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Items: 23


Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma.

Amini P, Nassiri S, Ettlin J, Malbon A, Markkanen E.

Dis Model Mech. 2019 Aug 8;12(8). pii: dmm040444. doi: 10.1242/dmm.040444.


MicroRNA Expression Profiling in the Prefrontal Cortex: Putative Mechanisms for the Cognitive Effects of Adolescent High Fat Feeding.

Labouesse MA, Polesel M, Clementi E, Müller F, Markkanen E, Mouttet F, Cattaneo A, Richetto J.

Sci Rep. 2018 May 29;8(1):8344. doi: 10.1038/s41598-018-26631-x.


Publisher Correction: Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Backe PH, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, Loon BV.

Sci Rep. 2018 Apr 12;8(1):6010. doi: 10.1038/s41598-018-24189-2.


Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts.

Legrand AJ, Poletto M, Pankova D, Clementi E, Moore J, Castro-Giner F, Ryan AJ, O'Neill E, Markkanen E, Dianov GL.

Oncotarget. 2018 Feb 7;9(17):13666-13681. doi: 10.18632/oncotarget.24446. eCollection 2018 Mar 2.


Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Backe PH, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B.

Sci Rep. 2017 Nov 8;7(1):15050. doi: 10.1038/s41598-017-15380-y. Erratum in: Sci Rep. 2018 Apr 12;8(1):6010.


Not breathing is not an option: How to deal with oxidative DNA damage.

Markkanen E.

DNA Repair (Amst). 2017 Nov;59:82-105. doi: 10.1016/j.dnarep.2017.09.007. Epub 2017 Sep 22. Review.


An optimised protocol for isolation of RNA from small sections of laser-capture microdissected FFPE tissue amenable for next-generation sequencing.

Amini P, Ettlin J, Opitz L, Clementi E, Malbon A, Markkanen E.

BMC Mol Biol. 2017 Aug 23;18(1):22. doi: 10.1186/s12867-017-0099-7.


Analysis of Gene Expression Signatures in Cancer-Associated Stroma from Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas.

Ettlin J, Clementi E, Amini P, Malbon A, Markkanen E.

Int J Mol Sci. 2017 May 20;18(5). pii: E1101. doi: 10.3390/ijms18051101.


DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond.

Markkanen E, Meyer U, Dianov GL.

Int J Mol Sci. 2016 Jun 1;17(6). pii: E856. doi: 10.3390/ijms17060856. Review.


Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer J, Tacconi EMC, Folio C, Badie S, Porru M, Klare K, Tumiati M, Markkanen E, Halder S, Ryan A, Jackson SP, Ramadan K, Kuznetsov SG, Biroccio A, Sale JE, Tarsounas M.

Mol Cell. 2016 Feb 4;61(3):449-460. doi: 10.1016/j.molcel.2015.12.004. Epub 2015 Dec 31.


Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.

Pfister SX, Markkanen E, Jiang Y, Sarkar S, Woodcock M, Orlando G, Mavrommati I, Pai CC, Zalmas LP, Drobnitzky N, Dianov GL, Verrill C, Macaulay VM, Ying S, La Thangue NB, D'Angiolella V, Ryan AJ, Humphrey TC.

Cancer Cell. 2015 Nov 9;28(5):557-568. doi: 10.1016/j.ccell.2015.09.015.


Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability.

Markkanen E, Fischer R, Ledentcova M, Kessler BM, Dianov GL.

Nucleic Acids Res. 2015 Apr 20;43(7):3667-79. doi: 10.1093/nar/gkv222. Epub 2015 Mar 23.


Gap-directed translesion DNA synthesis of an abasic site on circular DNA templates by a human replication complex.

Villani G, Shevelev I, Orlando E, Pospiech H, Syvaoja JE, Markkanen E, Hubscher U, Le Gac NT.

PLoS One. 2014 Apr 7;9(4):e93908. doi: 10.1371/journal.pone.0093908. eCollection 2014.


DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass.

Maga G, Crespan E, Markkanen E, Imhof R, Furrer A, Villani G, Hübscher U, van Loon B.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18850-5. doi: 10.1073/pnas.1308760110. Epub 2013 Nov 4.


MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA.

Markkanen E, Dorn J, Hübscher U.

Front Genet. 2013 Feb 28;4:18. doi: 10.3389/fgene.2013.00018. eCollection 2013.


Base excision repair in physiology and pathology of the central nervous system.

Bosshard M, Markkanen E, van Loon B.

Int J Mol Sci. 2012 Nov 30;13(12):16172-222. doi: 10.3390/ijms131216172. Review.


A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions.

Markkanen E, Castrec B, Villani G, Hübscher U.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20401-6. doi: 10.1073/pnas.1211532109. Epub 2012 Nov 21.


Regulation of oxidative DNA damage repair: the adenine:8-oxo-guanine problem.

Markkanen E, Hübscher U, van Loon B.

Cell Cycle. 2012 Mar 15;11(6):1070-5. doi: 10.4161/cc.11.6.19448. Epub 2012 Mar 15.


Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.

Markkanen E, van Loon B, Ferrari E, Parsons JL, Dianov GL, Hübscher U.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):437-42. doi: 10.1073/pnas.1110449109. Epub 2011 Dec 27.


In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta.

Villani G, Hubscher U, Gironis N, Parkkinen S, Pospiech H, Shevelev I, di Cicco G, Markkanen E, Syväoja JE, Tanguy Le Gac N.

J Biol Chem. 2011 Sep 16;286(37):32094-104. doi: 10.1074/jbc.M111.246611. Epub 2011 Jul 13.


Ubiquitylation of DNA polymerase λ.

Markkanen E, van Loon B, Ferrari E, Hübscher U.

FEBS Lett. 2011 Sep 16;585(18):2826-30. doi: 10.1016/j.febslet.2011.03.069. Epub 2011 Apr 8. Review.


Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine.

van Loon B, Markkanen E, Hübscher U.

DNA Repair (Amst). 2010 Jun 4;9(6):604-16. doi: 10.1016/j.dnarep.2010.03.004. Review.


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