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Items: 31

1.

NPY Induces Stress Resilience via Downregulation of Ih in Principal Neurons of Rat Basolateral Amygdala.

Silveira Villarroel H, Bompolaki M, Mackay JP, Miranda Tapia AP, Michaelson SD, Leitermann RJ, Marr RA, Urban JH, Colmers WF.

J Neurosci. 2018 May 9;38(19):4505-4520. doi: 10.1523/JNEUROSCI.3528-17.2018. Epub 2018 Apr 12.

PMID:
29650696
2.

Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production.

Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML.

Mol Ther. 2018 Jun 6;26(6):1539-1551. doi: 10.1016/j.ymthe.2018.02.029. Epub 2018 Mar 6.

PMID:
29628304
3.

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, James BD, Stutzmann GE, Bennett DA, Miller SA, Rigo F, Marr RA, Hastings ML.

EMBO Mol Med. 2016 Apr 1;8(4):328-45. doi: 10.15252/emmm.201505846.

4.

Editorial on, "Amyloid-beta clearance in Alzheimer's disease".

Marr RA.

Front Aging Neurosci. 2014 Nov 20;6:310. doi: 10.3389/fnagi.2014.00310. eCollection 2014. No abstract available.

5.

Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches.

Philibert KD, Marr RA, Norstrom EM, Glucksman MJ.

Front Aging Neurosci. 2014 Oct 9;6:265. doi: 10.3389/fnagi.2014.00265. eCollection 2014.

6.

Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance.

Marr RA, Hafez DM.

Front Aging Neurosci. 2014 Aug 13;6:187. doi: 10.3389/fnagi.2014.00187. eCollection 2014. Review.

7.

Of mice and men: neurogenesis, cognition and Alzheimer's disease.

Lazarov O, Marr RA.

Front Aging Neurosci. 2013 Aug 27;5:43. doi: 10.3389/fnagi.2013.00043. eCollection 2013.

8.

F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice.

Hafez DM, Huang JY, Richardson JC, Masliah E, Peterson DA, Marr RA.

Neuroscience. 2012 Oct 25;223:465-72. doi: 10.1016/j.neuroscience.2012.07.038. Epub 2012 Jul 31.

9.
10.

Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease.

Huang JY, Hafez DM, James BD, Bennett DA, Marr RA.

J Alzheimers Dis. 2012;28(2):433-41. doi: 10.3233/JAD-2011-111307.

11.

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

Bruno AM, Huang JY, Bennett DA, Marr RA, Hastings ML, Stutzmann GE.

Neurobiol Aging. 2012 May;33(5):1001.e1-6. doi: 10.1016/j.neurobiolaging.2011.03.011. Epub 2011 Apr 30.

12.

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.

Spencer B, Marr RA, Gindi R, Potkar R, Michael S, Adame A, Rockenstein E, Verma IM, Masliah E.

PLoS One. 2011 Jan 31;6(1):e16575. doi: 10.1371/journal.pone.0016575.

13.

Neprilysin-2 is an important β-amyloid degrading enzyme.

Hafez D, Huang JY, Huynh AM, Valtierra S, Rockenstein E, Bruno AM, Lu B, DesGroseillers L, Masliah E, Marr RA.

Am J Pathol. 2011 Jan;178(1):306-12. doi: 10.1016/j.ajpath.2010.11.012. Epub 2010 Dec 23.

14.

Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice.

Hanson LR, Hafez D, Svitak AL, Burns RB, Li X, Frey WH 2nd, Marr RA.

J Mol Neurosci. 2011 Mar;43(3):424-7. doi: 10.1007/s12031-010-9460-8. Epub 2010 Oct 13.

PMID:
20941644
15.

Insights into neurogenesis and aging: potential therapy for degenerative disease?

Marr RA, Thomas RM, Peterson DA.

Future Neurol. 2010 Jul 1;5(4):527-541.

16.

NEP-like endopeptidases and Alzheimer's disease [corrected].

Marr RA, Spencer BJ.

Curr Alzheimer Res. 2010 May;7(3):223-9. Review. Erratum in: Curr Alzheimer Res. 2010 Nov;7(7):652.

PMID:
20088804
17.

Neurogenesis and Alzheimer's disease: at the crossroads.

Lazarov O, Marr RA.

Exp Neurol. 2010 Jun;223(2):267-81. doi: 10.1016/j.expneurol.2009.08.009. Epub 2009 Aug 19. Review.

18.

Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease.

Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E.

J Neurosci. 2009 Jan 28;29(4):1115-25. doi: 10.1523/JNEUROSCI.4220-08.2009.

19.

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice.

Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E.

BMC Neurosci. 2008 Nov 12;9:109. doi: 10.1186/1471-2202-9-109.

20.

Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.

Huang JY, Bruno AM, Patel CA, Huynh AM, Philibert KD, Glucksman MJ, Marr RA.

Neuroscience. 2008 Jul 31;155(1):258-62. doi: 10.1016/j.neuroscience.2008.05.006. Epub 2008 May 16.

21.

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.

Hovatta I, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, Ellison JA, Schadt EE, Verma IM, Lockhart DJ, Barlow C.

Nature. 2005 Dec 1;438(7068):662-6. Epub 2005 Oct 23.

PMID:
16244648
22.

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.

Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E.

Nat Neurosci. 2005 Oct;8(10):1343-9. Epub 2005 Aug 28.

PMID:
16136043
23.

Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.

Dodart JC, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, Paul SM.

Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1211-6. Epub 2005 Jan 18.

24.

Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy.

Kankkonen HM, Vähäkangas E, Marr RA, Pakkanen T, Laurema A, Leppänen P, Jalkanen J, Verma IM, Ylä-Herttuala S.

Mol Ther. 2004 Apr;9(4):548-56.

25.

Neprilysin regulates amyloid Beta peptide levels.

Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB.

J Mol Neurosci. 2004;22(1-2):5-11.

PMID:
14742905
26.

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E.

J Neurosci. 2003 Mar 15;23(6):1992-6.

29.

Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.

Lei XF, Ohkawara Y, Stämpfli MR, Mastruzzo C, Marr RA, Snider D, Xing Z, Jordana M.

J Clin Invest. 1998 Mar 15;101(6):1342-53.

30.

Tumour therapy in mice using adenovirus vectors expressing human TNFa.

Marr RA, Hitt M, Muller WJ, Gauldie J, Graham FL.

Int J Oncol. 1998 Mar;12(3):509-15.

PMID:
9472086
31.

Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNF alpha.

Marr RA, Addison CL, Snider D, Muller WJ, Gauldie J, Graham FL.

Gene Ther. 1997 Nov;4(11):1181-8.

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