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Items: 1 to 50 of 220

1.

Overview of Metatarsalgia.

Charen DA, Markowitz JS, Cheung ZB, Matijakovich DJ, Chan JJ, Vulcano E.

Orthopedics. 2019 Jan 1;42(1):e138-e143. doi: 10.3928/01477447-20181206-06. Epub 2018 Dec 13.

PMID:
30540873
2.

Assessment of Bone Healing During Antegrade Intramedullary Rod Femur Lengthening Using Radiographic Pixel Density.

Vulcano E, Markowitz JS, Ali S, Nguyen J, Fragomen AT, Rozbruch SR.

J Am Acad Orthop Surg. 2018 Sep 15;26(18):e388-e394. doi: 10.5435/JAAOS-D-16-00949.

PMID:
30063547
3.

"…Not Intended to Diagnose, Treat, Cure or Prevent Any Disease." 25 Years of Botanical Dietary Supplement Research and the Lessons Learned.

Gurley BJ, Yates CR, Markowitz JS.

Clin Pharmacol Ther. 2018 Sep;104(3):470-483. doi: 10.1002/cpt.1131. Epub 2018 Jul 13.

PMID:
29882958
4.

Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study.

Li WY, Yu G, Hogan RM, Mohandas R, Frye RF, Gumpricht E, Markowitz JS.

Clin Ther. 2018 Jan;40(1):103-113.e1. doi: 10.1016/j.clinthera.2017.11.013. Epub 2017 Dec 19.

5.

Minimally invasive techniques for lumbar decompressions and fusions.

Narain AS, Hijji FY, Markowitz JS, Kudaravalli KT, Yom KH, Singh K.

Curr Rev Musculoskelet Med. 2017 Dec;10(4):559-566. doi: 10.1007/s12178-017-9446-z. Review.

6.

Joining the Effort: The Challenges in Establishing Guidelines for Sex- and Gender-specific Research Design in Clinical Therapeutic Studies.

McGregor AJ, Markowitz JS, Forrester J, Shader RI.

Clin Ther. 2017 Oct;39(10):1912-1916. doi: 10.1016/j.clinthera.2017.09.005. Epub 2017 Sep 21. No abstract available.

PMID:
28942335
7.

The Clinical Pharmacokinetics of Amphetamines Utilized in the Treatment of Attention-Deficit/Hyperactivity Disorder.

Markowitz JS, Patrick KS.

J Child Adolesc Psychopharmacol. 2017 Oct;27(8):678-689. doi: 10.1089/cap.2017.0071. Epub 2017 Sep 14. Review.

PMID:
28910145
8.

Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers.

Zhu HJ, Patrick KS, Straughn AB, Reeves OT 3rd, Bernstein H, Shi J, Johnson HJ, Knight JM, Smith AT, Malcolm RJ, Markowitz JS.

J Clin Psychopharmacol. 2017 Aug;37(4):419-428. doi: 10.1097/JCP.0000000000000721.

9.

The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.

Albassam AA, Frye RF, Markowitz JS.

Chem Biol Interact. 2017 Jun 1;271:24-29. doi: 10.1016/j.cbi.2017.04.025. Epub 2017 Apr 27.

PMID:
28457856
10.

An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis).

Albassam AA, Markowitz JS.

Planta Med. 2017 Apr;83(6):496-508. doi: 10.1055/s-0043-100934. Epub 2017 Jan 24. Review.

PMID:
28118673
11.

Cardiorenal Syndrome Type 1: Renal Dysfunction in Acute Decompensated Heart Failure.

Prins KW, Thenappan T, Markowitz JS, Pritzker MR.

J Clin Outcomes Manag. 2015 Sep;22(10):443-454.

12.

CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.

Zhu HJ, Langaee TY, Gong Y, Wang X, Pepine CJ, Cooper-DeHoff RM, Johnson JA, Markowitz JS.

Eur J Clin Pharmacol. 2016 Jun;72(6):681-7. doi: 10.1007/s00228-016-2029-x. Epub 2016 Feb 26.

13.

Atomoxetine: A Review of Its Pharmacokinetics and Pharmacogenomics Relative to Drug Disposition.

Yu G, Li GF, Markowitz JS.

J Child Adolesc Psychopharmacol. 2016 May;26(4):314-26. doi: 10.1089/cap.2015.0137. Epub 2016 Feb 9. Review.

14.

Career-Ending Among National Football League Players Who Were Placed on the Injured Reserve List.

Markowitz JS.

J Occup Environ Med. 2016 Jan;58(1):e15-7. doi: 10.1097/JOM.0000000000000633. No abstract available.

PMID:
26716855
15.

Carboxylesterase 1-mediated drug-drug interactions between clopidogrel and simvastatin.

Wang X, Zhu HJ, Markowitz JS.

Biol Pharm Bull. 2015;38(2):292-7. doi: 10.1248/bpb.b14-00679.

16.

CNS drugs: the needs are great, the advances, incremental.

Markowitz JS.

Clin Ther. 2015 Feb 1;37(2):272-4. doi: 10.1016/j.clinthera.2015.01.004. No abstract available.

PMID:
25727683
17.

An ex vivo approach to botanical-drug interactions: a proof of concept study.

Wang X, Zhu HJ, Munoz J, Gurley BJ, Markowitz JS.

J Ethnopharmacol. 2015 Apr 2;163:149-56. doi: 10.1016/j.jep.2015.01.021. Epub 2015 Jan 24.

18.

Development of a Longitudinal National Football League Injury and Injury Impacts (L-NFL-III) Database.

Markowitz JS, Papadopoulos G, Markowitz A.

Value Health. 2014 Nov;17(7):A728. doi: 10.1016/j.jval.2014.08.068. Epub 2014 Oct 26. No abstract available.

19.

Enzyme- and transporter-mediated drug interactions with small molecule tyrosine kinase inhibitors.

Shao J, Markowitz JS, Bei D, An G.

J Pharm Sci. 2014 Dec;103(12):3810-3833. doi: 10.1002/jps.24113. Epub 2014 Oct 10. Review.

PMID:
25308414
20.

Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.

Kristensen KE, Zhu HJ, Wang X, Gislason GH, Torp-Pedersen C, Rasmussen HB, Markowitz JS, Hansen PR.

Clin Pharmacol Ther. 2014 Dec;96(6):713-22. doi: 10.1038/clpt.2014.183. Epub 2014 Sep 15.

21.

The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.

Kawaguchi-Suzuki M, Frye RF, Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, Markowitz JS.

Drug Metab Dispos. 2014 Oct;42(10):1611-6. doi: 10.1124/dmd.114.057232. Epub 2014 Jul 15.

22.

A pharmacokinetic evaluation of oral edivoxetine hydrochloride for the treatment of attention deficit-hyperactivity disorder.

Markowitz JS, Brinda BJ.

Expert Opin Drug Metab Toxicol. 2014 Sep;10(9):1289-99. doi: 10.1517/17425255.2014.939955. Epub 2014 Jul 14. Review.

PMID:
25019201
23.

The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping.

Langaee TY, Zhu HJ, Wang X, El Rouby N, Markowitz JS, Goldstein JA, Johnson JA.

Pharmacogenet Genomics. 2014 Aug;24(8):381-6. doi: 10.1097/FPC.0000000000000068. Erratum in: Pharmacogenet Genomics. 2014 Dec;24(12):622.

24.

ABC transporters in multi-drug resistance and ADME-Tox of small molecule tyrosine kinase inhibitors.

Deng J, Shao J, Markowitz JS, An G.

Pharm Res. 2014 Sep;31(9):2237-55. doi: 10.1007/s11095-014-1389-0. Epub 2014 May 20. Review.

PMID:
24842659
25.

Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability.

Markowitz JS, Zhu HJ, Patrick KS.

J Child Adolesc Psychopharmacol. 2013 Dec;23(10):648-54. doi: 10.1089/cap.2013.0074. Epub 2013 Nov 21.

26.

An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.

Zhu HJ, Brinda BJ, Chavin KD, Bernstein HJ, Patrick KS, Markowitz JS.

Drug Metab Dispos. 2013 Sep;41(9):1679-85. doi: 10.1124/dmd.113.052423. Epub 2013 Jul 8.

27.

Transforming events: hepatic metabolism and individual variability.

Markowitz JS.

Clin Ther. 2013 Mar;35(3):202-4. doi: 10.1016/j.clinthera.2013.02.016. No abstract available.

PMID:
23497758
28.

Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation.

Zhu HJ, Wang X, Gawronski BE, Brinda BJ, Angiolillo DJ, Markowitz JS.

J Pharmacol Exp Ther. 2013 Mar;344(3):665-72. doi: 10.1124/jpet.112.201640. Epub 2012 Dec 28.

PMID:
23275066
29.

Carboxylesterase 1 (CES1) genetic polymorphisms and oseltamivir activation.

Zhu HJ, Markowitz JS.

Eur J Clin Pharmacol. 2013 Mar;69(3):733-4. doi: 10.1007/s00228-012-1350-2. Epub 2012 Jul 31. No abstract available.

PMID:
22847618
30.

Limitations of in vitro assessments of the drug interaction potential of botanical supplements.

Markowitz JS, Zhu HJ.

Planta Med. 2012 Sep;78(13):1421-7. doi: 10.1055/s-0032-1315025. Epub 2012 Jul 18. Review.

31.

A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma.

Brinda BJ, Zhu HJ, Markowitz JS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 1;902:1-9. doi: 10.1016/j.jchromb.2012.06.003. Epub 2012 Jun 12.

PMID:
22766231
32.

Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action.

Zhu HJ, Appel DI, Gründemann D, Richelson E, Markowitz JS.

Pharmacol Res. 2012 Apr;65(4):491-6. doi: 10.1016/j.phrs.2012.01.008. Epub 2012 Feb 8.

PMID:
22342816
33.

A liquid chromatography/tandem mass spectrometry assay for the analysis of atomoxetine in human plasma and in vitro cellular samples.

Appel DI, Brinda B, Markowitz JS, Newcorn JH, Zhu HJ.

Biomed Chromatogr. 2012 Nov;26(11):1364-70. doi: 10.1002/bmc.2706. Epub 2012 Jan 25.

34.

A discriminative analytical method for detection of CES1A1 and CES1A2/CES1A3 genetic variants.

Zhu HJ, Brinda B, Froehlich TE, Markowitz JS.

Pharmacogenet Genomics. 2012 Mar;22(3):215-8. doi: 10.1097/FPC.0b013e32834f03eb.

35.

Prediction and in vitro evaluation of selected protease inhibitor antiviral drugs as inhibitors of carboxylesterase 1: a potential source of drug-drug interactions.

Rhoades JA, Peterson YK, Zhu HJ, Appel DI, Peloquin CA, Markowitz JS.

Pharm Res. 2012 Apr;29(4):972-82. doi: 10.1007/s11095-011-0637-9. Epub 2011 Dec 9.

PMID:
22161308
36.

An in vitro evaluation of guanfacine as a substrate for P-glycoprotein.

Gillis NK, Zhu HJ, Markowitz JS.

Neuropsychiatr Dis Treat. 2011;7:501-5. doi: 10.2147/NDT.S24153. Epub 2011 Aug 26.

37.

Enantiospecific determination of DL-methylphenidate and DL-ethylphenidate in plasma by liquid chromatography-tandem mass spectrometry: application to human ethanol interactions.

Zhu HJ, Patrick KS, Markowitz JS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 1;879(11-12):783-8. doi: 10.1016/j.jchromb.2011.02.033. Epub 2011 Feb 25.

38.

Conjunctival melanoma: outcomes based on tumor origin in 382 consecutive cases.

Shields CL, Markowitz JS, Belinsky I, Schwartzstein H, George NS, Lally SE, Mashayekhi A, Shields JA.

Ophthalmology. 2011 Feb;118(2):389-95.e1-2. doi: 10.1016/j.ophtha.2010.06.021. Epub 2010 Aug 17.

PMID:
20723990
39.

Postoperative outcomes associated with topical skin adhesives among women having hysterectomies.

Murrmann SG, Markowitz JS, Gutterman EM, Magee G.

Surg Infect (Larchmt). 2010 Oct;11(5):441-7. doi: 10.1089/sur.2009.032.

PMID:
20673145
40.

Interaction of organic cation transporter 3 (SLC22A3) and amphetamine.

Zhu HJ, Appel DI, Gründemann D, Markowitz JS.

J Neurochem. 2010 Jul;114(1):142-9. doi: 10.1111/j.1471-4159.2010.06738.x. Epub 2010 Apr 6.

41.

Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions.

Zhu HJ, Appel DI, Peterson YK, Wang Z, Markowitz JS.

Toxicology. 2010 Apr 11;270(2-3):59-65. doi: 10.1016/j.tox.2010.01.009. Epub 2010 Jan 25.

PMID:
20097249
42.

Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver.

Zhu HJ, Appel DI, Jiang Y, Markowitz JS.

Drug Metab Dispos. 2009 Sep;37(9):1819-25. doi: 10.1124/dmd.109.028209. Epub 2009 Jun 1.

PMID:
19487248
43.

The psychostimulant d-threo-(R,R)-methylphenidate binds as an agonist to the 5HT(1A) receptor.

Markowitz JS, DeVane CL, Ramamoorthy S, Zhu HJ.

Pharmazie. 2009 Feb;64(2):123-5.

PMID:
19322953
44.

Aripiprazole brain concentration is altered in P-glycoprotein deficient mice.

Wang JS, Zhu HJ, Donovan JL, Yuan HJ, Markowitz JS, Geesey ME, Devane CL.

Schizophr Res. 2009 May;110(1-3):90-4. doi: 10.1016/j.schres.2009.01.011. Epub 2009 Feb 23.

PMID:
19239981
45.

Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril.

Zhu HJ, Appel DI, Johnson JA, Chavin KD, Markowitz JS.

Biochem Pharmacol. 2009 Apr 1;77(7):1266-72. doi: 10.1016/j.bcp.2008.12.017. Epub 2009 Jan 6.

PMID:
19185566
46.

Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants.

Zhu HJ, Markowitz JS.

Drug Metab Dispos. 2009 Feb;37(2):264-7. doi: 10.1124/dmd.108.024943. Epub 2008 Nov 20.

PMID:
19022936
47.

Antipsychotic drugs inhibit the function of breast cancer resistance protein.

Wang JS, Zhu HJ, Markowitz JS, Donovan JL, Yuan HJ, Devane CL.

Basic Clin Pharmacol Toxicol. 2008 Oct;103(4):336-41. doi: 10.1111/j.1742-7843.2008.00298.x.

48.

Differential pharmacokinetics and pharmacodynamics of methylphenidate enantiomers: does chirality matter?

Markowitz JS, Patrick KS.

J Clin Psychopharmacol. 2008 Jun;28(3 Suppl 2):S54-61. doi: 10.1097/JCP.0b013e3181733560. Review.

PMID:
18480678
49.

Given the multifaceted nature of ADHD, namely its physiologic, cognitive, psychological, and behavioral manifestations, multimodal approaches to treatment are advocated. Introduction.

Markowitz JS, Patrick KS.

J Clin Psychopharmacol. 2008 Jun;28(3 Suppl 2):S37-8. doi: 10.1097/JCP.0b013e3181733143. No abstract available.

PMID:
18480675
50.

Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.

Zhu HJ, Patrick KS, Yuan HJ, Wang JS, Donovan JL, DeVane CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS.

Am J Hum Genet. 2008 Jun;82(6):1241-8. doi: 10.1016/j.ajhg.2008.04.015. Epub 2008 May 15.

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