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Long non-coding RNAs influence the transcriptome in pulmonary arterial hypertension: the role of PAXIP1-AS1.

Jandl K, Thekkekara Puthenparampil H, Marsh LM, Hoffmann J, Wilhelm J, Veith C, Sinn K, Klepetko W, Olschewski H, Olschewski A, Brock M, Kwapiszewska G.

J Pathol. 2018 Nov 18. doi: 10.1002/path.5195. [Epub ahead of print]


Lessons from Transcriptomics in Hypoxia Induced Pulmonary Hypertension: Does the Mouse Strain Matter?

Marsh LM, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2018 Oct 18. doi: 10.1165/rcmb.2018-0307ED. [Epub ahead of print] No abstract available.


Fra2 Overexpression in Mice Leads to Non-allergic Asthma Development in an IL-13 Dependent Manner.

Gungl A, Biasin V, Wilhelm J, Olschewski A, Kwapiszewska G, Marsh LM.

Front Immunol. 2018 Sep 5;9:2018. doi: 10.3389/fimmu.2018.02018. eCollection 2018.


Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis.

Kwapiszewska G, Gungl A, Wilhelm J, Marsh LM, Thekkekara Puthenparampil H, Sinn K, Didiasova M, Klepetko W, Kosanovic D, Schermuly RT, Wujak L, Weiss B, Schaefer L, Schneider M, Kreuter M, Olschewski A, Seeger W, Olschewski H, Wygrecka M.

Eur Respir J. 2018 Nov 22;52(5). pii: 1800564. doi: 10.1183/13993003.00564-2018. Print 2018 Nov.


Rho-Kinase Inhibition Ameliorates Dasatinib-Induced Endothelial Dysfunction and Pulmonary Hypertension.

Fazakas C, Nagaraj C, Zabini D, Végh AG, Marsh LM, Wilhelm I, Krizbai IA, Olschewski H, Olschewski A, Bálint Z.

Front Physiol. 2018 May 15;9:537. doi: 10.3389/fphys.2018.00537. eCollection 2018.


The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension.

Marsh LM, Jandl K, Grünig G, Foris V, Bashir M, Ghanim B, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Eur Respir J. 2018 Jan 25;51(1). pii: 1701214. doi: 10.1183/13993003.01214-2017. Print 2018 Jan.


Resident cell lineages are preserved in pulmonary vascular remodeling.

Crnkovic S, Marsh LM, El Agha E, Voswinckel R, Ghanim B, Klepetko W, Stacher-Priehse E, Olschewski H, Bloch W, Bellusci S, Olschewski A, Kwapiszewska G.

J Pathol. 2018 Apr;244(4):485-498. doi: 10.1002/path.5044. Epub 2018 Mar 9.


Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.

Nagaraj C, Tabeling C, Nagy BM, Jain PP, Marsh LM, Papp R, Pienn M, Witzenrath M, Ghanim B, Klepetko W, Weir EK, Heschl S, Kwapiszewska G, Olschewski A, Olschewski H.

Eur Respir J. 2017 Jul 20;50(1). pii: 1601651. doi: 10.1183/13993003.01651-2016. Print 2017 Jul.


Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma.

Nagaraj C, Haitchi HM, Heinemann A, Howarth PH, Olschewski A, Marsh LM.

Antioxid Redox Signal. 2017 Dec 20;27(18):1460-1472. doi: 10.1089/ars.2016.6863. Epub 2017 Jun 26.


Meprin β contributes to collagen deposition in lung fibrosis.

Biasin V, Wygrecka M, Marsh LM, Becker-Pauly C, Brcic L, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G.

Sci Rep. 2017 Jan 6;7:39969. doi: 10.1038/srep39969.


Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC.


Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension.

Nagaraj C, Tang B, Nagy BM, Papp R, Jain PP, Marsh LM, Meredith AL, Ghanim B, Klepetko W, Kwapiszewska G, Weir EK, Olschewski H, Olschewski A.

Eur Respir J. 2016 Oct;48(4):1127-1136. doi: 10.1183/13993003.01814-2015. Epub 2016 Aug 18.


Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways.

Kretschmer S, Pieper M, Hüttmann G, Bölke T, Wollenberg B, Marsh LM, Garn H, König P.

Lab Invest. 2016 Aug;96(8):918-31. doi: 10.1038/labinvest.2016.69. Epub 2016 Jul 11.


Functional and molecular factors associated with TAPSE in hypoxic pulmonary hypertension.

Crnkovic S, Schmidt A, Egemnazarov B, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Olschewski A, Olschewski H, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L59-73. doi: 10.1152/ajplung.00381.2015. Epub 2016 Apr 22.


CD133+ cells in pulmonary arterial hypertension.

Foris V, Kovacs G, Marsh LM, Bálint Z, Tötsch M, Avian A, Douschan P, Ghanim B, Klepetko W, Olschewski A, Olschewski H.

Eur Respir J. 2016 Aug;48(2):459-69. doi: 10.1183/13993003.01523-2015. Epub 2016 Apr 21.


Activation of EP4 receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function.

Konya V, Maric J, Jandl K, Luschnig P, Aringer I, Lanz I, Platzer W, Theiler A, Bärnthaler T, Frei R, Marsche G, Marsh LM, Olschewski A, Lippe IT, Heinemann A, Schuligoi R.

Br J Pharmacol. 2015 Sep;172(18):4454-4468. doi: 10.1111/bph.13229. Epub 2015 Jul 31.


Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K.

Crit Care. 2015 May 12;19:226. doi: 10.1186/s13054-015-0933-6.


Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

Hoffmann J, Marsh LM, Pieper M, Stacher E, Ghanim B, Kovacs G, König P, Wilkens H, Haitchi HM, Hoefler G, Klepetko W, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1002-13. doi: 10.1152/ajplung.00383.2014. Epub 2015 Apr 3.


Pressure Overload Creates Right Ventricular Diastolic Dysfunction in a Mouse Model: Assessment by Echocardiography.

Egemnazarov B, Schmidt A, Crnkovic S, Sydykov A, Nagy BM, Kovacs G, Weissmann N, Olschewski H, Olschewski A, Kwapiszewska G, Marsh LM.

J Am Soc Echocardiogr. 2015 Jul;28(7):828-43. doi: 10.1016/j.echo.2015.02.014. Epub 2015 Apr 1.


High-mobility group box-1 induces vascular remodelling processes via c-Jun activation.

Zabini D, Crnkovic S, Xu H, Tscherner M, Ghanim B, Klepetko W, Olschewski A, Kwapiszewska G, Marsh LM.

J Cell Mol Med. 2015 May;19(5):1151-61. doi: 10.1111/jcmm.12519. Epub 2015 Feb 28.


Interleukin 13- and interleukin 17A-induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution.

Park SH, Chen WC, Esmaeil N, Lucas B, Marsh LM, Reibman J, Grunig G.

Pulm Circ. 2014 Dec;4(4):654-68. doi: 10.1086/678511.


Impact of atomization technique on the stability and transport efficiency of nebulized liposomes harboring different surface characteristics.

Lehofer B, Bloder F, Jain PP, Marsh LM, Leitinger G, Olschewski H, Leber R, Olschewski A, Prassl R.

Eur J Pharm Biopharm. 2014 Nov;88(3):1076-85.


Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries.

Jain PP, Leber R, Nagaraj C, Leitinger G, Lehofer B, Olschewski H, Olschewski A, Prassl R, Marsh LM.

Int J Nanomedicine. 2014 Jul 7;9:3249-61. doi: 10.2147/IJN.S63190. eCollection 2014.


Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.

Biasin V, Chwalek K, Wilhelm J, Best J, Marsh LM, Ghanim B, Klepetko W, Fink L, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G.

Int J Biochem Cell Biol. 2014 Sep;54:137-48. doi: 10.1016/j.biocel.2014.06.020. Epub 2014 Jul 10.


Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature.

Grunig G, Marsh LM, Esmaeil N, Jackson K, Gordon T, Reibman J, Kwapiszewska G, Park SH.

Pulm Circ. 2014 Mar;4(1):25-35. doi: 10.1086/674902. Review.


Distinct differences in gene expression patterns in pulmonary arteries of patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis with pulmonary hypertension.

Hoffmann J, Wilhelm J, Marsh LM, Ghanim B, Klepetko W, Kovacs G, Olschewski H, Olschewski A, Kwapiszewska G.

Am J Respir Crit Care Med. 2014 Jul 1;190(1):98-111. doi: 10.1164/rccm.201401-0037OC.


NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension.

Crnkovic S, Egemnazarov B, Jain P, Seay U, Gattinger N, Marsh LM, Bálint Z, Kovacs G, Ghanim B, Klepetko W, Schermuly RT, Weissmann N, Olschewski A, Kwapiszewska G.

Br J Pharmacol. 2014 Aug;171(16):3895-907. doi: 10.1111/bph.12751.


Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model.

Alrifai M, Marsh LM, Dicke T, Kılıç A, Conrad ML, Renz H, Garn H.

PLoS One. 2014 Jan 21;9(1):e85839. doi: 10.1371/journal.pone.0085839. eCollection 2014.


Meprin β, a novel mediator of vascular remodelling underlying pulmonary hypertension.

Biasin V, Marsh LM, Egemnazarov B, Wilhelm J, Ghanim B, Klepetko W, Wygrecka M, Olschewski H, Eferl R, Olschewski A, Kwapiszewska G.

J Pathol. 2014 May;233(1):7-17. doi: 10.1002/path.4303. Epub 2014 Jan 31.


Resting electroencephalography correlates of pseudoneglect: an individual differences approach.

Simon-Dack SL, Holtgraves T, Marsh LM, Fogle KL.

Neuroreport. 2013 Oct 23;24(15):827-30. doi: 10.1097/WNR.0b013e328364125b.


Visualization of intrapulmonary lymph vessels in healthy and inflamed murine lung using CD90/Thy-1 as a marker.

Kretschmer S, Dethlefsen I, Hagner-Benes S, Marsh LM, Garn H, König P.

PLoS One. 2013;8(2):e55201. doi: 10.1371/journal.pone.0055201. Epub 2013 Feb 8.


Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene.

Park SH, Chen WC, Hoffman C, Marsh LM, West J, Grunig G.

PLoS One. 2013;8(1):e55180. doi: 10.1371/journal.pone.0055180. Epub 2013 Jan 29.


Flow cytometry-based cell type-specific assessment of target regulation by pulmonary siRNA delivery.

Merkel OM, Marsh LM, Garn H, Kissel T.

Methods Mol Biol. 2013;948:263-73. doi: 10.1007/978-1-62703-140-0_18.


BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension.

Kwapiszewska G, Chwalek K, Marsh LM, Wygrecka M, Wilhelm J, Best J, Egemnazarov B, Weisel FC, Osswald SL, Schermuly RT, Olschewski A, Seeger W, Weissmann N, Eickelberg O, Fink L.

Am J Pathol. 2012 Dec;181(6):2018-29. doi: 10.1016/j.ajpath.2012.08.028. Epub 2012 Oct 8.


Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension.

Veith C, Marsh LM, Wygrecka M, Rutschmann K, Seeger W, Weissmann N, Kwapiszewska G.

Am J Pathol. 2012 Nov;181(5):1621-33. doi: 10.1016/j.ajpath.2012.07.026. Epub 2012 Sep 6.


Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma.

Hagner S, Welz H, Kicic A, Alrifai M, Marsh LM, Sutanto EN, Ling KM, Stick SM, Müller B, Weissmann N, Renz H.

Allergy. 2012 Aug;67(8):998-1006. doi: 10.1111/j.1398-9995.2012.02851.x. Epub 2012 Jun 12.


PAR-2 inhibition reverses experimental pulmonary hypertension.

Kwapiszewska G, Markart P, Dahal BK, Kojonazarov B, Marsh LM, Schermuly RT, Taube C, Meinhardt A, Ghofrani HA, Steinhoff M, Seeger W, Preissner KT, Olschewski A, Weissmann N, Wygrecka M.

Circ Res. 2012 Apr 27;110(9):1179-91. doi: 10.1161/CIRCRESAHA.111.257568. Epub 2012 Mar 29.


Origin of neomuscularized vessels in mice exposed to chronic hypoxia.

Crnkovic S, Hrzenjak A, Marsh LM, Olschewski A, Kwapiszewska G.

Respir Physiol Neurobiol. 2011 Dec 15;179(2-3):342-5. doi: 10.1016/j.resp.2011.09.016. Epub 2011 Oct 1.


Clara cells drive eosinophil accumulation in allergic asthma.

Sonar SS, Ehmke M, Marsh LM, Dietze J, Dudda JC, Conrad ML, Renz H, Nockher WA.

Eur Respir J. 2012 Feb;39(2):429-38. doi: 10.1183/09031936.00197810. Epub 2011 Aug 4.


Maternal signals for progeny prevention against allergy and asthma.

Marsh LM, Pfefferle PI, Pinkenburg O, Renz H.

Cell Mol Life Sci. 2011 Jun;68(11):1851-62. doi: 10.1007/s00018-011-0644-3. Epub 2011 Mar 3. Review.


Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis.

Avcuoglu S, Wygrecka M, Marsh LM, Günther A, Seeger W, Weissmann N, Fink L, Morty RE, Kwapiszewska G.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):768-80. doi: 10.1165/rcmb.2010-0195OC. Epub 2011 Feb 17.


Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension.

Hecker M, Zaslona Z, Kwapiszewska G, Niess G, Zakrzewicz A, Hergenreider E, Wilhelm J, Marsh LM, Sedding D, Klepetko W, Lohmeyer J, Dimmeler S, Seeger W, Weissmann N, Schermuly RT, Kneidinger N, Eickelberg O, Morty RE.

Am J Respir Crit Care Med. 2010 Sep 15;182(6):805-18. doi: 10.1164/rccm.200909-1367OC. Epub 2010 Jun 3.


Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.

Cakarova L, Marsh LM, Wilhelm J, Mayer K, Grimminger F, Seeger W, Lohmeyer J, Herold S.

Am J Respir Crit Care Med. 2009 Sep 15;180(6):521-32. doi: 10.1164/rccm.200812-1837OC. Epub 2009 Jul 9.


Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung.

Wygrecka M, Marsh LM, Morty RE, Henneke I, Guenther A, Lohmeyer J, Markart P, Preissner KT.

Blood. 2009 May 28;113(22):5588-98. doi: 10.1182/blood-2008-08-170837. Epub 2009 Jan 30.


Transcriptome profiling of primary murine monocytes, lung macrophages and lung dendritic cells reveals a distinct expression of genes involved in cell trafficking.

Zasłona Z, Wilhelm J, Cakarova L, Marsh LM, Seeger W, Lohmeyer J, von Wulffen W.

Respir Res. 2009 Jan 16;10:2. doi: 10.1186/1465-9921-10-2.


Surface expression of CD74 by type II alveolar epithelial cells: a potential mechanism for macrophage migration inhibitory factor-induced epithelial repair.

Marsh LM, Cakarova L, Kwapiszewska G, von Wulffen W, Herold S, Seeger W, Lohmeyer J.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L442-52. doi: 10.1152/ajplung.00525.2007. Epub 2009 Jan 9.


Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model.

Kamlah F, Eul BG, Li S, Lang N, Marsh LM, Seeger W, Grimminger F, Rose F, Hänze J.

Cancer Gene Ther. 2009 Mar;16(3):195-205. doi: 10.1038/cgt.2008.71. Epub 2008 Sep 26.


Fhl-1, a new key protein in pulmonary hypertension.

Kwapiszewska G, Wygrecka M, Marsh LM, Schmitt S, Trösser R, Wilhelm J, Helmus K, Eul B, Zakrzewicz A, Ghofrani HA, Schermuly RT, Bohle RM, Grimminger F, Seeger W, Eickelberg O, Fink L, Weissmann N.

Circulation. 2008 Sep 9;118(11):1183-94. doi: 10.1161/CIRCULATIONAHA.107.761916. Epub 2008 Aug 25.


Lung dendritic cells elicited by Fms-like tyrosine 3-kinase ligand amplify the lung inflammatory response to lipopolysaccharide.

von Wulffen W, Steinmueller M, Herold S, Marsh LM, Bulau P, Seeger W, Welte T, Lohmeyer J, Maus UA.

Am J Respir Crit Care Med. 2007 Nov 1;176(9):892-901. Epub 2007 Aug 9.


PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages.

Cabanski M, Steinmüller M, Marsh LM, Surdziel E, Seeger W, Lohmeyer J.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):26-31. Epub 2007 Aug 9.


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