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Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.

Valentinova K, Tchenio A, Trusel M, Clerke JA, Lalive AL, Tzanoulinou S, Matera A, Moutkine I, Maroteaux L, Paolicelli RC, Volterra A, Bellone C, Mameli M.

Nat Neurosci. 2019 Jul;22(7):1053-1056. doi: 10.1038/s41593-019-0421-4. Epub 2019 Jun 17.


Withdrawal: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta.

Li Y, Cooper A, Odibo IN, Ahmed A, Murphy P, Koonce R, Dajani NK, Lowery CL, Roberts DJ, Maroteaux L, Kilic F.

J Biol Chem. 2019 Jun 14;294(24):9656. doi: 10.1074/jbc.W119.009465. No abstract available.


Expression of Concern: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta.

Li Y, Cooper A, Odibo IN, Ahmed A, Murphy P, Koonce R, Dajani NK, Lowery CL, Roberts DJ, Maroteaux L, Kilic F.

J Biol Chem. 2019 Mar 29;294(13):5208. doi: 10.1074/jbc.EC119.008295. No abstract available.


Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin.

Sibon D, Coman T, Rossignol J, Lamarque M, Kosmider O, Bayard E, Fouquet G, Rignault R, Topçu S, Bonneau P, Bernex F, Dussiot M, Deroy K, Laurent L, Callebert J, Launay JM, Georgin-Lavialle S, Courtois G, Maroteaux L, Vaillancourt C, Fontenay M, Hermine O, Côté F.

Cell Rep. 2019 Mar 19;26(12):3246-3256.e4. doi: 10.1016/j.celrep.2019.02.071.


Two-photon Imaging of Microglial Processes' Attraction Toward ATP or Serotonin in Acute Brain Slices.

Etienne F, Mastrolia V, Maroteaux L, Girault JA, Gervasi N, Roumier A.

J Vis Exp. 2019 Jan 31;(143). doi: 10.3791/58788.


Dimers of serotonin receptors: Impact on ligand affinity and signaling.

Maroteaux L, Béchade C, Roumier A.

Biochimie. 2019 Jun;161:23-33. doi: 10.1016/j.biochi.2019.01.009. Epub 2019 Jan 24. Review.


Somato-Dendritic Regulation of Raphe Serotonin Neurons; A Key to Antidepressant Action.

Quentin E, Belmer A, Maroteaux L.

Front Neurosci. 2018 Dec 20;12:982. doi: 10.3389/fnins.2018.00982. eCollection 2018. Review.


A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population.

Lacoste J, Lamy S, Ramoz N, Ballon N, Jehel L, Maroteaux L, Thibaut F.

World J Biol Psychiatry. 2019 Jan 4:1-6. doi: 10.1080/15622975.2018.1563721. [Epub ahead of print]


Frontiers of Serotonin Beyond the Brain.

Maroteaux L, Kilic F.

Pharmacol Res. 2019 Feb;140:1-6. doi: 10.1016/j.phrs.2018.10.022. Epub 2018 Oct 22. No abstract available.


Regulation of raphe serotonin neurons by serotonin 1A and 2B receptors.

Belmer A, Maroteaux L.

Neuropsychopharmacology. 2019 Jan;44(1):218-219. doi: 10.1038/s41386-018-0214-6. No abstract available.


Evolutionary considerations on 5-HT2 receptors.

Moutkine I, Collins EL, Béchade C, Maroteaux L.

Pharmacol Res. 2019 Feb;140:14-20. doi: 10.1016/j.phrs.2018.09.014. Epub 2018 Sep 14. Review.


Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.

Nicolas S, Debayle D, Béchade C, Maroteaux L, Gay AS, Bayer P, Heurteaux C, Guyon A, Chabry J.

Transl Psychiatry. 2018 Aug 16;8(1):159. doi: 10.1038/s41398-018-0210-y.


Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.

Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J.

Mol Psychiatry. 2018 Dec;23(12):2277-2286. doi: 10.1038/s41380-018-0077-6. Epub 2018 Jun 6.


Positive regulation of raphe serotonin neurons by serotonin 2B receptors.

Belmer A, Quentin E, Diaz SL, Guiard BP, Fernandez SP, Doly S, Banas SM, Pitychoutis PM, Moutkine I, Muzerelle A, Tchenio A, Roumier A, Mameli M, Maroteaux L.

Neuropsychopharmacology. 2018 Jun;43(7):1623-1632. doi: 10.1038/s41386-018-0013-0. Epub 2018 Feb 5.


Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress.

Jean A, Laurent L, Delaunay S, Doly S, Dusticier N, Linden D, Neve R, Maroteaux L, Nieoullon A, Compan V.

Cell Rep. 2017 Oct 24;21(4):901-909. doi: 10.1016/j.celrep.2017.10.003.


Serotonin 2B Receptors in Mesoaccumbens Dopamine Pathway Regulate Cocaine Responses.

Doly S, Quentin E, Eddine R, Tolu S, Fernandez SP, Bertran-Gonzalez J, Valjent E, Belmer A, Viñals X, Callebert J, Faure P, Meye FJ, Hervé D, Robledo P, Mameli M, Launay JM, Maldonado R, Maroteaux L.

J Neurosci. 2017 Oct 25;37(43):10372-10388. doi: 10.1523/JNEUROSCI.1354-17.2017. Epub 2017 Sep 21.


The role of 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.

Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, Gasser B, Mazzucotelli JP, Hermine O, Maroteaux L, Monassier L.

Br J Pharmacol. 2017 Nov;174(22):4123-4139. doi: 10.1111/bph.13981. Epub 2017 Oct 15.


Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.

Moutkine I, Quentin E, Guiard BP, Maroteaux L, Doly S.

J Biol Chem. 2017 Apr 14;292(15):6352-6368. doi: 10.1074/jbc.M117.779041. Epub 2017 Mar 3.


Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.

Hadden C, Fahmi T, Cooper A, Savenka AV, Lupashin VV, Roberts DJ, Maroteaux L, Hauguel-de Mouzon S, Kilic F.

J Cell Physiol. 2017 Dec;232(12):3520-3529. doi: 10.1002/jcp.25812. Epub 2017 Apr 12.


Cardiovascular remodeling and the peripheral serotonergic system.

Ayme-Dietrich E, Aubertin-Kirch G, Maroteaux L, Monassier L.

Arch Cardiovasc Dis. 2017 Jan;110(1):51-59. doi: 10.1016/j.acvd.2016.08.002. Epub 2016 Dec 21. Review.


New therapeutic opportunities for 5-HT2 receptor ligands.

Maroteaux L, Ayme-Dietrich E, Aubertin-Kirch G, Banas S, Quentin E, Lawson R, Monassier L.

Pharmacol Ther. 2017 Feb;170:14-36. doi: 10.1016/j.pharmthera.2016.10.008. Epub 2016 Oct 19. Review.


[Pulmonary arterial hypertension, bone marrow, endothelial cell precursors and serotonin].

Ayme-Dietrich E, Banas SM, Monassier L, Maroteaux L.

Biol Aujourdhui. 2016;210(2):79-88. doi: 10.1051/jbio/2016012. Epub 2016 Sep 30. French.


Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta.

Li Y, Cooper A, Odibo IN, Ahmed A, Murphy P, Koonce R, Dajani NK, Lowery CL, Roberts DJ, Maroteaux L, Kilic F.

J Biol Chem. 2016 Apr 29;291(18):9657-65. doi: 10.1074/jbc.M116.713693. Epub 2016 Feb 26. Retraction in: J Biol Chem. 2019 Jun 14;294(24):9656.


Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis.

El Oussini H, Bayer H, Scekic-Zahirovic J, Vercruysse P, Sinniger J, Dirrig-Grosch S, Dieterlé S, Echaniz-Laguna A, Larmet Y, Müller K, Weishaupt JH, Thal DR, van Rheenen W, van Eijk K, Lawson R, Monassier L, Maroteaux L, Roumier A, Wong PC, van den Berg LH, Ludolph AC, Veldink JH, Witting A, Dupuis L.

Acta Neuropathol. 2016 Mar;131(3):465-80. doi: 10.1007/s00401-016-1534-4. Epub 2016 Jan 7.


Mice lacking the serotonin 5-HT2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants.

Diaz SL, Narboux-Nême N, Boutourlinsky K, Doly S, Maroteaux L.

Eur Neuropsychopharmacol. 2016 Feb;26(2):265-279. doi: 10.1016/j.euroneuro.2015.12.012. Epub 2015 Dec 11.


Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift.

Banas SM, Diaz SL, Doly S, Belmer A, Maroteaux L.

Front Behav Neurosci. 2015 Aug 5;9:207. doi: 10.3389/fnbeh.2015.00207. eCollection 2015. No abstract available.


Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats.

Ayme-Dietrich E, Marzak H, Lawson R, Mokni W, Wendling O, Combe R, Becker J, El Fertak L, Champy MF, Matz R, Andriantsitohaina R, Doly S, Boutourlinsky K, Maroteaux L, Monassier L.

J Hypertens. 2015 Nov;33(11):2310-21. doi: 10.1097/HJH.0000000000000695.


Mice Lacking the Serotonin Htr2B Receptor Gene Present an Antipsychotic-Sensitive Schizophrenic-Like Phenotype.

Pitychoutis PM, Belmer A, Moutkine I, Adrien J, Maroteaux L.

Neuropsychopharmacology. 2015 Nov;40(12):2764-73. doi: 10.1038/npp.2015.126. Epub 2015 May 4.


Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections.

Kolodziejczak M, Béchade C, Gervasi N, Irinopoulou T, Banas SM, Cordier C, Rebsam A, Roumier A, Maroteaux L.

ACS Chem Neurosci. 2015 Jul 15;6(7):1219-30. doi: 10.1021/cn5003489. Epub 2015 Apr 17.


GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake.

Li Y, Hadden C, Singh P, Mercado CP, Murphy P, Dajani NK, Lowery CL, Roberts DJ, Maroteaux L, Kilic F.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705. doi: 10.1073/pnas.1416675112. Epub 2014 Dec 15.


Role of the N-terminal region in G protein-coupled receptor functions: negative modulation revealed by 5-HT2B receptor polymorphisms.

Belmer A, Doly S, Setola V, Banas SM, Moutkine I, Boutourlinsky K, Kenakin T, Maroteaux L.

Mol Pharmacol. 2014 Jan;85(1):127-38. doi: 10.1124/mol.113.089086. Epub 2013 Oct 30.


A serotonin-induced N-glycan switch regulates platelet aggregation.

Mercado CP, Quintero MV, Li Y, Singh P, Byrd AK, Talabnin K, Ishihara M, Azadi P, Rusch NJ, Kuberan B, Maroteaux L, Kilic F.

Sci Rep. 2013 Sep 30;3:2795. doi: 10.1038/srep02795.


Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ß/δ in osteoblasts.

Chabbi-Achengli Y, Launay JM, Maroteaux L, de Vernejoul MC, Collet C.

PLoS One. 2013 Sep 17;8(9):e75783. doi: 10.1371/journal.pone.0075783. eCollection 2013.


Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin.

Diaz SL, Narboux-Nême N, Trowbridge S, Scotto-Lomassese S, Kleine Borgmann FB, Jessberger S, Giros B, Maroteaux L, Deneris E, Gaspar P.

Eur J Neurosci. 2013 Sep;38(5):2650-8. doi: 10.1111/ejn.12297. Epub 2013 Jul 10.


Overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation.

Maroteaux L.

Hypertension. 2013 Apr;61(4):e28-9. doi: 10.1161/HYPERTENSIONAHA.111.00702. Epub 2013 Feb 4. No abstract available.


Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain.

Urtikova N, Berson N, Van Steenwinckel J, Doly S, Truchetto J, Maroteaux L, Pohl M, Conrath M.

Pain. 2012 Jun;153(6):1320-31. doi: 10.1016/j.pain.2012.03.024. Epub 2012 Apr 22.


Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension.

Launay JM, Hervé P, Callebert J, Mallat Z, Collet C, Doly S, Belmer A, Diaz SL, Hatia S, Côté F, Humbert M, Maroteaux L.

Blood. 2012 Feb 16;119(7):1772-80. doi: 10.1182/blood-2011-06-358374. Epub 2011 Dec 20.


5-HT(2B) receptors are required for serotonin-selective antidepressant actions.

Diaz SL, Doly S, Narboux-Nême N, Fernández S, Mazot P, Banas SM, Boutourlinsky K, Moutkine I, Belmer A, Roumier A, Maroteaux L.

Mol Psychiatry. 2012 Feb;17(2):154-63. doi: 10.1038/mp.2011.159. Epub 2011 Dec 13.


Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffré F, Maroteaux L, Mann DA.

Nat Med. 2011 Nov 27;17(12):1668-73. doi: 10.1038/nm.2490.


Platelet-derived serotonin links vascular disease and tissue fibrosis.

Dees C, Akhmetshina A, Zerr P, Reich N, Palumbo K, Horn A, Jüngel A, Beyer C, Krönke G, Zwerina J, Reiter R, Alenina N, Maroteaux L, Gay S, Schett G, Distler O, Distler JH.

J Exp Med. 2011 May 9;208(5):961-72. doi: 10.1084/jem.20101629. Epub 2011 Apr 25.


Implication of 5-HT(2B) receptors in the serotonin syndrome.

Diaz SL, Maroteaux L.

Neuropharmacology. 2011 Sep;61(3):495-502. doi: 10.1016/j.neuropharm.2011.01.025. Epub 2011 Jan 26.


A population-specific HTR2B stop codon predisposes to severe impulsivity.

Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T, Zhou Z, Wedenoja J, Maroteaux L, Diaz S, Belmer A, Hodgkinson CA, Dell'osso L, Suvisaari J, Coccaro E, Rose RJ, Peltonen L, Virkkunen M, Goldman D.

Nature. 2010 Dec 23;468(7327):1061-6. doi: 10.1038/nature09629. Erratum in: Nature. 2011 Feb 17;470(7334):424.


Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.

Banas SM, Doly S, Boutourlinsky K, Diaz SL, Belmer A, Callebert J, Collet C, Launay JM, Maroteaux L.

Neuropsychopharmacology. 2011 Jan;36(2):423-33. doi: 10.1038/npp.2010.173. Epub 2010 Oct 6.


Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin.

Monassier L, Laplante MA, Ayadi T, Doly S, Maroteaux L.

Pharmacol Ther. 2010 Dec;128(3):559-67. doi: 10.1016/j.pharmthera.2010.08.004. Epub 2010 Sep 7. Review.


Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice.

Doly S, Bertran-Gonzalez J, Callebert J, Bruneau A, Banas SM, Belmer A, Boutourlinsky K, Hervé D, Launay JM, Maroteaux L.

PLoS One. 2009 Nov 23;4(11):e7952. doi: 10.1371/journal.pone.0007952.


Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo.

Tharayil VS, Wouters MM, Stanich JE, Roeder JL, Lei S, Beyder A, Gomez-Pinilla PJ, Gershon MD, Maroteaux L, Gibbons SJ, Farrugia G.

Neurogastroenterol Motil. 2010 Apr;22(4):462-9, e109-10. doi: 10.1111/j.1365-2982.2009.01435.x. Epub 2009 Nov 26.


Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.

Jaffré F, Bonnin P, Callebert J, Debbabi H, Setola V, Doly S, Monassier L, Mettauer B, Blaxall BC, Launay JM, Maroteaux L.

Circ Res. 2009 Jan 2;104(1):113-23. doi: 10.1161/CIRCRESAHA.108.180976. Epub 2008 Nov 20.


Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice.

Monassier L, Laplante MA, Jaffré F, Bousquet P, Maroteaux L, de Champlain J.

Hypertension. 2008 Aug;52(2):301-7. doi: 10.1161/HYPERTENSIONAHA.107.105551. Epub 2008 Jun 30.


Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro.

Doly S, Valjent E, Setola V, Callebert J, Hervé D, Launay JM, Maroteaux L.

J Neurosci. 2008 Mar 12;28(11):2933-40. doi: 10.1523/JNEUROSCI.5723-07.2008.


The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation.

Collet C, Schiltz C, Geoffroy V, Maroteaux L, Launay JM, de Vernejoul MC.

FASEB J. 2008 Feb;22(2):418-27. Epub 2007 Sep 10.

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