch RL.

Expert Opin Drug Discov. 2014 Aug;9(8):969-84. doi: 10.1517/17460441.2014.920816. Epub 2014 May 23. Review.

PMID:
24857041
3.

Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened.

Tang T, Tang JY, Li D, Reich M, Callahan CA, Fu L, Yauch RL, Wang F, Kotkow K, Chang KS, Shpall E, Wu A, Rubin LL, Marsters JC Jr, Epstein EH Jr, Caro I, de Sauvage FJ.

Clin Cancer Res. 2011 May 15;17(10):3378-87. doi: 10.1158/1078-0432.CCR-10-3370. Epub 2011 May 10.

4.

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.

Castanedo GM, Wang S, Robarge KD, Blackwood E, Burdick D, Chang C, Dijkgraaf GJ, Gould S, Gunzner J, Guichert O, Halladay J, Khojasteh C, Lee L, Marsters JC Jr, Murray L, Peterson D, Plise E, Salphati L, de Sauvage FJ, Wong S, Sutherlin DP.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6748-53. doi: 10.1016/j.bmcl.2010.08.134. Epub 2010 Sep 15.

PMID:
20875741
5.

Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.

Wong H, Theil FP, Cui Y, Marsters JC Jr, Khojasteh SC, Vernillet L, La H, Song X, Wang H, Morinello EJ, Deng Y, Hop CE.

Drug Metab Dispos. 2010 Jul;38(7):1029-38. doi: 10.1124/dmd.110.032680. Epub 2010 Apr 20.

PMID:
20406853
6.

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.

Wong H, Chen JZ, Chou B, Halladay JS, Kenny JR, La H, Marsters JC Jr, Plise E, Rudewicz PJ, Robarge K, Shin Y, Wong S, Zhang C, Khojasteh SC.

Xenobiotica. 2009 Nov;39(11):850-61. doi: 10.3109/00498250903180289.

PMID:
19845436
7.

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Mackey HM, Lum BL, Darbonne WC, Marsters JC Jr, de Sauvage FJ, Low JA.

N Engl J Med. 2009 Sep 17;361(12):1164-72. doi: 10.1056/NEJMoa0905360. Epub 2009 Sep 2.

8.

GDC-0449-a potent inhibitor of the hedgehog pathway.

Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, Jia W, Khojasteh C, Koehler MF, Kotkow K, La H, Lalonde RL, Lau K, Lee L, Marshall D, Marsters JC Jr, Murray LJ, Qian C, Rubin LL, Salphati L, Stanley MS, Stibbard JH, Sutherlin DP, Ubhayaker S, Wang S, Wong S, Xie M.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5576-81. doi: 10.1016/j.bmcl.2009.08.049. Epub 2009 Aug 15. Erratum in: Bioorg Med Chem Lett. 2010 Jan 15;20(2):771.

PMID:
19716296
9.

A paracrine requirement for hedgehog signalling in cancer.

Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ.

Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27.

PMID:
18754008
10.

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

Keating SM, Clark KR, Stefanich LD, Arellano F, Edwards CP, Bodary SC, Spencer SA, Gadek TR, Marsters JC Jr, Beresini MH.

Protein Sci. 2006 Feb;15(2):290-303. Epub 2005 Dec 29.

11.

CDK2/cyclinA inhibitors: targeting the cyclinA recruitment site with small molecules derived from peptide leads.

Castanedo G, Clark K, Wang S, Tsui V, Wong M, Nicholas J, Wickramasinghe D, Marsters JC Jr, Sutherlin D.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1716-20. Epub 2005 Dec 27.

PMID:
16384702
12.

A structure-based database of antibody variable domain diversity.

Bond CJ, Wiesmann C, Marsters JC Jr, Sidhu SS.

J Mol Biol. 2005 May 6;348(3):699-709.

PMID:
15826665
13.

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.

Burdick DJ, Marsters JC Jr, Aliagas-Martin I, Stanley M, Beresini M, Clark K, McDowell RS, Gadek TR.

Bioorg Med Chem Lett. 2004 May 3;14(9):2055-9.

PMID:
15080978
14.
15.

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.

Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1015-8.

PMID:
12643901
16.

Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.

Castanedo GM, Sailes FC, Dubree NJ, Nicholas JB, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Marsters JC Jr, Jackson DY, Sutherlin DP.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2913-7.

PMID:
12270174
17.

Selective detection of membrane proteins without antibodies: a mass spectrometric version of the Western blot.

Arnott D, Kishiyama A, Luis EA, Ludlum SG, Marsters JC Jr, Stults JT.

Mol Cell Proteomics. 2002 Feb;1(2):148-56.

18.

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.

Gerber HP, Malik AK, Solar GP, Sherman D, Liang XH, Meng G, Hong K, Marsters JC, Ferrara N.

Nature. 2002 Jun 27;417(6892):954-8.

PMID:
12087404
19.

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC Jr, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC.

Science. 2002 Feb 8;295(5557):1086-9.

20.

Synthesis of 3-Amino-l-CarboxymethyI-Benzodiazepine (BZA) Peptidomimetics.

Marsters JC Jr, Rawson TE.

Methods Mol Med. 1999;23:385-96. doi: 10.1385/0-89603-517-4:385.

PMID:
21380908
21.

Use of a prenylation inhibitor as a novel antiviral agent.

Glenn JS, Marsters JC Jr, Greenberg HB.

J Virol. 1998 Nov;72(11):9303-6.

22.
23.

Benzodiazepine peptidomimetic inhibitors of farnesyltransferase.

Marsters JC Jr, McDowell RS, Reynolds ME, Oare DA, Somers TC, Stanley MS, Rawson TE, Struble ME, Burdick DJ, Chan KS, et al.

Bioorg Med Chem. 1994 Sep;2(9):949-57.

PMID:
7712130
24.

Synthetic chimeras of mouse growth factor-associated glandular kallikreins. I. Kinetic properties.

Blaber M, Isackson PJ, Burnier JP, Marsters JC Jr, Bradshaw RA.

Protein Sci. 1993 Aug;2(8):1210-9.

25.

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.

James GL, Goldstein JL, Brown MS, Rawson TE, Somers TC, McDowell RS, Crowley CW, Lucas BK, Levinson AD, Marsters JC Jr.

Science. 1993 Jun 25;260(5116):1937-42.

PMID:
8316834
26.

Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation.

Brown MS, Goldstein JL, Paris KJ, Burnier JP, Marsters JC Jr.

Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8313-6.

27.

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates.

Shea RG, Marsters JC, Bischofberger N.

Nucleic Acids Res. 1990 Jul 11;18(13):3777-83.

28.

Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland.

Blaber M, Isackson PJ, Marsters JC Jr, Burnier JP, Bradshaw RA.

Biochemistry. 1989 Sep 19;28(19):7813-9.

PMID:
2611215
29.

More on general practitioners and orthodontics.

Marsters JC.

Am J Orthod Dentofacial Orthop. 1988 Sep;94(3):264. No abstract available.

PMID:
3166335
30.

Picosecond geminate recombination of nitrosylmyoglobins.

Jongeward KA, Marsters JC, Mitchell MJ, Magde D, Sharma VS.

Biochem Biophys Res Commun. 1986 Nov 14;140(3):962-6.

PMID:
3778495
31.

Tuning in to deaf children.

Marsters JC.

Dent Manage. 1979 Jul;19(7):40-4. No abstract available.

PMID:
162177

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