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Items: 1 to 50 of 55

1.

Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam.

Mangat CS, Vadlamani G, Holicek V, Chu M, Larmour VLC, Vocadlo DJ, Mulvey MR, Mark BL.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02112-18. doi: 10.1128/AAC.02112-18. Print 2019 Apr.

PMID:
30782990
2.

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.

Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA.

Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub 2018 Sep 4.

PMID:
30178799
3.

Structural and mechanistic analysis of a β-glycoside phosphorylase identified by screening a metagenomic library.

Macdonald SS, Patel A, Larmour VLC, Morgan-Lang C, Hallam SJ, Mark BL, Withers SG.

J Biol Chem. 2018 Mar 2;293(9):3451-3467. doi: 10.1074/jbc.RA117.000948. Epub 2018 Jan 9.

4.

Structure and Function of Viral Deubiquitinating Enzymes.

Bailey-Elkin BA, Knaap RCM, Kikkert M, Mark BL.

J Mol Biol. 2017 Nov 10;429(22):3441-3470. doi: 10.1016/j.jmb.2017.06.010. Epub 2017 Jun 16. Review.

PMID:
28625850
5.

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.

Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson GG, van Kasteren PB, McLeish NJ, Gu J, He W, Kikkert M, Mark BL, Sidhu SS.

PLoS Pathog. 2017 May 18;13(5):e1006372. doi: 10.1371/journal.ppat.1006372. eCollection 2017 May.

6.

Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics.

Bouquet J, King DT, Vadlamani G, Benzie GR, Iorga B, Ide D, Adachi I, Kato A, Vocadlo DJ, Mark BL, Blériot Y, Désiré J.

Org Biomol Chem. 2017 May 31;15(21):4609-4619. doi: 10.1039/c7ob00838d.

PMID:
28513749
7.

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance.

Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL.

Protein Sci. 2017 Jun;26(6):1161-1170. doi: 10.1002/pro.3166. Epub 2017 Apr 7.

8.

Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa.

Hamou-Segarra M, Zamorano L, Vadlamani G, Chu M, Sanchez-Diener I, Juan C, Blazquez J, Hattie M, Stubbs KA, Mark BL, Oliver A.

J Antimicrob Chemother. 2017 Feb;72(2):448-454. doi: 10.1093/jac/dkw456. Epub 2016 Dec 20.

PMID:
27999022
9.

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance.

Perley-Robertson GE, Yadav AK, Winogrodzki JL, Stubbs KA, Mark BL, Vocadlo DJ.

ACS Chem Biol. 2016 Sep 16;11(9):2626-35. doi: 10.1021/acschembio.6b00552. Epub 2016 Aug 5.

10.

N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases.

Santana AG, Vadlamani G, Mark BL, Withers SG.

Chem Commun (Camb). 2016 Jun 28;52(51):7943-6. doi: 10.1039/c6cc02520j. Epub 2016 Jun 2.

PMID:
27253678
11.

Systemic Gene Transfer of a Hexosaminidase Variant Using an scAAV9.47 Vector Corrects GM2 Gangliosidosis in Sandhoff Mice.

Osmon KJ, Woodley E, Thompson P, Ong K, Karumuthil-Melethil S, Keimel JG, Mark BL, Mahuran D, Gray SJ, Walia JS.

Hum Gene Ther. 2016 Jul;27(7):497-508. doi: 10.1089/hum.2016.015.

PMID:
27199088
12.

Novel Vector Design and Hexosaminidase Variant Enabling Self-Complementary Adeno-Associated Virus for the Treatment of Tay-Sachs Disease.

Karumuthil-Melethil S, Nagabhushan Kalburgi S, Thompson P, Tropak M, Kaytor MD, Keimel JG, Mark BL, Mahuran D, Walia JS, Gray SJ.

Hum Gene Ther. 2016 Jul;27(7):509-21. doi: 10.1089/hum.2016.013.

13.

Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo.

Tropak MB, Yonekawa S, Karumuthil-Melethil S, Thompson P, Wakarchuk W, Gray SJ, Walia JS, Mark BL, Mahuran D.

Mol Ther Methods Clin Dev. 2016 Mar 2;3:15057. doi: 10.1038/mtm.2015.57. eCollection 2016.

14.

Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium.

Zaloba P, Bailey-Elkin BA, Derksen M, Mark BL.

PLoS One. 2016 Feb 12;11(2):e0149204. doi: 10.1371/journal.pone.0149204. eCollection 2016.

15.

Producing glucose 6-phosphate from cellulosic biomass: structural insights into levoglucosan bioconversion.

Bacik JP, Klesmith JR, Whitehead TA, Jarboe LR, Unkefer CJ, Mark BL, Michalczyk R.

J Biol Chem. 2015 Oct 30;290(44):26638-48. doi: 10.1074/jbc.M115.674614. Epub 2015 Sep 9.

16.

The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide.

Vadlamani G, Thomas MD, Patel TR, Donald LJ, Reeve TM, Stetefeld J, Standing KG, Vocadlo DJ, Mark BL.

J Biol Chem. 2015 Jan 30;290(5):2630-43. doi: 10.1074/jbc.M114.618199. Epub 2014 Dec 5.

17.

Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.

Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL.

J Biol Chem. 2014 Dec 12;289(50):34667-82. doi: 10.1074/jbc.M114.609644. Epub 2014 Oct 15.

18.

Transactivation of programmed ribosomal frameshifting by a viral protein.

Li Y, Treffers EE, Napthine S, Tas A, Zhu L, Sun Z, Bell S, Mark BL, van Veelen PA, van Hemert MJ, Firth AE, Brierley I, Snijder EJ, Fang Y.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2172-81. doi: 10.1073/pnas.1321930111. Epub 2014 May 13.

19.

Viral OTU deubiquitinases: a structural and functional comparison.

Bailey-Elkin BA, van Kasteren PB, Snijder EJ, Kikkert M, Mark BL.

PLoS Pathog. 2014 Mar 27;10(3):e1003894. doi: 10.1371/journal.ppat.1003894. eCollection 2014 Mar. Review.

20.

Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle.

Bacik JP, Tavassoli M, Patel TR, McKenna SA, Vocadlo DJ, Khajehpour M, Mark BL.

J Biol Chem. 2014 Feb 14;289(7):4504-14. doi: 10.1074/jbc.M113.521633. Epub 2013 Dec 20.

21.

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams.

Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Blériot Y.

Chem Commun (Camb). 2013 Dec 4;49(93):10983-5. doi: 10.1039/c3cc46646a.

PMID:
24136176
22.

The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams.

Stubbs KA, Bacik JP, Perley-Robertson GE, Whitworth GE, Gloster TM, Vocadlo DJ, Mark BL.

Chembiochem. 2013 Oct 11;14(15):1973-81. doi: 10.1002/cbic.201300395. Epub 2013 Sep 5.

23.

In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside.

Sinici I, Yonekawa S, Tkachyova I, Gray SJ, Samulski RJ, Wakarchuk W, Mark BL, Mahuran DJ.

PLoS One. 2013;8(3):e57908. doi: 10.1371/journal.pone.0057908. Epub 2013 Mar 4.

24.

Platelet hexosaminidase a enzyme assay effectively detects carriers missed by targeted DNA mutation analysis.

Nakagawa S, Zhan J, Sun W, Ferreira JC, Keiles S, Hambuch T, Kammesheidt A, Mark BL, Schneider A, Gross S, Schreiber-Agus N.

JIMD Rep. 2012;6:1-6. doi: 10.1007/8904_2011_120. Epub 2012 Jan 31.

25.

Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.

van Kasteren PB, Bailey-Elkin BA, James TW, Ninaber DK, Beugeling C, Khajehpour M, Snijder EJ, Mark BL, Kikkert M.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E838-47. doi: 10.1073/pnas.1218464110. Epub 2013 Feb 11.

26.

Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion.

Bacik JP, Whitworth GE, Stubbs KA, Vocadlo DJ, Mark BL.

Chem Biol. 2012 Nov 21;19(11):1471-82. doi: 10.1016/j.chembiol.2012.09.016.

27.

Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway.

Mark BL, Vocadlo DJ, Oliver A.

Future Microbiol. 2011 Dec;6(12):1415-27. doi: 10.2217/fmb.11.128. Review. Erratum in: Future Microbiol. 2012 Feb;7(2):306.

PMID:
22122439
28.

Experimental mapping of soluble protein domains using a hierarchical approach.

Pedelacq JD, Nguyen HB, Cabantous S, Mark BL, Listwan P, Bell C, Friedland N, Lockard M, Faille A, Mourey L, Terwilliger TC, Waldo GS.

Nucleic Acids Res. 2011 Oct;39(18):e125. doi: 10.1093/nar/gkr548. Epub 2011 Jul 19.

29.

Phenylalanine induces Burkholderia cenocepacia phenylacetic acid catabolism through degradation to phenylacetyl-CoA in synthetic cystic fibrosis sputum medium.

Yudistira H, McClarty L, Bloodworth RA, Hammond SA, Butcher H, Mark BL, Cardona ST.

Microb Pathog. 2011 Sep;51(3):186-93. doi: 10.1016/j.micpath.2011.04.002. Epub 2011 Apr 13.

PMID:
21511027
30.

AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains.

Zamorano L, Reeve TM, Juan C, Moyá B, Cabot G, Vocadlo DJ, Mark BL, Oliver A.

Antimicrob Agents Chemother. 2011 May;55(5):1990-6. doi: 10.1128/AAC.01688-10. Epub 2011 Feb 28.

31.

Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase.

Bacik JP, Whitworth GE, Stubbs KA, Yadav AK, Martin DR, Bailey-Elkin BA, Vocadlo DJ, Mark BL.

J Biol Chem. 2011 Apr 8;286(14):12283-91. doi: 10.1074/jbc.M110.198317. Epub 2011 Feb 2.

32.

Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.

James TW, Frias-Staheli N, Bacik JP, Levingston Macleod JM, Khajehpour M, García-Sastre A, Mark BL.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2222-7. doi: 10.1073/pnas.1013388108. Epub 2011 Jan 18.

33.

Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase.

Balcewich MD, Reeve TM, Orlikow EA, Donald LJ, Vocadlo DJ, Mark BL.

J Mol Biol. 2010 Jul 30;400(5):998-1010. doi: 10.1016/j.jmb.2010.05.040. Epub 2010 May 31.

PMID:
20594961
34.

NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa.

Zamorano L, Reeve TM, Deng L, Juan C, Moyá B, Cabot G, Vocadlo DJ, Mark BL, Oliver A.

Antimicrob Agents Chemother. 2010 Sep;54(9):3557-63. doi: 10.1128/AAC.00385-10. Epub 2010 Jun 21.

35.

Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ.

Balcewich MD, Stubbs KA, He Y, James TW, Davies GJ, Vocadlo DJ, Mark BL.

Protein Sci. 2009 Jul;18(7):1541-51. doi: 10.1002/pro.137.

36.

Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome.

Armistead J, Khatkar S, Meyer B, Mark BL, Patel N, Coghlan G, Lamont RE, Liu S, Wiechert J, Cattini PA, Koetter P, Wrogemann K, Greenberg CR, Entian KD, Zelinski T, Triggs-Raine B.

Am J Hum Genet. 2009 Jun;84(6):728-39. doi: 10.1016/j.ajhg.2009.04.017. Epub 2009 May 21.

37.

Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa.

Asgarali A, Stubbs KA, Oliver A, Vocadlo DJ, Mark BL.

Antimicrob Agents Chemother. 2009 Jun;53(6):2274-82. doi: 10.1128/AAC.01617-08. Epub 2009 Mar 9.

38.

Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ.

Stubbs KA, Scaffidi A, Debowski AW, Mark BL, Stick RV, Vocadlo DJ.

J Am Chem Soc. 2008 Jan 9;130(1):327-35. Epub 2007 Dec 8.

PMID:
18067297
39.

Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance.

Stubbs KA, Balcewich M, Mark BL, Vocadlo DJ.

J Biol Chem. 2007 Jul 20;282(29):21382-91. Epub 2007 Apr 16.

40.

Evaluation of the risk for Tay-Sachs disease in individuals of French Canadian ancestry living in new England.

Martin DC, Mark BL, Triggs-Raine BL, Natowicz MR.

Clin Chem. 2007 Mar;53(3):392-8. Epub 2007 Jan 26.

41.

Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.

Lemieux MJ, Mark BL, Cherney MM, Withers SG, Mahuran DJ, James MN.

J Mol Biol. 2006 Jun 16;359(4):913-29. Epub 2006 Apr 27.

42.

Vitamin D and autoimmune disease--implications for practice from the multiple sclerosis literature.

Mark BL, Carson JA.

J Am Diet Assoc. 2006 Mar;106(3):418-24. Review.

PMID:
16503232
43.
44.

Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.

Mark BL, Mahuran DJ, Cherney MM, Zhao D, Knapp S, James MN.

J Mol Biol. 2003 Apr 11;327(5):1093-109.

45.
46.

Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.

Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN.

J Biol Chem. 2002 Oct 18;277(42):39960-6. Epub 2002 Aug 5.

47.

Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.

Mark BL, Vocadlo DJ, Zhao D, Knapp S, Withers SG, James MN.

J Biol Chem. 2001 Nov 9;276(45):42131-7. Epub 2001 Aug 24.

48.

(E)-1-(2'-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-(2-iodovinyl)benzene.

Mark BL, Parrish JC, Wang ZX, Wiebe LI, Knaus EE, James MN.

Acta Crystallogr C. 2001 Jun;57(Pt 6):758-60. Epub 2001 Jun 12.

PMID:
11408697
49.

Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.

Mark BL, Vocadlo DJ, Knapp S, Triggs-Raine BL, Withers SG, James MN.

J Biol Chem. 2001 Mar 30;276(13):10330-7. Epub 2000 Dec 21.

50.

Structural and functional characterization of Streptomyces plicatus beta-N-acetylhexosaminidase by comparative molecular modeling and site-directed mutagenesis.

Mark BL, Wasney GA, Salo TJ, Khan AR, Cao Z, Robbins PW, James MN, Triggs-Raine BL.

J Biol Chem. 1998 Jul 31;273(31):19618-24.

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