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A humanized mouse model of HIV-1 latency with enrichment of latent virus in PD-1+ and TIGIT+ CD4 T cells.

Llewellyn GN, Seclèn E, Wietgrefe S, Liu S, Chateau M, Pei H, Perkey K, Marsden MD, Hinkley SJ, Paschon DE, Holmes MC, Zack JA, Louie SG, Haase AT, Cannon PM.

J Virol. 2019 Mar 6. pii: JVI.02086-18. doi: 10.1128/JVI.02086-18. [Epub ahead of print]


Coagulopathy, cryoprecipitate and CRYOSTAT-2: realising the potential of a nationwide trauma system for a national clinical trial.

Marsden M, Benger J, Brohi K, Curry N, Foley C, Green L, Lucas J, Rossetto A, Stanworth S, Thomas H, Davenport R; CRYOSTAT-2 investigators.

Br J Anaesth. 2019 Feb;122(2):164-169. doi: 10.1016/j.bja.2018.10.055. Epub 2018 Nov 28. No abstract available.


IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine.

McLaren JE, Clement M, Marsden M, Miners KL, Llewellyn-Lacey S, Grant EJ, Rubina A, Gimeno Brias S, Gostick E, Stacey MA, Orr SJ, Stanton RJ, Ladell K, Price DA, Humphreys IR.

J Immunol. 2019 Feb 1;202(3):943-955. doi: 10.4049/jimmunol.1701757.


Pre-hospital Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for exsanguinating pelvic haemorrhage.

Lendrum R, Perkins Z, Chana M, Marsden M, Davenport R, Grier G, Sadek S, Davies G.

Resuscitation. 2019 Feb;135:6-13. doi: 10.1016/j.resuscitation.2018.12.018. Epub 2018 Dec 27.


Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane.

Smith SE, Busse DC, Binter S, Weston S, Diaz Soria C, Laksono BM, Clare S, Van Nieuwkoop S, Van den Hoogen BG, Clement M, Marsden M, Humphreys IR, Marsh M, de Swart RL, Wash RS, Tregoning JS, Kellam P.

J Virol. 2019 Mar 5;93(6). pii: e02003-18. doi: 10.1128/JVI.02003-18. Print 2019 Mar 15.


Combined ultrasound and Sestamibi scintigraphy provides accurate preoperative localisation for patients with primary hyperparathyroidism.

Scattergood S, Marsden M, Kyrimi E, Ishii H, Doddi S, Sinha P.

Ann R Coll Surg Engl. 2019 Feb;101(2):97-102. doi: 10.1308/rcsann.2018.0158. Epub 2018 Oct 5.


Development of a major incident triage tool: the importance of evidence from implementation studies.

Marsden MER, Mossadegh S, Marsh W, Tai N.

J R Army Med Corps. 2018 Sep 26. pii: jramc-2018-001057. doi: 10.1136/jramc-2018-001057. [Epub ahead of print] No abstract available.


Outcomes following trauma laparotomy for hypotensive trauma patients: A UK military and civilian perspective.

Marsden M, Carden R, Navaratne L, Smith IM, Penn-Barwell JG, Kraven LM, Brohi K, Tai NRM, Bowley DM.

J Trauma Acute Care Surg. 2018 Sep;85(3):620-625. doi: 10.1097/TA.0000000000001988.


Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.

Marsden MD, Wu X, Navab SM, Loy BA, Schrier AJ, DeChristopher BA, Shimizu AJ, Hardman CT, Ho S, Ramirez CM, Wender PA, Zack JA.

Virology. 2018 Jul;520:83-93. doi: 10.1016/j.virol.2018.05.006. Epub 2018 May 26.


Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection.

Gimeno Brias S, Marsden M, Forbester J, Clement M, Brandt C, Harcourt K, Kane L, Chapman L, Clare S, Humphreys IR.

PLoS One. 2018 May 16;13(5):e0197596. doi: 10.1371/journal.pone.0197596. eCollection 2018.


Peptide and peptide-carbon nanotube hydrogels as scaffolds for tissue & 3D tumor engineering.

Sheikholeslam M, Wheeler SD, Duke KG, Marsden M, Pritzker M, Chen P.

Acta Biomater. 2018 Mar 15;69:107-119. doi: 10.1016/j.actbio.2017.12.012. Epub 2017 Dec 15.


Cost-effectiveness of routine imaging of suspected appendicitis.

D'Souza N, Marsden M, Bottomley S, Nagarajah N, Scutt F, Toh S.

Ann R Coll Surg Engl. 2018 Jan;100(1):47-51. doi: 10.1308/rcsann.2017.0132. Epub 2017 Oct 19.


Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity.

Rai TS, Glass M, Cole JJ, Rather MI, Marsden M, Neilson M, Brock C, Humphreys IR, Everett RD, Adams PD.

Nucleic Acids Res. 2017 Nov 16;45(20):11673-11683. doi: 10.1093/nar/gkx771.


In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.

Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA.

PLoS Pathog. 2017 Sep 21;13(9):e1006575. doi: 10.1371/journal.ppat.1006575. eCollection 2017 Sep.


NBEAL2 is required for neutrophil and NK cell function and pathogen defense.

Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA, Hoenderdos K, Harcourt K, Marsden M, Abdul-Karim J, Clement M, Antrobus R, Umrania Y, Barton PR, Flint SM, Juss JK, Condliffe AM, Lyons PA, Humphreys IR, Chilvers ER, Ouwehand WH, Dougan G, Smith KG.

J Clin Invest. 2017 Sep 1;127(9):3521-3526. doi: 10.1172/JCI91684. Epub 2017 Aug 7.


Humanized Mouse Models for Human Immunodeficiency Virus Infection.

Marsden MD, Zack JA.

Annu Rev Virol. 2017 Sep 29;4(1):393-412. doi: 10.1146/annurev-virology-101416-041703. Epub 2017 Jul 26. Review.


The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis.

Stacey MA, Clare S, Clement M, Marsden M, Abdul-Karim J, Kane L, Harcourt K, Brandt C, Fielding CA, Smith SE, Wash RS, Brias SG, Stack G, Notley G, Cambridge EL, Isherwood C, Speak AO, Johnson Z, Ferlin W, Jones SA, Kellam P, Humphreys IR.

J Clin Invest. 2017 Apr 3;127(4):1463-1474. doi: 10.1172/JCI84889. Epub 2017 Feb 27.


Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.

Clement M, Marsden M, Stacey MA, Abdul-Karim J, Gimeno Brias S, Costa Bento D, Scurr MJ, Ghazal P, Weaver CT, Carlesso G, Clare S, Jones SA, Godkin A, Jones GW, Humphreys IR.

PLoS Pathog. 2016 Dec 7;12(12):e1006050. doi: 10.1371/journal.ppat.1006050. eCollection 2016 Dec.


Correction: Integrin α5β1 Function Is Regulated by XGIPC/kermit2 Mediated Endocytosis during Xenopus laevis Gastrulation.

Spicer E, Suckert C, Al-Attar H, Marsden M.

PLoS One. 2015 Nov 25;10(11):e0143904. doi: 10.1371/journal.pone.0143904. eCollection 2015. No abstract available.


British Military surgical key performance indicators: time for an update?

Marsden ME, Sharrock AE, Hansen CL, Newton NJ, Bowley DM, Midwinter M.

J R Army Med Corps. 2016 Oct;162(5):373-378. doi: 10.1136/jramc-2015-000521. Epub 2015 Nov 17.


Disruption of Type I Interferon Induction by HIV Infection of T Cells.

Sanchez DJ, Miranda D Jr, Marsden MD, Dizon TM, Bontemps JR, Davila SJ, Del Mundo LE, Ha T, Senaati A, Zack JA, Cheng G.

PLoS One. 2015 Sep 16;10(9):e0137951. doi: 10.1371/journal.pone.0137951. eCollection 2015.


Defining our destiny: trainee working group consensus statement on the future of emergency surgery training in the United Kingdom.

Sharrock AE, Gokani VJ, Harries RL, Pearce L, Smith SR, Ali O, Chu H, Dubois A, Ferguson H, Humm G, Marsden M, Nepogodiev D, Venn M, Singh S, Swain C, Kirkby-Bott J.

World J Emerg Surg. 2015 Jun 30;10:26. doi: 10.1186/s13017-015-0019-4. eCollection 2015.


RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice.

Shimizu S, Ringpis GE, Marsden MD, Cortado RV, Wilhalme HM, Elashoff D, Zack JA, Chen IS, An DS.

Mol Ther Nucleic Acids. 2015 Feb 17;4:e227. doi: 10.1038/mtna.2015.3.


Studies of retroviral infection in humanized mice.

Marsden MD, Zack JA.

Virology. 2015 May;479-480:297-309. doi: 10.1016/j.virol.2015.01.017. Epub 2015 Feb 11. Review.


Double trouble: HIV latency and CTL escape.

Marsden MD, Zack JA.

Cell Host Microbe. 2015 Feb 11;17(2):141-2. doi: 10.1016/j.chom.2015.01.008.


CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.

Stack G, Jones E, Marsden M, Stacey MA, Snelgrove RJ, Lacaze P, Jacques LC, Cuff SM, Stanton RJ, Gallimore AM, Hussell T, Wilkinson GW, Ghazal P, Taylor PR, Humphreys IR.

PLoS Pathog. 2015 Feb 5;11(2):e1004641. doi: 10.1371/journal.ppat.1004641. eCollection 2015 Feb.


Experimental Approaches for Eliminating Latent HIV.

Marsden MD, Zack JA.

For Immunopathol Dis Therap. 2015;6(1-2):91-99.


Scanning and War: Utility of FAST and CT in the Assessment of Battlefield Abdominal Trauma.

Smith IM, Naumann DN, Marsden ME, Ballard M, Bowley DM.

Ann Surg. 2015 Aug;262(2):389-96. doi: 10.1097/SLA.0000000000001002.


Intrasaccular caecal adenocarcinoma presenting as enlarging right inguinoscrotal hernia.

Marsden M, Curtis N, McGee S, Bracey E, Branagan G, Sleight S.

Int J Surg Case Rep. 2014;5(10):643-5. doi: 10.1016/j.ijscr.2014.07.012. Epub 2014 Aug 12.


Neutralizing the HIV reservoir.

Marsden MD, Zack JA.

Cell. 2014 Aug 28;158(5):971-972. doi: 10.1016/j.cell.2014.08.010.


Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery.

Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH.

ACS Nano. 2014 Aug 26;8(8):7723-32. doi: 10.1021/nn5002694. Epub 2014 Jul 31.


Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW, Humphreys IR.

Cell Host Microbe. 2014 Apr 9;15(4):471-83. doi: 10.1016/j.chom.2014.03.003.


Label-free DNA sensing using millimeter-wave silicon WGM resonator.

Taeb A, Basha MA, Gigoyan S, Marsden M, Safavi-Naeini S.

Opt Express. 2013 Aug 26;21(17):19467-72. doi: 10.1364/OE.21.019467.


Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo.

Beans EJ, Fournogerakis D, Gauntlett C, Heumann LV, Kramer R, Marsden MD, Murray D, Chun TW, Zack JA, Wender PA.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11698-703. doi: 10.1073/pnas.1302634110. Epub 2013 Jun 28.


HIV/AIDS eradication.

Marsden MD, Zack JA.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4003-10. doi: 10.1016/j.bmcl.2013.05.032. Epub 2013 May 18. Review.


Successful management of acute-onset torticollis in a giraffe (Giraffa camelopardalis reticulata).

Dadone LI, Haussler KK, Brown G, Marsden M, Gaynor J, Johnston MS, Garelle D.

J Zoo Wildl Med. 2013 Mar;44(1):181-5.


Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol.

Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G.

Immunity. 2013 Jan 24;38(1):92-105. doi: 10.1016/j.immuni.2012.11.005. Epub 2012 Dec 27.


Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity.

Humphreys IR, Clement M, Marsden M, Ladell K, McLaren JE, Smart K, Hindley JP, Bridgeman HM, van den Berg HA, Price DA, Ager A, Wooldridge L, Godkin A, Gallimore AM.

Eur J Immunol. 2012 Dec;42(12):3235-42. doi: 10.1002/eji.201242575. Epub 2012 Oct 16.


Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro.

DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA.

Nat Chem. 2012 Sep;4(9):705-10. doi: 10.1038/nchem.1395. Epub 2012 Jul 15.


Virological evidence supporting the use of raltegravir in HIV post-exposure prophylaxis regimens.

Marsden MD, Krogstad PA, Zack JA.

Antivir Ther. 2012;17(7):1375-9. doi: 10.3851/IMP2255. Epub 2012 Jul 20.


The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity.

Twohig JP, Marsden M, Cuff SM, Ferdinand JR, Gallimore AM, Perks WV, Al-Shamkhani A, Humphreys IR, Wang EC.

FASEB J. 2012 Aug;26(8):3575-86. doi: 10.1096/fj.11-200618. Epub 2012 May 16.


Allosteric modulation of beta1 integrin function induces lung tissue repair.

Aljamal-Naylor R, Wilson L, McIntyre S, Rossi F, Harrison B, Marsden M, Harrison DJ.

Adv Pharmacol Sci. 2012;2012:768720. doi: 10.1155/2012/768720. Epub 2012 Feb 26.


Glucocorticoid receptor signaling is essential for mesoderm formation and muscle development in zebrafish.

Nesan D, Kamkar M, Burrows J, Scott IC, Marsden M, Vijayan MM.

Endocrinology. 2012 Mar;153(3):1288-300. doi: 10.1210/en.2011-1559. Epub 2012 Jan 10.


The selective use of splenic flexure mobilization is safe in both laparoscopic and open anterior resections.

Marsden MR, Conti JA, Zeidan S, Flashman KG, Khan JS, O'Leary DP, Parvaiz A.

Colorectal Dis. 2012 Oct;14(10):1255-61. doi: 10.1111/j.1463-1318.2011.02927.x.


Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis.

Dweck MR, Jones C, Joshi NV, Fletcher AM, Richardson H, White A, Marsden M, Pessotto R, Clark JC, Wallace WA, Salter DM, McKillop G, van Beek EJ, Boon NA, Rudd JH, Newby DE.

Circulation. 2012 Jan 3;125(1):76-86. doi: 10.1161/CIRCULATIONAHA.111.051052. Epub 2011 Nov 16.


HIV latency in the humanized BLT mouse.

Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA.

J Virol. 2012 Jan;86(1):339-47. doi: 10.1128/JVI.06366-11. Epub 2011 Nov 9.


IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection.

Stacey MA, Marsden M, Wang EC, Wilkinson GW, Humphreys IR.

J Immunol. 2011 Sep 15;187(6):2944-52. doi: 10.4049/jimmunol.1101021. Epub 2011 Aug 17.


HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes.

Marsden MD, Burke BP, Zack JA.

Virology. 2011 Sep 1;417(2):394-9. doi: 10.1016/j.virol.2011.06.024. Epub 2011 Jul 20.


Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages.

Marsden MD, Avancena P, Kitchen CM, Hubbard T, Zack JA.

Antimicrob Agents Chemother. 2011 Aug;55(8):3696-702. doi: 10.1128/AAC.00566-11. Epub 2011 May 31.


Activation of latent HIV using drug-loaded nanoparticles.

Kovochich M, Marsden MD, Zack JA.

PLoS One. 2011 Apr 5;6(4):e18270. doi: 10.1371/journal.pone.0018270.

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