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Items: 1 to 50 of 96

1.

Patient-reported distress can aid clinical decision-making in idiopathic pulmonary fibrosis: analysis of the PROFILE cohort.

Stewart I, McKeever T, Braybrooke R, Oballa E, Simpson JK, Maher TM, Marshall RP, Lukey PT, Fahy WA, Jenkins G, Saini G.

Eur Respir J. 2019 May 9;53(5). pii: 1801925. doi: 10.1183/13993003.01925-2018. Print 2019 May.

PMID:
30846471
2.

A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis.

Lukey PT, Harrison SA, Yang S, Man Y, Holman BF, Rashidnasab A, Azzopardi G, Grayer M, Simpson JK, Bareille P, Paul L, Woodcock HV, Toshner R, Saunders P, Molyneaux PL, Thielemans K, Wilson FJ, Mercer PF, Chambers RC, Groves AM, Fahy WA, Marshall RP, Maher TM.

Eur Respir J. 2019 Mar 18;53(3). pii: 1801992. doi: 10.1183/13993003.01992-2018. Print 2019 Mar.

PMID:
30765508
3.

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.

Woodcock HV, Eley JD, Guillotin D, Platé M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC.

Nat Commun. 2019 Jan 2;10(1):6. doi: 10.1038/s41467-018-07858-8.

4.

Defining renal phenotype in Alström syndrome.

Baig S, Paisey R, Dawson C, Barrett T, Maffei P, Hodson J, Rambhatla SB, Chauhan P, Bolton S, Dassie F, Francomano C, Marshall RP, Belal M, Skordilis K, Hayer M, Price AM, Cramb R, Edwards N, Steeds RP, Geberhiwot T.

Nephrol Dial Transplant. 2018 Oct 10. doi: 10.1093/ndt/gfy293. [Epub ahead of print]

PMID:
30307515
5.

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.

Procopiou PA, Anderson NA, Barrett J, Barrett TN, Crawford MHJ, Fallon BJ, Hancock AP, Le J, Lemma S, Marshall RP, Morrell J, Pritchard JM, Rowedder JE, Saklatvala P, Slack RJ, Sollis SL, Suckling CJ, Thorp LR, Vitulli G, Macdonald SJF.

J Med Chem. 2018 Sep 27;61(18):8417-8443. doi: 10.1021/acs.jmedchem.8b00959. Epub 2018 Sep 14.

PMID:
30215258
6.

Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants.

Maden CH, Fairman D, Chalker M, Costa MJ, Fahy WA, Garman N, Lukey PT, Mant T, Parry S, Simpson JK, Slack RJ, Kendrick S, Marshall RP.

Eur J Clin Pharmacol. 2018 Jun;74(6):701-709. doi: 10.1007/s00228-018-2435-3. Epub 2018 Mar 12.

7.

The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis.

Usmani OS, Biddiscombe MF, Yang S, Meah S, Oballa E, Simpson JK, Fahy WA, Marshall RP, Lukey PT, Maher TM.

Respir Res. 2018 Feb 6;19(1):25. doi: 10.1186/s12931-018-0732-0.

8.

Somatotrope Pituitary Function in Professional Soccer Players.

Roser P, Wehrhahn T, Krogmann H, Riedel N, Marshall RP, Gille J, Flitsch J, Aberle J.

Exp Clin Endocrinol Diabetes. 2018 May;126(5):306-308. doi: 10.1055/s-0043-119876. Epub 2017 Nov 17.

PMID:
29165725
9.

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study.

Maher TM, Oballa E, Simpson JK, Porte J, Habgood A, Fahy WA, Flynn A, Molyneaux PL, Braybrooke R, Divyateja H, Parfrey H, Rassl D, Russell AM, Saini G, Renzoni EA, Duggan AM, Hubbard R, Wells AU, Lukey PT, Marshall RP, Jenkins RG.

Lancet Respir Med. 2017 Dec;5(12):946-955. doi: 10.1016/S2213-2600(17)30430-7. Epub 2017 Nov 14.

10.

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Allen RJ, Porte J, Braybrooke R, Flores C, Fingerlin TE, Oldham JM, Guillen-Guio B, Ma SF, Okamoto T, John AE, Obeidat M, Yang IV, Henry A, Hubbard RB, Navaratnam V, Saini G, Thompson N, Booth HL, Hart SP, Hill MR, Hirani N, Maher TM, McAnulty RJ, Millar AB, Molyneaux PL, Parfrey H, Rassl DM, Whyte MKB, Fahy WA, Marshall RP, Oballa E, Bossé Y, Nickle DC, Sin DD, Timens W, Shrine N, Sayers I, Hall IP, Noth I, Schwartz DA, Tobin MD, Wain LV, Jenkins RG.

Lancet Respir Med. 2017 Nov;5(11):869-880. doi: 10.1016/S2213-2600(17)30387-9. Epub 2017 Oct 20.

11.

Reduced need for surgery in severe nasal polyposis with mepolizumab: Randomized trial.

Bachert C, Sousa AR, Lund VJ, Scadding GK, Gevaert P, Nasser S, Durham SR, Cornet ME, Kariyawasam HH, Gilbert J, Austin D, Maxwell AC, Marshall RP, Fokkens WJ.

J Allergy Clin Immunol. 2017 Oct;140(4):1024-1031.e14. doi: 10.1016/j.jaci.2017.05.044. Epub 2017 Jul 4.

12.

Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation.

Sousa AR, Marshall RP, Warnock LC, Bolton S, Hastie A, Symon F, Hargadon B, Marshall H, Richardson M, Brightling CE, Haldar P, Milone R, Chalk P, Williamson R, Panettieri R Jr, Knowles R, Bleecker ER, Wardlaw AJ.

Clin Exp Allergy. 2017 Jul;47(7):890-899. doi: 10.1111/cea.12954. Epub 2017 Jun 16.

PMID:
28493293
13.

Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling.

Berair R, Hartley R, Mistry V, Sheshadri A, Gupta S, Singapuri A, Gonem S, Marshall RP, Sousa AR, Shikotra A, Kay R, Wardlaw A, Bradding P, Siddiqui S, Castro M, Brightling CE.

Eur Respir J. 2017 May 1;49(5). pii: 1601507. doi: 10.1183/13993003.01507-2016. Print 2017 May.

14.

Severe asthma: Differential chemokine response of airway epithelial cells.

Thomas B, Hirst RA, Brett-Pitt MH, Williams G, Andrew PW, Sousa AR, Marshall RP, Brightling C, O'Callaghan C.

J Allergy Clin Immunol. 2017 Oct;140(4):1149-1152.e10. doi: 10.1016/j.jaci.2017.02.040. Epub 2017 Apr 12. No abstract available.

PMID:
28412395
15.

How the European eel (Anguilla anguilla) loses its skeletal framework across lifetime.

Rolvien T, Nagel F, Milovanovic P, Wuertz S, Marshall RP, Jeschke A, Schmidt FN, Hahn M, Witten PE, Amling M, Busse B.

Proc Biol Sci. 2016 Oct 26;283(1841). pii: 20161550.

16.

Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts.

Taylor A, Budd DC, Shih B, Seifert O, Beaton A, Wright T, Dempsey M, Kelly F, Egerton J, Marshall RP, Aston N, Bayat A.

Acta Derm Venereol. 2017 Jan 4;97(1):10-16. doi: 10.2340/00015555-2462.

17.

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.

Mercer PF, Woodcock HV, Eley JD, Platé M, Sulikowski MG, Durrenberger PF, Franklin L, Nanthakumar CB, Man Y, Genovese F, McAnulty RJ, Yang S, Maher TM, Nicholson AG, Blanchard AD, Marshall RP, Lukey PT, Chambers RC.

Thorax. 2016 Aug;71(8):701-11. doi: 10.1136/thoraxjnl-2015-207429. Epub 2016 Apr 21.

18.

Daily Home Spirometry: An Effective Tool for Detecting Progression in Idiopathic Pulmonary Fibrosis.

Russell AM, Adamali H, Molyneaux PL, Lukey PT, Marshall RP, Renzoni EA, Wells AU, Maher TM.

Am J Respir Crit Care Med. 2016 Oct 15;194(8):989-997.

19.

Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study.

Hartley RA, Barker BL, Newby C, Pakkal M, Baldi S, Kajekar R, Kay R, Laurencin M, Marshall RP, Sousa AR, Parmar H, Siddiqui S, Gupta S, Brightling CE.

J Allergy Clin Immunol. 2016 May;137(5):1413-1422.e12. doi: 10.1016/j.jaci.2016.02.001. Epub 2016 Mar 19.

20.

Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells.

Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall RP, Mautner A, Duchstein L, Otto B, Horst AK, Amling M, Kreienkamp HJ, Schinke T.

J Immunol. 2015 Oct 15;195(8):3675-84. doi: 10.4049/jimmunol.1402392. Epub 2015 Sep 11.

21.

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.

Nanthakumar CB, Hatley RJ, Lemma S, Gauldie J, Marshall RP, Macdonald SJ.

Nat Rev Drug Discov. 2015 Oct;14(10):693-720. doi: 10.1038/nrd4592. Epub 2015 Sep 4. Review.

PMID:
26338155
22.

Role of a functional polymorphism in the F2R gene promoter in sarcoidosis.

Platé M, Lawson PJ, Hill MR, Marshall RP, Booth HL, Kumari M, Laurent GJ, Hurst JR, Chambers RC.

Respirology. 2015 Nov;20(8):1285-7. doi: 10.1111/resp.12608. Epub 2015 Aug 17.

23.

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study.

Jenkins RG, Simpson JK, Saini G, Bentley JH, Russell AM, Braybrooke R, Molyneaux PL, McKeever TM, Wells AU, Flynn A, Hubbard RB, Leeming DJ, Marshall RP, Karsdal MA, Lukey PT, Maher TM.

Lancet Respir Med. 2015 Jun;3(6):462-72. doi: 10.1016/S2213-2600(15)00048-X. Epub 2015 Mar 12.

24.

The phenotypic and molecular genetic spectrum of Alström syndrome in 44 Turkish kindreds and a literature review of Alström syndrome in Turkey.

Ozantürk A, Marshall JD, Collin GB, Düzenli S, Marshall RP, Candan Ş, Tos T, Esen İ, Taşkesen M, Çayır A, Öztürk Ş, Üstün İ, Ataman E, Karaca E, Özdemir TR, Erol İ, Eroğlu FK, Torun D, Parıltay E, Yılmaz-Güleç E, Karaca E, Atabek ME, Elçioğlu N, Satman İ, Möller C, Muller J, Naggert JK, Özgül RK.

J Hum Genet. 2015 Jan;60(1):51. doi: 10.1038/jhg.2014.101. No abstract available.

PMID:
25619591
25.

Temporal assessment of airway remodeling in severe asthma using quantitative computed tomography.

Gupta S, Hartley R, Singapuri A, Hargadon B, Monteiro W, Pavord ID, Sousa AR, Marshall RP, Subramanian D, Parr D, Entwisle JJ, Siddiqui S, Raj V, Brightling CE.

Am J Respir Crit Care Med. 2015 Jan 1;191(1):107-10. doi: 10.1164/rccm.201406-1128LE. No abstract available.

26.

The phenotypic and molecular genetic spectrum of Alström syndrome in 44 Turkish kindreds and a literature review of Alström syndrome in Turkey.

Ozantürk A, Marshall JD, Collin GB, Düzenli S, Marshall RP, Candan Ş, Tos T, Esen İ, Taşkesen M, Çayır A, Öztürk Ş, Üstün İ, Ataman E, Karaca E, Özdemir TR, Erol İ, Eroğlu FK, Torun D, Parıltay E, Yılmaz-Güleç E, Karaca E, Atabek ME, Elçioğlu N, Satman İ, Möller C, Muller J, Naggert JK, Özgül RK.

J Hum Genet. 2015 Jan;60(1):1-9. doi: 10.1038/jhg.2014.85. Epub 2014 Oct 9. Review. Erratum in: J Hum Genet. 2015 Jan;60(1):51.

27.

Registration of 2D histological sections with 3D micro-CT datasets from small animal vertebrae and tibiae.

Museyko O, Marshall RP, Lu J, Hess A, Schett G, Amling M, Kalender WA, Engelke K.

Comput Methods Biomech Biomed Engin. 2015;18(15):1658-73. doi: 10.1080/10255842.2014.941824. Epub 2014 Aug 19.

PMID:
25136982
28.

Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients.

Gupta S, Hartley R, Khan UT, Singapuri A, Hargadon B, Monteiro W, Pavord ID, Sousa AR, Marshall RP, Subramanian D, Parr D, Entwisle JJ, Siddiqui S, Raj V, Brightling CE.

J Allergy Clin Immunol. 2014 Mar;133(3):729-38.e18. doi: 10.1016/j.jaci.2013.09.039. Epub 2013 Nov 12.

29.

Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.

Kollmann K, Pestka JM, Kühn SC, Schöne E, Schweizer M, Karkmann K, Otomo T, Catala-Lehnen P, Failla AV, Marshall RP, Krause M, Santer R, Amling M, Braulke T, Schinke T.

EMBO Mol Med. 2013 Dec;5(12):1871-86. doi: 10.1002/emmm.201302979. Epub 2013 Oct 15.

30.

Issues in interstudy comparisons of bone microarchitecture.

Djuric M, Milovanovic P, Djonic D, Hahn M, Marshall RP, Amling M.

Int Orthop. 2013 Oct;37(10):2091-2. doi: 10.1007/s00264-013-2069-0. Epub 2013 Aug 21. No abstract available.

31.

Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.

Desai D, Newby C, Symon FA, Haldar P, Shah S, Gupta S, Bafadhel M, Singapuri A, Siddiqui S, Woods J, Herath A, Anderson IK, Bradding P, Green R, Kulkarni N, Pavord I, Marshall RP, Sousa AR, May RD, Wardlaw AJ, Brightling CE.

Am J Respir Crit Care Med. 2013 Sep 15;188(6):657-63. doi: 10.1164/rccm.201208-1470OC.

32.

The SERM raloxifene improves diaphyseal fracture healing in mice.

Spiro AS, Khadem S, Jeschke A, Marshall RP, Pogoda P, Ignatius A, Amling M, Beil FT.

J Bone Miner Metab. 2013 Nov;31(6):629-36. doi: 10.1007/s00774-013-0461-x. Epub 2013 Apr 2.

PMID:
23546819
33.

Strategies for biomarker discovery in fibrotic disease.

Marshall RP, Simpson JK, Lukey PT.

Biochim Biophys Acta. 2013 Jul;1832(7):1079-87. doi: 10.1016/j.bbadis.2013.01.018. Epub 2013 Jan 31. Review.

34.

Pharmacological estrogen administration causes a FSH-independent osteo-anabolic effect requiring ER alpha in osteoblasts.

Seitz S, Keller J, Schilling AF, Jeschke A, Marshall RP, Stride BD, Wintermantel T, Beil FT, Amling M, Schütz G, Tuckermann J, Schinke T.

PLoS One. 2012;7(11):e50301. doi: 10.1371/journal.pone.0050301. Epub 2012 Nov 27.

35.

High bone mass in the STR/ort mouse results from increased bone formation and impaired bone resorption and is associated with extramedullary hematopoiesis.

Pasold J, Engelmann R, Keller J, Joost S, Marshall RP, Frerich B, Müller-Hilke B.

J Bone Miner Metab. 2013 Jan;31(1):71-81. doi: 10.1007/s00774-012-0394-9. Epub 2012 Nov 29.

PMID:
23192248
36.

Enhanced trabecular micro-architecture of the femoral neck in hip osteoarthritis vs. healthy controls: a micro-computer tomography study in postmenopausal women.

Djuric M, Zagorac S, Milovanovic P, Djonic D, Nikolic S, Hahn M, Zivkovic V, Bumbasirevic M, Amling M, Marshall RP.

Int Orthop. 2013 Jan;37(1):21-6. doi: 10.1007/s00264-012-1713-4. Epub 2012 Nov 24.

37.

Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization.

Koehne T, Marshall RP, Jeschke A, Kahl-Nieke B, Schinke T, Amling M.

Bone. 2013 Mar;53(1):25-33. doi: 10.1016/j.bone.2012.11.009. Epub 2012 Nov 19.

PMID:
23174213
38.

Stress fractures in elderly patients.

Breer S, Krause M, Marshall RP, Oheim R, Amling M, Barvencik F.

Int Orthop. 2012 Dec;36(12):2581-7. doi: 10.1007/s00264-012-1708-1. Epub 2012 Nov 9.

39.

Influence of non-traumatic thoracic and lumbar vertebral fractures on sagittal spine alignment assessed by radiation-free spinometry.

Krause M, Breer S, Mohrmann B, Vettorazzi E, Marshall RP, Amling M, Barvencik F.

Osteoporos Int. 2013 Jun;24(6):1859-68. doi: 10.1007/s00198-012-2156-x. Epub 2012 Oct 13.

PMID:
23064371
40.

Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo.

Dieckmann M, Beil FT, Mueller B, Bartelt A, Marshall RP, Koehne T, Amling M, Ruether W, Cooper JA, Humphries SE, Herz J, Niemeier A.

J Bone Miner Res. 2013 Feb;28(2):236-45. doi: 10.1002/jbmr.1757.

41.

Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/⁺Gr-1⁺ myeloid cells--brief report.

Bickert T, Marshall RP, Zhang Z, Ludewig P, Binder M, Klinke A, Rottbauer W, Amling M, Wagener C, Ito WD, Horst AK.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2566-8. doi: 10.1161/ATVBAHA.112.300015. Epub 2012 Sep 6.

PMID:
22962327
42.

Spontaneous osteonecrosis of the knee (SONK).

Breer S, Oheim R, Krause M, Marshall RP, Amling M, Barvencik F.

Knee Surg Sports Traumatol Arthrosc. 2013 Feb;21(2):340-5. doi: 10.1007/s00167-012-2017-3. Epub 2012 Apr 26.

PMID:
22534975
43.

Application of ex vivo micro-computed tomography for assessment of in vivo fluorescence and plain radiographic imaging for monitoring bone metastases and osteolytic lesions.

Tiwari S, Schem C, Lorenzen AC, Kayser O, Wiese C, Graeff C, Peña J, Marshall RP, Heller M, Kalthoff H, Jonat W, Glüer CC.

J Bone Miner Metab. 2012 May;30(3):373-80. doi: 10.1007/s00774-011-0335-z. Epub 2011 Dec 2.

PMID:
22130787
44.

Micro-structural basis for particular vulnerability of the superolateral neck trabecular bone in the postmenopausal women with hip fractures.

Milovanovic P, Djonic D, Marshall RP, Hahn M, Nikolic S, Zivkovic V, Amling M, Djuric M.

Bone. 2012 Jan;50(1):63-8. doi: 10.1016/j.bone.2011.09.044. Epub 2011 Sep 22.

PMID:
21964412
45.

Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis.

Gevaert P, Van Bruaene N, Cattaert T, Van Steen K, Van Zele T, Acke F, De Ruyck N, Blomme K, Sousa AR, Marshall RP, Bachert C.

J Allergy Clin Immunol. 2011 Nov;128(5):989-95.e1-8. doi: 10.1016/j.jaci.2011.07.056. Epub 2011 Sep 28.

PMID:
21958585
46.

Control of bone formation by the serpentine receptor Frizzled-9.

Albers J, Schulze J, Beil FT, Gebauer M, Baranowsky A, Keller J, Marshall RP, Wintges K, Friedrich FW, Priemel M, Schilling AF, Rueger JM, Cornils K, Fehse B, Streichert T, Sauter G, Jakob F, Insogna KL, Pober B, Knobeloch KP, Francke U, Amling M, Schinke T.

J Cell Biol. 2011 Mar 21;192(6):1057-72. doi: 10.1083/jcb.201008012. Epub 2011 Mar 14.

47.

Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo.

Prawitt J, Beil FT, Marshall RP, Bartelt A, Ruether W, Heeren J, Amling M, Staels B, Niemeier A.

Bone. 2011 Feb;48(2):339-46. doi: 10.1016/j.bone.2010.08.018. Epub 2010 Sep 15.

PMID:
20817130
48.

Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.

Schulze J, Seitz S, Saito H, Schneebauer M, Marshall RP, Baranowsky A, Busse B, Schilling AF, Friedrich FW, Albers J, Spiro AS, Zustin J, Streichert T, Ellwanger K, Niehrs C, Amling M, Baron R, Schinke T.

PLoS One. 2010 Apr 27;5(4):e10309. doi: 10.1371/journal.pone.0010309.

49.

Increased trabecular bone formation in mice lacking the growth factor midkine.

Neunaber C, Catala-Lehnen P, Beil FT, Marshall RP, Kanbach V, Baranowsky A, Lehmann W, Streichert T, Ignatius A, Muramatsu T, Schinke T, Amling M.

J Bone Miner Res. 2010 Aug;25(8):1724-35. doi: 10.1002/jbmr.75.

50.

Skeletal analysis and comparison of bog bodies from Northern European peat bogs.

Pestka JM, Barvencik F, Beil FT, Marshall RP, Jopp E, Schilling AF, Bauerochse A, Fansa M, Püschel K, Amling M.

Naturwissenschaften. 2010 Apr;97(4):393-402. doi: 10.1007/s00114-010-0653-3. Epub 2010 Feb 25.

PMID:
20182683

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