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Items: 1 to 50 of 163

1.

Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models.

Motwani M, Pawaria S, Bernier J, Moses S, Henry K, Fang T, Burkly L, Marshak-Rothstein A, Fitzgerald KA.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7941-7950. doi: 10.1073/pnas.1818281116. Epub 2019 Apr 3.

PMID:
30944222
2.

Soluble Fas ligand blocks destructive corneal inflammation in mouse models of corneal epithelial debridement and LPS induced keratitis.

Gregory-Ksander M, Perez VL, Marshak-Rothstein A, Ksander BR.

Exp Eye Res. 2019 Feb;179:47-54. doi: 10.1016/j.exer.2018.10.013. Epub 2018 Oct 23.

PMID:
30365944
3.

Advances in Cutaneous Lupus Erythematosus and Dermatomyositis: A Report from the 4th International Conference on Cutaneous Lupus Erythematosus-An Ongoing Need for International Consensus and Collaborations.

Concha JSS, Patsatsi A, Marshak-Rothstein A, Liu ML, Sinha AA, Lee LA, Merola JF, Jabbari A, Gudjonsson JE, Chasset F, Jarrett P, Chong B, Arkin L, Fernandez AP, Caproni M, Greenberg SA, Kim HJ, Pearson DR, Femia A, Vleugels RA, Fiorentino D, Fujimoto M, Wenzel J, Werth VP.

J Invest Dermatol. 2019 Feb;139(2):270-276. doi: 10.1016/j.jid.2018.08.017. Epub 2018 Sep 19. No abstract available.

PMID:
30243657
4.

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.

Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A.

J Clin Invest. 2018 Jul 2;128(7):2966-2978. doi: 10.1172/JCI98219. Epub 2018 Jun 11.

5.

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E.

Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011.

6.

Correction: Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.

O'Donnell JA, Lehman J, Roderick JE, Martinez-Marin D, Zelic M, Doran C, Hermance N, Lyle S, Pasparakis M, Fitzgerald KA, Marshak-Rothstein A, Kelliher MA.

J Immunol. 2018 Apr 15;200(8):3020-3021. doi: 10.4049/jimmunol.1800240. Epub 2018 Mar 12. No abstract available.

7.

Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.

O'Donnell JA, Lehman J, Roderick JE, Martinez-Marin D, Zelic M, Doran C, Hermance N, Lyle S, Pasparakis M, Fitzgerald KA, Marshak-Rothstein A, Kelliher MA.

J Immunol. 2018 Jan 15;200(2):737-748. doi: 10.4049/jimmunol.1701229. Epub 2017 Dec 6. Erratum in: J Immunol. 2018 Mar 12;:.

8.

A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.

Sindhava VJ, Oropallo MA, Moody K, Naradikian M, Higdon LE, Zhou L, Myles A, Green N, Nündel K, Stohl W, Schmidt AM, Cao W, Dorta-Estremera S, Kambayashi T, Marshak-Rothstein A, Cancro MP.

J Clin Invest. 2017 May 1;127(5):1651-1663. doi: 10.1172/JCI89931. Epub 2017 Mar 27.

9.

Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation.

Giles JR, Neves AT, Marshak-Rothstein A, Shlomchik MJ.

JCI Insight. 2017 Feb 23;2(4):e90870. doi: 10.1172/jci.insight.90870.

10.

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma.

Krishnan A, Fei F, Jones A, Busto P, Marshak-Rothstein A, Ksander BR, Gregory-Ksander M.

J Immunol. 2016 Dec 15;197(12):4626-4638. Epub 2016 Nov 14.

11.

STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.

Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM.

Arthritis Rheumatol. 2017 Feb;69(2):460-471. doi: 10.1002/art.39863.

12.

Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?

Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A.

J Leukoc Biol. 2017 Jan;101(1):121-126. doi: 10.1189/jlb.3MR0316-115R. Epub 2016 Aug 16. Review.

13.

TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus.

Bossaller L, Christ A, Pelka K, Nündel K, Chiang PI, Pang C, Mishra N, Busto P, Bonegio RG, Schmidt RE, Latz E, Marshak-Rothstein A.

J Immunol. 2016 Aug 15;197(4):1044-53. doi: 10.4049/jimmunol.1501943. Epub 2016 Jun 27.

14.

Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells.

Moody KL, Uccellini MB, Avalos AM, Marshak-Rothstein A, Viglianti GA.

Methods Mol Biol. 2016;1390:249-72. doi: 10.1007/978-1-4939-3335-8_16.

PMID:
26803634
15.

Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.

Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A.

J Immunol. 2016 Feb 1;196(3):1348-54. doi: 10.4049/jimmunol.1502130. Epub 2016 Jan 4.

16.

Autoimmunity--promoting and stabilizing innate immunity 'UNWUCHT'.

Marshak-Rothstein A.

Immunol Rev. 2016 Jan;269(1):7-10. doi: 10.1111/imr.12387. No abstract available.

PMID:
26683141
17.

Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium.

Matsumoto H, Murakami Y, Kataoka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG.

Cell Death Dis. 2015 Nov 19;6:e1986. doi: 10.1038/cddis.2015.334.

18.

IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells.

Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A.

J Immunol. 2015 Dec 1;195(11):5251-60. doi: 10.4049/jimmunol.1500777. Epub 2015 Oct 30.

19.

An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.

Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S70-3. Epub 2015 Oct 12. Review.

20.

Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation.

Sharma S, Fitzgerald KA, Cancro MP, Marshak-Rothstein A.

J Immunol. 2015 Oct 15;195(8):3507-12. doi: 10.4049/jimmunol.1500964. Review.

21.

Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses.

Nündel K, Green NM, Shaffer AL, Moody KL, Busto P, Eilat D, Miyake K, Oropallo MA, Cancro MP, Marshak-Rothstein A.

J Immunol. 2015 Mar 15;194(6):2504-12. doi: 10.4049/jimmunol.1402425. Epub 2015 Feb 13.

22.

Suppression of systemic autoimmunity by the innate immune adaptor STING.

Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E710-7. doi: 10.1073/pnas.1420217112. Epub 2015 Feb 2.

23.

Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.

Pawaria S, Moody K, Busto P, Nündel K, Choi CH, Ghayur T, Marshak-Rothstein A.

J Immunol. 2015 Feb 15;194(4):1403-7. doi: 10.4049/jimmunol.1402893. Epub 2015 Jan 19.

24.

Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.

Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM.

J Immunol. 2015 Feb 1;194(3):873-7. doi: 10.4049/jimmunol.1402573. Epub 2014 Dec 29.

25.

Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.

Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E.

J Immunol. 2014 Oct 1;193(7):3257-61. doi: 10.4049/jimmunol.1301886. Epub 2014 Sep 3.

26.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

27.

Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation.

Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J.

Ann Rheum Dis. 2015 Nov;74(11):2062-9. doi: 10.1136/annrheumdis-2013-204900. Epub 2014 Jun 9.

28.

Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.

Gratz IK, Rosenblum MD, Maurano MM, Paw JS, Truong HA, Marshak-Rothstein A, Abbas AK.

J Immunol. 2014 Feb 15;192(4):1351-5. doi: 10.4049/jimmunol.1301777. Epub 2014 Jan 17.

29.

Organ-specific and systemic autoimmune diseases.

Lehuen A, Marshak-Rothstein A.

Curr Opin Immunol. 2013 Dec;25(6):667-9. doi: 10.1016/j.coi.2013.10.014. Epub 2013 Nov 16. No abstract available.

PMID:
24246387
30.

Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.

Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A.

J Immunol. 2013 Sep 1;191(5):2104-14. doi: 10.4049/jimmunol.1300341. Epub 2013 Aug 5.

31.

The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.

Nündel K, Busto P, Debatis M, Marshak-Rothstein A.

J Leukoc Biol. 2013 Nov;94(5):865-75. doi: 10.1189/jlb.0313126. Epub 2013 Jun 26.

32.

Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.

Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR.

Int Immunol. 2013 May;25(5):295-306. doi: 10.1093/intimm/dxs114. Epub 2013 Jan 4.

33.

Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.

Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E.

J Immunol. 2012 Dec 15;189(12):5508-12. doi: 10.4049/jimmunol.1202121. Epub 2012 Nov 9.

34.

Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands.

Green NM, Moody KS, Debatis M, Marshak-Rothstein A.

J Biol Chem. 2012 Nov 16;287(47):39789-99. doi: 10.1074/jbc.M112.383000. Epub 2012 Sep 27.

35.

Natural antibody to apoptotic cell membranes inhibits the proinflammatory properties of lupus autoantibody immune complexes.

Vas J, Grönwall C, Marshak-Rothstein A, Silverman GJ.

Arthritis Rheum. 2012 Oct;64(10):3388-98. doi: 10.1002/art.34537.

36.

Role of type I interferons in the activation of autoreactive B cells.

Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A.

Immunol Cell Biol. 2012 May;90(5):498-504. doi: 10.1038/icb.2012.10. Epub 2012 Mar 20. Review.

37.

Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma.

Han H, Xu W, Headley MB, Jessup HK, Lee KS, Omori M, Comeau MR, Marshak-Rothstein A, Ziegler SF.

Mucosal Immunol. 2012 May;5(3):342-51. doi: 10.1038/mi.2012.14. Epub 2012 Feb 22. Erratum in: Mucosal Immunol. 2012 Jul;5(4):468.

38.

Beyond transitional selection: New roles for BLyS in peripheral tolerance.

Oropallo MA, Kiefer K, Marshak-Rothstein A, Cancro MP.

Drug Dev Res. 2011 Dec;72(8):779-787.

39.

Selective binding of anti-DNA antibodies to native dsDNA fragments of differing sequence.

Uccellini MB, Busto P, Debatis M, Marshak-Rothstein A, Viglianti GA.

Immunol Lett. 2012 Mar 30;143(1):85-91. doi: 10.1016/j.imlet.2012.01.003. Epub 2012 Jan 21.

40.

Response to self antigen imprints regulatory memory in tissues.

Rosenblum MD, Gratz IK, Paw JS, Lee K, Marshak-Rothstein A, Abbas AK.

Nature. 2011 Nov 27;480(7378):538-42. doi: 10.1038/nature10664.

41.

Editorial: Interfering with B cell immunity.

Harris JE, Marshak-Rothstein A.

J Leukoc Biol. 2011 Jun;89(6):805-6. doi: 10.1189/jlb.0111042. No abstract available.

PMID:
21628334
42.

Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death.

Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR.

PLoS One. 2011 Mar 29;6(3):e17659. doi: 10.1371/journal.pone.0017659.

43.

Toll-like receptor driven B cell activation in the induction of systemic autoimmunity.

Green NM, Marshak-Rothstein A.

Semin Immunol. 2011 Apr;23(2):106-12. doi: 10.1016/j.smim.2011.01.016. Review.

44.

FcγRIIB regulation of BCR/TLR-dependent autoreactive B-cell responses.

Avalos AM, Uccellini MB, Lenert P, Viglianti GA, Marshak-Rothstein A.

Eur J Immunol. 2010 Oct;40(10):2692-8. doi: 10.1002/eji.200940184.

45.

G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.

Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE.

J Exp Med. 2010 Aug 2;207(8):1775-89. doi: 10.1084/jem.20092735. Epub 2010 Jul 12.

46.

Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis.

Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R.

J Invest Dermatol. 2010 Nov;130(11):2583-93. doi: 10.1038/jid.2010.200. Epub 2010 Jul 8.

47.

The 2010 Midwinter Conference of Immunologists at Asilomar.

Schoenberger SP, Cheroutre H, Uittenbogaart C, Marshak-Rothstein A.

Nat Immunol. 2010 May;11(5):359-61. doi: 10.1038/ni0510-359. No abstract available.

PMID:
20404845
48.

RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes.

Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A.

Autoimmunity. 2010 Feb;43(1):103-10. doi: 10.3109/08916930903384591.

49.

Regulation of autoreactive B cell responses to endogenous TLR ligands.

Avalos AM, Busconi L, Marshak-Rothstein A.

Autoimmunity. 2010 Feb;43(1):76-83. doi: 10.3109/08916930903374618. Review.

50.

IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.

Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR.

J Immunol. 2010 Jan 15;184(2):796-806. doi: 10.4049/jimmunol.0901748. Epub 2009 Dec 9.

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