Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 211

1.

Another piece of the puzzle added to understand t(4;11) leukemia better.

Marschalek R.

Haematologica. 2019 Jun;104(6):1098-1100. doi: 10.3324/haematol.2018.213397. No abstract available.

2.

A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia.

Capela de Matos RR, Ney Garcia DR, Othman MAK, Moura Ferreira G, Melo JB, Carreira IM, Meyer C, Marschalek R, Costa ES, Land MGP, Liehr T, Ribeiro RC, Silva MLM.

Cytogenet Genome Res. 2019;157(4):213-219. doi: 10.1159/000499640. Epub 2019 Apr 12.

PMID:
30974445
3.

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions.

Meyer C, Lopes BA, Caye-Eude A, Cavé H, Arfeuille C, Cuccuini W, Sutton R, Venn NC, Oh SH, Tsaur G, Escherich G, Feuchtinger T, Kosasih HJ, Khaw SL, Ekert PG, Pombo-de-Oliveira MS, Bidet A, Djahanschiri B, Ebersberger I, Zaliova M, Zuna J, Zermanova Z, Juvonen V, Grümayer RP, Fazio G, Cazzaniga G, Larghero P, Emerenciano M, Marschalek R.

Leukemia. 2019 Sep;33(9):2306-2340. doi: 10.1038/s41375-019-0451-7. Epub 2019 Mar 21. No abstract available.

4.

IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia.

Lopes BA, Meyer C, Barbosa TC, Poubel CP, Mansur MB, Duployez N, Bashton M, Harrison CJ, Zur Stadt U, Horstmann M, Pombo-de-Oliveira MS, Palmi C, Cazzaniga G, Venn NC, Sutton R, Alonso CN, Tsaur G, Gupta SK, Bakhshi S, Marschalek R, Emerenciano M.

Transl Oncol. 2019 May;12(5):726-732. doi: 10.1016/j.tranon.2019.02.002. Epub 2019 Mar 13.

5.

Genetically engineered CAR NK cells display selective cytotoxicity against FLT3-positive B-ALL and inhibit in vivo leukemia growth.

Oelsner S, Waldmann A, Billmeier A, Röder J, Lindner A, Ullrich E, Marschalek R, Dotti G, Jung G, Große-Hovest L, Oberoi P, Bader P, Wels WS.

Int J Cancer. 2019 Oct 1;145(7):1935-1945. doi: 10.1002/ijc.32269. Epub 2019 Mar 24.

PMID:
30860598
6.

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.

Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambilet D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P.

Haematologica. 2019 Jun;104(6):1189-1201. doi: 10.3324/haematol.2018.202044. Epub 2019 Jan 24.

7.

Acute myeloid leukemia with t(10;11)(p11-12;q23.3): Results of Russian Pediatric AML registration study.

Zerkalenkova E, Lebedeva S, Kazakova A, Tsaur G, Starichkova Y, Timofeeva N, Soldatkina O, Aprelova E, Popov A, Ponomareva N, Baidun L, Meyer C, Novichkova G, Maschan M, Maschan A, Marschalek R, Olshanskaya Y.

Int J Lab Hematol. 2019 Apr;41(2):287-292. doi: 10.1111/ijlh.12969. Epub 2019 Jan 9.

PMID:
30624859
8.

A new complex rearrangement in infant ALL: t(X;11;17)(p11.2;q23;q12).

Brassesco MS, Valera ET, Meyer C, Marschalek R, Lopes BA, Queiroz RGP, Calado RT, Scrideli CA, Tone LG.

Cancer Genet. 2018 Dec;228-229:110-114. doi: 10.1016/j.cancergen.2018.10.006. Epub 2018 Oct 28.

PMID:
30553463
9.

Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis.

Remy J, Linder B, Weirauch U, Konovalova J, Marschalek R, Aigner A, Kögel D.

Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):175-189. doi: 10.1016/j.bbamcr.2018.10.017. Epub 2018 Oct 30.

PMID:
30389373
10.

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice.

Heckl BC, Carlet M, Vick B, Roolf C, Alsadeq A, Grunert M, Liu WH, Liebl A, Hiddemann W, Marschalek R, Schewe DM, Spiekermann K, Junghanss C, Jeremias I.

Leuk Lymphoma. 2019 Mar;60(3):848-851. doi: 10.1080/10428194.2018.1509314. Epub 2018 Sep 20. No abstract available.

PMID:
30234406
11.

Prenatal origin of KRAS mutation in a child with an acute myelomonocytic leukaemia bearing the KMT2A/MLL-AFDN/MLLT4/AF6 fusion transcript.

Andriano N, Iachelli V, Bonaccorso P, La Rosa M, Meyer C, Marschalek R, Lo Nigro L.

Br J Haematol. 2019 May;185(3):563-566. doi: 10.1111/bjh.15534. Epub 2018 Aug 21. No abstract available.

PMID:
30132801
12.

A case of pediatric acute myeloid leukemia with t(11;16)(q23;q24) leading to a novel KMT2A-USP10 fusion gene.

Zerkalenkova E, Lebedeva S, Kazakova A, Baryshev P, Meyer C, Marschalek R, Novichkova G, Maschan M, Maschan A, Olshanskaya Y.

Genes Chromosomes Cancer. 2018 Oct;57(10):522-524. doi: 10.1002/gcc.22646. Epub 2018 Aug 14.

PMID:
30107050
13.

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34+ cells.

Prieto C, Marschalek R, Kühn A, Bursen A, Bueno C, Menéndez P.

Oncotarget. 2017 Jul 26;8(47):81936-81941. doi: 10.18632/oncotarget.19567. eCollection 2017 Oct 10.

14.

Targeted Next-Generation Sequencing for Detecting MLL Gene Fusions in Leukemia.

Afrin S, Zhang CRC, Meyer C, Stinson CL, Pham T, Bruxner TJC, Venn NC, Trahair TN, Sutton R, Marschalek R, Fink JL, Moore AS.

Mol Cancer Res. 2018 Feb;16(2):279-285. doi: 10.1158/1541-7786.MCR-17-0569. Epub 2017 Nov 13.

15.

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

Smith MJ, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T, Ikura M.

Nat Commun. 2017 Oct 23;8(1):1099. doi: 10.1038/s41467-017-01326-5.

16.

How to effectively treat acute leukemia patients bearing MLL-rearrangements ?

Steinhilber D, Marschalek R.

Biochem Pharmacol. 2018 Jan;147:183-190. doi: 10.1016/j.bcp.2017.09.007. Epub 2017 Sep 21. Review.

17.

TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation.

Saul MJ, Groher F, Hegewald AB, Müller-McNicoll M, Marschalek R, Suess B, Steinhilber D.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:60-67. doi: 10.1016/j.prostaglandins.2017.07.006. Epub 2017 Aug 11.

PMID:
28803964
18.

A Case of Acute Myeloid Leukemia with Novel Translocation t(6;11)(p22.2;q23) and Concurrent Insertion ins(11;9)(q23;p21.3p21.3).

Malinowska I, Sikorska-Fic B, Romiszewska M, Stefaniak A, Pastwińska A, Górska E, Popko K, Meyer C, Marschalek R, Szczepański T.

Adv Exp Med Biol. 2017;1021:93-98. doi: 10.1007/5584_2017_86.

PMID:
28785923
19.

The MLL recombinome of acute leukemias in 2017.

Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, van der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Göhring G, Kustanovich A, Aleinikova O, Schäfer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, van den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Möricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grümayer R, Sedék L, Szczepański T, Caye A, Suarez L, Cavé H, Marschalek R.

Leukemia. 2018 Feb;32(2):273-284. doi: 10.1038/leu.2017.213. Epub 2017 Jul 13.

20.

Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12.

Ball AK, Beilstein K, Wittmann S, Sürün D, Saul MJ, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):561-571. doi: 10.1016/j.bbalip.2017.02.015. Epub 2017 Feb 28.

PMID:
28257804
21.

Identification of a Cryptic Insertion ins(11;X)(q23;q28q12) Resulting in a KMT2A-FLNA Fusion in a 13-Month-Old Child with Acute Myelomonocytic Leukemia.

Lentes J, Thomay K, Schneider DT, Bernbeck B, Reinhardt D, Marschalek R, Meyer C, Schlegelberger B, Göhring G.

Cytogenet Genome Res. 2016;150(3-4):281-286. doi: 10.1159/000458165. Epub 2017 Mar 3.

PMID:
28253492
22.

Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial-Mesenchymal Transition.

Ibrahim AA, Schmithals C, Kowarz E, Köberle V, Kakoschky B, Pleli T, Kollmar O, Nitsch S, Waidmann O, Finkelmeier F, Zeuzem S, Korf HW, Schmid T, Weigert A, Kronenberger B, Marschalek R, Piiper A.

Clin Cancer Res. 2017 Jul 15;23(14):3896-3905. doi: 10.1158/1078-0432.CCR-16-1762. Epub 2017 Feb 6.

23.

DDX6 transfers P-TEFb kinase to the AF4/AF4N (AFF1) super elongation complex.

Mück F, Bracharz S, Marschalek R.

Am J Blood Res. 2016 Sep 15;6(3):28-45. eCollection 2016.

24.

COBL is a novel hotspot for IKZF1 deletions in childhood acute lymphoblastic leukemia.

Lopes BA, Meyer C, Barbosa TC, Zur Stadt U, Horstmann M, Venn NC, Heatley S, White DL, Sutton R, Pombo-de-Oliveira MS, Marschalek R, Emerenciano M.

Oncotarget. 2016 Aug 16;7(33):53064-53073. doi: 10.18632/oncotarget.10590.

25.

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami.

Obser T, Ledford-Kraemer M, Oyen F, Brehm MA, Denis CV, Marschalek R, Montgomery RR, Sadler JE, Schneppenheim S, Budde U, Schneppenheim R.

J Thromb Haemost. 2016 Sep;14(9):1725-35. doi: 10.1111/jth.13398. Epub 2016 Aug 20.

26.

Molecular characterization of KMT2A fusion partner genes in 13 cases of pediatric leukemia with complex or cryptic karyotypes.

Ney Garcia DR, de Souza MT, de Figueiredo AF, Othman MAK, Rittscher K, Abdelhay E, Capela de Matos RR, Meyer C, Marschalek R, Land MGP, Liehr T, Ribeiro RC, Silva MLM.

Hematol Oncol. 2017 Dec;35(4):760-768. doi: 10.1002/hon.2299. Epub 2016 Jun 10.

PMID:
27282883
27.

The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism.

Kühn A, Löscher D, Marschalek R.

Oncotarget. 2016 Jun 7;7(23):35341-52. doi: 10.18632/oncotarget.9241.

28.

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair.

Castaño J, Herrero AB, Bursen A, González F, Marschalek R, Gutiérrez NC, Menendez P.

Oncotarget. 2016 May 24;7(21):30440-52. doi: 10.18632/oncotarget.8938.

29.

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia.

Prieto C, Stam RW, Agraz-Doblas A, Ballerini P, Camos M, Castaño J, Marschalek R, Bursen A, Varela I, Bueno C, Menendez P.

Cancer Res. 2016 Apr 15;76(8):2478-89. doi: 10.1158/0008-5472.CAN-15-2769. Epub 2016 Feb 2.

30.

Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways.

Marschalek R.

Ann Lab Med. 2016 Mar;36(2):85-100. doi: 10.3343/alm.2016.36.2.85. Review.

31.

Long-term remission of therapy-related acute myeloid leukemia with a new t(11;18)(q23;q21.2) translocation and KMT2A-ME2 (MLL-ME2) fusion gene.

Szotkowski T, Jarošová M, Zimmermannová O, Meyer C, Marschalek R, Zuna J, Hubáček J, Indrák K.

Cancer Genet. 2015 Dec;208(12):610-4. doi: 10.1016/j.cancergen.2015.09.004. Epub 2015 Sep 15.

PMID:
26556690
32.

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia.

Sanjuan-Pla A, Bueno C, Prieto C, Acha P, Stam RW, Marschalek R, Menéndez P.

Blood. 2015 Dec 17;126(25):2676-85. doi: 10.1182/blood-2015-09-667378. Epub 2015 Oct 13. Review.

33.

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3.

Ahmad K, Scholz B, Capelo R, Schweighöfer I, Kahnt AS, Marschalek R, Steinhilber D.

Oncotarget. 2015 Sep 22;6(28):25784-800. doi: 10.18632/oncotarget.4703.

34.

AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions.

Scholz B, Kowarz E, Rössler T, Ahmad K, Steinhilber D, Marschalek R.

Am J Blood Res. 2015 Jun 15;5(1):10-24. eCollection 2015.

35.

Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein.

Sabiani S, Geppert T, Engelbrecht C, Kowarz E, Schneider G, Marschalek R.

EBioMedicine. 2015 Apr 16;2(5):386-95. doi: 10.1016/j.ebiom.2015.04.009. eCollection 2015 May.

36.

A new variant of KMT2A(MLL)-FLNA fusion transcript in acute myeloid leukemia with ins(X;11)(q28;q23q23).

Matveeva E, Kazakova A, Olshanskaya Y, Tsaur G, Shelikhova L, Meyer C, Marschalek R, Novichkova G, Maschan M, Maschan A.

Cancer Genet. 2015 Apr;208(4):148-51. doi: 10.1016/j.cancergen.2015.03.001. Epub 2015 Mar 7.

PMID:
25892123
37.

Molecular studies reveal a MLL-MLLT3 gene fusion displaced in a case of childhood acute lymphoblastic leukemia with complex karyotype.

Ney Garcia DR, Liehr T, Emerenciano M, Meyer C, Marschalek R, Pombo-de-Oliveira Mdo S, Ribeiro RC, Poirot Land MG, Macedo Silva ML.

Cancer Genet. 2015 Apr;208(4):143-7. doi: 10.1016/j.cancergen.2015.02.002. Epub 2015 Feb 19.

38.

MLL leukemia and future treatment strategies.

Marschalek R.

Arch Pharm (Weinheim). 2015 Apr;348(4):221-8. doi: 10.1002/ardp.201400449. Epub 2015 Mar 4. Review.

PMID:
25740345
39.

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines.

Kowarz E, Löscher D, Marschalek R.

Biotechnol J. 2015 Apr;10(4):647-53. doi: 10.1002/biot.201400821. Epub 2015 Mar 2.

PMID:
25650551
40.

Subclonality and prenatal origin of RAS mutations in KMT2A (MLL)-rearranged infant acute lymphoblastic leukaemia.

Emerenciano M, Barbosa Tda C, de Almeida Lopes B, Meyer C, Marschalek R, Pombo-de-Oliveira MS.

Br J Haematol. 2015 Jul;170(2):268-71. doi: 10.1111/bjh.13279. Epub 2015 Jan 22. No abstract available.

PMID:
25613690
41.

Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia.

Richmond J, Carol H, Evans K, High L, Mendomo A, Robbins A, Meyer C, Venn NC, Marschalek R, Henderson M, Sutton R, Kurmasheva RT, Kees UR, Houghton PJ, Smith MA, Lock RB.

Clin Cancer Res. 2015 Mar 15;21(6):1395-405. doi: 10.1158/1078-0432.CCR-14-2300. Epub 2015 Jan 8.

42.

Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrations in acute leukemias.

Burmeister T, Meyer C, Gröger D, Hofmann J, Marschalek R.

Leuk Res. 2015 Feb;39(2):242-7. doi: 10.1016/j.leukres.2014.11.017. Epub 2014 Nov 29. Erratum in: Leuk Res. 2015 Aug;39(8):925.

PMID:
25510485
43.

Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells.

Wegner MS, Wanger RA, Oertel S, Brachtendorf S, Hartmann D, Schiffmann S, Marschalek R, Schreiber Y, Ferreirós N, Geisslinger G, Grösch S.

Biochem Pharmacol. 2014 Dec 15;92(4):577-89. doi: 10.1016/j.bcp.2014.10.007. Epub 2014 Oct 22.

PMID:
25451689
44.

Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL.

Ahmad K, Katryniok C, Scholz B, Merkens J, Löscher D, Marschalek R, Steinhilber D.

Oncogenesis. 2014 Nov 17;3:e127. doi: 10.1038/oncsis.2014.39.

45.

MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature.

Douet-Guilbert N, Eveillard JR, Meyer C, Ugo V, Le Bris MJ, Basinko A, Morel F, Marschalek R, De Braekeleer M.

Leuk Res. 2014 Nov;38(11):1316-9. doi: 10.1016/j.leukres.2014.08.011. Epub 2014 Aug 29. Review.

PMID:
25205603
46.

Functional characterisation of different MLL fusion proteins by using inducible Sleeping Beauty vectors.

Wächter K, Kowarz E, Marschalek R.

Cancer Lett. 2014 Oct 1;352(2):196-202. doi: 10.1016/j.canlet.2014.06.016. Epub 2014 Jul 9.

47.

Complex MLL rearrangement in non-infiltrated bone marrow in an infant with stage II precursor B-lymphoblastic lymphoma.

Ahlmann M, Meyer C, Marschalek R, Burkhardt B, Koehler G, Klapper W, Juergens H, Rossig C.

Eur J Haematol. 2014 Oct;93(4):349-53. doi: 10.1111/ejh.12314. Epub 2014 Apr 28.

PMID:
24635731
48.

Secondary acute monocytic leukemia positive for 11q23 rearrangement in Nijmegen breakage syndrome.

Pastorczak A, Szczepanski T, Trelinska J, Finalet Ferreiro J, Wlodarska I, Mycko K, Polucha A, Sedek L, Meyer C, Marschalek R, Młynarski W.

Pediatr Blood Cancer. 2014 Aug;61(8):1469-71. doi: 10.1002/pbc.24994. Epub 2014 Mar 11.

PMID:
24619942
49.

ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia.

Emerenciano M, Barbosa TC, Lopes BA, Blunck CB, Faro A, Andrade C, Meyer C, Marschalek R, Pombo-de-Oliveira MS; Brazilian Collaborative Study Group of Infant Acute Leukemia.

BMC Cancer. 2014 Feb 25;14:127. doi: 10.1186/1471-2407-14-127.

50.

Molecular characterization and clinical course of MLL-ACTN4 rearrangement in therapy-related hematologic malignancies.

Yang JJ, Park TS, Lee ST, Seo JY, Oh SH, Cho EH, Burmeister T, Ludwig WD, Meyer C, Marschalek R, Kim HJ, Kim SH.

Haematologica. 2014 Apr;99(4):e49-51. doi: 10.3324/haematol.2013.102798. Epub 2014 Feb 21. No abstract available.

Supplemental Content

Loading ...
Support Center