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Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus.

Moore KM, Desai A, Delgado BL, Trabulo SMD, Reader C, Brown NF, Murray ER, Brentnall A, Howard P, Masterson L, Zammarchi F, Hartley JA, van Berkel PH, Marshall JF.

Theranostics. 2020 Feb 12;10(7):2930-2942. doi: 10.7150/thno.38702. eCollection 2020.


Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma.

Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR, Marshall JF.

Pancreatology. 2020 Feb 15. pii: S1424-3903(20)30042-9. doi: 10.1016/j.pan.2020.02.006. [Epub ahead of print] Review.


Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment.

Brown NF, Marshall JF.

Cancers (Basel). 2019 Aug 21;11(9). pii: E1221. doi: 10.3390/cancers11091221. Review.


Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control.

Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratsch T, Palma M.

Faraday Discuss. 2019 Oct 30;219(0):203-219. doi: 10.1039/c9fd00023b.


The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.

Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM, Marshall JF.

J Pathol. 2019 Nov;249(3):332-342. doi: 10.1002/path.5320. Epub 2019 Jul 30.


Absence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birds.

Zhu H, Damdinjav B, Gonzalez G, Patrono LV, Ramirez-Mendoza H, Amat JAR, Crispell J, Parr YA, Hammond TA, Shiilegdamba E, Leung YHC, Peiris M, Marshall JF, Hughes J, Gilbert M, Murcia PR.

PLoS Pathog. 2019 Feb 7;15(2):e1007531. doi: 10.1371/journal.ppat.1007531. eCollection 2019 Feb.


DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single-Molecule Control.

Huang D, Patel K, Perez-Garrido S, Marshall JF, Palma M.

ACS Nano. 2019 Jan 22;13(1):728-736. doi: 10.1021/acsnano.8b08010. Epub 2018 Dec 31.


A framework for the development of effective anti-metastatic agents.

Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D, Jones PS, Jones R, Marshall JF, Panico MB, Shaw JA, Steeg PS, Sullivan M, Tong W, Westwell AD, Ritchie JWA; Cancer Research UK and Cancer Therapeutics CRC Australia Metastasis Working Group.

Nat Rev Clin Oncol. 2019 Mar;16(3):185-204. doi: 10.1038/s41571-018-0134-8.


Proportion of nonsteroidal anti-inflammatory drug prescription in equine practice.

Duz M, Marshall JF, Parkin TD.

Equine Vet J. 2019 Mar;51(2):147-153. doi: 10.1111/evj.12997. Epub 2018 Aug 21.


Correlative 3D Structured Illumination Microscopy and Single-Molecule Localization Microscopy for Imaging Cancer Invasion.

Pinnington SJL, Marshall JF, Wheeler AP.

Methods Mol Biol. 2018;1764:253-265. doi: 10.1007/978-1-4939-7759-8_15.


PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.

Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR, Grose RP.

Cell Rep. 2018 Feb 27;22(9):2469-2481. doi: 10.1016/j.celrep.2018.02.028.


The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.

Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL, Halldén G.

Mol Cancer Ther. 2018 Feb;17(2):575-587. doi: 10.1158/1535-7163.MCT-17-0671.


Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.

Chauché C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza AI, Gu Q, Parrish CR, Martínez-Sobrido L, Marshall JF, Murcia PR.

J Virol. 2018 Feb 12;92(5). pii: e01875-17. doi: 10.1128/JVI.01875-17. Print 2018 Mar 1.


Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?

Marshall JF.

Clin Cancer Res. 2018 Jan 15;24(2):253-255. doi: 10.1158/1078-0432.CCR-17-2823. Epub 2017 Oct 30.


Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells.

Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A, Costa-Guerra JA, Violette S, Itamochi H, Ghaem-Maghami S, Vallath S, Marshall JF, Maher J.

Mol Ther. 2017 Oct 4;25(10):2427. doi: 10.1016/j.ymthe.2017.09.018. Epub 2017 Sep 23. No abstract available.


Integrins as Therapeutic Targets: Successes and Cancers.

Raab-Westphal S, Marshall JF, Goodman SL.

Cancers (Basel). 2017 Aug 23;9(9). pii: E110. doi: 10.3390/cancers9090110. Review.


Validation of an Improved Computer-Assisted Technique for Mining Free-Text Electronic Medical Records.

Duz M, Marshall JF, Parkin T.

JMIR Med Inform. 2017 Jun 29;5(2):e17. doi: 10.2196/medinform.7123.


Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez MA, Kiely P, Moutasim KA, Frampton SJ, Sabnis D, Fine DR, Johnson C, Marshall JF, Scita G, Jenei V, Thomas GJ.

J Pathol. 2017 Sep;243(1):37-50. doi: 10.1002/path.4923. Epub 2017 Aug 7.


Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality.

Hung KY, Harris PWR, Desai A, Marshall JF, Brimble MA.

Eur J Med Chem. 2017 Aug 18;136:154-164. doi: 10.1016/j.ejmech.2017.05.008. Epub 2017 May 3.


Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy.

Hodgins NO, Al-Jamal WT, Wang JT, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J, Al-Jamal KT.

J Control Release. 2017 Jun 28;256:141-152. doi: 10.1016/j.jconrel.2017.04.025. Epub 2017 Apr 18.


Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells.

Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A, Costa-Guerra JA, Violette S, Itamochi H, Ghaem-Maghami S, Vallath S, Marshall JF, Maher J.

Mol Ther. 2017 Jan 4;25(1):259-273. doi: 10.1016/j.ymthe.2016.10.012. Epub 2017 Jan 4. Erratum in: Mol Ther. 2017 Oct 4;25(10):2427.


Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: A cohort study of free-text electronic medical records.

Welsh CE, Duz M, Parkin TDH, Marshall JF.

Prev Vet Med. 2017 Jan 1;136:11-18. doi: 10.1016/j.prevetmed.2016.11.012. Epub 2016 Nov 22.


Objective assessment of the compensatory effect of clinical hind limb lameness in horses: 37 cases (2011-2014).

Maliye S, Marshall JF.

J Am Vet Med Assoc. 2016 Oct 15;249(8):940-944.


Use of large-scale veterinary data for the investigation of antimicrobial prescribing practices in equine medicine.

Welsh CE, Parkin TDH, Marshall JF.

Equine Vet J. 2017 Jul;49(4):425-432. doi: 10.1111/evj.12638. Epub 2016 Oct 5.


Prevalence, survival analysis and multimorbidity of chronic diseases in the general veterinarian-attended horse population of the UK.

Welsh CE, Duz M, Parkin TDH, Marshall JF.

Prev Vet Med. 2016 Sep 1;131:137-145. doi: 10.1016/j.prevetmed.2016.07.011. Epub 2016 Jul 26.


The role of integrins in TGFβ activation in the tumour stroma.

Khan Z, Marshall JF.

Cell Tissue Res. 2016 Sep;365(3):657-73. doi: 10.1007/s00441-016-2474-y. Epub 2016 Aug 12. Review.


Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2.

Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC.

Pharmacology. 2016;97(3-4):114-25. doi: 10.1159/000443180. Epub 2016 Jan 7.


Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.

Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF, O'Toole EA.

J Natl Cancer Inst. 2015 Oct 16;108(1). pii: djv293. doi: 10.1093/jnci/djv293. Print 2016 Jan.


Clinical Research Abstracts of the British Equine Veterinary Association Congress 2015.

Hammersley E, Duz M, Marshall JF.

Equine Vet J. 2015 Sep;47 Suppl 48:24. doi: 10.1111/evj.12486_54.


Naturally-occurring forelimb lameness in the horse results in significant compensatory load redistribution during trotting.

Maliye S, Voute LC, Marshall JF.

Vet J. 2015 May;204(2):208-13. doi: 10.1016/j.tvjl.2015.03.005. Epub 2015 Mar 9.


Effect of flunixin meglumine and firocoxib on ex vivo cyclooxygenase activity in horses undergoing elective surgery.

Duz M, Parkin TD, Cullander RM, Marshall JF.

Am J Vet Res. 2015 Mar;76(3):208-15. doi: 10.2460/ajvr.76.3.208.


A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T, Marshall JF, Kocher HM, Crnogorac-Jurcevic T, Scarpa A, Lemoine NR, Chelala C.

Genome Med. 2014 Dec 3;6(12):105. doi: 10.1186/s13073-014-0105-3. eCollection 2014.


αvβ6 Expression in myoepithelial cells: a novel marker for predicting DCIS progression with therapeutic potential.

Allen MD, Marshall JF, Jones JL.

Cancer Res. 2014 Nov 1;74(21):5942-7. doi: 10.1158/0008-5472.CAN-14-1841. Epub 2014 Oct 15.


Retrieval-induced NMDA receptor-dependent Arc expression in two models of cocaine-cue memory.

Alaghband Y, O'Dell SJ, Azarnia S, Khalaj AJ, Guzowski JF, Marshall JF.

Neurobiol Learn Mem. 2014 Dec;116:79-89. doi: 10.1016/j.nlm.2014.09.001. Epub 2014 Sep 16.


A second opinion: response to 100 professors.

Wechter D, Harrison D, Adams R Sr, Beard S, Blaskiewicz R, Bush F, Calhoun B, Cirucci CA, Christiansen S, Cook C, Davenport M, DeCook J, Delgado G, Dood JJ, Dotto M, Dumpe K, Friedman WH, Glass T, Gray TL, Gray JP, Hale KA, Hersh C, Hines J, Jackson A, Johannson J, Keenan JA, Linn J, Long JD, Marshall JF, McDonald DP, McCloskey L, Mickelson J, Pestoff MR, Parker EW Jr, Sawyer AT, Schwering C, Seale F, Schoutko W, Showalter A, Skakalski T, Skop I, Smith LF, Stalter W, Steele A, Thiele SA, Varasteh N, Ward DG, Wittingen JA.

Issues Law Med. 2014 Spring;29(1):147-64.


Therapeutic targeting of integrin αvβ6 in breast cancer.

Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper WJ, Thompson AM, Quinlan P, Jordan L, Gillett C, Brentnall A, Violette S, Weinreb PH, Kendrew J, Barry ST, Hart IR, Jones JL, Marshall JF.

J Natl Cancer Inst. 2014 Jun 28;106(8). pii: dju169. doi: 10.1093/jnci/dju169. Print 2014 Aug.


Positive and negative feedback learning and associated dopamine and serotonin transporter binding after methamphetamine.

Stolyarova A, O'Dell SJ, Marshall JF, Izquierdo A.

Behav Brain Res. 2014 Sep 1;271:195-202. doi: 10.1016/j.bbr.2014.06.031. Epub 2014 Jun 21.


Infection and pathogenesis of canine, equine, and human influenza viruses in canine tracheas.

Gonzalez G, Marshall JF, Morrell J, Robb D, McCauley JW, Perez DR, Parrish CR, Murcia PR.

J Virol. 2014 Aug;88(16):9208-19. doi: 10.1128/JVI.00887-14. Epub 2014 Jun 4.


Running wheel exercise before a binge regimen of methamphetamine does not protect against striatal dopaminergic damage.

O'dell SJ, Marshall JF.

Synapse. 2014 Sep;68(9):419-25. doi: 10.1002/syn.21754. Epub 2014 Jun 19.


Rigidity sensing and adaptation through regulation of integrin types.

Elosegui-Artola A, Bazellières E, Allen MD, Andreu I, Oria R, Sunyer R, Gomm JJ, Marshall JF, Jones JL, Trepat X, Roca-Cusachs P.

Nat Mater. 2014 Jun;13(6):631-7. doi: 10.1038/nmat3960. Epub 2014 May 4.


Identification of differences in immunotherapy knowledge and practice patterns among oncologists from six European countries.

Borrello IM, Schaffer MM, Roehrl E, Marshall JF.

Mol Clin Oncol. 2014 Mar;2(2):269-274. Epub 2014 Jan 14.


Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

Moutasim KA, Mellows T, Mellone M, Lopez MA, Tod J, Kiely PC, Sapienza K, Greco A, Neill GW, Violette S, Weinreb PH, Marshall JF, Ottensmeier CH, Sayan AE, Jenei V, Thomas GJ.

J Pathol. 2014 Jun;233(2):196-208. doi: 10.1002/path.4342. Epub 2014 Apr 29.


An inertial sensor-based system can objectively assess diagnostic anaesthesia of the equine foot.

Maliye S, Voute L, Lund D, Marshall JF.

Equine Vet J Suppl. 2013 Dec;(45):26-30. doi: 10.1111/evj.12158.


Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.


Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.

John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, Ludbrook S, Blanchard AD, Perkins AC, Jenkins RG, Marshall JF.

J Nucl Med. 2013 Dec;54(12):2146-52. doi: 10.2967/jnumed.113.120592. Epub 2013 Oct 28.


Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence.

Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA, Dickinson S, Edwards DR, Pennington CJ, Sestak I, Cuzick J, Marshall JF, Hart IR, Jones JL.

Clin Cancer Res. 2014 Jan 15;20(2):344-57. doi: 10.1158/1078-0432.CCR-13-1504. Epub 2013 Oct 22.


Generation and characterization of a diabody targeting the αvβ6 integrin.

Kogelberg H, Miranda E, Burnet J, Ellison D, Tolner B, Foster J, Picón C, Thomas GJ, Meyer T, Marshall JF, Mather SJ, Chester K.

PLoS One. 2013 Sep 4;8(9):e73260. doi: 10.1371/journal.pone.0073260. eCollection 2013.


Structural guided scaffold phage display libraries as a source of bio-therapeutics.

Man YK, DiCara D, Chan N, Vessillier S, Mather SJ, Rowe ML, Howard MJ, Marshall JF, Nissim A.

PLoS One. 2013 Aug 9;8(8):e70452. doi: 10.1371/journal.pone.0070452. eCollection 2013.


Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma.

Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J, Chelala C, Gribben JG, Ramsay AG, Kocher HM.

Gastroenterology. 2013 Nov;145(5):1121-32. doi: 10.1053/j.gastro.2013.07.025. Epub 2013 Jul 25.


Use of a wireless, inertial sensor-based system to objectively evaluate flexion tests in the horse.

Marshall JF, Lund DG, Voute LC.

Equine Vet J Suppl. 2012 Dec;(43):8-11.


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