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Items: 1 to 50 of 51

1.

[A novel class of polycationic macromolecules against multiresistant pathogens].

Marsault É.

Med Sci (Paris). 2018 Oct;34(10):791-795. doi: 10.1051/medsci/2018198. Epub 2018 Nov 19. French. No abstract available.

PMID:
30451669
2.

Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8-13).

Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É.

J Med Chem. 2018 Aug 23;61(16):7103-7115. doi: 10.1021/acs.jmedchem.8b00175. Epub 2018 Aug 13.

PMID:
30035538
3.

Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome.

Klarskov K, Gagnon H, Racine M, Boudreault PL, Normandin C, Marsault E, Gleich GJ, Naylor S.

Toxicol Lett. 2018 Sep 15;294:193-204. doi: 10.1016/j.toxlet.2018.05.027. Epub 2018 May 22.

PMID:
29800716
4.

Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C.

Lamontagne Boulet M, Isabelle C, Guay I, Brouillette E, Langlois JP, Jacques PÉ, Rodrigue S, Brzezinski R, Beauregard PB, Bouarab K, Boyapelly K, Boudreault PL, Marsault É, Malouin F.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02197-17. doi: 10.1128/AAC.02197-17. Print 2018 Jun.

5.

In Search of the Optimal Macrocyclization Site for Neurotensin.

Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É.

ACS Med Chem Lett. 2018 Jan 29;9(3):227-232. doi: 10.1021/acsmedchemlett.7b00500. eCollection 2018 Mar 8.

6.

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.

Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.

Pharmacol Res. 2018 May;131:7-16. doi: 10.1016/j.phrs.2018.02.032. Epub 2018 Mar 9.

PMID:
29530600
7.

A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects.

Trân K, Murza A, Sainsily X, Coquerel D, Côté J, Belleville K, Haroune L, Longpré JM, Dumaine R, Salvail D, Lesur O, Auger-Messier M, Sarret P, Marsault É.

J Med Chem. 2018 Mar 22;61(6):2266-2277. doi: 10.1021/acs.jmedchem.7b01353. Epub 2018 Feb 26.

PMID:
29461833
8.

Tomatidine and analog FC04-100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp.

Guay I, Boulanger S, Isabelle C, Brouillette E, Chagnon F, Bouarab K, Marsault E, Malouin F.

BMC Pharmacol Toxicol. 2018 Feb 13;19(1):7. doi: 10.1186/s40360-018-0197-2.

9.

The apelinergic system as an alternative to catecholamines in low-output septic shock.

Coquerel D, Sainsily X, Dumont L, Sarret P, Marsault É, Auger-Messier M, Lesur O.

Crit Care. 2018 Jan 19;22(1):10. doi: 10.1186/s13054-018-1942-z.

10.

Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.

Yan LH, Le Roux A, Boyapelly K, Lamontagne AM, Archambault MA, Picard-Jean F, Lalonde-Seguin D, St-Pierre E, Najmanovich RJ, Fortier LC, Lafontaine D, Marsault É.

Eur J Med Chem. 2018 Jan 1;143:755-768. doi: 10.1016/j.ejmech.2017.11.079. Epub 2017 Dec 2.

PMID:
29220796
11.

Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer.

Paquette M, Vilera-Perez LG, Beaudoin S, Ekindi-Ndongo N, Boudreaut PL, Bonin MA, Battista MC, Bentourkia M, Lopez AF, Lecomte R, Marsault E, Guérin B, Sabbagh R, Leyton JV.

Oncoimmunology. 2017 May 19;6(10):e1331195. doi: 10.1080/2162402X.2017.1331195. eCollection 2017.

12.

Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome.

Klarskov K, Gagnon H, Boudreault PL, Normandin C, Plancq B, Marsault E, Gleich GJ, Naylor S.

Toxicol Lett. 2018 Jan 5;282:71-80. doi: 10.1016/j.toxlet.2017.10.012. Epub 2017 Oct 14.

PMID:
29037509
13.

ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock.

Coquerel D, Chagnon F, Sainsily X, Dumont L, Murza A, Côté J, Dumaine R, Sarret P, Marsault É, Salvail D, Auger-Messier M, Lesur O.

Crit Care Med. 2017 Nov;45(11):e1139-e1148. doi: 10.1097/CCM.0000000000002639.

PMID:
28777197
14.

The signaling signature of the neurotensin type 1 receptor with endogenous ligands.

Besserer-Offroy É, Brouillette RL, Lavenus S, Froehlich U, Brumwell A, Murza A, Longpré JM, Marsault É, Grandbois M, Sarret P, Leduc R.

Eur J Pharmacol. 2017 Jun 15;805:1-13. doi: 10.1016/j.ejphar.2017.03.046. Epub 2017 Mar 22.

PMID:
28341345
15.

Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin.

Boyapelly K, Bonin MA, Traboulsi H, Cloutier A, Phaneuf SC, Fortin D, Cantin AM, Richter MV, Marsault E.

J Nat Prod. 2017 Apr 28;80(4):879-886. doi: 10.1021/acs.jnatprod.6b00600. Epub 2017 Mar 2.

PMID:
28252963
16.

Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.

St-Georges C, Désilets A, Béliveau F, Ghinet M, Dion SP, Colombo É, Boudreault PL, Najmanovich RJ, Leduc R, Marsault É.

Eur J Med Chem. 2017 Mar 31;129:110-123. doi: 10.1016/j.ejmech.2017.02.006. Epub 2017 Feb 11.

PMID:
28219045
17.

Structure-activity relationship of novel macrocyclic biased apelin receptor agonists.

Murza A, Sainsily X, Côté J, Bruneau-Cossette L, Besserer-Offroy É, Longpré JM, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.

Org Biomol Chem. 2017 Jan 4;15(2):449-458. doi: 10.1039/c6ob02247b.

PMID:
27924341
18.

Design, synthesis, and biological evaluation of CXCR4 ligands.

Mona CE, Besserer-Offroy É, Cabana J, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.

Org Biomol Chem. 2016 Nov 2;14(43):10298-10311.

PMID:
27752700
19.

Bis-Michael Acceptors as Novel Probes to Study the Keap1/Nrf2/ARE Pathway.

Deny LJ, Traboulsi H, Cantin AM, Marsault É, Richter MV, Bélanger G.

J Med Chem. 2016 Oct 27;59(20):9431-9442. Epub 2016 Oct 5.

PMID:
27682717
20.

Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction.

Chagnon F, Coquerel D, Salvail D, Marsault E, Dumaine R, Auger-Messier M, Sarret P, Lesur O.

Crit Care Med. 2017 Apr;45(4):e391-e398. doi: 10.1097/CCM.0000000000002097.

PMID:
27571457
21.

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer.

Zoratti GL, Tanabe LM, Hyland TE, Duhaime MJ, Colombo É, Leduc R, Marsault E, Johnson MD, Lin CY, Boerner J, Lang JE, List K.

Oncotarget. 2016 Sep 6;7(36):58162-58173. doi: 10.18632/oncotarget.11262.

22.

Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists.

Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E.

J Med Chem. 2016 Aug 25;59(16):7512-24. doi: 10.1021/acs.jmedchem.6b00566. Epub 2016 Aug 11.

PMID:
27434274
23.

Intracuff 160 mg alkalinized lidocaine reduces cough upon emergence from N2O-free general anesthesia: a randomized controlled trial.

Souissi H, Fréchette Y, Murza A, Masse MH, Marsault É, Sarret P, D'Aragon F, Parent AJ, Sansoucy Y.

Can J Anaesth. 2016 Jul;63(7):862-70. doi: 10.1007/s12630-016-0652-8. Epub 2016 Apr 13.

PMID:
27075030
24.

Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.

Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, Longpré JM, Lainé J, Reversade B, Salvail D, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É.

J Med Chem. 2016 Apr 14;59(7):2962-72. doi: 10.1021/acs.jmedchem.5b01549. Epub 2016 Mar 30.

PMID:
26986036
25.

Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions.

Boulanger S, Mitchell G, Bouarab K, Marsault É, Cantin A, Frost EH, Déziel E, Malouin F.

Antimicrob Agents Chemother. 2015 Dec;59(12):7458-64. doi: 10.1128/AAC.01711-15. Epub 2015 Sep 21.

26.

The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection.

Traboulsi H, Cloutier A, Boyapelly K, Bonin MA, Marsault É, Cantin AM, Richter MV.

Antimicrob Agents Chemother. 2015 Oct;59(10):6317-27. doi: 10.1128/AAC.01098-15. Epub 2015 Jul 27.

27.

Smart imaging of acute lung injury: exploration of myeloperoxidase activity using in vivo endoscopic confocal fluorescence microscopy.

Chagnon F, Bourgouin A, Lebel R, Bonin MA, Marsault E, Lepage M, Lesur O.

Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15;309(6):L543-51. doi: 10.1152/ajplung.00289.2014. Epub 2015 Jul 31.

28.

Solid-Phase Parallel Synthesis of Functionalised Medium-to-Large Cyclic Peptidomimetics through Three-Component Coupling Driven by Aziridine Aldehyde Dimers.

Treder AP, Hickey JL, Tremblay MC, Zaretsky S, Scully CC, Mancuso J, Doucet A, Yudin AK, Marsault E.

Chemistry. 2015 Jun 15;21(25):9249-55. doi: 10.1002/chem.201500068. Epub 2015 May 26.

PMID:
26014974
29.

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.

Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang JE, Molinolo AA, Leduc R, Marsault E, Boerner J, List K.

Nat Commun. 2015 Apr 15;6:6776. doi: 10.1038/ncomms7776.

30.

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.

Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É.

J Med Chem. 2015 Mar 12;58(5):2431-40. doi: 10.1021/jm501916k. Epub 2015 Feb 24.

PMID:
25668242
31.

Macrocyclic cell penetrating peptides: a study of structure-penetration properties.

Traboulsi H, Larkin H, Bonin MA, Volkov L, Lavoie CL, Marsault É.

Bioconjug Chem. 2015 Mar 18;26(3):405-11. doi: 10.1021/acs.bioconjchem.5b00023. Epub 2015 Feb 19.

PMID:
25654426
32.

One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties.

Tremblay H, St-Georges C, Legault MA, Morin C, Fortin S, Marsault E.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5635-5638. doi: 10.1016/j.bmcl.2014.10.084. Epub 2014 Nov 1.

PMID:
25466189
33.

Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2.

Duchêne D, Colombo E, Désilets A, Boudreault PL, Leduc R, Marsault E, Najmanovich R.

J Med Chem. 2014 Dec 11;57(23):10198-204. doi: 10.1021/jm5015633. Epub 2014 Nov 21.

PMID:
25387268
34.

Solid-phase synthesis of piperazinones via disrupted Ugi condensation.

Treder AP, Tremblay MC, Yudin AK, Marsault E.

Org Lett. 2014 Sep 5;16(17):4674-7. doi: 10.1021/ol5023118. Epub 2014 Aug 25.

PMID:
25153611
35.

Unraveling the structure-activity relationship of tomatidine, a steroid alkaloid with unique antibiotic properties against persistent forms of Staphylococcus aureus.

Chagnon F, Guay I, Bonin MA, Mitchell G, Bouarab K, Malouin F, Marsault É.

Eur J Med Chem. 2014 Jun 10;80:605-20. doi: 10.1016/j.ejmech.2013.11.019.

PMID:
24877760
36.

Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid.

Murza A, Belleville K, Longpré JM, Sarret P, Marsault É.

Biopolymers. 2014 Jul;102(4):297-303. doi: 10.1002/bip.22498.

PMID:
24728860
37.

Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties.

Demeule M, Beaudet N, Régina A, Besserer-Offroy É, Murza A, Tétreault P, Belleville K, Ché C, Larocque A, Thiot C, Béliveau R, Longpré JM, Marsault É, Leduc R, Lachowicz JE, Gonias SL, Castaigne JP, Sarret P.

J Clin Invest. 2014 Mar;124(3):1199-213. doi: 10.1172/JCI70647. Epub 2014 Feb 17.

38.

Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.

Beaulieu A, Gravel É, Cloutier A, Marois I, Colombo É, Désilets A, Verreault C, Leduc R, Marsault É, Richter MV.

J Virol. 2013 Apr;87(8):4237-51. doi: 10.1128/JVI.03005-12. Epub 2013 Jan 30.

39.

Experimental treatment of Staphylococcus aureus bovine intramammary infection using a guanine riboswitch ligand analog.

Ster C, Allard M, Boulanger S, Lamontagne Boulet M, Mulhbacher J, Lafontaine DA, Marsault E, Lacasse P, Malouin F.

J Dairy Sci. 2013 Feb;96(2):1000-8. doi: 10.3168/jds.2012-5890. Epub 2012 Dec 14.

40.

Design and synthesis of potent, selective inhibitors of matriptase.

Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E.

ACS Med Chem Lett. 2012 Apr 11;3(7):530-4. doi: 10.1021/ml3000534. eCollection 2012 Jul 12.

41.

Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É.

ChemMedChem. 2012 Feb 6;7(2):318-25. doi: 10.1002/cmdc.201100492. Epub 2011 Dec 13.

PMID:
22170700
42.

Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression.

Mitchell G, Lafrance M, Boulanger S, Séguin DL, Guay I, Gattuso M, Marsault E, Bouarab K, Malouin F.

J Antimicrob Chemother. 2012 Mar;67(3):559-68. doi: 10.1093/jac/dkr510. Epub 2011 Nov 30.

PMID:
22129590
43.

Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic.

Hoveyda HR, Marsault E, Gagnon R, Mathieu AP, Vézina M, Landry A, Wang Z, Benakli K, Beaubien S, Saint-Louis C, Brassard M, Pinault JF, Ouellet L, Bhat S, Ramaseshan M, Peng X, Foucher L, Beauchemin S, Bhérer P, Veber DF, Peterson ML, Fraser GL.

J Med Chem. 2011 Dec 22;54(24):8305-20. doi: 10.1021/jm2007062. Epub 2011 Nov 22.

PMID:
22106937
44.

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.

Marsault E, Peterson ML.

J Med Chem. 2011 Apr 14;54(7):1961-2004. doi: 10.1021/jm1012374. Epub 2011 Mar 7. Review. No abstract available.

PMID:
21381769
45.

Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells.

Mitchell G, Gattuso M, Grondin G, Marsault É, Bouarab K, Malouin F.

Antimicrob Agents Chemother. 2011 May;55(5):1937-45. doi: 10.1128/AAC.01468-10. Epub 2011 Feb 28.

46.

High throughput solid phase parallel synthesis of macrocyclic peptidomimetics.

Marsault E, Hoveyda HR, Peterson ML, Gagnon R, Vézina M, Pinault JF, Landry A, Saint-Louis C, Ouellet LG, Beauchemin S, Benakli K, Beaubien S, Brassard M, Wang Z, Champagne M, Galaud F, Fortin N, Fortin D, Plourde V, Ramaseshan M, Bhat S, Bilodeau F, Lonergan D, Lan R, Li S, Berthiaume G, Foucher L, Peng X, Dory Y, Deslongchamps P.

Adv Exp Med Biol. 2009;611:15-6. No abstract available.

PMID:
19400074
47.

Parallel solid-phase synthesis of macrocyclic peptidomimetics using Ru-catalyzed ring-closing metathesis and a new application of cross metathesis.

Beaubien S, Hoveyda HR, Vézina M, Marsault E, Tremblay H, Foucher L, Benakli K.

Adv Exp Med Biol. 2009;611:13-4. No abstract available.

PMID:
19400073
48.

Efficient parallel synthesis of macrocyclic peptidomimetics.

Marsault E, Hoveyda HR, Gagnon R, Peterson ML, Vézina M, Saint-Louis C, Landry A, Pinault JF, Ouellet L, Beauchemin S, Beaubien S, Mathieu A, Benakli K, Wang Z, Brassard M, Lonergan D, Bilodeau F, Ramaseshan M, Fortin N, Lan R, Li S, Galaud F, Plourde V, Champagne M, Doucet A, Bhérer P, Gauthier M, Olsen G, Villeneuve G, Bhat S, Foucher L, Fortin D, Peng X, Bernard S, Drouin A, Déziel R, Berthiaume G, Dory YL, Fraser GL, Deslongchamps P.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4731-5. doi: 10.1016/j.bmcl.2008.06.085. Epub 2008 Jun 28.

PMID:
18640834
49.

Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids.

Marsault E, Benakli K, Beaubien S, Saint-Louis C, Déziel R, Fraser G.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4187-90. Epub 2007 May 18.

PMID:
17533127
50.

Discovery of a new class of macrocyclic antagonists to the human motilin receptor.

Marsault E, Hoveyda HR, Peterson ML, Saint-Louis C, Landry A, Vézina M, Ouellet L, Wang Z, Ramaseshan M, Beaubien S, Benakli K, Beauchemin S, Déziel R, Peeters T, Fraser GL.

J Med Chem. 2006 Nov 30;49(24):7190-7.

PMID:
17125271

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