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Items: 1 to 50 of 195

1.

Biochemical and structural analysis of N-terminal acetyltransferases.

Gottlieb L, Marmorstein R.

Methods Enzymol. 2019;626:271-299. doi: 10.1016/bs.mie.2019.07.016. Epub 2019 Aug 12.

PMID:
31606079
2.

Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.

Deng S, Magin RS, Wei X, Pan B, Petersson EJ, Marmorstein R.

Structure. 2019 Jul 2;27(7):1057-1070.e4. doi: 10.1016/j.str.2019.04.014. Epub 2019 May 30.

PMID:
31155310
3.

Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15.

Cheng H, Gottlieb L, Marchi E, Kleyner R, Bhardwaj P, Rope AF, Rosenheck S, Moutton S, Philippe C, Eyaid W, Alkuraya FS, Toribio J, Mena R, Prada CE, Stessman H, Bernier R, Wermuth M, Kauffmann B, Blaumeiser B, Kooy RF, Baralle D, Mancini GMS, Conway SJ, Xia F, Chen Z, Meng L, Mihajlovic L, Marmorstein R, Lyon GJ.

Hum Mol Genet. 2019 Sep 1;28(17):2900-2919. doi: 10.1093/hmg/ddz111.

PMID:
31127942
4.

The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity.

Ricketts MD, Dasgupta N, Fan J, Han J, Gerace M, Tang Y, Black BE, Adams PD, Marmorstein R.

J Biol Chem. 2019 Jun 7;294(23):9239-9259. doi: 10.1074/jbc.RA119.007480. Epub 2019 Apr 30.

PMID:
31040182
5.

ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis.

Bazilevsky GA, Affronti HC, Wei X, Campbell SL, Wellen KE, Marmorstein R.

J Biol Chem. 2019 May 3;294(18):7259-7268. doi: 10.1074/jbc.RA118.006685. Epub 2019 Mar 15.

PMID:
30877197
6.

PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer.

Rebecca VW, Nicastri MC, Fennelly C, Chude CI, Barber-Rotenberg JS, Ronghe A, McAfee Q, McLaughlin NP, Zhang G, Goldman AR, Ojha R, Piao S, Noguera-Ortega E, Martorella A, Alicea GM, Lee JJ, Schuchter LM, Xu X, Herlyn M, Marmorstein R, Gimotty PA, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2019 Feb;9(2):220-229. doi: 10.1158/2159-8290.CD-18-0706. Epub 2018 Nov 15.

PMID:
30442709
7.

Molecular basis for chromatin assembly and modification by multiprotein complexes.

Ricketts MD, Han J, Szurgot MR, Marmorstein R.

Protein Sci. 2019 Feb;28(2):329-343. doi: 10.1002/pro.3535. Epub 2018 Dec 13.

PMID:
30350439
8.

Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.

Emptage RP, Lemmon MA, Ferguson KM, Marmorstein R.

Structure. 2018 Aug 7;26(8):1137-1143.e3. doi: 10.1016/j.str.2018.05.008. Epub 2018 Jun 28.

9.

Actin's N-terminal acetyltransferase uncovered.

Arnesen T, Marmorstein R, Dominguez R.

Cytoskeleton (Hoboken). 2018 Jul;75(7):318-322. doi: 10.1002/cm.21455. Epub 2018 Aug 26.

10.

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.

Ray-Gallet D, Ricketts MD, Sato Y, Gupta K, Boyarchuk E, Senda T, Marmorstein R, Almouzni G.

Nat Commun. 2018 Aug 6;9(1):3103. doi: 10.1038/s41467-018-05581-y.

11.

Mechanism of BRAF Activation through Biochemical Characterization of the Recombinant Full-Length Protein.

Cope N, Candelora C, Wong K, Kumar S, Nan H, Grasso M, Novak B, Li Y, Marmorstein R, Wang Z.

Chembiochem. 2018 Sep 17;19(18):1988-1997. doi: 10.1002/cbic.201800359. Epub 2018 Aug 17.

12.

Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Kluge AF, Patane MA, Van Drie JH, Wang C, McElligott D, Kesicki EA, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2018 Jun;558(7710):E1. doi: 10.1038/s41586-018-0111-5.

PMID:
29769713
13.

Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.

Gottlieb L, Marmorstein R.

Structure. 2018 Jul 3;26(7):925-935.e8. doi: 10.1016/j.str.2018.04.003. Epub 2018 May 10.

14.

N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers.

Grasso M, Estrada MA, Berrios KN, Winkler JD, Marmorstein R.

J Med Chem. 2018 Jun 14;61(11):5034-5046. doi: 10.1021/acs.jmedchem.8b00499. Epub 2018 May 18.

15.

Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.

Goris M, Magin RS, Foyn H, Myklebust LM, Varland S, Ree R, Drazic A, Bhambra P, Støve SI, Baumann M, Haug BE, Marmorstein R, Arnesen T.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4405-4410. doi: 10.1073/pnas.1719251115. Epub 2018 Mar 26.

16.

CTCF-Induced Circular DNA Complexes Observed by Atomic Force Microscopy.

Mawhinney MT, Liu R, Lu F, Maksimoska J, Damico K, Marmorstein R, Lieberman PM, Urbanc B.

J Mol Biol. 2018 Mar 16;430(6):759-776. doi: 10.1016/j.jmb.2018.01.012. Epub 2018 Jan 31.

17.

The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate.

Han J, Lachance C, Ricketts MD, McCullough CE, Gerace M, Black BE, Côté J, Marmorstein R.

J Biol Chem. 2018 Mar 23;293(12):4498-4509. doi: 10.1074/jbc.RA117.000677. Epub 2018 Jan 30.

18.

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.

Michaelides MR, Kluge A, Patane M, Van Drie JH, Wang C, Hansen TM, Risi RM, Mantei R, Hertel C, Karukurichi K, Nesterov A, McElligott D, de Vries P, Langston JW, Cole PA, Marmorstein R, Liu H, Lasko L, Bromberg KD, Lai A, Kesicki EA.

ACS Med Chem Lett. 2017 Dec 13;9(1):28-33. doi: 10.1021/acsmedchemlett.7b00395. eCollection 2018 Jan 11.

19.

Characterization of histone acylations links chromatin modifications with metabolism.

Simithy J, Sidoli S, Yuan ZF, Coradin M, Bhanu NV, Marchione DM, Klein BJ, Bazilevsky GA, McCullough CE, Magin RS, Kutateladze TG, Snyder NW, Marmorstein R, Garcia BA.

Nat Commun. 2017 Oct 26;8(1):1141. doi: 10.1038/s41467-017-01384-9.

20.

Probing the interaction between NatA and the ribosome for co-translational protein acetylation.

Magin RS, Deng S, Zhang H, Cooperman B, Marmorstein R.

PLoS One. 2017 Oct 10;12(10):e0186278. doi: 10.1371/journal.pone.0186278. eCollection 2017.

21.

Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase-associated 1 domain.

Emptage RP, Schoenberger MJ, Ferguson KM, Marmorstein R.

J Biol Chem. 2017 Nov 17;292(46):19024-19033. doi: 10.1074/jbc.M117.811265. Epub 2017 Sep 25.

22.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, Faivre E, Ferguson D, Buchanan FG, Martin RL, Torrent M, Chiang GG, Karukurichi K, Langston JW, Weinert BT, Choudhary C, de Vries P, Van Drie JH, McElligott D, Kesicki E, Marmorstein R, Sun C, Cole PA, Rosenberg SH, Michaelides MR, Lai A, Bromberg KD.

Nature. 2017 Oct 5;550(7674):128-132. doi: 10.1038/nature24028. Epub 2017 Sep 27. Erratum in: Nature. 2018 May 16;:.

23.

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12.

24.

Epigenetics meets metabolism through PHB-mediated histone H3.3 deposition by HIRA.

Marmorstein R, Adams PD.

Stem Cell Investig. 2017 May 26;4:46. doi: 10.21037/sci.2017.05.08. eCollection 2017. No abstract available.

25.

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

Hwang AW, Trzeciakiewicz H, Friedmann D, Yuan CX, Marmorstein R, Lee VM, Cohen TJ.

PLoS One. 2016 Dec 21;11(12):e0168913. doi: 10.1371/journal.pone.0168913. eCollection 2016.

26.

Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase.

Feng Z, Wang L, Sun Y, Jiang Z, Domsic J, An C, Xing B, Tian J, Liu X, Metz DC, Yang X, Marmorstein R, Ma X, Hua X.

Cancer Res. 2017 Jan 15;77(2):401-411. doi: 10.1158/0008-5472.CAN-16-1567. Epub 2016 Nov 21.

27.

A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function.

Ricketts MD, Marmorstein R.

J Mol Biol. 2017 Jun 30;429(13):1924-1933. doi: 10.1016/j.jmb.2016.11.010. Epub 2016 Nov 19. Review.

28.

Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1.

Rivera-Colón Y, Maguire A, Liszczak GP, Olia AS, Marmorstein R.

J Biol Chem. 2016 Dec 16;291(51):26468-26477. Epub 2016 Nov 1.

29.

Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAFV600E Conformation.

Grasso M, Estrada MA, Ventocilla C, Samanta M, Maksimoska J, Villanueva J, Winkler JD, Marmorstein R.

ACS Chem Biol. 2016 Oct 21;11(10):2876-2888. Epub 2016 Sep 6.

30.

Preface.

Marmorstein R.

Methods Enzymol. 2016;574:xv-xvii. doi: 10.1016/S0076-6879(16)30150-1. No abstract available.

PMID:
27423870
31.

Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion.

Rong Z, Ouyang Z, Magin RS, Marmorstein R, Yu H.

J Biol Chem. 2016 Sep 2;291(36):19079-91. doi: 10.1074/jbc.M116.737585. Epub 2016 Jul 15.

32.

Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation.

McCullough CE, Song S, Shin MH, Johnson FB, Marmorstein R.

J Biol Chem. 2016 Aug 26;291(35):18190-8. doi: 10.1074/jbc.M116.736264. Epub 2016 Jul 5.

33.

Preface.

Marmorstein R.

Methods Enzymol. 2016;573:xvii-xix. doi: 10.1016/S0076-6879(16)30122-7. No abstract available.

PMID:
27372767
34.

In Vitro Activity Assays for MYST Histone Acetyltransferases and Adaptation for High-Throughput Inhibitor Screening.

McCullough CE, Marmorstein R.

Methods Enzymol. 2016;573:139-60. doi: 10.1016/bs.mie.2016.01.016. Epub 2016 Feb 23.

35.

Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation.

Støve SI, Magin RS, Foyn H, Haug BE, Marmorstein R, Arnesen T.

Structure. 2016 Jul 6;24(7):1044-56. doi: 10.1016/j.str.2016.04.020. Epub 2016 Jun 16.

36.

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.

Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E.

Elife. 2016 May 31;5. pii: e11156. doi: 10.7554/eLife.11156.

37.

The N-terminal Acetyltransferase Naa10/ARD1 Does Not Acetylate Lysine Residues.

Magin RS, March ZM, Marmorstein R.

J Biol Chem. 2016 Mar 4;291(10):5270-7. doi: 10.1074/jbc.M115.709428. Epub 2016 Jan 11.

38.

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

Ndubaku CO, Crawford JJ, Drobnick J, Aliagas I, Campbell D, Dong P, Dornan LM, Duron S, Epler J, Gazzard L, Heise CE, Hoeflich KP, Jakubiak D, La H, Lee W, Lin B, Lyssikatos JP, Maksimoska J, Marmorstein R, Murray LJ, O'Brien T, Oh A, Ramaswamy S, Wang W, Zhao X, Zhong Y, Blackwood E, Rudolph J.

ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6. doi: 10.1021/acsmedchemlett.5b00398. eCollection 2015 Dec 10.

39.

Molecular Basis for Histone Acetyltransferase Regulation by Binding Partners, Associated Domains, and Autoacetylation.

McCullough CE, Marmorstein R.

ACS Chem Biol. 2016 Mar 18;11(3):632-42. doi: 10.1021/acschembio.5b00841. Epub 2015 Dec 2. Review.

40.

Autophagy mediates degradation of nuclear lamina.

Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL.

Nature. 2015 Nov 5;527(7576):105-9. doi: 10.1038/nature15548. Epub 2015 Oct 28.

41.

Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B).

Haigney A, Ricketts MD, Marmorstein R.

J Biol Chem. 2015 Dec 18;290(51):30648-57. doi: 10.1074/jbc.M115.688523. Epub 2015 Nov 1.

42.

Structural biology: Hypoxia response becomes crystal clear.

Marmorstein R, Simon MC.

Nature. 2015 Aug 20;524(7565):298-300. doi: 10.1038/nature14641. Epub 2015 Aug 5. No abstract available.

PMID:
26245369
43.

Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.

Ricketts MD, Frederick B, Hoff H, Tang Y, Schultz DC, Singh Rai T, Grazia Vizioli M, Adams PD, Marmorstein R.

Nat Commun. 2015 Jul 10;6:7711. doi: 10.1038/ncomms8711.

44.

Nonenzymatic Protein Acetylation Detected by NAPPA Protein Arrays.

Olia AS, Barker K, McCullough CE, Tang HY, Speicher DW, Qiu J, LaBaer J, Marmorstein R.

ACS Chem Biol. 2015 Sep 18;10(9):2034-47. doi: 10.1021/acschembio.5b00342. Epub 2015 Jun 23.

45.

The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD.

Magin RS, Liszczak GP, Marmorstein R.

Structure. 2015 Feb 3;23(2):332-41. doi: 10.1016/j.str.2014.10.025. Epub 2015 Jan 22.

46.

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

Myklebust LM, Van Damme P, Støve SI, Dörfel MJ, Abboud A, Kalvik TV, Grauffel C, Jonckheere V, Wu Y, Swensen J, Kaasa H, Liszczak G, Marmorstein R, Reuter N, Lyon GJ, Gevaert K, Arnesen T.

Hum Mol Genet. 2015 Apr 1;24(7):1956-76. doi: 10.1093/hmg/ddu611. Epub 2014 Dec 8.

47.

Development of organometallic S6K1 inhibitors.

Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R.

J Med Chem. 2015 Jan 8;58(1):305-14. doi: 10.1021/jm5011868. Epub 2014 Nov 13.

48.

Viral reprogramming of the Daxx histone H3.3 chaperone during early Epstein-Barr virus infection.

Tsai K, Chan L, Gibeault R, Conn K, Dheekollu J, Domsic J, Marmorstein R, Schang LM, Lieberman PM.

J Virol. 2014 Dec;88(24):14350-63. doi: 10.1128/JVI.01895-14. Epub 2014 Oct 1.

49.

Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket.

Leu JI, Zhang P, Murphy ME, Marmorstein R, George DL.

ACS Chem Biol. 2014 Nov 21;9(11):2508-16. doi: 10.1021/cb500236y. Epub 2014 Aug 28.

50.

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate.

Zhang P, Leu JI, Murphy ME, George DL, Marmorstein R.

PLoS One. 2014 Jul 24;9(7):e103518. doi: 10.1371/journal.pone.0103518. eCollection 2014.

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