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Obsessive-Compulsive Behavior Isn't Necessarily a Bad Thing.

Marrack P.

Annu Rev Immunol. 2019 Oct 8. doi: 10.1146/annurev-immunol-072319-033325. [Epub ahead of print]


Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules.

Krovi SH, Kappler JW, Marrack P, Gapin L.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22252-22261. doi: 10.1073/pnas.1909504116. Epub 2019 Sep 30.


How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S.

Sci Immunol. 2019 Apr 5;4(34). pii: eaav7517. doi: 10.1126/sciimmunol.aav7517.


Age (autoimmunity) associated B cells (ABCs) and their relatives.

Phalke S, Marrack P.

Curr Opin Immunol. 2018 Dec;55:75-80. doi: 10.1016/j.coi.2018.09.007. Epub 2018 Oct 31. Review.


TCR signal strength controls thymic differentiation of iNKT cell subsets.

Tuttle KD, Krovi SH, Zhang J, Bedel R, Harmacek L, Peterson LK, Dragone LL, Lefferts A, Halluszczak C, Riemondy K, Hesselberth JR, Rao A, O'Connor BP, Marrack P, Scott-Browne J, Gapin L.

Nat Commun. 2018 Jul 9;9(1):2650. doi: 10.1038/s41467-018-05026-6.


Where Have All the Flowers Gone?

Marrack P.

J Immunol. 2018 Jul 1;201(1):5-6. doi: 10.4049/jimmunol.1800635. No abstract available.


Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.

Liu H, Wang C, Lee S, Ning F, Wang Y, Zhang Q, Chen Z, Zang J, Nix J, Dai S, Marrack P, Hagman J, Kappler J, Zhang G.

Sci Rep. 2018 Feb 19;8(1):3275. doi: 10.1038/s41598-018-21432-8.


C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.

Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):162-167. doi: 10.1073/pnas.1716527115. Epub 2017 Dec 18.


Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins.

Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM.

J Immunol. 2018 Jan 1;200(1):316-326. doi: 10.4049/jimmunol.1602017. Epub 2017 Nov 29.


The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.

Marrack P, Krovi SH, Silberman D, White J, Kushnir E, Nakayama M, Crooks J, Danhorn T, Leach S, Anselment R, Scott-Browne J, Gapin L, Kappler J.

Elife. 2017 Nov 17;6. pii: e30918. doi: 10.7554/eLife.30918.


Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.

Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7717-E7726. doi: 10.1073/pnas.1706831114. Epub 2017 Aug 28.


Old and new adjuvants.

McKee AS, Marrack P.

Curr Opin Immunol. 2017 Aug;47:44-51. doi: 10.1016/j.coi.2017.06.005. Epub 2017 Jul 19. Review.


T-bet expressing B cells - Novel target for autoimmune therapies?

Rubtsov AV, Marrack P, Rubtsova K.

Cell Immunol. 2017 Nov;321:35-39. doi: 10.1016/j.cellimm.2017.04.011. Epub 2017 May 23. Review.


The domestic cat antibody response to feline herpesvirus-1 increases with age.

Munks MW, Montoya AM, Pywell CM, Talmage G, Forssen A, Campbell TL, Dodge DD, Kappler JW, Marrack P.

Vet Immunol Immunopathol. 2017 Jun;188:65-70. doi: 10.1016/j.vetimm.2017.05.002. Epub 2017 May 4.


Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis.

Bai X, Stitzel JA, Bai A, Zambrano CA, Phillips M, Marrack P, Chan ED.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):324-333. doi: 10.1165/rcmb.2016-0270OC.


B cells expressing the transcription factor T-bet drive lupus-like autoimmunity.

Rubtsova K, Rubtsov AV, Thurman JM, Mennona JM, Kappler JW, Marrack P.

J Clin Invest. 2017 Apr 3;127(4):1392-1404. doi: 10.1172/JCI91250. Epub 2017 Feb 27.


T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses.

Rubtsova K, Rubtsov AV, Halemano K, Li SX, Kappler JW, Santiago ML, Marrack P.

PLoS One. 2016 Nov 23;11(11):e0166322. doi: 10.1371/journal.pone.0166322. eCollection 2016.


Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736-2742.

Kubo RT, Born W, Kappler JW, Marrack P, Pigeon M.

J Immunol. 2016 Nov 1;197(9):3437-3443. No abstract available.


Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors.

Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5608-17. doi: 10.1073/pnas.1609717113. Epub 2016 Sep 1.


Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines.

Noges LE, White J, Cambier JC, Kappler JW, Marrack P.

J Immunol. 2016 Aug 15;197(4):1221-30. doi: 10.4049/jimmunol.1501565. Epub 2016 Jun 29.


N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.

Jin N, Wang Y, Crawford F, White J, Marrack P, Dai S, Kappler JW.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13318-23. doi: 10.1073/pnas.1517862112. Epub 2015 Oct 9.


A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas.

Liu H, White J, Crawford F, Jin N, Ju X, Liu K, Jiang C, Marrack P, Zhang G, Kappler JW.

PLoS One. 2015 Aug 28;10(8):e0136613. doi: 10.1371/journal.pone.0136613. eCollection 2015.


Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity.

Rubtsova K, Rubtsov AV, Cancro MP, Marrack P.

J Immunol. 2015 Sep 1;195(5):1933-7. doi: 10.4049/jimmunol.1501209. Review.


CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs.

Rubtsov AV, Rubtsova K, Kappler JW, Jacobelli J, Friedman RS, Marrack P.

J Immunol. 2015 Jul 1;195(1):71-9. doi: 10.4049/jimmunol.1500055. Epub 2015 Jun 1.


Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts.

Atif SM, Nelsen MK, Gibbings SL, Desch AN, Kedl RM, Gill RG, Marrack P, Murphy KM, Grazia TJ, Henson PM, Jakubzick CV.

J Immunol. 2015 Jul 1;195(1):46-50. doi: 10.4049/jimmunol.1500669. Epub 2015 Jun 1.


Sexual dimorphism in autoimmunity.

Rubtsova K, Marrack P, Rubtsov AV.

J Clin Invest. 2015 Jun;125(6):2187-93. doi: 10.1172/JCI78082. Epub 2015 Apr 27. Review.


TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity.

Rubtsova K, Marrack P, Rubtsov AV.

Cell Immunol. 2015 Apr;294(2):80-3. doi: 10.1016/j.cellimm.2014.12.002. Epub 2014 Dec 13. Review.


Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.

Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S, Kappler JW.

Cell. 2014 Jul 3;158(1):132-42. doi: 10.1016/j.cell.2014.04.048.


Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease.

Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8553-8. doi: 10.1073/pnas.1408048111. Epub 2014 May 27.


Molecules in medicine mini review: the αβ T cell receptor.

Clambey ET, Davenport B, Kappler JW, Marrack P, Homann D.

J Mol Med (Berl). 2014 Jul;92(7):735-41. doi: 10.1007/s00109-014-1145-2. Epub 2014 May 22. Review.


Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation.

David A, Crawford F, Garside P, Kappler JW, Marrack P, MacLeod M.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7735-40. doi: 10.1073/pnas.1406218111. Epub 2014 May 12.


Intrinsic autoimmune capacities of hematopoietic cells from female New Zealand hybrid mice.

David A, Trigunaite A, Macleod MK, Johnson AC, Marrack P, Jørgensen TN.

Genes Immun. 2014 Apr-May;15(3):153-61. doi: 10.1038/gene.2014.2. Epub 2014 Jan 30.


Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.

Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. doi: 10.1073/pnas.1320777110. Epub 2013 Dec 16.


T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance.

Rubtsova K, Rubtsov AV, van Dyk LF, Kappler JW, Marrack P.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3216-24. doi: 10.1073/pnas.1312348110. Epub 2013 Aug 6.


Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.

Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP.

J Exp Med. 2013 Jul 1;210(7):1403-18.


Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence.

Macleod MK, David A, Jin N, Noges L, Wang J, Kappler JW, Marrack P.

PLoS One. 2013 Apr 16;8(4):e61775. doi: 10.1371/journal.pone.0061775. Print 2013.


The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.

Clambey ET, Collins B, Young MH, Eberlein J, David A, Kappler JW, Marrack P.

PLoS One. 2013;8(2):e57435. doi: 10.1371/journal.pone.0057435. Epub 2013 Feb 26.


Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.

McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1122-31. doi: 10.1073/pnas.1300392110. Epub 2013 Feb 27.


CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function.

Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM.

J Immunol. 2013 Mar 1;190(5):1936-47. doi: 10.4049/jimmunol.1203149. Epub 2013 Jan 25.


MAIT cell recognition of MR1 on bacterially infected and uninfected cells.

Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L.

PLoS One. 2013;8(1):e53789. doi: 10.1371/journal.pone.0053789. Epub 2013 Jan 14.


Recognition of self and altered self by T cells in autoimmunity and allergy.

Yin L, Dai S, Clayton G, Gao W, Wang Y, Kappler J, Marrack P.

Protein Cell. 2013 Jan;4(1):8-16. doi: 10.1007/s13238-012-2077-7. Epub 2013 Jan 11. Review.


Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.

Collins B, Clambey ET, Scott-Browne J, White J, Marrack P, Hagman J, Kappler JW.

Eur J Immunol. 2013 Feb;43(2):521-32. doi: 10.1002/eji.201242757. Epub 2012 Dec 27.


T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.

Yin L, Crawford F, Marrack P, Kappler JW, Dai S.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18517-22. doi: 10.1073/pnas.1215928109. Epub 2012 Oct 22.


T cells and their eons-old obsession with MHC.

Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P.

Immunol Rev. 2012 Nov;250(1):49-60. doi: 10.1111/imr.12004. Review.


Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?

Marrack P, Kappler JW.

Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a007765. doi: 10.1101/cshperspect.a007765. Review.


TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice.

Rubtsov AV, Rubtsova K, Kappler JW, Marrack P.

Immunol Res. 2013 Mar;55(1-3):210-6. doi: 10.1007/s12026-012-8365-8.


iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma.

Bjordahl RL, Gapin L, Marrack P, Refaeli Y.

PLoS One. 2012;7(8):e42635. doi: 10.1371/journal.pone.0042635. Epub 2012 Aug 7.


Lower TCR repertoire diversity in Traj18-deficient mice.

Bedel R, Matsuda JL, Brigl M, White J, Kappler J, Marrack P, Gapin L.

Nat Immunol. 2012 Jul 19;13(8):705-6. doi: 10.1038/ni.2347. No abstract available.


A closer look at TCR germline recognition.

Garcia KC, Gapin L, Adams JJ, Birnbaum ME, Scott-Browne JP, Kappler JW, Marrack P.

Immunity. 2012 Jun 29;36(6):887-8. doi: 10.1016/j.immuni.2012.05.018. Epub 2012 Jun 14. No abstract available.


Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity.

Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1092-100. doi: 10.1073/pnas.1203019109. Epub 2012 Apr 2.

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