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Items: 40


Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease.

Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Khoshaein N, Marsh EK, Peachell P, Sun SC, Dockrell DH, Marriott HM, Sabroe I, Condliffe AM, Prince LR.

Front Immunol. 2019 Jul 31;10:1721. doi: 10.3389/fimmu.2019.01721. eCollection 2019.


Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia.

Preston JA, Bewley MA, Marriott HM, McGarry Houghton A, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH.

Am J Respir Crit Care Med. 2019 Jul 1;200(1):84-97. doi: 10.1164/rccm.201804-0646OC.


Divergent Roles for TRAIL in Lung Diseases.

Braithwaite AT, Marriott HM, Lawrie A.

Front Med (Lausanne). 2018 Jul 27;5:212. doi: 10.3389/fmed.2018.00212. eCollection 2018. Review.


HIV gp120 in the Lungs of Antiretroviral Therapy-treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci.

Collini PJ, Bewley MA, Mohasin M, Marriott HM, Miller RF, Geretti AM, Beloukas A, Papadimitropoulos A, Read RC, Noursadeghi M, Dockrell DH.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1604-1615. doi: 10.1164/rccm.201708-1755OC.


Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.


Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.

Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH.

Am J Respir Crit Care Med. 2017 Oct 1;196(7):845-855. doi: 10.1164/rccm.201608-1714OC.


Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.


Evaluation of the anti-inflammatory effects of β-adrenoceptor agonists on human lung macrophages.

Gill SK, Marriott HM, Suvarna SK, Peachell PT.

Eur J Pharmacol. 2016 Dec 15;793:49-55. doi: 10.1016/j.ejphar.2016.11.005. Epub 2016 Nov 7.


The anti-inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor.

Gill SK, Yao Y, Kay LJ, Bewley MA, Marriott HM, Peachell PT.

Br J Pharmacol. 2016 Nov;173(21):3099-3109. doi: 10.1111/bph.13565. Epub 2016 Sep 6.


Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages.

Jubrail J, Morris P, Bewley MA, Stoneham S, Johnston SA, Foster SJ, Peden AA, Read RC, Marriott HM, Dockrell DH.

Cell Microbiol. 2016 Jan;18(1):80-96. doi: 10.1111/cmi.12485. Epub 2015 Sep 2.


RIPOSTE: a framework for improving the design and analysis of laboratory-based research.

Masca NG, Hensor EM, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C, Goldin RD, Harris J, Hinchliffe RF, Junaid H, Kingston S, Martin-Ruiz C, Nelson CP, Peacock J, Seed PT, Shinkins B, Staples KJ, Toombs J, Wright AK, Teare MD.

Elife. 2015 May 7;4. doi: 10.7554/eLife.05519.


Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation.

Bewley MA, Naughton M, Preston J, Mitchell A, Holmes A, Marriott HM, Read RC, Mitchell TJ, Whyte MK, Dockrell DH.

MBio. 2014 Oct 7;5(5):e01710-14. doi: 10.1128/mBio.01710-14.


Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6.


Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing.

Aberdein JD, Cole J, Bewley MA, Marriott HM, Dockrell DH.

Clin Exp Immunol. 2013 Nov;174(2):193-202. doi: 10.1111/cei.12170. Review.


Mechanistic links between acute respiratory tract infections and acute coronary syndromes.

Bazaz R, Marriott HM, Francis SE, Dockrell DH.

J Infect. 2013 Jan;66(1):1-17. doi: 10.1016/j.jinf.2012.09.009. Epub 2012 Oct 6.


Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.

Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott HM, LeClair EE, Bingle CD.

Cell Tissue Res. 2012 Dec;350(3):455-64. doi: 10.1007/s00441-012-1490-9. Epub 2012 Sep 18.


Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.

Daigneault M, De Silva TI, Bewley MA, Preston JA, Marriott HM, Mitchell AM, Mitchell TJ, Read RC, Whyte MK, Dockrell DH.

PLoS Pathog. 2012;8(7):e1002814. doi: 10.1371/journal.ppat.1002814. Epub 2012 Jul 19.


A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.

Marriott HM, Daigneault M, Thompson AA, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MK, Dockrell DH.

Thorax. 2012 Nov;67(11):985-92. doi: 10.1136/thoraxjnl-2012-201591. Epub 2012 Jun 26.


Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AA, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH, Whyte MK.

Thorax. 2012 Sep;67(9):796-803. doi: 10.1136/thoraxjnl-2011-200863. Epub 2012 Apr 11.


Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages.

Marriott HM, Gascoyne KA, Gowda R, Geary I, Nicklin MJ, Iannelli F, Pozzi G, Mitchell TJ, Whyte MK, Sabroe I, Dockrell DH.

Infect Immun. 2012 Mar;80(3):1140-9. doi: 10.1128/IAI.05697-11. Epub 2011 Dec 12.


TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.

McGrath EE, Marriott HM, Lawrie A, Francis SE, Sabroe I, Renshaw SA, Dockrell DH, Whyte MK.

J Leukoc Biol. 2011 Nov;90(5):855-65. doi: 10.1189/jlb.0211062. Epub 2011 May 11.


Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.

Bewley MA, Pham TK, Marriott HM, Noirel J, Chu HP, Ow SY, Ryazanov AG, Read RC, Whyte MK, Chain B, Wright PC, Dockrell DH.

Mol Cell Proteomics. 2011 Jun;10(6):M111.008193. doi: 10.1074/mcp.M111.008193. Epub 2011 Apr 7.


Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK.

J Clin Invest. 2011 Mar;121(3):1053-63. doi: 10.1172/JCI43273. Epub 2011 Feb 7.


A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MK, Dockrell DH.

PLoS Pathog. 2011 Jan 27;7(1):e1001262. doi: 10.1371/journal.ppat.1001262.


Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MK, Dockrell DH.

J Immunol. 2010 Sep 1;185(5):2968-79. doi: 10.4049/jimmunol.1000805. Epub 2010 Jul 23.


The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.

Daigneault M, Preston JA, Marriott HM, Whyte MK, Dockrell DH.

PLoS One. 2010 Jan 13;5(1):e8668. doi: 10.1371/journal.pone.0008668.


Pneumolysin: a double-edged sword during the host-pathogen interaction.

Marriott HM, Mitchell TJ, Dockrell DH.

Curr Mol Med. 2008 Sep;8(6):497-509. Review.


Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.

Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH, Whyte MK.

J Immunol. 2008 Mar 1;180(5):3502-11.


Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.

Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MK, Dockrell DH.

Am J Respir Crit Care Med. 2008 Apr 15;177(8):887-95. doi: 10.1164/rccm.200707-990OC. Epub 2008 Jan 17.


The role of the macrophage in lung disease mediated by bacteria.

Marriott HM, Dockrell DH.

Exp Lung Res. 2007 Dec;33(10):493-505. Review.


Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A, Whyte MK.

J Immunol. 2007 Dec 15;179(12):8544-53.


Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW, Whyte MK.

Am J Respir Crit Care Med. 2008 Jan 1;177(1):35-43. Epub 2007 Oct 4.


Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.

Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MK, Dockrell DH.

J Immunol. 2006 Nov 1;177(9):6480-8.


Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae.

Marriott HM, Hellewell PG, Whyte MK, Dockrell DH.

Vaccine. 2007 Mar 22;25(13):2485-90. Epub 2006 Sep 20.


Streptococcus pneumoniae: the role of apoptosis in host defense and pathogenesis.

Marriott HM, Dockrell DH.

Int J Biochem Cell Biol. 2006;38(11):1848-54. Epub 2006 Jun 15. Review.


Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.

Tunbridge AJ, Stevanin TM, Lee M, Marriott HM, Moir JW, Read RC, Dockrell DH.

Infect Immun. 2006 Jan;74(1):729-33.


Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance.

Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MK, Dockrell DH.

J Clin Invest. 2005 Feb;115(2):359-68.


Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MK, Dockrell DH.

FASEB J. 2004 Jul;18(10):1126-8. Epub 2004 May 7.


Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.

Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG, Whyte MK.

J Immunol. 2003 Nov 15;171(10):5380-8.


Circulating nitrite anions are a directly acting vasodilator and are donors for nitric oxide.

Demoncheaux EA, Higenbottam TW, Foster PJ, Borland CD, Smith AP, Marriott HM, Bee D, Akamine S, Davies MB.

Clin Sci (Lond). 2002 Jan;102(1):77-83.


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