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Items: 45


Structural model of a2-subunit N-terminus and its binding interface for Arf-GEF CTH2: Implication for regulation of V-ATPase, CTH2 function and rational drug design.

Marshansky V, Hosokawa H, Merkulova M, Bakulina A, Dip PV, Thaker YR, Bjargava A, Tonra JR, Ausiello DA, Grüber G.

Curr Top Membr. 2019;83:77-106. doi: 10.1016/bs.ctm.2019.01.008. Epub 2019 Mar 22.


Ablation of the Stimulatory G Protein α-Subunit in Renal Proximal Tubules Leads to Parathyroid Hormone-Resistance With Increased Renal Cyp24a1 mRNA Abundance and Reduced Serum 1,25-Dihydroxyvitamin D.

Zhu Y, He Q, Aydin C, Rubera I, Tauc M, Chen M, Weinstein LS, Marshansky V, Jüppner H, Bastepe M.

Endocrinology. 2016 Feb;157(2):497-507. doi: 10.1210/en.2015-1639. Epub 2015 Dec 15.


Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.

Merkulova M, Păunescu TG, Azroyan A, Marshansky V, Breton S, Brown D.

Sci Rep. 2015 Oct 7;5:14827. doi: 10.1038/srep14827.


Eukaryotic V-ATPase: novel structural findings and functional insights.

Marshansky V, Rubinstein JL, Grüber G.

Biochim Biophys Acta. 2014 Jun;1837(6):857-79. doi: 10.1016/j.bbabio.2014.01.018. Epub 2014 Feb 4. Review.


Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone resistance owing to heterozygous Gαs disruption.

Turan S, Fernandez-Rebollo E, Aydin C, Zoto T, Reyes M, Bounoutas G, Chen M, Weinstein LS, Erben RG, Marshansky V, Bastepe M.

J Bone Miner Res. 2014 Mar;29(3):749-60. doi: 10.1002/jbmr.2070.


The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.

Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Grüber G, Marshansky V.

J Biol Chem. 2013 Feb 22;288(8):5896-913. doi: 10.1074/jbc.M112.409169. Epub 2013 Jan 3.


Solution structure of subunit a, a₁₀₄₋₃₆₃, of the Saccharomyces cerevisiae V-ATPase and the importance of its C-terminus in structure formation.

Dip PV, Saw WG, Roessle M, Marshansky V, Grüber G.

J Bioenerg Biomembr. 2012 Jun;44(3):341-50. doi: 10.1007/s10863-012-9442-3. Epub 2012 May 5.


Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.

Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1442-55. doi: 10.1152/ajpcell.00076.2010. Epub 2011 Feb 9.


Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo.

Liu Z, Segawa H, Aydin C, Reyes M, Erben RG, Weinstein LS, Chen M, Marshansky V, Fröhlich LF, Bastepe M.

Endocrinology. 2011 Apr;152(4):1222-33. doi: 10.1210/en.2010-1034. Epub 2011 Feb 8.


Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ.

Zhuang Z, Marshansky V, Breton S, Brown D.

Am J Physiol Renal Physiol. 2011 Jan;300(1):F199-206. doi: 10.1152/ajprenal.00513.2010. Epub 2010 Oct 27.


N-terminal domain of the V-ATPase a2-subunit displays integral membrane protein properties.

Merkulova M, McKee M, Dip PV, Grüber G, Marshansky V.

Protein Sci. 2010 Oct;19(10):1850-62. doi: 10.1002/pro.470.


The absence of a clathrin adapter confers unique polarity essential to proximal tubule function.

Schreiner R, Frindt G, Diaz F, Carvajal-Gonzalez JM, Perez Bay AE, Palmer LG, Marshansky V, Brown D, Philp NJ, Rodriguez-Boulan E.

Kidney Int. 2010 Aug;78(4):382-8. doi: 10.1038/ki.2010.166. Epub 2010 Jun 9.


Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.

Merkulova M, Bakulina A, Thaker YR, Grüber G, Marshansky V.

Biochim Biophys Acta. 2010 Aug;1797(8):1398-409. doi: 10.1016/j.bbabio.2010.02.009. Epub 2010 Feb 11.


Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking.

Brown D, Paunescu TG, Breton S, Marshansky V.

J Exp Biol. 2009 Jun;212(Pt 11):1762-72. doi: 10.1242/jeb.028803. Review.


Sensing, signaling and sorting events in kidney epithelial cell physiology.

Brown D, Breton S, Ausiello DA, Marshansky V.

Traffic. 2009 Mar;10(3):275-84. doi: 10.1111/j.1600-0854.2008.00867.x. Epub 2009 Jan 8. Review.


New insights into structure-function relationships between archeal ATP synthase (A1A0) and vacuolar type ATPase (V1V0).

Grüber G, Marshansky V.

Bioessays. 2008 Nov;30(11-12):1096-109. doi: 10.1002/bies.20827. Review.


The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function.

Marshansky V, Futai M.

Curr Opin Cell Biol. 2008 Aug;20(4):415-26. doi: 10.1016/ Epub 2008 May 27. Review.


The V-ATPase a2-subunit as a putative endosomal pH-sensor.

Marshansky V.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1092-9. Review.


V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.

Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V.

Nat Cell Biol. 2006 Feb;8(2):124-36. Epub 2006 Jan 15.


Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice.

Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G, Grasso L, Marshansky V, Bechoua S, Hurtado-Lorenzo A, Marcocci C, Brown D, McCluskey RT, Marinò M.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C1160-7. Epub 2005 Nov 23.


Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis.

Pietrement C, Sun-Wada GH, Silva ND, McKee M, Marshansky V, Brown D, Futai M, Breton S.

Biol Reprod. 2006 Jan;74(1):185-94. Epub 2005 Sep 28.


Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.

Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA.

Am J Physiol Cell Physiol. 2005 Jun;288(6):C1390-401. Epub 2005 Jan 26.


Renal vacuolar H+-ATPase.

Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP.

Physiol Rev. 2004 Oct;84(4):1263-314. Review.


Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.

Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D.

Am J Physiol Cell Physiol. 2004 Jul;287(1):C149-62. Epub 2004 Mar 10.


Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ.

El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V.

Am J Physiol Cell Physiol. 2004 Apr;286(4):C768-78. Epub 2003 Dec 18.


Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy.

Tremblay J, Chen H, Peng J, Kunes J, Vu MD, Der Sarkissian S, deBlois D, Bolton AE, Gaboury L, Marshansky V, Gouadon E, Hamet P.

Transplantation. 2002 Nov 27;74(10):1425-33.


Physiological importance of endosomal acidification: potential role in proximal tubulopathies.

Marshansky V, Ausiello DA, Brown D.

Curr Opin Nephrol Hypertens. 2002 Sep;11(5):527-37. Review.


Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.

Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W.

Brain Res Mol Brain Res. 2001 Nov 30;96(1-2):14-20.


Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.

Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V.

J Biol Chem. 2001 May 25;276(21):18540-50. Epub 2001 Feb 13.


Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells.

Marshansky V, Wang X, Bertrand R, Luo H, Duguid W, Chinnadurai G, Kanaan N, Vu MD, Wu J.

J Immunol. 2001 Mar 1;166(5):3130-42.


Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition.

Bagnis C, Marshansky V, Breton S, Brown D.

Am J Physiol Renal Physiol. 2001 Mar;280(3):F437-48.


Cytosolic phospholipase A(2) regulates golgi structure and modulates intracellular trafficking of membrane proteins.

Choukroun GJ, Marshansky V, Gustafson CE, McKee M, Hajjar RJ, Rosenzweig A, Brown D, Bonventre JV.

J Clin Invest. 2000 Oct;106(8):983-93.


RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.

Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM.

Mol Biol Cell. 2000 Sep;11(9):3155-68.


The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.

Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, Brown D.

J Biol Chem. 2000 Jun 16;275(24):18219-24.


Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney.

Londoño I, Marshansky V, Bourgoin S, Vinay P, Bendayan M.

Kidney Int. 1999 Apr;55(4):1407-16.


Receptor-mediated endocytosis in kidney proximal tubules: recent advances and hypothesis.

Marshansky V, Bourgoin S, Londoño I, Bendayan M, Maranda B, Vinay P.

Electrophoresis. 1997 Dec;18(14):2661-76. Review.


Identification of ADP-ribosylation factor-6 in brush-border membrane and early endosomes of human kidney proximal tubules.

Marshansky V, Bourgoin S, Londoño I, Bendayan M, Vinay P.

Electrophoresis. 1997 Mar-Apr;18(3-4):538-47.


Proton gradient formation in early endosomes from proximal tubules.

Marshansky V, Vinay P.

Biochim Biophys Acta. 1996 Oct 23;1284(2):171-80.


Isolation of heavy endosomes from dog proximal tubules in suspension.

Marshansky V, Fleser A, Noël J, Bourgoin S, Vinay P.

J Membr Biol. 1996 Sep;153(1):59-73.


Mechanisms of proximal proton secretion in BBM of herbivorous, omnivorous, and carnivorous species.

Duplain M, Noel J, Fleser A, Marshansky V, Gougoux A, Vinay P.

Am J Physiol. 1995 Jul;269(1 Pt 2):R104-12.


Cross-talk between the Na(+)-K(+)-ATPase and the H(+)-ATPase in proximal tubules in suspension.

Fleser A, Marshansky V, Duplain M, Noël J, Hoang A, Tejedor A, Vinay P.

Ren Physiol Biochem. 1995 May-Jun;18(3):140-52.


Regulation of lipid peroxidation by ATP synthetase substrates in rat liver mitochondria.

Marshansky VN, Yaguzhinsky LS.

Biochim Biophys Acta. 1986 May 21;876(3):567-71.


Relationships of respiratory chain and ATP-synthetase in energized mitochondria.

Krasinskaya IP, Marshansky VN, Dragunova SF, Yaguzhinsky LS.

FEBS Lett. 1984 Feb 13;167(1):176-80.

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