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Items: 1 to 50 of 120

1.

Rhythmic expression of the melatonergic biosynthetic pathway and its differential modulation in vitro by LPS and IL10 in bone marrow and spleen.

Córdoba-Moreno MO, de Souza EDS, Quiles CL, Dos Santos-Silva D, Kinker GS, Muxel SM, Markus RP, Fernandes PA.

Sci Rep. 2020 Mar 16;10(1):4799. doi: 10.1038/s41598-020-61652-5.

2.

A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor.

Viana MN, Leiguez E, Gutiérrez JM, Rucavado A, Markus RP, Marçola M, Teixeira C, Fernandes CM.

Sci Rep. 2020 Feb 24;10(1):3269. doi: 10.1038/s41598-020-59095-z.

3.

Immune-pineal axis protects rat lungs exposed to polluted air.

Carvalho-Sousa CE, Pereira EP, Kinker GS, Veras M, Ferreira ZS, Barbosa-Nunes FP, Martins JO, Saldiva PHN, Reiter RJ, Fernandes PA, da Silveira Cruz-Machado S, Markus RP.

J Pineal Res. 2020 Feb 11:e12636. doi: 10.1111/jpi.12636. [Epub ahead of print]

PMID:
32043640
4.

Dysregulation of Circadian Rhythms in Autism Spectrum Disorders.

Pinato L, Galina Spilla CS, Markus RP, da Silveira Cruz-Machado S.

Curr Pharm Des. 2019;25(41):4379-4393. doi: 10.2174/1381612825666191102170450.

PMID:
31682208
5.
6.

STAT1-NFκB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production.

Barbosa Lima LE, Muxel SM, Kinker GS, Carvalho-Sousa CE, da Silveira Cruz-Machado S, Markus RP, Fernandes PACM.

J Pineal Res. 2019 Oct;67(3):e12599. doi: 10.1111/jpi.12599. Epub 2019 Sep 1.

PMID:
31356684
7.

Site-Specific Reprogramming of Macrophage Responsiveness to Bacterial Lipopolysaccharide in Obesity.

Komegae EN, Fonseca MT, da Silveira Cruz-Machado S, Turato WM, Filgueiras LR, Markus RP, Steiner AA.

Front Immunol. 2019 Jun 28;10:1496. doi: 10.3389/fimmu.2019.01496. eCollection 2019.

8.

PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia.

Lima K, Coelho-Silva JL, Kinker GS, Pereira-Martins DA, Traina F, Fernandes PACM, Markus RP, Lucena-Araujo AR, Machado-Neto JA.

Cancer Genet. 2019 Apr;233-234:56-66. doi: 10.1016/j.cancergen.2019.04.002. Epub 2019 Apr 11.

PMID:
31109595
9.

Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression.

Fernandes JCR, Aoki JI, Maia Acuña S, Zampieri RA, Markus RP, Floeter-Winter LM, Muxel SM.

Front Cell Infect Microbiol. 2019 Mar 20;9:60. doi: 10.3389/fcimb.2019.00060. eCollection 2019.

10.

Night work effects on salivary cytokines TNF, IL-1β and IL-6.

Reinhardt ÉL, Fernandes PACM, Markus RP, Fischer FM.

Chronobiol Int. 2019 Jan;36(1):11-26. doi: 10.1080/07420528.2018.1515771. Epub 2018 Sep 19.

PMID:
30230913
11.

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.

Golan K, Kumari A, Kollet O, Khatib-Massalha E, Subramaniam MD, Ferreira ZS, Avemaria F, Rzeszotek S, García-García A, Xie S, Flores-Figueroa E, Gur-Cohen S, Itkin T, Ludin-Tal A, Massalha H, Bernshtein B, Ciechanowicz AK, Brandis A, Mehlman T, Bhattacharya S, Bertagna M, Cheng H, Petrovich-Kopitman E, Janus T, Kaushansky N, Cheng T, Sagi I, Ratajczak MZ, Méndez-Ferrer S, Dick JE, Markus RP, Lapidot T.

Cell Stem Cell. 2018 Oct 4;23(4):572-585.e7. doi: 10.1016/j.stem.2018.08.002. Epub 2018 Aug 30.

12.

Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation.

Sagrillo-Fagundes L, Assunção Salustiano EM, Ruano R, Markus RP, Vaillancourt C.

J Pineal Res. 2018 Nov;65(4):e12520. doi: 10.1111/jpi.12520. Epub 2018 Sep 3.

PMID:
30091210
13.

β-Adrenoceptors Trigger Melatonin Synthesis in Phagocytes.

Pires-Lapa MA, Carvalho-Sousa CE, Cecon E, Fernandes PA, Markus RP.

Int J Mol Sci. 2018 Jul 26;19(8). pii: E2182. doi: 10.3390/ijms19082182.

14.

An antibody-based platform for melatonin quantification.

Brazaca LC, Bramorski CB, Cancino-Bernardi J, da Silveira Cruz-Machado S, Markus RP, Janegitz BC, Zucolotto V.

Colloids Surf B Biointerfaces. 2018 Nov 1;171:94-100. doi: 10.1016/j.colsurfb.2018.07.006. Epub 2018 Jul 7.

PMID:
30015143
15.

Expression of the Circadian Clock Gene BMAL1 Positively Correlates With Antitumor Immunity and Patient Survival in Metastatic Melanoma.

de Assis LVM, Kinker GS, Moraes MN, Markus RP, Fernandes PA, Castrucci AML.

Front Oncol. 2018 Jun 12;8:185. doi: 10.3389/fonc.2018.00185. eCollection 2018.

16.

Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes.

Markus RP, Fernandes PA, Kinker GS, da Silveira Cruz-Machado S, Marçola M.

Br J Pharmacol. 2018 Aug;175(16):3239-3250. doi: 10.1111/bph.14083. Epub 2017 Dec 15. Review.

17.

Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program.

da Silveira Cruz-Machado S, Tamura EK, Carvalho-Sousa CE, Rocha VA, Pinato L, Fernandes PAC, Markus RP.

Sci Rep. 2017 May 18;7(1):2091. doi: 10.1038/s41598-017-02286-y.

18.

Chronic nicotine treatment decreases LPS signaling through NF-κB and TLR-4 modulation in the hippocampus.

Café-Mendes CC, Garay-Malpartida HM, Malta MB, de Sá Lima L, Scavone C, Ferreira ZS, Markus RP, Marcourakis T.

Neurosci Lett. 2017 Jan 1;636:218-224. doi: 10.1016/j.neulet.2016.10.056. Epub 2016 Oct 29.

PMID:
27984197
19.

Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.

Mack JM, Schamne MG, Sampaio TB, Pértile RA, Fernandes PA, Markus RP, Prediger RD.

Oxid Med Cell Longev. 2016;2016:3472032. Epub 2016 Oct 18. Review.

20.

Update on melatonin receptors: IUPHAR Review 20.

Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP.

Br J Pharmacol. 2016 Sep;173(18):2702-25. doi: 10.1111/bph.13536. Epub 2016 Aug 8. Review.

21.

Short sleep duration increases salivary IL-6 production.

Reinhardt ÉL, Fernandes PA, Markus RP, Fischer FM.

Chronobiol Int. 2016;33(6):780-2. doi: 10.3109/07420528.2016.1167710. Epub 2016 Apr 12.

PMID:
27070477
22.

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis.

Fernandes PA, Tamura EK, D'Argenio-Garcia L, Muxel SM, da Silveira Cruz-Machado S, Marçola M, Carvalho-Sousa CE, Cecon E, Ferreira ZS, Markus RP.

Neuroendocrinology. 2017;104(2):126-134. Epub 2016 Mar 9.

PMID:
26954684
23.

The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages.

Muxel SM, Laranjeira-Silva MF, Carvalho-Sousa CE, Floeter-Winter LM, Markus RP.

J Pineal Res. 2016 May;60(4):394-404. doi: 10.1111/jpi.12321. Epub 2016 Mar 2.

PMID:
26887983
24.

Adenosine triphosphate inhibits melatonin synthesis in the rat pineal gland.

Souza-Teodoro LH, Dargenio-Garcia L, Petrilli-Lapa CL, Souza Eda S, Fernandes PA, Markus RP, Ferreira ZS.

J Pineal Res. 2016 Mar;60(2):242-9. doi: 10.1111/jpi.12309. Epub 2016 Jan 29.

PMID:
26732366
25.

Light/Dark Environmental Cycle Imposes a Daily Profile in the Expression of microRNAs in Rat CD133(+) Cells.

Marçola M, Lopes-Ramos CM, Pereira EP, Cecon E, Fernandes PA, Tamura EK, Camargo AA, Parmigiani RB, Markus RP.

J Cell Physiol. 2016 Sep;231(9):1953-63. doi: 10.1002/jcp.25300. Epub 2016 Jan 14.

PMID:
26728119
26.

Melatonergic system-based two-gene index is prognostic in human gliomas.

Kinker GS, Oba-Shinjo SM, Carvalho-Sousa CE, Muxel SM, Marie SK, Markus RP, Fernandes PA.

J Pineal Res. 2016 Jan;60(1):84-94. doi: 10.1111/jpi.12293. Epub 2015 Nov 20.

PMID:
26510398
27.

Melatonin attenuates Leishmania (L.) amazonensis infection by modulating arginine metabolism.

Laranjeira-Silva MF, Zampieri RA, Muxel SM, Floeter-Winter LM, Markus RP.

J Pineal Res. 2015 Nov;59(4):478-87. doi: 10.1111/jpi.12279. Epub 2015 Oct 10.

PMID:
26383232
28.

Shift Work in Rats Results in Increased Inflammatory Response after Lipopolysaccharide Administration: A Role for Food Consumption.

Guerrero-Vargas NN, Guzmán-Ruiz M, Fuentes R, García J, Salgado-Delgado R, Basualdo Mdel C, Escobar C, Markus RP, Buijs RM.

J Biol Rhythms. 2015 Aug;30(4):318-30. doi: 10.1177/0748730415586482. Epub 2015 May 27.

PMID:
26017928
29.

Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway.

Cecon E, Chen M, Marçola M, Fernandes PA, Jockers R, Markus RP.

FASEB J. 2015 Jun;29(6):2566-82. doi: 10.1096/fj.14-265678. Epub 2015 Mar 10.

PMID:
25757565
30.

Ebola virus: melatonin as a readily available treatment option.

Anderson G, Maes M, Markus RP, Rodriguez M.

J Med Virol. 2015 Apr;87(4):537-43. doi: 10.1002/jmv.24130. Epub 2015 Jan 21. Review.

PMID:
25611054
31.

The cellular state determines the effect of melatonin on the survival of mixed cerebellar cell culture.

Franco DG, Markus RP.

PLoS One. 2014 Sep 3;9(9):e106332. doi: 10.1371/journal.pone.0106332. eCollection 2014.

32.

Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis.

Pinato L, da Silveira Cruz-Machado S, Franco DG, Campos LM, Cecon E, Fernandes PA, Bittencourt JC, Markus RP.

Brain Struct Funct. 2015 Mar;220(2):827-40. doi: 10.1007/s00429-013-0686-4. Epub 2013 Dec 22.

33.

Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells.

Pires-Lapa MA, Tamura EK, Salustiano EM, Markus RP.

J Pineal Res. 2013 Oct;55(3):240-6. doi: 10.1111/jpi.12066. Epub 2013 Jun 10.

PMID:
23745599
34.

Immune-pineal axis: nuclear factor κB (NF-kB) mediates the shift in the melatonin source from pinealocytes to immune competent cells.

Markus RP, Cecon E, Pires-Lapa MA.

Int J Mol Sci. 2013 May 24;14(6):10979-97. doi: 10.3390/ijms140610979. Review.

35.

The concept of the immune-pineal axis tested in patients undergoing an abdominal hysterectomy.

de Oliveira Tatsch-Dias M, Levandovski RM, Custódio de Souza IC, Gregianin Rocha M, Magno Fernandes PA, Torres IL, Hidalgo MP, Markus RP, Caumo W.

Neuroimmunomodulation. 2013;20(4):205-12. doi: 10.1159/000347160. Epub 2013 May 8.

PMID:
23689687
36.

NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene.

Muxel SM, Pires-Lapa MA, Monteiro AW, Cecon E, Tamura EK, Floeter-Winter LM, Markus RP.

PLoS One. 2012;7(12):e52010. doi: 10.1371/journal.pone.0052010. Epub 2012 Dec 21.

37.

Endothelial cell adhesiveness is a function of environmental lighting and melatonin level.

Marçola M, da Silveira Cruz-Machado S, Fernandes PA, Monteiro AW, Markus RP, Tamura EK.

J Pineal Res. 2013 Mar;54(2):162-9. doi: 10.1111/j.1600-079X.2012.01025.x. Epub 2012 Jul 19.

PMID:
22812624
38.

Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF).

da Silveira Cruz-Machado S, Pinato L, Tamura EK, Carvalho-Sousa CE, Markus RP.

PLoS One. 2012;7(7):e40142. doi: 10.1371/journal.pone.0040142. Epub 2012 Jul 2.

39.

Daily rhythm of salivary IL-1ß, cortisol and melatonin in day and night workers.

Reinhardt ÉL, Fernandes PA, Markus RP, Fischer FM.

Work. 2012;41 Suppl 1:5788-90. doi: 10.3233/WOR-2012-0952-5788.

PMID:
22317688
40.

Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling.

de Lima CB, Tamura EK, Montero-Melendez T, Palermo-Neto J, Perretti M, Markus RP, Farsky SH.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):918-23. doi: 10.1016/j.bbrc.2011.12.078. Epub 2011 Dec 22.

41.
42.

Plasma corticosterone elevation inhibits the activation of nuclear factor kappa B (NFKB) in the Syrian hamster pineal gland.

Ferreira ZS, Bothorel B, Markus RP, Simonneaux V.

Stress. 2012 May;15(3):339-47. doi: 10.3109/10253890.2011.627070. Epub 2011 Dec 20.

PMID:
22043926
43.

6‐Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients.

Hidalgo MP, Caumo W, Dantas G, Franco DG, Torres IL, Pezzi J, Elisabetsky E, Detanico BC, Piato Â, Markus RP.

Hum Psychopharmacol. 2011 Apr;26(3):252-7. doi: 10.1002/hup.1204.

PMID:
21681816
44.

Nitric oxide modulates lipopolysaccharide-induced endothelial platelet endothelial cell adhesion molecule expression via interleukin-10.

Hebeda CB, Teixeira SA, Tamura EK, Muscará MN, de Mello SB, Markus RP, Farsky SH.

Clin Exp Immunol. 2011 Aug;165(2):172-9. doi: 10.1111/j.1365-2249.2011.04396.x. Epub 2011 May 12.

45.

Purinergic signalling is involved in the malaria parasite Plasmodium falciparum invasion to red blood cells.

Levano-Garcia J, Dluzewski AR, Markus RP, Garcia CR.

Purinergic Signal. 2010 Dec;6(4):365-72. doi: 10.1007/s11302-010-9202-y. Epub 2010 Oct 17.

46.

Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor.

Carvalho-Sousa CE, da Silveira Cruz-Machado S, Tamura EK, Fernandes PA, Pinato L, Muxel SM, Cecon E, Markus RP.

Front Endocrinol (Lausanne). 2011 May 13;2:10. doi: 10.3389/fendo.2011.00010. eCollection 2011.

47.

Long-lasting priming of endothelial cells by plasma melatonin levels.

Tamura EK, Fernandes PA, Marçola M, da Silveira Cruz-Machado S, Markus RP.

PLoS One. 2010 Nov 12;5(11):e13958. doi: 10.1371/journal.pone.0013958.

48.

Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.

Beraldo FH, Arantes CP, Santos TG, Queiroz NG, Young K, Rylett RJ, Markus RP, Prado MA, Martins VR.

J Biol Chem. 2010 Nov 19;285(47):36542-50. doi: 10.1074/jbc.M110.157263. Epub 2010 Sep 13.

49.

TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway.

da Silveira Cruz-Machado S, Carvalho-Sousa CE, Tamura EK, Pinato L, Cecon E, Fernandes PA, de Avellar MC, Ferreira ZS, Markus RP.

J Pineal Res. 2010 Sep;49(2):183-92. doi: 10.1111/j.1600-079X.2010.00785.x. Epub 2010 Jun 25.

PMID:
20586888
50.

Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?

Markus RP, Silva CL, Franco DG, Barbosa EM Jr, Ferreira ZS.

Pharmacol Ther. 2010 Jun;126(3):251-62. doi: 10.1016/j.pharmthera.2010.02.009. Epub 2010 Apr 14. Review.

PMID:
20398699

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