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Items: 1 to 50 of 411

1.

Apathy is associated with large-scale white matter network disruption in small vessel disease.

Tay J, Tuladhar AM, Hollocks MJ, Brookes RL, Tozer DJ, Barrick TR, Husain M, de Leeuw FE, Markus HS.

Neurology. 2019 Feb 8. pii: 10.1212/WNL.0000000000007095. doi: 10.1212/WNL.0000000000007095. [Epub ahead of print]

PMID:
30737341
2.

Genetics of Vascular Cognitive Impairment.

Markus HS, Schmidt R.

Stroke. 2019 Jan 21:STROKEAHA118020379. doi: 10.1161/STROKEAHA.118.020379. [Epub ahead of print] No abstract available.

PMID:
30661498
3.

Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).

Traylor M, Tozer DJ, Croall ID, Lisiecka Ford DM, Olorunda AO, Boncoraglio G, Dichgans M, Lemmens R, Rosand J, Rost NS, Rothwell PM, Sudlow CLM, Thijs V, Rutten-Jacobs L, Markus HS; International Stroke Genetics Consortium.

Neurology. 2019 Jan 18. pii: 10.1212/WNL.0000000000006952. doi: 10.1212/WNL.0000000000006952. [Epub ahead of print]

PMID:
30659137
4.

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851. [Epub ahead of print]

PMID:
30651383
5.

Telemedicine for Follow-Up of Rare Neurological Disease.

Walsh J, Markus HS.

Stroke. 2019 Jan 17:STROKEAHA118023779. doi: 10.1161/STROKEAHA.118.023779. [Epub ahead of print]

PMID:
30651041
6.

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.

Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222.

PMID:
30642436
7.

Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients.

Drazyk AM, Tan RYY, Tay J, Traylor M, Das T, Markus HS.

Stroke. 2019 Feb;50(2):283-290. doi: 10.1161/STROKEAHA.118.023661.

PMID:
30636574
8.

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ.

Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5.

9.

Interpreting CT perfusion in stroke.

Wing SC, Markus HS.

Pract Neurol. 2018 Nov 13. pii: practneurol-2018-001917. doi: 10.1136/practneurol-2018-001917. [Epub ahead of print]

PMID:
30425127
10.

Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis.

Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS.

JAMA Neurol. 2018 Oct 22. doi: 10.1001/jamaneurol.2018.3122. [Epub ahead of print]

PMID:
30422209
11.

Genome-wide meta-analysis identifies 3 novel loci associated with stroke.

Malik R, Rannikmäe K, Traylor M, Georgakis MK, Sargurupremraj M, Markus HS, Hopewell JC, Debette S, Sudlow CLM, Dichgans M; MEGASTROKE consortium and the International Stroke Genetics Consortium.

Ann Neurol. 2018 Dec;84(6):934-939. doi: 10.1002/ana.25369. Epub 2018 Nov 30.

PMID:
30383316
12.

Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Larsson SC, Traylor M, Markus HS.

Nutrients. 2018 Oct 25;10(11). pii: E1575. doi: 10.3390/nu10111575.

13.

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.

Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmäe K; MEGASTROKE consortium; International Stroke Genetics Consortium, Sudlow CL, Dichgans M, Markus HS, Traylor M.

BMJ. 2018 Oct 24;363:k4168. doi: 10.1136/bmj.k4168.

14.

Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes.

Larsson SC, Traylor M, Mishra A, Howson JMM, Michaëlsson K, Markus HS; MEGASTROKE Project of the International Stroke Genetics Consortium.

Stroke. 2018 Oct;49(10):2508-2511. doi: 10.1161/STROKEAHA.118.022242.

PMID:
30355092
15.

Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease.

Le Heron C, Manohar S, Plant O, Muhammed K, Griffanti L, Nemeth A, Douaud G, Markus HS, Husain M.

Brain. 2018 Nov 1;141(11):3193-3210. doi: 10.1093/brain/awy257.

16.

The role of clinical and neuroimaging features in the diagnosis of CADASIL.

Bersano A, Bedini G, Markus HS, Vitali P, Colli-Tibaldi E, Taroni F, Gellera C, Baratta S, Mosca L, Carrera P, Ferrari M, Cereda C, Grieco G, Lanfranconi S, Mazucchelli F, Zarcone D, De Lodovici ML, Bono G, Boncoraglio GB, Parati EA, Calloni MV, Perrone P, Bordo BM, Motto C, Agostoni E, Pezzini A, Padovani A, Micieli G, Cavallini A, Molini G, Sasanelli F, Sessa M, Comi G, Checcarelli N, Carmerlingo M, Corato M, Marcheselli S, Fusi L, Grampa G, Uccellini D, Beretta S, Ferrarese C, Incorvaia B, Tadeo CS, Adobbati L, Silani V, Faragò G, Trobia N, Grond-Ginsbach C, Candelise L; Lombardia GENS-group.

J Neurol. 2018 Dec;265(12):2934-2943. doi: 10.1007/s00415-018-9072-8. Epub 2018 Oct 11.

PMID:
30311053
17.

Memory decline in elderly with cerebral small vessel disease explained by temporal interactions between white matter hyperintensities and hippocampal atrophy.

van Leijsen EMC, Tay J, van Uden IWM, Kooijmans ECM, Bergkamp MI, van der Holst HM, Ghafoorian M, Platel B, Norris DG, Kessels RPC, Markus HS, Tuladhar AM, de Leeuw FE.

Hippocampus. 2018 Oct 11. doi: 10.1002/hipo.23039. [Epub ahead of print]

PMID:
30307080
18.

Correction: The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1-6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7-34 pathogenic variant.

Rutten JW, Van Eijsden BJ, Duering M, Jouvent E, Opherk C, Pantoni L, Federico A, Dichgans M, Markus HS, Chabriat H, Oberstein SAJL.

Genet Med. 2018 Sep 20. doi: 10.1038/s41436-018-0306-z. [Epub ahead of print]

PMID:
30237574
19.

Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study.

Larsson SC, Traylor M, Markus HS, Michaëlsson K.

Nutrients. 2018 Sep 6;10(9). pii: E1243. doi: 10.3390/nu10091243.

20.

Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Flaherty K, Duley L, England TJ, Havard D, Heptinstall S, James M, Kasonde C, Krishnan K, Markus HS, Montgomery AA, Pocock S, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N.

Health Technol Assess. 2018 Aug;22(48):1-76. doi: 10.3310/hta22480.

21.

Framingham vascular age is associated with worse cognitive performance in the middle-aged and elderly.

Badran A, Hollocks MJ, Brookes RL, Morris RG, Markus HS.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2018 Jul 27:1-10. doi: 10.1080/13825585.2018.1499866. [Epub ahead of print]

PMID:
30053789
22.

Top research priorities for stroke genetics.

Woo D, Anderson CD, Maguire J, Fornage M, Lee JM, Seshadri S, Markus HS, Majersik JJ, Jimenez-Conde J, Crawford K, Lindgren AG, Debette S.

Lancet Neurol. 2018 Aug;17(8):663-665. doi: 10.1016/S1474-4422(18)30243-6. Epub 2018 Jul 17. No abstract available.

PMID:
30033056
23.

The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1-6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7-34 pathogenic variant.

Rutten JW, Van Eijsden BJ, Duering M, Jouvent E, Opherk C, Pantoni L, Federico A, Dichgans M, Markus HS, Chabriat H, Lesnik Oberstein SAJ.

Genet Med. 2018 Jul 22. doi: 10.1038/s41436-018-0088-3. [Epub ahead of print] Erratum in: Genet Med. 2018 Sep 20;:.

PMID:
30032161
24.

Identifying preclinical vascular dementia in symptomatic small vessel disease using MRI.

Lambert C, Zeestraten E, Williams O, Benjamin P, Lawrence AJ, Morris RG, Mackinnon AD, Barrick TR, Markus HS.

Neuroimage Clin. 2018 Jun 20;19:925-938. doi: 10.1016/j.nicl.2018.06.023. eCollection 2018.

25.

Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer's Disease? A Systematic Review and Meta-Analysis.

Larsson SC, Markus HS.

J Alzheimers Dis. 2018;64(2):657-668. doi: 10.3233/JAD-180288.

PMID:
29914039
26.

Texture Analysis of T1-Weighted and Fluid-Attenuated Inversion Recovery Images Detects Abnormalities That Correlate With Cognitive Decline in Small Vessel Disease.

Tozer DJ, Zeestraten E, Lawrence AJ, Barrick TR, Markus HS.

Stroke. 2018 Jul;49(7):1656-1661. doi: 10.1161/STROKEAHA.117.019970. Epub 2018 Jun 4.

27.

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.

Rutten-Jacobs LCA, Tozer DJ, Duering M, Malik R, Dichgans M, Markus HS, Traylor M.

Stroke. 2018 Jun;49(6):1340-1347. doi: 10.1161/STROKEAHA.118.020811. Epub 2018 May 11.

28.

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Review.

PMID:
29712883
29.

Longitudinal decline in structural networks predicts dementia in cerebral small vessel disease.

Lawrence AJ, Zeestraten EA, Benjamin P, Lambert CP, Morris RG, Barrick TR, Markus HS.

Neurology. 2018 May 22;90(21):e1898-e1910. doi: 10.1212/WNL.0000000000005551. Epub 2018 Apr 25.

30.

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis.

Liu J, Rutten-Jacobs L, Liu M, Markus HS, Traylor M.

Stroke. 2018 Jun;49(6):1325-1331. doi: 10.1161/STROKEAHA.117.020536. Epub 2018 Apr 23.

31.

PET imaging of the neurovascular interface in cerebrovascular disease.

Evans NR, Tarkin JM, Buscombe JR, Markus HS, Rudd JHF, Warburton EA.

Nat Rev Neurol. 2018 May;14(5):313. doi: 10.1038/nrneurol.2018.42. Epub 2018 Apr 3.

PMID:
29611539
32.

A comparison of functional and tractography based networks in cerebral small vessel disease.

Lawrence AJ, Tozer DJ, Stamatakis EA, Markus HS.

Neuroimage Clin. 2018 Feb 8;18:425-432. doi: 10.1016/j.nicl.2018.02.013. eCollection 2018.

33.

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study.

Hindy G, Engström G, Larsson SC, Traylor M, Markus HS, Melander O, Orho-Melander M; Stroke Genetics Network (SiGN).

Stroke. 2018 Apr;49(4):820-827. doi: 10.1161/STROKEAHA.117.019653. Epub 2018 Mar 13.

34.

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith NL, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, Hoed MD, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Amin N, Aparicio HS, Arnett DK, Attia J, Beiser AS, Berr C, Buring JE, Bustamante M, Caso V, Cheng YC, Choi SH, Chowhan A, Cullell N, Dartigues JF, Delavaran H, Delgado P, Dörr M, Engström G, Ford I, Gurpreet WS, Hamsten A, Heitsch L, Hozawa A, Ibanez L, Ilinca A, Ingelsson M, Iwasaki M, Jackson RD, Jood K, Jousilahti P, Kaffashian S, Kalra L, Kamouchi M, Kitazono T, Kjartansson O, Kloss M, Koudstaal PJ, Krupinski J, Labovitz DL, Laurie CC, Levi CR, Li L, Lind L, Lindgren CM, Lioutas V, Liu YM, Lopez OL, Makoto H, Martinez-Majander N, Matsuda K, Minegishi N, Montaner J, Morris AP, Muiño E, Müller-Nurasyid M, Norrving B, Ogishima S, Parati EA, Peddareddygari LR, Pedersen NL, Pera J, Perola M, Pezzini A, Pileggi S, Rabionet R, Riba-Llena I, Ribasés M, Romero JR, Roquer J, Rudd AG, Sarin AP, Sarju R, Sarnowski C, Sasaki M, Satizabal CL, Satoh M, Sattar N, Sawada N, Sibolt G, Sigurdsson Á, Smith A, Sobue K, Soriano-Tárraga C, Stanne T, Stine OC, Stott DJ, Strauch K, Takai T, Tanaka H, Tanno K, Teumer A, Tomppo L, Torres-Aguila NP, Touze E, Tsugane S, Uitterlinden AG, Valdimarsson EM, van der Lee SJ, Völzke H, Wakai K, Weir D, Williams SR, Wolfe CDA, Wong Q, Xu H, Yamaji T, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STARNET; BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGASTROKE Consortium; MEGASTROKE Consortium:.

Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. Epub 2018 Mar 12.

35.

Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease: The PRESERVE Randomized Clinical Trial.

Croall ID, Tozer DJ, Moynihan B, Khan U, O'Brien JT, Morris RG, Cambridge VC, Barrick TR, Blamire AM, Ford GA, Markus HS; PRESERVE Study Team.

JAMA Neurol. 2018 Jun 1;75(6):720-727. doi: 10.1001/jamaneurol.2017.5153.

36.

Involvement of the reward network is associated with apathy in cerebral small vessel disease.

Lisiecka-Ford DM, Tozer DJ, Morris RG, Lawrence AJ, Barrick TR, Markus HS.

J Affect Disord. 2018 May;232:116-121. doi: 10.1016/j.jad.2018.02.006. Epub 2018 Feb 15.

37.

Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease.

Benjamin P, Trippier S, Lawrence AJ, Lambert C, Zeestraten E, Williams OA, Patel B, Morris RG, Barrick TR, MacKinnon AD, Markus HS.

Stroke. 2018 Mar;49(3):586-593. doi: 10.1161/STROKEAHA.117.017526. Epub 2018 Feb 2.

38.

Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke.

McGlasson S, Rannikmäe K, Bevan S, Logan C, Bicknell LS, Jury A; UK Young Lacunar Stroke Study, Jackson AP, Markus HS, Sudlow C, Hunt DPJ.

Wellcome Open Res. 2017 Nov 2;2:106. doi: 10.12688/wellcomeopenres.12631.1. eCollection 2017.

39.

Location, number and factors associated with cerebral microbleeds in an Italian-British cohort of CADASIL patients.

Nannucci S, Rinnoci V, Pracucci G, MacKinnon AD, Pescini F, Adib-Samii P, Bianchi S, Dotti MT, Federico A, Inzitari D, Markus HS, Pantoni L.

PLoS One. 2018 Jan 25;13(1):e0190878. doi: 10.1371/journal.pone.0190878. eCollection 2018.

40.

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Bath PM, Woodhouse LJ, Appleton JP, Beridze M, Christensen H, Dineen RA, Duley L, England TJ, Flaherty K, Havard D, Heptinstall S, James M, Krishnan K, Markus HS, Montgomery AA, Pocock SJ, Randall M, Ranta A, Robinson TG, Scutt P, Venables GS, Sprigg N; TARDIS Investigators.

Lancet. 2018 Mar 3;391(10123):850-859. doi: 10.1016/S0140-6736(17)32849-0. Epub 2017 Dec 20.

41.

Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack.

Brookes RL, Crichton S, Wolfe CDA, Yi Q, Li L, Hankey GJ, Rothwell PM, Markus HS.

Stroke. 2018 Jan;49(1):54-61. doi: 10.1161/STROKEAHA.117.016674. Epub 2017 Dec 15.

42.

Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.

Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project.

BMJ. 2017 Dec 6;359:j5375. doi: 10.1136/bmj.j5375.

43.

Cerebrovascular abnormalities in Alzheimer's dementia: a more tractable treatment target?

Markus HS.

Brain. 2017 Jul 1;140(7):1822-1825. doi: 10.1093/brain/awx161. No abstract available.

PMID:
29177500
44.

Cerebral amyloid angiopathy associated with inflammation: A systematic review of clinical and imaging features and outcome.

Corovic A, Kelly S, Markus HS.

Int J Stroke. 2018 Apr;13(3):257-267. doi: 10.1177/1747493017741569. Epub 2017 Nov 14.

PMID:
29134927
45.

Recent advances in the management of symptomatic vertebral artery stenosis.

Drazyk AM, Markus HS.

Curr Opin Neurol. 2018 Feb;31(1):1-7. doi: 10.1097/WCO.0000000000000515. Review.

PMID:
29084065
46.

Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis.

Larsson SC, Markus HS.

Sci Rep. 2017 Oct 19;7(1):13604. doi: 10.1038/s41598-017-12931-1.

47.

PET imaging of the neurovascular interface in cerebrovascular disease.

Evans NR, Tarkin JM, Buscombe JR, Markus HS, Rudd JHF, Warburton EA.

Nat Rev Neurol. 2017 Nov;13(11):676-688. doi: 10.1038/nrneurol.2017.129. Epub 2017 Oct 6. Review. Erratum in: Nat Rev Neurol. 2018 Apr 03;:.

PMID:
28984315
48.

Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease.

Zeestraten EA, Lawrence AJ, Lambert C, Benjamin P, Brookes RL, Mackinnon AD, Morris RG, Barrick TR, Markus HS.

Neurology. 2017 Oct 31;89(18):1869-1876. doi: 10.1212/WNL.0000000000004594. Epub 2017 Oct 4.

49.

Cervical artery dissection and iliac artery aneurysm in an SMAD-4 mutation carrier.

Wiener E, Martin P, Mehta S, Markus HS.

Neurol Genet. 2017 Sep 25;3(5):e191. doi: 10.1212/NXG.0000000000000191. eCollection 2017 Oct. No abstract available.

50.

Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke.

Phuah CL, Dave T, Malik R, Raffeld MR, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Jagiella JM, Hansen BM, Norrving B, Jimenez-Conde J, Roquer J, Pichler A, Enzinger C, Montaner J, Fernandez-Cadenas I, Lindgren A, Slowik A, Schmidt R, Biffi A, Rost N, Langefeld CD, Markus HS, Mitchell BD, Worrall BB, Kittner SJ, Woo D, Dichgans M, Rosand J, Anderson CD; METASTROKE; NINDS-SiGN Consortium; International Stroke Genetics Consortium.

Brain. 2017 Oct 1;140(10):2663-2672. doi: 10.1093/brain/awx220.

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