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Items: 1 to 50 of 366

1.

APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study.

Iacono D, Zandi P, Gross M, Markesbery WR, Pletnikova O, Rudow G, Troncoso JC.

Oncotarget. 2015 Jun 10;6(16):14082-91.

2.

Age group differences in positive and negative affect among oldest-old adults: findings from the Georgia Centenarian Study.

Cho J, Martin P, Poon LW; Georgia Centenarian Study, MacDonald M, Jazwinski SM, Green RC, Gearing M, Johnson MA, Markesbery WR, Woodard JL, Tenover JS, Siegler LC, Rott C, Rodgers WL, Hausman D, Arnold J, Davey A.

Int J Aging Hum Dev. 2013;77(4):261-88.

PMID:
24547613
3.

Correlates of functional capacity among centenarians.

Martin P, MacDonald M, Margrett J, Siegler I, Poon LW, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Woodard JL, Johnson MA, Tenover JS, Rodgers WL, Hausman D, Rott C, Davey A, Arnold J.

J Appl Gerontol. 2013 Apr;32(3):324-46. doi: 10.1177/0733464811420563. Epub 2011 Sep 19.

4.

Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.

Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE 3rd, Bernier M, Lee J, Markesbery WR, Mattson MP, Jo DG.

Aging Cell. 2012 Aug;11(4):559-68. doi: 10.1111/j.1474-9726.2012.00817.x. Epub 2012 Apr 9.

5.

Increased 5S rRNA oxidation in Alzheimer's disease.

Ding Q, Zhu H, Zhang B, Soriano A, Burns R, Markesbery WR.

J Alzheimers Dis. 2012;29(1):201-9. doi: 10.3233/JAD-2012-111058.

PMID:
22232003
6.
7.

Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.

Sultana R, Robinson RA, Di Domenico F, Abdul HM, St Clair DK, Markesbery WR, Cai J, Pierce WM, Butterfield DA.

J Proteomics. 2011 Oct 19;74(11):2430-40. doi: 10.1016/j.jprot.2011.06.015. Epub 2011 Jun 25.

8.

Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression.

Bradley MA, Xiong-Fister S, Markesbery WR, Lovell MA.

Neurobiol Aging. 2012 Jun;33(6):1034-44. doi: 10.1016/j.neurobiolaging.2010.08.016. Epub 2010 Oct 20.

9.

Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks.

Gleichmann M, Zhang Y, Wood WH 3rd, Becker KG, Mughal MR, Pazin MJ, van Praag H, Kobilo T, Zonderman AB, Troncoso JC, Markesbery WR, Mattson MP.

Neurobiol Aging. 2012 Jan;33(1):205.e1-18. doi: 10.1016/j.neurobiolaging.2010.08.012. Epub 2010 Oct 13.

10.

Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: insights into memory loss in MCI.

Aluise CD, Robinson RA, Cai J, Pierce WM, Markesbery WR, Butterfield DA.

J Alzheimers Dis. 2011;23(2):257-69. doi: 10.3233/JAD-2010-101083.

PMID:
20930294
11.

Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress.

Ebenezer PJ, Weidner AM, LeVine H 3rd, Markesbery WR, Murphy MP, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Gavilán E, Keller JN.

J Alzheimers Dis. 2010;22(3):839-48. doi: 10.3233/JAD-2010-101161.

12.

Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment.

Huang Q, Aluise CD, Joshi G, Sultana R, St Clair DK, Markesbery WR, Butterfield DA.

J Neurosci Res. 2010 Sep;88(12):2618-29. doi: 10.1002/jnr.22422.

PMID:
20648652
13.

Association between male gender and cortical Lewy body pathology in large autopsy series.

Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR.

J Neurol. 2010 Nov;257(11):1875-81. doi: 10.1007/s00415-010-5630-4. Epub 2010 Jun 20.

14.

Cognitive performance in centenarians and the oldest old: norms from the Georgia Centenarian Study.

Miller LS, Mitchell MB, Woodard JL, Davey A, Martin P, Poon LW, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Johnson MA, Tenover JS, Rodgers WL, Hausman DB, Arnold J, Siegler IC.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2010 Sep;17(5):575-90. doi: 10.1080/13825585.2010.481355. Epub 2010 Jun 2.

15.

Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.

Kramer PL, Xu H, Woltjer RL, Westaway SK, Clark D, Erten-Lyons D, Kaye JA, Welsh-Bohmer KA, Troncoso JC, Markesbery WR, Petersen RC, Turner RS, Kukull WA, Bennett DA, Galasko D, Morris JC, Ott J.

Neurobiol Aging. 2011 Dec;32(12):2113-22. doi: 10.1016/j.neurobiolaging.2010.01.010. Epub 2010 May 7.

16.

Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics.

Aluise CD, Robinson RA, Beckett TL, Murphy MP, Cai J, Pierce WM, Markesbery WR, Butterfield DA.

Neurobiol Dis. 2010 Aug;39(2):221-8. doi: 10.1016/j.nbd.2010.04.011. Epub 2010 Apr 23.

17.

Omega-3 fatty acids: potential role in the management of early Alzheimer's disease.

Jicha GA, Markesbery WR.

Clin Interv Aging. 2010 Apr 7;5:45-61. Review.

18.

Increased protein hydrophobicity in response to aging and Alzheimer disease.

Dasuri K, Ebenezer P, Zhang L, Fernandez-Kim SO, Bruce-Keller AJ, Markesbery WR, Keller JN.

Free Radic Biol Med. 2010 May 15;48(10):1330-7. doi: 10.1016/j.freeradbiomed.2010.02.012. Epub 2010 Feb 24.

19.

Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease.

Bradley MA, Markesbery WR, Lovell MA.

Free Radic Biol Med. 2010 Jun 15;48(12):1570-6. doi: 10.1016/j.freeradbiomed.2010.02.016. Epub 2010 Feb 18.

20.

Social resources and longevity: findings from the Georgia centenarian study.

Randall GK, Martin P, McDonald M, Poon LW; Georgia Centenarian Study, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Woodard JL, Johnson MA, Tenover JS, Siegler IC, Rodgers WL, Hausman DB, Rott C, Davey A, Arnold J.

Gerontology. 2010;56(1):106-11. doi: 10.1159/000272026. Epub 2010 Jan 26.

21.

Distal and proximal resource influences on economic dependency among the oldest old.

MacDonald M, Aneja A, Martin P, Margrett J, Poon LW; Georgia Centenarian Study, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Woodard JL, Johnson MA, Tenover JS, Siegler IC, Rodgers WL, Hausman DB, Rott C, Davey A, Arnold J.

Gerontology. 2010;56(1):100-5. doi: 10.1159/000272025. Epub 2010 Jan 26.

22.

Depression among centenarians and the oldest old: contributions of cognition and personality.

Margrett J, Martin P, Woodard JL, Miller LS, MacDonald M, Baenziger J, Siegler IC, Davey A, Poon L; Georgia Centenarian Study, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Johnson MA, Tenover JS, Rodgers WL, Hausman DB, Rott C, Arnold J.

Gerontology. 2010;56(1):93-9. doi: 10.1159/000272018. Epub 2010 Jan 26.

23.

Predicting happiness among centenarians.

Bishop AJ, Martin P, MacDonald M, Poon L; Georgia Centenarian Study, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Woodard JL, Johnson MA, Tenover JS, Siegler IC, Rodgers WL, Hausman DB, Rott C, Davey A, Arnold J.

Gerontology. 2010;56(1):88-92. doi: 10.1159/000272017. Epub 2010 Jan 26.

24.

Family history and adaptation among centenarians and octogenarians.

Hensley B, Martin P, MacDonald M, Poon L; Georgia Centenarian Study, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Woodard JL, Johnson MA, Tenover JS, Siegler IC, Rodgers WL, Hausman DB, Rott C, Davey A, Arnold J.

Gerontology. 2010;56(1):83-7. doi: 10.1159/000271955. Epub 2010 Jan 26.

25.

Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease.

Bader Lange ML, St Clair D, Markesbery WR, Studzinski CM, Murphy MP, Butterfield DA.

Neurobiol Dis. 2010 Apr;38(1):104-15. doi: 10.1016/j.nbd.2010.01.004. Epub 2010 Jan 18.

26.

Quantitative changes in the mitochondrial proteome from subjects with mild cognitive impairment, early stage, and late stage Alzheimer's disease.

Lynn BC, Wang J, Markesbery WR, Lovell MA.

J Alzheimers Dis. 2010;19(1):325-39. doi: 10.3233/JAD-2010-1254.

27.

Neuropathologic alterations in mild cognitive impairment: a review.

Markesbery WR.

J Alzheimers Dis. 2010;19(1):221-8. doi: 10.3233/JAD-2010-1220. Review.

28.

NOX activity is increased in mild cognitive impairment.

Bruce-Keller AJ, Gupta S, Parrino TE, Knight AG, Ebenezer PJ, Weidner AM, LeVine H 3rd, Keller JN, Markesbery WR.

Antioxid Redox Signal. 2010 Jun 15;12(12):1371-82. doi: 10.1089/ars.2009.2823.

29.

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain.

Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, Younkin SG, Bu G, Estus S.

Mol Neurodegener. 2009 Nov 4;4:46. doi: 10.1186/1750-1326-4-46.

30.

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies.

Nelson PT, Kryscio RJ, Jicha GA, Abner EL, Schmitt FA, Xu LO, Cooper G, Smith CD, Markesbery WR.

Neurology. 2009 Oct 6;73(14):1127-33. doi: 10.1212/WNL.0b013e3181bacf9e.

31.

Low sensitivity in clinical diagnoses of dementia with Lewy bodies.

Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR.

J Neurol. 2010 Mar;257(3):359-66. doi: 10.1007/s00415-009-5324-y. Epub 2009 Oct 1.

32.

The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life.

Iacono D, Markesbery WR, Gross M, Pletnikova O, Rudow G, Zandi P, Troncoso JC.

Neurology. 2009 Sep 1;73(9):665-73. doi: 10.1212/WNL.0b013e3181b01077. Epub 2009 Jul 8.

33.

Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials.

Carr SA, Davis R, Spencer D, Smart M, Hudson J, Freeman S, Cooper GE, Schmitt FA, Markesbery WR, Danner D, Jicha GA.

Alzheimer Dis Assoc Disord. 2010 Apr-Jun;24(2):165-70. doi: 10.1097/WAD.0b013e3181aba927.

34.

Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease.

Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Santacruz K, Smith CD, Patel E, Markesbery WR.

J Neuropathol Exp Neurol. 2009 Jul;68(7):774-84. doi: 10.1097/NEN.0b013e3181aacbe9.

35.

Lewy body pathology in normal elderly subjects.

Markesbery WR, Jicha GA, Liu H, Schmitt FA.

J Neuropathol Exp Neurol. 2009 Jul;68(7):816-22. doi: 10.1097/NEN.0b013e3181ac10a7.

36.

The effect of APOE-epsilon4 on dementia is mediated by Alzheimer neuropathology.

Mortimer JA, Snowdon DA, Markesbery WR.

Alzheimer Dis Assoc Disord. 2009 Apr-Jun;23(2):152-7.

37.

Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease.

Price JL, McKeel DW Jr, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC.

Neurobiol Aging. 2009 Jul;30(7):1026-36. doi: 10.1016/j.neurobiolaging.2009.04.002. Epub 2009 Apr 18.

38.

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD.

Reed TT, Pierce WM, Markesbery WR, Butterfield DA.

Brain Res. 2009 Jun 5;1274:66-76. doi: 10.1016/j.brainres.2009.04.009. Epub 2009 Apr 15.

PMID:
19374891
39.

Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.

Lyubartseva G, Smith JL, Markesbery WR, Lovell MA.

Brain Pathol. 2010 Mar;20(2):343-50. doi: 10.1111/j.1750-3639.2009.00283.x. Epub 2009 Apr 7.

40.

Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice.

Lovell MA, Xiong S, Lyubartseva G, Markesbery WR.

Free Radic Biol Med. 2009 Jun 1;46(11):1527-33. doi: 10.1016/j.freeradbiomed.2009.03.008. Epub 2009 Mar 19.

41.

Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB.

Nelson PT, Kryscio RJ, Abner EL, Schmitt FA, Jicha GA, Mendiondo MS, Cooper G, Smith CB, Markesbery WR.

J Alzheimers Dis. 2009;16(1):29-34. doi: 10.3233/JAD-2009-0926.

42.

Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship.

Nelson PT, Braak H, Markesbery WR.

J Neuropathol Exp Neurol. 2009 Jan;68(1):1-14. doi: 10.1097/NEN.0b013e3181919a48. Review.

43.

Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.

Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim SO, Zhang L, Weidner AM, Markesbery WR, Murphy MP, Keller JN.

J Neurochem. 2009 Feb;108(4):860-6. doi: 10.1111/j.1471-4159.2008.05798.x. Epub 2008 Nov 27.

44.

Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease.

Jicha GA, Schmitt FA, Abner E, Nelson PT, Cooper GE, Smith CD, Markesbery WR.

Neurobiol Aging. 2010 Oct;31(10):1805-13. doi: 10.1016/j.neurobiolaging.2008.09.017. Epub 2008 Nov 20.

45.

Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons.

Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Davis DG, Poduska JW, Patel E, Mendiondo MS, Markesbery WR.

Brain Pathol. 2010 Jan;20(1):66-79. doi: 10.1111/j.1750-3639.2008.00244.x. Epub 2008 Nov 19.

46.

Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment.

Nelson PT, Abner EL, Scheff SW, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Patel E, Markesbery WR.

Neurosci Lett. 2009 Feb 6;450(3):336-9. doi: 10.1016/j.neulet.2008.11.006. Epub 2008 Nov 8.

47.

Serum zinc in the progression of Alzheimer's disease.

Dong J, Robertson JD, Markesbery WR, Lovell MA.

J Alzheimers Dis. 2008 Nov;15(3):443-50.

48.

Human cerebral neuropathology of Type 2 diabetes mellitus.

Nelson PT, Smith CD, Abner EA, Schmitt FA, Scheff SW, Davis GJ, Keller JN, Jicha GA, Davis D, Wang-Xia W, Hartman A, Katz DG, Markesbery WR.

Biochim Biophys Acta. 2009 May;1792(5):454-69. doi: 10.1016/j.bbadis.2008.08.005. Epub 2008 Aug 22. Review.

49.

Improved predictive model for pre-symptomatic mild cognitive impairment and Alzheimer's disease.

Smith CD, Chebrolu H, Markesbery WR, Liu J.

Neurol Res. 2008 Dec;30(10):1091-6. doi: 10.1179/174313208X327973. Epub 2008 Sep 3.

PMID:
18768112
50.

Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age.

Abdul HM, Sultana R, St Clair DK, Markesbery WR, Butterfield DA.

Free Radic Biol Med. 2008 Nov 15;45(10):1420-5. doi: 10.1016/j.freeradbiomed.2008.08.012. Epub 2008 Aug 16.

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